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Com.lem.nt-dependent neuroinflam.ation in spinal cord injury:from.path.logy to th.rapeutic im.lications

Neural regeneration research 2025年第5期20卷 1324-1335页

作者： h.ssan Saad Bach.r El Baba Ali Tfaily Firas Kobeissy Juanm.rco Gutierrez Gonzalez daniel refai Gerald r.rodts Ch.istian m.stroph.David Gim.el Jonath.n Grossberg daniel L.Barrow m.tth.w F.Gary Ali m.Alawieh departm.nt of Neurosurgery Emory University School of MedicineAtlantaGAUSA departm.nt of Neurology Yale UniversityNew HavenCTUSA Center for Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury rem.ins a m.jor cause of disability in young adults,and beyond acute decom.ression and reh.bilitation,th.re are no ph.rm.cological treatm.nts to lim.t th. progression of injury and optim.ze recovery in th.s *** th. th.rough.investigation of th. com.lem.nt system.in triggering and propagating cerebral neuroinflam.ation,a sim.lar role for com.lem.nt in spinal neuroinflam.ation is a focus of ongoing *** th.s work,we survey th. current literature investigating th. role of com.lem.nt in spinal cord injury including th. sources of com.lem.nt proteins,triggers of com.lem.nt activation,and role of effector functions in th. *** study relevant data dem.nstrating th. different triggers of com.lem.nt activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to dam.ge-associated m.lecular *** effector functions of com.lem.nt h.ve been im.licated in spinal cord injury,and we critically evaluate recent studies on th. dual role of com.lem.nt anaph.latoxins in spinal cord injury wh.le em.h.sizing th. lack of path.ph.siological understanding of th. role of opsonins in spinal cord *** th.s path.ph.siological review,we system.tically review th. different translational approach.s used in preclinical m.dels of spinal cord injury and discuss th. ch.llenges for future translation into h.m.n *** review em.h.sizes th. need for future studies to dissect th. roles of different com.lem.nt path.ays in th. path.logy of spinal cord injury,to evaluate th. ph.ses of involvem.nt of opsonins and anaph.latoxins,and to study th. role of com.lem.nt in wh.te m.tter degeneration and regeneration using translational strategies to supplem.nt genetic m.dels.

关键词： com.lem.nt neuroinflam.ation neuroplasticity regeneration spinal cord injury targeted th.rapy

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Potential of Sorgh.m.as an Alternative to Corn Forage

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Am.rican Journal of Plant Sciences 2016年第7期7卷 1106-1121页

作者： Girm. Getach.w daniel h. putnam.ch.istoph.r m. de ben Edward J. de Peters departm.nt of Plant Sciences University of California Davis CA USA departm.nt of Anim.l Science University of California Davis CA USA

Clim.te ch.nge, wh.ch.is currently ch.racterized by increased atm.sph.ric CO2, rising tem.erature, and altered pattern of precipitation, is affecting agricultural productivity. rising tem.eratures and sh.fting precipitation patterns will alter th. ability to m.et crop water requirem.nts, water availability, crop productivity, and costs of water access across th. agricultural landscape. Search.ng for alternative crops with.lower water requirem.nts increased yield or organic m.tter per unit of water are im.ortant for agricultural sustainability. Sorgh.m.is one of th. world’s im.ortant crops;a crop th.t is adapted to a variety of agronom.c and environm.ntal conditions, particularly to areas with.low rainfall or lim.ted access of irrigation water. Forage Sorgh.m.is able to produce com.arable yield to corn suggesting th.t th.re is a potential for Sorgh.m.to replace corn in areas wh.re water supply is lim.ted. But, th.re is a cost since corn silage, because of its h.gh.grain content, wh.ch.is typically superior in digestible energy content to Sorgh.m.forages. Th.re is also a lack of inform.tion on th. feeding value of Sorgh.m.silages in h.gh.producing dairy cows as well as strategies th.t m.y be used for sorgh.m.silage to replace a portion of th. corn silage in dairy cattle diets.

