检索结果-南通市图书馆

Early-onset colorectal cancer:A separate subset of colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第46期20卷 17288-17296页

作者： Irene Osorio Silla daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea Department of Surgery 12 de Octubre University HospitalMadrid 28041Spain Molecular Biology laboratory 12 de Octubre University HospitalMadrid 28041Spain Department of Pathology 12 de Octubre University HospitalMadrid 28041Spain Centre for Cancer Research Medical University of SalamancaSalamanca 37008Spain

Colorectal cancer(CRC)has a great impact on the world *** increasing frequency,CRC is described according to the presenting phenotype,based on its molecular *** of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized ***-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of *** molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial ***,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular *** purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular ***,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC.

关键词： Chromosomal instability CpG island methylator phenotype Early-onset colorectal cancer Lynch syndrome Microsatellite instability

Gastric polyps are not created equal: Know your enemy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 144-146页

作者： Fady daniel Department of Gastroenterology and Hepatology American University of Beirut Medical CenterBeirut 11072020Lebanon

Gastric polyps are commonly detected during upper gastrointestinal *** are most often benign and rarely become ***,adequate knowledge,diagnostic modalities,and management strategies should be the endoscopist’s readily available“weapons”to defeat the potentially malignant“enemies”.This article sheds light on the valuable effort by Costa et al to generate a new classification system of gastric polyps as“good”,“bad”,and“ugly”.This comprehensive overview provides clinicians with a simplified decision-making process.

关键词： Gastric polyps Polypoid subepithelial lesions Early gastric cancer Endoscopic ultrasonography Electronic chromoendoscopy

Kernel-Based State-Space Kriging for Predictive Control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2023年第5期10卷 1263-1275页

作者： A.daniel Carnerero daniel R.Ramirez daniel Limon Teodoro Alamo the Department of System Engineering and Automation University of SevilleSevilla 41020Spain the School of Engineering Tokyo Institute of TechnologyTokyo 152-8552Japan Department of System Engineering and Automation University of SevilleSevilla 41020Spain

In this paper, we extend the state-space kriging(SSK) modeling technique presented in a previous work by the authors in order to consider non-autonomous systems. SSK is a data-driven method that computes predictions as linear combinations of past outputs. To model the nonlinear dynamics of the system, we propose the kernel-based state-space kriging(K-SSK), a new version of the SSK where kernel functions are used instead of resorting to considerations about the locality of the data. Also, a Kalman filter can be used to improve the predictions at each time step in the case of noisy measurements. A constrained tracking nonlinear model predictive control(NMPC) scheme using the black-box input-output model obtained by means of the K-SSK prediction method is proposed. Finally, a simulation example and a real experiment are provided in order to assess the performance of the proposed controller.

关键词： Data-driven methods model identification Kernel methods predictive control

Nanosecond modulation of thermal emission

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 574-576页

作者： daniel Wasserman Department of Electrical and Computer Engineering University of Texas AustinAustinTX 78758USA

Femtosecond laser pulses are used to modulate the thermal emission from semiconductor materials at the nanosecond timescale.A visible-frequency laser photoexcites energetic free carriers in intrinsic Si and GaAs *** these free carriers return to equilibrium,they not only emit thermal radiation on a picosecond time scale but also modulate the semiconductor thermal emission on a nanosecond to microsecond time scale,offering a novel route towards ultrafast infrared optical pulses.

关键词： thermal laser Femto

Space Deformations,Surface Deformations and the Opportunities In-Between

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2009年第1期24卷 2-5页

作者： daniel Cohen-Or School of Computer Science Tel-Aviv UniversityIsrael

In recent years we have witnessed a large interest in surface deformation techniques. This has been a reaction that can be attributed to the ability to develop techniques which are detail-preserving. Space deformation techniques, on the other hand, received less attention, but nevertheless they have many advantages over surface-based techniques. This paper explores the potential of these two approaches to deformation and discusses the opportunities that the fusion of the two may lead to.

关键词： space deformation mesh editing digital surfaces

Low-power SiPM readout BETA ASIC for space applications

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第3期35卷 153-169页

作者： Anand Sanmukh Sergio Gómez Albert Comerma Joan Mauricio Rafel Manera Andreu Sanuy daniel Guberman Roger Catala Albert Espinya Marina Orta Oscar de la Torre David Gascon Departament de Física Quàntica i Astrofísica(FQA) Institut de Ciències del Cosmos(ICCUB)Universitat de Barcelona(UB)08028 BarcelonaSpain Institut d’Estudis Espacials de Catalunya(IEEC) 08034 BarcelonaSpain Electronics Department Serra Hunter fellow at Polytechnic University of Catalonia(UPC)08019 BarcelonaSpain

The BETA application-specific integrated circuit(ASIC)is a fully programmable chip designed to amplify,shape and digitize the signal of up to 64 Silicon photomultiplier(SiPM)channels,with a power consumption of approximately~1 mW/*** to its dual-path gain,the BETA chip is capable of resolving single photoelectrons(phes)with a signal-to-noise ratio(SNR)>5 while simultaneously achieving a dynamic range of~4000 ***,BETA can provide a cost-effective solution for the readout of SiPMs in space missions and other applications with a maximum rate below 10 *** this study,we describe the key characteristics of the BETA ASIC and present an evaluation of the performance of its 16-channel version,which is implemented using 130 nm *** ASIC also contains two discriminators that can provide trigger signals with a time jitter down to 400 ps FWHM for 10 *** linearity error of the charge gain measurement was less than 2%for a dynamic range as large as 15 bits.

