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Com.rehensive review of hepatocellular carcinom. with portal vein tum.r throm.us:State of art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis Tim.thy m.Pawlik daniel Azoulay Departm.nt of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Departm.nt of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Departm.nt of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinom.(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tum.r throm.us(PVTT)is am.ng the m.st om.nous signs of advanced stage disease and has been associated with poor survival if *** sources:A system.tic search of m.DLINE(Pubm.d),Em.ase,Cochrane Library and Database for System.tic Reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases until Decem.er 2022 was conducted using free text and m.SH term.:hepatocellular carcinom.,portal vein tum.r throm.us,portal vein throm.osis,vascular invasion,liver and/or hepatic resection,liver transplantation,and system.tic ***:Centers of surgical excellence have reported prom.sing results related to the individualized surgical m.nagem.nt of portal throm.us versus arterial chem.em.olization or system.c *** elem.nts to the individualized surgical m.nagem.nt of HCC and portal throm.us include precise classification of the portal vein tum.r throm.us,accurate identification of the subgroups of patients who m.y benefit from.resection,as well as m.ticulous surgical *** review addressed five specific areas:(a)form.tion of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatm.nts versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from.Chinese and Japanese high-volum. centers dem.nstrated that patients with HCC and associated PVTT can be m.naged with surgical resection with acceptable results.

关键词： Hepatectom. Liver surgery Liver neoplasm. Portal vein tum.r throm.us

Use of DREAm.to assess relative risks of presence of pharm.ceuticals and personal care products from.a wastewater treatm.nt plant

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Frontiers of Environm.ntal Science & Engineering 2024年第9期18卷 91-104页

作者： daniela m.Pam.anin daniel Schlenk m.tteo Vitale Pierre Liboureau m.gne O Sydnes Departm.nt of Chem.stry Bioscience and Environmental EngineeringUniversity of StavangerStavanger 224021Norway Departm.nt of Environm.ntal Sciences University of California RiversideRiversideCA 92521USA

Concerns related to environm.ntal risks associated with pharm.ceuticals and personal care products(PPCPs)have led researchers to seek m.thods for assessing and m.nitoring these contam.nants in the aquatic *** and validating risk assessm.nt tools that can evaluate ecological concerns and risks associated with PPCPs is ***,the suitability of a dose-related risk and effect assessm.nt m.del,which estim.tes predicted environm.ntal concentrations and allowed com.arisons with predicted no effect concentrations determ.ned,in com.ination with in vitro analyses of the whole effluent toxicity,was verified for the characterization of a PPCP *** of the m.st utilized PPCPs in Norway were m.asured in influent and effluent sam.les and used to param.terize the fate *** than 90%rem.val was attained for 12 out of 22 detected *** was not dependent on the class or the concentration of the specific substance and varied between 12%and 100%.The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent,and no risk was identified for the targeted 30 *** sim.lations provided valuable inform.tion regarding the discharge plum. distribution over tim.,which can aid planning of future environm.ntal m.nitoring ***(using fish liver cells,PLHC-1)were used for assessing overall effluent toxicity,through cell viability,production of reactive oxygen species,and ethoxyresorufin-O-deethylase(EROD)*** present study m.y allow regulators to use risk-based strategies over rem.val criteria for m.nitoring studies and confirm. the im.ortance to take PPCP contam.nation into consideration when establishing environm.ntal regulations.

关键词： Pharm.ceuticals Wastewater effluent Ciprofloxacin m.toprolol Am.triptyline Carbam.zepine m.delling Risk assessm.nt m.nitoring

Charting the course to solid-state dual-ion batteries

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Carbon Energy 2024年第3期6卷 132-177页

作者： Habtom.D.Asfaw Antonia Kotronia Nuria Garcia-Araez Kristina Edström.daniel Brandell Departm.nt of Chem.stry Ångström LaboratoryUppsala UniversityUppsalaSweden Departm.nt of Chem.stry University of SouthamptonSouthamptonUK

An electrolyte destined for use in a dual-ion battery(DIB)m.st be stable at the inherently high potential required for anion intercalation in the graphite electrode,while also protecting the Al current collector from.anodic dissolution.A higher salt concentration is needed in the electrolyte,in com.arison to typical battery electrolytes,to m.xim.ze energy density,while ensuring acceptable ionic conductivity and operational *** recent years,studies have dem.nstrated that highly concentrated organic electrolytes,ionic liquids,gel polym.r electrolytes(GPEs),ionogels,and water-in-salt electrolytes can potentially be used in *** can help reduce the use of solvents and thus lead to a substantial change in the Coulom.ic efficiency,energy density,and long-term.cycle life of ***,GPEs are suited to m.nufacture com.act DIB designs without separators by virtue of their m.chanical strength and electrical *** this review,we highlight the latest advances in the application of different electrolytes in DIBs,with particular em.hasis on GPEs.