关键词： Sorgh.m Clim.te Ch.nge Drough. Tolerance Salinity

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design and im.lem.ntation of a leader-follower cooperative control system.for unm.nned h.licopters

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控制理论与应用（英文版） 2010年第1期8卷 61-68页

作者： ben YUN ben m. Ch.N Kai Yew LUm.Tong h. LEE departm.nt of Electrical & Com.uter Engineering National University of Singapore Singapore 117576 Tem.sek Laboratories National University of Singapore Singapore 117508

In th.s paper, we present a full sch.m. for th. cooperative control of m.ltiple unm.nned aerial veh.cle （UAV） h.licopters. We adopt th. leader-follower pattern to m.intain a fixed geom.trical form.tion wh.le navigating th. UAVs following certain trajectories. m.re specifically, th. leader is com.anded to fly on som. predefined trajectories, and each.follower is controlled to m.intain its position in form.tion using th. m.asurem.nt of its inertial position and th. inform.tion of th. leader position and velocity, obtained th.ough.a wireless m.dem. m.re specifications are m.de for m.ltiple UAV form.tion fligh.. In order to avoid possible collisions of UAV h.licopters in th. actual form.tion fligh. test, a collision avoidance sch.m. based on som. predefined alert zones and protected zones is em.loyed. Sim.lations and experim.ntal results are presented to verify our design.

关键词： Unm.nned aerialveh.cles Cooperative control Fligh. form.tion Collision avoidance

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A m.TLAB toolkit for com.osite nonlinear feedback control–im.roving transient response in tracking control

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控制理论与应用（英文版） 2010年第3期8卷 271-279页

作者： Guoyang Ch.NG ben m. Ch.N Kem.o PENG Tong h. LEE College of Electrical Engineering and Autom.tion Fuzhou University Fuzhou Fujian 350108 China departm.nt of Electrical and Com.uter Engineering National University of Singapore Singapore 117576 Tem.sek Laboratories National University of Singapore Singapore 117508

We present in th.s article a m.TLAB toolkit with.a user-friendly graph.cal interface for com.osite nonlinear feedback control system.design. Th. toolkit can be utilized to design a fast and sm.oth.tracking controller for a class of linear system. and nonlinear system. with.actuator and oth.r nonlinearities as well as with.external disturbances. Th. param.ters of th. controller can be tuned easily on th. user panel or autotuned by th. toolkit. Th. toolkit is capable of displaying both.tim.-dom.in and frequency-dom.in responses on its m.in panel and generating th.ee different types of con- trol laws, nam.ly, th. state feedback, th. full-order m.asurem.nt feedback and th. reduced-order m.asurem.nt feedback controllers. Th. usage and design procedure of th. toolkit are illustrated by practical exam.les on a rotational/translational actuator （rTAC） system.and a h.rd disk drive servo system. Th. toolkit can be utilized to design servo system. th.t deal with.point-and-sh.ot fast targeting.

关键词： Nonlinear control Actuator saturation Tracking control Com.uter-aided design

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developm.nt of a vision-based ground target detection and tracking system.for a sm.ll unm.nned h.licopter

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Science in Ch.na(Series F) 2009年第11期52卷 2201-2215页

作者： LUm.Kai-Yew Ch.N ben m. LEE Tong h. departm.nt of Electrical & Com.uter Engineering National University of Singapore

It is undoubted th.t th. latest trend in th. unm.nned aerial veh.cles （UAVs） com.unity is towards vision-based unm.nned sm.ll-scale h.licopter, utilizing th. m.neuvering capabilities of th. h.licopter and th. rich.inform.tion of visual sensors, in order to arrive at a versatile platform.for a variety of applications such.as navigation, surveillance, tracking, etc. In th.s paper, we present th. developm.nt of a vision-based ground target detection and tracking system.for a sm.ll UAV h.licopter. m.re specifically, we propose a real-tim. vision algorith., based on m.m.nt invariants and two-stage pattern recognition, to ach.eve autom.tic ground target detection. In th. proposed algorith., th. key geom.try features of th. target are extracted to detect and identify th. target. Sim.ltaneously, a Kalm.n filter is used to estim.te and predict th. position of th. target, referred to as dynam.c features, based on its m.tion m.del. Th.se dynam.c features are th.n com.ined with.geom.try features to identify th. target in th. second-stage of pattern recognition, wh.n geom.try features of th. target ch.nge significantly due to noise and disturbance in th. environm.nt. Once th. target is identified, an autom.tic control sch.m. is utilized to control th. pan/tilt visual m.ch.nism.m.unted on th. h.licopter such.th.t th. identified target is to be tracked at th. center of th. captured im.ges. Experim.ntal results based on im.ges captured by th. sm.ll-scale unm.nned h.licopter, Sh.Lion, in actual fligh. tests dem.nstrate th. effectiveness and robustness of th. overall system.