关键词： Radiation detectors Silicon photomultipliers Photon sensors Front-end electronics Mixed-mode ASICs Space technology

Fluidization behavior and reducibility of iron ore fines during hydrogen-induced fluidized bed reduction

在线全文

学校读者我要写书评

暂无评论

Particuology 2020年第5期18卷 36-46页

作者： daniel Spreitzer Johannes Schenk Chair of Ferrous Metallurgy Montanuniversitaet LeobenFranz-Josef-Straβe 188700 LeobenAustria

A laboratory fluidized bed reactor was used to investigate the fluidization behavior and reducibility of various iron ore *** was chosen as a reducing agent across a temperature range of 873-1073 *** magnetite ore used exhibited strong sticking behavior after the initiation of metallic iron *** other tested ores fluidized sufficiently well when subjected to the same high reduction *** kinetic analysis was conducted using a previously developed model to include three rate-limiting step *** trend of apparent activation energy was correlated with the degree of ***,the influence of varying the specific gas rate was *** results show the variation in reducibility as a result of different interactions,which influence the rate-limiting mechanisms of nucleation and the undertaken chemical reactions,which vary as a function of temperature and degree of *** apparent activation energies,determined from the reduction of wtistite to metallic iron,were in the range of 15-60 kJ/mol,depending on the iron ore used and the degree of *** change in apparent activation energy deriving from the increased specific gas rate can be explained by an increasing nucleation effect,especially at lower reduction temperatures.

关键词： Fluidized bed Iron ore reduction Hydrogen Fluidization behavior Kinetic analysis

Interplay of transport processes and interfacial chemistry affecting chromium reduction and reoxidation with iron and manganese

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2020年第5期14卷 55-63页

作者： Chao Pan daniel Giammar Department of Energy Environmentaland Chemical EngineeringWashington University in St.LouisSt.LouisMO 63130USA Present affiliation:Glenn *** Institute Physical&Life SciencesLawrence Livermore National LaboratoryLivermoreCA 94550USA

Hexavalent chromium(Cr(Ⅵ))is a water-soluble pollutant in soil and groundwater,the mobility,bioavailability,and toxicity of which can be controlled by transforming to less mobile and more environmentally benign Cr(Ⅲ)by ways of *** review focused on recent advances in identifying the reaction pathways,kinetics,and products of iron-based techniques for Cr(Ⅵ)*** also examines new information regarding remobilization of Cr(Ⅲ)in the existence of complexing ligands and manganese(Mn)of different oxidation states.A range of iron-based techniques can remove Cr(Ⅵ)from water by adsorption or reduction-coprecipitation ***,the success of a chromium treatment or remediation strategy requires the stability of the Cr(Ⅲ)-containing solids with respect to solubilization or reoxidation in the settings they are *** is ubiquitous in aquatic and terrestrial environments,and the redox cycling of manganese may greatly influence the fate,transport,and distribution of *** of redox reactions of chromium,iron,and manganese involves reaction pathways not only in the aqueous phase but also at solid-aqueous *** provide a quantitative understanding of these processes,it is essential to develop mechanistically based kinetic and transport *** research should be made on iron-based treatment of Cr(Ⅵ)-contaminated water and soils and the stability of the subsequently produced Cr(Ⅲ)-containing solids at environmentally relevant conditions,which will support improved predictions of chromium's environmental fate and transport and aid in decision-making for remediation and treatment of Cr contamination.

关键词： Chromium(Ⅵ)contamination Redox reaction Iron oxide Manganese oxide Modeling

Neuronal circuitry reconstruction after stem cell therapy in damaged brain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第9期17卷 1959-1960页

作者： daniel Tornero Department of Biomedical Sciences Institute of Neuroscience and Production and Validation Center of Advanced Therapies(Creatio)University of Barcelona August Pi I Sunyer Biomedical Research Institute(IDIBAPS) Network Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED) BarcelonaSpain

Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brain trauma and *** functional integration of grafted neurons differentiated from stem cells into the host injured neuronal circuitry has been a major challenge in cell therapy strategies for brain repair(Palma-Tortosa et al.,2021).Even though other cell types or mechanisms may provide modest clinical improvements,neuronal replacement and reconstruction of the damaged area are crucial for an optimal and long-term recovery.

关键词： diseases damaged