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All-hydrocarbon,all-conjugated cycloparaphenylene-polycyclic aromatic hydrocarbon host–guest complexes stabilized by CH–πinteractions

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Nano Research 2022年第6期15卷 5545-5555页

作者： Hyejin Kwon carson.j.Bruns Paul M.Rady Department of Mechanical Engineering University of ColoradoBoulder427 UCB1111 Engineering DriveBoulderCO 80309USA ATLAS Institute 112518th St.320 UCBBoulderCO 80309USA

Polycyclic aromatic hydrocarbons(PAHs)are promising nanocarbon materials with diverse optoelectronic properties,yet they also pose concerning environmental and health *** the ubiquity of PAHs in the environment(crude oil,emissions,and biomass),most supermolecules rely on heteroatoms for *** discovered and characterized a family of all-hydrocarbon,all-π-conjugated[n]cycloparaphenylene-PAH host–guest *** built a theoretical framework to rapidly select these complexes and predict their stabilities,driven exclusively by CH–π*** than a dozen complexes were confirmed experimentally and assembled directly from commercially available *** motif offers a versatile way to combine the advantageous properties of organic semiconductors with the rich dynamic,stereochemical,stimulus-responsive,and stressdissipative behavior of host–guest complexes,while creating new opportunities for bespoke PAH separation or remediation materials.

关键词： cycloparaphenylenes density functional calculations host−guest systems hydrocarbons polycycles self-assembly supramolecular chemistry

Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 383-392页

作者： Rishikesh M Kulkarni Louis W Kutcher William D Stuart daniel j.carson Mike A Leonis Susan E Waltz Departments of Cancer and Cell Biology University of CincinnatiCincinnatiOH 45267-0521USA Biology University of CincinnatiCincinnatiOH 45267-0521USA Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229USA Department of Research Shriner's Hospital for Children and Cincinnati Veterans Affairs Medical CenterCincinnatiOH 45267-0521USA

BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized *** aim of this study was to identify the role of Ron in the regulation of hepatic gene ***:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of *** array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture ***:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and *** hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as jAK-STAT pathway activation were prominent in TK-/livers compared to ***:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and jAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.

关键词： Mst1R suppressors of cytokine signaling Met receptor hepatocyte growth factor-like protein

Anatomical changes correlated with chronic pain in forensic medicine

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Forensic Sciences Research 2017年第3期2卷 145-151页

作者： Henry j.carson Linn County Medical Examiner’s Office(retired) Cedar RapidsIAUSA

This study was performed to determine the relationships between chronic pain and anatomic changes that may occur in the *** were performed on fatalities that required death investigation in Linn County,IA,or adjacent and nearby *** with chronic pain were older than the control population at the time of ***,hypertension and depression were more common in persons with chronic *** causes of death may also have been related to chronic *** heart,lungs,liver,spleen and kidneys were significantly heavier in persons with chronic pain;emphysema and pleural and abdominal adhesions were more common in persons with chronic *** appear to have been diffuse changes in the body related to chronic *** changes may have been mediated by a number of systemic mechanisms that are involved with chronic pain,including cardiovascular activity,the immune system,the neuroendocrine system and others.

关键词： Forensic medicine pain,chronic depression emphysema adhesions tissue

Disturbance history,species diversity,and structural complexity of a temperate deciduous forest

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journal of Forestry Research 2020年第2期31卷 397-414页

作者： jonathan D.Goode carson R.Barefoot justin L.Hart daniel C.Dey Department of Geography University of AlabamaTuscaloosaAL 35487USA Northern Research Station USDA Forest ServiceColumbiaMO 65211USA