关键词： target tracking unm.nned aerial veh.cle im.ge processing pattern recognition Kalm.n filtering

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recovery of valuable m.tals from.waste cables by em.loying m.ch.nical processing followed by spouted bed elutriation

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Particuology 2019年第4期17卷 74-80页

作者： Eduardo h. Tanabe roger m. Silva Daliom.r L. Oliveira Junior daniel A. Bertuol Environm.ntal Processes Laboratory (LAPAm. Chemical Engineering Department Federal University of Santa Maria - UFSM Santa Maria RS Brazil

Cables and wires, wh.ch.are essential parts of equipm.nt for th. transm.ssion of both.inform.tion and electricity, contain valuable m.terials including copper (Cu) and alum.num.(Al). Th.s experim.ntal work evaluates th. use of m.ch.nical processing (grinding and sieving), followed by spouted bed elutriation, for separation of th. valuable m.terials (steel-coated copper, copper, and alum.num. present in waste coaxial and internet cables. A recovery efficiency of approxim.tely 90% was ach.eved for th. steel-coated copper in coaxial cables. For in ternet cables, th. copper recovery efficiency was approxim.tely 87%. Th.se findings dem.on strate th.t it is possible to separate, recover, and recycle th. valuable m.terials (m.tals) present in waste cables using sim.le, low-cost, and efficient m.ch.nical processing followed by spouted bed elutriation.

关键词： Waste cable Elutriation Copper recycling m.ch.nical process

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regulator of G protein signaling 6 m.diates exercise-induced recovery of h.ppocam.al neurogenesis,learning,and m.m.ry in a m.use m.del of Alzh.im.r’s disease

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Neural regeneration research 2025年第10期20卷 2969-2981页

作者： m.ckenzie m.Spicer Jianqi Yang daniel Fu Alison N.deVore m.risol Lauffer Nilufer S.Atasoy deniz Atasoy rory A.Fish.r departm.nt of Neuroscience and Ph.rm.cology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program.in m.lecular m.dicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Beh.vior Core University of Iowa Carver College of MedicineIowa CityIAUSA

h.ppocam.al neuronal loss causes cognitive dysfunction in Alzh.im.r’s *** h.ppocam.al neurogenesis is reduced in patients with.Alzh.im.r’s *** stim.lates adult h.ppocam.al neurogenesis in rodents and im.roves m.m.ry and slows cognitive decline in patients with.Alzh.im.r’s ***,th. m.lecular path.ays for exercise-induced adult h.ppocam.al neurogenesis and im.roved cognition in Alzh.im.r’s disease are poorly ***,regulator of G protein signaling 6(rGS6)was identified as th. m.diator of voluntary running-induced adult h.ppocam.al neurogenesis in ***,we generated novel rGS6fl/fl;APP_(SWE) m.ce and used retroviral approach.s to exam.ne th. im.act of rGS6 deletion from.dentate gyrus neuronal progenitor cells on voluntary running-induced adult h.ppocam.al neurogenesis and cognition in an am.loid-based Alzh.im.r’s disease m.use *** found th.t voluntary running in APP_(SWE) m.ce restored th.ir h.ppocam.al cognitive im.airm.nts to th.t of control *** cognitive rescue was abolish.d by rGS6 deletion in dentate gyrus neuronal progenitor cells,wh.ch.also abolish.d running-m.diated increases in adult h.ppocam.al *** h.ppocam.al neurogenesis was reduced in sedentary APP_(SWE) m.ce versus control m.ce,with.basal adult h.ppocam.al neurogenesis reduced by rGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons with.n th. dentate gyrus of patients with.Alzh.im.r’s disease with.significant loss of th.se rGS6-expressing ***,rGS6 m.diated voluntary running-induced rescue of im.aired cognition and adult h.ppocam.al neurogenesis in APP_(SWE) m.ce,identifying rGS6 in dentate gyrus neural precursor cells as a possible th.rapeutic target in Alzh.im.r’s disease.

关键词： adult h.ppocam.al neurogenesis Alzh.im.r’s disease dentate gyrus exercise learning/m.m.ry neural precursor cells regulator of G protein signaling 6(rGS6)

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Substrate Tem.erature-dependent Ph.sical Properties of Th.rm.lly Evaporated Sn4Sb6S13 Th.n Film.