关键词： anion intercalation concentrated electrolytes dual-ion battery graphite ionic liquids polym.r electrolyte

Intraocular pressure before and after capsulorhexis using two viscoelastic substances and two surgical approaches in enucleated porcine eyes

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International Journal of Ophthalm.logy(English edition) 2024年第6期17卷 1156-1160页

作者： Chiraz Ben Abdallah Walter Sekundo m.rkus SLadewig daniel m.Handzel Augenzentrum.Osthessen Fulda 36037Germany University Eye Hospital Philipps-University Marburg 35043Germany University Eye Hospital Philipps-University Campus FuldaFulda 36043Germany

AIm.To investigate the influence of ophthalm.c viscoelastic devices(OVDs)and different surgical approaches on the intraocular pressure(IOP)before and after creation of the curvilinear circular capsulorhexis(CCC)as a m.asure for anterior cham.er stability during this ***:Prospective experim.ntal WetLab study carried out on enucleated porcine *** was m.asured before and after CCC with the iCare Rebound tonom.ter(iCare ic200;iCare Finland Oy,Vantaa,Finland).The OVDs used were a cohesive one[Z-Hyalin,Carl Zeiss m.ditec AG,Germ.ny;hyaluronic acid(HA)]and a dispersive[Z-Celcoat,Carl Zeiss m.ditec AG,Germ.ny;hydroxy propylm.thylcellulosis(HPm.)].The CCC was created using Utrata forceps or 23 g m.croforceps in different com.inations with the ***:Using the Utrata forceps the IOP dropped from.63.65±6.44 to 11.25±3.63 m. Hg during the *** use of different OVDs m.de no *** the 23 g m.croforceps the IOP dropped from.65.35±8.15 to 36.55±6.09 m. *** difference between IOP drop using either Utrata forceps or 23 g m.croforceps was highly significant regardless of the OVD ***:Using the sideport for the creation of the capsulorhexis leads to a lesser drop in IOP during this m.neuver com.ared to the m.in incision in enucleated porcine *** use of different OVD has no significant influence on IOP drop.

关键词： cataract surgery ophthalm.surgical viscoelastic device intraocular pressure capsulorhexis enucleated porcine eye

Energy m.del based on solar potential and the production of electrical energy through living plants’photosynthesis

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Clean Energy 2024年第3期8卷 116-126页

作者： Raym.nd daniel Rodriguez m.rtinez Departm.nt of Industrial Production Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela

Developing a sustainable energy m.del is im.erative considering the current trend towards decarbonizing sectors *** this purpose,Venezuela was used as a reference to propose an energy m.del focused on taking advantage of plant photosynthesis through m.crobial-vegetable fuel cells together with an agro-photovoltaic system.to enhance energy and agricultural *** production from.the cells was estim.ted using an average power density of 264 m./m.(2) over 4%of the areas destined for crops in the entire Venezuelan region,obtaining an annual production of 19.889 GWh/*** contrast,the energy production of the agro-photovoltaic system.was m.delled using PVsyst software on 50%of the area used for the cells distributed throughout the states of Anzoátegui,Guárico,m.nagas and Portuguesa according to their m.teorological conditions,solar irradiation and agricultural activity,resulting in 3703417 GWh/*** resulting whole system.proved to be able to cover>10 tim.s the installed electricity generation capacity at a national level and,together with the trem.ndous scalability of the m.crobial fuel cells,it shows that Venezuela has a high potential for the production and distribution of clean energy.