Stand structural complexity enhancement is an increasingly popular management objective,especially on public *** stand structures are hypothesized to support a relatively high degree of native forest diversity and be more resistant and resilient to *** structures are characterized by the presence of deadwood and heterogeneity of tree-size classes and tree *** little is known about how discrete disturbance events affect structural complexity and compositional diversity in Quercus-dominated stands at fine spatial scales(***).We established 200.05 ha fixed-radius plots on the Sipsey Wilderness of William *** National Forest in northern Alabama to quantify woody plant species composition and *** were mapped on each plot to quantify overstory structural complexity and compositional *** extracted two cores from all canopy Quercus spp.C 5 cm diameter at breast height to quantify age,recruitment pulses,and reconstruct canopy disturbance *** species diversity in the sampled area was 1.75 for trees,2.08 for saplings,and 1.69 for *** alba had the greatest basal area,and Ostrya virginiana had the highest *** stand exhibited a reverse j-shaped distribution with a q-factor of *** oldest Quercus dated to 1795,and the largest recruitment pulse occurred in the *** mean return interval for intermediateseverity disturbance was 38 *** we documented no relationships between disturbance frequency and compositional diversity at the neighborhood scale(0.05 ha),less frequent disturbance was associated with higher structural complexity(r^2=0.258,p=0.026)at the neighborhood *** suggest that localized disturbance increases species diversity and structural complexity,but these processes are manifest at the stand level and not at the neighborhood *** conclude that the spatial variability(***,shape,orientation,microsite conditions)is likel

关键词： Canopy gap Quercus(oak) Stand development Succession

Do ankle braces provide similar effects on ankle biomechanical variables in subjects with and without chronic ankle instability during landing?

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journal of Sport and Health Science 2012年第2期1卷 114-120页

作者： Songning Zhang Michael Wortley julia Freedman Silvernail daniel carson Maxime R.Paquette Biomechanics/Sports Medicine Laboratory Department of KinesiologyRecreation and Sport StudiesThe University of TennesseeKnoxvilleTN 37934.USA Pellissippi State Community College KnoxvilleTN 37933USA Department of Kinesiology University of MassachusettsAmherstMA 01003USA Biomechanics/Sports Medicine Laboratory Department of KinesiologyRecreation and Sport StudiesThe University of TennesseeKnoxvilleTN 37934USA

Purpose:The purpose of this study was to examine effects of a sport version of a semi-rigid ankle brace (ElementTM) and a soft ankle brace (ASO) on ankle biomechanics and ground reaction forces (GRFs) during a drop landing activity in subjects with chronic ankle instability (CAI)compared to healthy subjects with no history of ***:Ten healthy subjects and 10 subjects who had multiple ankle sprains participated in the study as the control and unstable subjects,*** CAI subjects were age,body mass index and gender matched with the control *** arch index and ankle functions of the subjects were measured in a subject screening *** the biomechanical test session,participants performed five trials of drop landing from 0.6 m,wearing no brace ( NB),ElementTM brace and ASO *** recording of three-dimensional kinematic (240 Hz)and GRF (1200 Hz) data were ***:The CAI subjects had lower ankle functional survey *** arch index and deformity results showed greater arch deformity of ElementTM against a static load than in NB and ASO due to greater initial arch position held by the *** participants had greater eversion velocity than healthy *** ASO brace reduced the first peak vertical GRF whereas ElementTM increased 2nd peak vertical *** brace reduced eversion range of motion (ROM) and peak eversion velocity compared to NB and *** addition,ElementTM reduced dorsiflexion ROM and increased peak plantarflexion moment compared to NB and ***:Results of static arch measurements and dynamic ankle motion suggest that the restrictions offered by both braces are in part due to more dorsiflexed ankle positions at contact,and higher initial arch position and stiffer ankle for ElementTM.

关键词： Drop landing Lateral ankle sprain Recurrent ankle sprain Semi-rigid ankle brace Soft ankle brace

Laser cut hole matrices in novel armour plate steel for appliqué battlefield vehicle protection

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Defence Technology（防务技术） 2016年第5期12卷 351-359页

作者： daniel j. THOMAS Engineering Manufacturing Centre College of Engineering Swansea University Swansea UK

During this research, experimental rolled homogeneous armour steel was cast, annealed and laser cut to form an appliqué plate. This Martensitic–Bainitic microstructure steel grade was used to test a novel means of engineering lightweight armour. It was determined that a laser cutting speed of 1200 mm/min produced optimum hole formations with limited distortion. The array of holes acts as a double-edged solution, in that they provide weight saving of 45%, providing a protective advantage and increasing the surface area. Data collected were used to generate laser cut-edge hole projections in order to identify the optimum cutting speed, edge condition, cost and deformation performance. These parameters resulted in the generation of a surface, with less stress raising features. This can result in a distribution of stress across the wider surface. Provided that appropriate process parameters are used to generate laser cut edges, then the hardness properties of the surface can be controlled. This is due to compressive residual stresses produced in the near edge region as a result of metallurgical transformations. This way the traverse cutting speed parameter can be adjusted to alter critical surface characteristics and microstructural properties in close proximity to the cut-edge. A relationship was identified between the width of the laser HAZ and the hardness of the cut edge. It is the thickness of the HAZ that is affected by the laser process parameters which can be manipulated with adjusting the traverse cutting speed.