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Acta m.tallurgica Sinica(English.Letters) 2016年第1期29卷 79-88页

作者： A. h.rizi m. ben rabeh.m. Kanzari Laboratoire de Ph.tovoltaique et m.teriaux Sem.conducteurs departem.nt genie industriel ENIT-Universite Tunis E1 Manar BP 37 Le belvedere 1002 Tunis Tunisie Institut Preparatoire aux Etudes d'Ingenieurs de Tunis Universite de Tunisie Montfleury Tunisia

In th.s work, th. h.m.genous th.n film. of sulfosalt Sn4Sb6S13 were successfully synth.sized by th. th.rm.l evaporation tech.ique onto com.ng 7059 glass substrates h.ated at various tem.eratures in th. range of 30--200 ℃. Th. surface m.rph.logy and structural ch.racteristics of Sn4Sb6S13 film. were analyzed by atom.c force m.croscopy, X-ray diffraction, and energy-dispersive X-ray, respectively. Th. X-ray diffraction analysis revealed th.t Sn4Sb6S13 th.n film. crystallized in m.noclinic structure according to a preferential direction （6 11）. An im.rovem.nt in th. structural properties by increasing th. substrate tem.erature was observed. Th. values of som. im.ortant param.ters such.as absorption coefficient （x）, band gap （Eg）, refractive index （n）, extinction coefficient （k）, and dielectric constant （Eg） of th.n film.were determ.ned. Th. absorption coefficient was larger th.n 105 cm.l in th. visible range. Th. electron transition of Sn4Sb6S13 film. was direct allowed with.th. values th.t decreased （2-1.69 eV） by increasing substrate tem.erature from.30 to 200 ℃,Th. dispersion data obeyed th. single oscillator relation of th. Wem.le-DiDom.nico m.del and Cauch. m.del. Th. electrical free carrier susceptibility and th. carrier concentration of th. effective m.ss ratio were estim.ted according to th. m.del of Spitzer and Fan.

关键词： Th.n film Th.rm.l evaporation tech.ique X-ray diffraction Optical param.ters

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Cooperative Target Fencing of m.ltiple Veh.cles for a General Target with.Connectivity Preservation and Collision Avoidance

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Journal of System. Science & Com.lexity 2024年第1期37卷 136-151页

作者： PAN Zini Ch.N ben m departm.nt of m.ch.nical and Autom.tion Engineering The Chinese University of Hong KongHong KongChina

In th.s paper,th. auth.rs study th. cooperative target-fencing problem.for n-dim.nsional system. and a target with.a general *** using th. velocity of th. veh.cles,a position feedback control law is proposed to fence th. general target into th. convex h.ll form.d by th. ***,th. dynam.cs of each.veh.cle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of th. com.unication network and collision avoidance am.ng th. *** proposed approach.can deal with.a target wh.se trajectory is any twice continuously differentiable function of *** effectiveness of th. result is verified by a num.rical exam.le.

关键词： m.lti-agent system. networked system. target fencing

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A CALCULUS FOr SErVICES INNOVATION

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Journal of System. Science and System. Engineering 2007年第2期16卷 129-165页

作者： Jam.s m. TIEN daniel BErG departm.nt of decision Sciences and Engineering System. Rensselaer Polytechnic Institute Troy New York USA

Innovation in th. services area - especially in th. electronic services （e-services） dom.in - can be system.tically developed by first considering th. strategic drivers and foci, th.n th. tactical principles and enablers, and finally th. operational decision attributes, all of wh.ch.constitute a process or calculus of services innovation. m.re specifically, th.re are four custom.r drivers （i.e., collaboration, custom.zation, integration and adaptation）, th.ee business foci （i.e., creation-focused, solution-focused and com.etition-focused）, six business principles （i.e., reconstruct m.rket boundaries, focus on th. big picture not num.ers, reach.beyond existing dem.nd, get strategic sequence righ., overcom. organizational h.rdles and build execution into strategy）, eigh. tech.ical enablers （i.e., software algorith.s, autom.tion, telecom.unication, collaboration, standardization, custom.zation, organization, and globalization）, and six attributes of decision inform.tics （i.e., decision-driven, inform.tion-based, real-tim., continuously-adaptive, custom.r-centric and com.utationally-intensive）. It sh.uld be noted th.t th. four custom.r drivers are all directed at em.owering th. individual - th.t is, at recognizing th.t th. individual can, respectively, contribute in a collaborative situation, receive custom.zed or personalized attention, access an integrated system.or process, and obtain adaptive real-tim. or just-in-tim. input. Th. developed process or calculus serves to identify th. potential wh.te spaces or blue oceans for innovation. In addition to expanding on current innovations in services and related experiences, wh.te spaces are identified for possible future innovations; th.y include th.se th.t can m.tigate th. unforeseen consequences or abuses of earlier innovations, safeguard our righ.s to privacy, protect us from.th. always-on, interconnected world, provide us with.an auth.ritative search.engine, and generate a GDP m.tric th.t can adequately m.asure th. gro

关键词： Services innovation decision inform.tics software algorith.s autom.tion globalization collaboration custom.zation integration adaptation standardization telecom.unication organization business principles

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