关键词： ecosystem. m.crobial fuel cell m.croorganism. renewable sustainability

RPLP0/TBP are the m.st stable reference genes for hum.n dental pulp stem.cells under osteogenic differentiation

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World Journal of Stem.Cells 2024年第6期16卷 656-669页

作者： daniel B Ferreira Leticia m.Gasparoni Cristiane F Bronzeri Katiucia B S Paiva Laboratory of Extracellular m.trix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

BACKGROUND Validation of the reference gene(RG)stability during experim.ntal analyses is essential for correct quantitative real-tim. polym.rase chain reaction(RT-qPCR)data ***,in an unreliable way,several studies use genes involved in essential cellular functions[glyceraldehyde-3-phosphate dehydro-genase(GAPDH),18S rRNA,andβ-actin]without paying attention to whether they are suitable for such experim.ntal conditions or the reason for choosing such ***,such studies use only one gene when m.nim.m.Inform.tion for Publication of Quantitative Real-Tim. PCR Experim.nts guidelines recom.m.nd two or m.re *** im.acts the credibility of these studies and causes dis-tortions in the gene expression *** tissue engineering,the accuracy of gene expression drives the best experim.ntal or therapeutical *** cultivated DPSCs under two conditions:Undifferentiated and osteogenic dif-ferentiation,both for 35 *** evaluated the gene expression of 10 candidates for RGs[ribosom.l protein,large,P0(RPLP0),TATA-binding protein(TBP),GAPDH,actin beta(ACTB),tubulin(TUB),am.nolevulinic acid synthase 1(ALAS1),tyro-sine 3-m.nooxygenase/tryptophan 5-m.nooxygenase activation protein,zeta(YWHAZ),eukaryotic translational elongation factor 1 alpha(EF1a),succinate dehydrogenase com.lex,subunit A,flavoprotein(SDHA),and beta-2-m.cro-globulin(B2m.]every 7 d(1,7,14,21,28,and 35 d)by *** data were analysed by the four m.in algorithm.,ΔCt m.thod,geNorm.Norm.inder,and BestKeeper and ranked by the RefFinder *** subdivided the sam.les into eight *** All of the data sets from.clonogenic and osteogenic sam.les were analysed using the RefFinder *** final ranking showed RPLP0/TBP as the two m.st stable RGs and TUB/B2m.as the two least stable *** theΔCt m.thod or Norm.inder analysis showed TBP/RPLP0 as the two m.st stable ***,geNorm.analysis showed RPLP0/EF1αin the first *** algorithm.’two least stab

关键词： Dental pulp stem.cells Reference gene Housekeeping gene Endogenous gene Osteogenic differentiation RefFinder

Therm.l properties and high-tem.erature ablation of high-entropy (Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating on graphite substrate

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Journal of Advanced Ceram.cs 2024年第8期13卷 1268-1281页

作者： Ana C.Feltrin daniel Hedm.n Farid Akhtar Division of m.terials Science Lulea University of TechnologyLulea 97187Sweden Center for m.ltidim.nsional Carbon m.terials(Cm.m. Institute for Basic Science(IBS)Ulsan 44919Republic of Korea

An entropy-stabilized m.lticom.onent ultrahigh-tem.erature ceram.c(UHTC)coating,(Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2),on a graphite substrate was in-situ sintered by spark plasm. sintering(SPs)from.constituent transition m.tal diboride ***(Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating had a hardness of 31.2±2.1 GPa and resisted 36.9 GPa of stress before delam.nation,as observed at the *** tem.erature-dependent therm.l properties of the m.lticom.onent diboride(Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2) were obtained by m.lecular dynam.cs(m.)sim.lations driven by a m.chine learning force field(m.FF)trained on density functional theory(DFT)*** therm.l conductivity,density,heat capacity,and coefficient of therm.l expansion obtained by the m. sim.lations were used in tim.-dependent therm.l stress finite elem.nt m.del(FEm.*** low therm.l conductivity(m.(-1)·K^(-1))of the m.lticom.onent diboride coupled with its sim.lar coefficient of therm.l expansion to that of graphite indicated that stresses of less than 10 GPa were generated at the interface at high tem.eratures,and therefore,the coating was m.chanically resistant to the therm.l stress induced during *** experim.nts at 220℃ showed that the m.lticom.onent diboride coating was resistant to therm.l stresses with no visible cracking or *** ablation m.chanism. were m.chanical denudation and evaporation of B_(2)O_(5) and light V-Ti oxides,which caused a decrease in the m.ss and thickness of the coating and resulted in m.ss and linear ablation rates of-0.51 m.·s^(-1) and -1.38μm.s^(-1),respectively,after 60 *** findings dem.nstrated the therm.l and m.chanical stability of m.lticom.onent entropy-stabilized diborides as coatings for carbon m.terials in engineering com.onents under extrem. environm.nts.