关键词： Armour steels Defence systems Steel processing Armour engineering

The PACTUM model:Product analysis of cost and time using mathematics

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International journal of Modeling, Simulation, and Scientific Computing 2014年第S01期5卷 51-70页

作者： daniel j.Easters Department of Fashion Marketing Management&Communication School of Art&Design Nottingham Trent University Nottingham NG14BUUK

Establishing a mathematical supply-chain model is a proposition that has received attention due to its inherent benefits of evolving global supply-chain *** paper discusses the prevailing relationships found within apparel supply-chain environments,and contemplates the complex issues indicated for constituting a mathematical *** results identified within the data suggest,that the multifarious nature of global supply-chain activities require a degree of simplification in order to fully dilate the necessary factors which affect,each subsection of the ***,the research findings allowed the division of supply-chain components into subsections,which amassed a coherent method of product development ***,the supply-chain model was found to allow systematic mathematical formulae analysis,of cost and time,within the multiple contexts of each subsection *** paper indicates the supplychain model structure,the mathematics,and considers how product analysis of cost and time can improve the comprehension of product lifecycle management.

关键词： Fashion supply-chain mathematics

Recent advances in the targeted fluorescent probes for the detection of metastatic bone cancer

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Science China Chemistry 2021年第8期64卷 1283-1296页

作者： Peng Wu daniel j.Siegwart Hu Xiong Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin300071China Department of Biochemistry Simmons Comprehensive Cancer CenterThe University of Texas Southwestern Medical CenterDallasTexas75390USA

Tumors of the breast,prostate,and lung are most likely to metastasize to the bone and typically indicates a poor cure and survival rate in cancer *** of metastatic bone cancer in early stage would save many lives and greatly improve patients’quality of ***,bone scintigraphy is often utilized to visualize bone metastases due to its relatively low cost and high ***,a growth number of analytical researches aimed at developing targeted fluorescent probes to noninvasively image bone metastases with improved spatial resolution and specificity has been *** this review,we will summarize and discuss the recent published fluorescent probes on the accurate detection of metastatic bone ***,the design principles of various targeted probes for imaging bone metastases will be presented,highlighting the signal moieties,targeting ligands,and physicochemical properties of the bone-specific ***,the up-to-date bone-targeting fluorescent probes will be summarized and ***,future perspectives and challenges confronting the researchers in this field will be *** believe this review will encourage novel ideas to develop smart targeted molecular probes for bone metastasis imaging,image-guided surgery,and therapeutic imaging materials.

关键词： bone metastasis targeted probes fluorescence imaging smart design bone-targeting moieties

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Overcoming obstacles to implementation: addressing political,institutional and behavioral problems in earthquake hazard mitigation policies

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Earthquake Engineering and Engineering Vibration 2002年第1期1卷 152-158页

作者： daniel j.Alesch William j.Petak Department of Public and Environmental Affairs University of Wisconsin-Green BayGreen BayWisconsin54311USA Professor School of Policy Planning and DevelopmentUniversity of Southern California650 Childs WayRoom 201eLos AngelesCalifornia90089-0626USA Professor

This project is aimed at bridging the three planes,from basic research,through enabling processes,to engineered *** the basic research plane,we have been working to improve our collective understanding about obstacles to implementing mitigation practices,owner decision processes (in connection with other MCEER projects),and public policy *** the level of enabling processes,we have been seeking to develop an understanding of how obstacles to greater mitigation can be overcome by improved policy design and *** the engineered systems plane, our work is intended to result in practical guidelines for devising policies and programs with appropriate motivation and incentives for implementing policies and programs once *** phase of the research has been aimed,first,at a thorough,multidisciplinary review of the literature concerning obstacles to ***,the research has focused on advancing the state of the art by developing means for integrating the insights offered by diverse perspectives on the implementation process from the several social,behavioral,and decision *** research establishes a basis for testing our understanding of these processes in the case of hospital retrofit decisions.

关键词： earthquake mitigation earthquake mitigation policies earthquake losses