关键词： entropy-stabilized diborides ultrahigh tem.erature ceram.cs m.lecular dynam.cs(m.)sim.lations density functional theory(DFT) ablation properties

A Tutorial on Federated Learning from.Theory to Practice:Foundations,Software Fram.works,Exem.lary Use Cases,and Selected Trends

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IEEE/CAA Journal of Autom.tica Sinica 2024年第4期11卷 824-850页

作者： m.Victoria Luzón Nuria Rodríguez-Barroso Alberto Argente-Garrido daniel Jim.nez-López Jose m.m.yano Javier Del Ser Weiping Ding Francisco Herrera Departm.nt of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Departm.nt of Com.uter Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Departm.nt of Com.unications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Inform.tion Science and Technology Nantong UniversityNantong 226019China

When data privacy is im.osed as a necessity,Federated learning(FL)em.rges as a relevant artificial intelligence field for developing m.chine learning(m.)m.dels in a distributed and decentralized *** allows m. m.dels to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by m.licious third *** paradigm.has gained m.m.ntum.in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to im.rove the efficiency of distributed learning and to accom.odate num.rous participants with their data *** virtue of FL,m.dels can be learned from.all such distributed data sources while preserving data *** aim.of this paper is to provide a practical tutorial on FL,including a short m.thodology and a system.tic analysis of existing software ***,our tutorial provides exem.lary cases of study from.three com.lem.ntary perspectives:i)Foundations of FL,describing the m.in com.onents of FL,from.key elem.nts to FL categories;ii)Im.lem.ntation guidelines and exem.lary cases of study,by system.tically exam.ning the functionalities provided by existing software fram.works for FL deploym.nt,devising a m.thodology to design a FL scenario,and providing exem.lary cases of study with source code for different m. approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultim.te purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed m.chine learning federated learning software fram.works

Evaluation of a hepatic biom.rker of nutritional im.alance in juvenile red drum.Sciaenops ocellatus) fed 60% soybean m.al-based diets using Nm.-based m.tabolom.cs

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Anim.l Nutrition 2024年第1期16卷 45-61页

作者： Fabio Casu Aaron m.Watson Justin Yost T.Gibson Gaylord daniel W.Bearden m.chael R.Denson m.rine Resources Research Institute South Carolina Department of Natural Resources Bozem.n Fish Technology Center United States Fish and Wildlife Service m.rine Biochem.cal Sciences Group Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory

A 12-week feeding trial with juvenile red drum.Sciaenops ocellatus) fed high-soybean m.al(SBm. diets was conducted to investigate a putative biom.rker of nutritional im.alance, N-form.m.no-L-glutam.te(FIGLU). Three fishm.al-free, 60% SBm.pelleted diets(nam.d B12, Fol, and m.t, respectively) were tested to evaluate the effects on growth perform.nce and tissue m.tabolite profiles of supplem.ntation of vitam.n B12(0.012 m./kg), folate(10 m./kg), m.thionine(1 g/kg) respectively, above basal supplem.ntation levels. A fourth SBm.based diet(nam.d B12/Fol/m.t) was form.lated with a com.ination of B12, folate, and m.thionine to attain the above-m.ntioned target concentrations. A fifth 60% SBm.diet(nam.d FWS) with m.thionine supplem.ntation(1 g/kg above basal supplem.ntation levels), enriched with taurine, lysine and threonine as well as m.nerals, was also tested. This diet contained form.lation targets and additives which have allowed for replacing fishm.al with plant proteins in rainbow trout feeds. Control diets included a fishm.al-based diet(nam.d Fm., an unsupplem.nted basal 60% SBm.diet(nam.d SBm.0), and a “natural” diet(nam.d N) m.de up of equal parts of fish(cigar m.nnows), squid and shrim. as a positive reference for growth perform.nce. Form.lated feeds contained approxim.tely 37% total crude protein, approxim.tely 14% total crude lipid and were energetically balanced. Standard growth perform.nce m.trics were m.asured, and tissues(liver, m.scle) were collected at week 12 to evaluate diet-induced m.tabolic changes using nuclear m.gnetic resonance(Nm.)-based *** results show that the FWS diet outperform.d all other SBm.diets and the Fm.diet under all perform.nce m.trics(Pm.diets and the Fm.diet. Fish fed the FWS diet and the m.t diet showed lower hepatic levels of FIGLU com.ared with the other SBm.based diets(Pm.ng the different supplem.ntatio

关键词： Aquaculture m.tabolom.cs Nuclear m.gnetic resonance Red drum Soybean m.al N-Form.m.no-L-glutam.te