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Using transcription factors for direct reprogramming of neurons in vitro

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World Journal of Stem Cells 2019年第7期11卷 431-444页

作者： Layal El Wazan daniel Urrutia-cabrera Raymond Ching-Bong Wong Cellular Reprogramming Unit Centre for Eye Research AustraliaMelbourne 3004Australia Department of Surgery University of MelbourneMelbourne 3002Australia Ophthalmology Shenzhen Eye HospitalShenzhen 518040Guangdong ProvinceChina

Cell therapy offers great promises in replacing the neurons lost due to neurodegenerative diseases or ***,a key challenge is the cellular source for transplantation which is often limited by donor *** reprogramming provides an exciting avenue to generate specialized neuron subtypes in vitro,which have the potential to be used for autologous transplantation,as well as generation of patient-specific disease models in the lab for drug discovery and testing gene *** we present a detailed review on transcription factors that promote direct reprogramming of specific neuronal subtypes with particular focus on glutamatergic,GABAergic,dopaminergic,sensory and retinal *** will discuss the developmental role of master transcriptional regulators and specification factors for neuronal subtypes,and summarize their use in promoting direct reprogramming into different neuronal ***,we will discuss up-and-coming technologies that advance the cell reprogramming field,including the use of computational prediction of reprogramming factors,opportunity of cellular reprogramming using small chemicals and microRNA,as well as the exciting potential for applying direct reprogramming in vivo as a novel approach to promote neuro-regeneration within the ***,we will highlight the clinical potential of direct reprogramming and discuss the hurdles that need to be overcome for clinical translation.

关键词： Cell reprogramming Neuronal subtypes Transcription factors Direct reprogramming Glutamatergic neurons GABAergic neurons Retinal neurons

The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data

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World Journal of Gastroenterology 2020年第48期26卷 7693-7706页

作者： Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia daniel cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 8320000Chile Department of Internal Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile School of Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile Facultad de Ciencias Médicas Universidad Bernardo O'HigginsSantiago 8320000Chile Department of Laboratory Medicine and Pathology Mayo Clinic RochesterMinnesotaMN 55902United States Católica de Chile Santiago 8320000Chile Division of Gastroenterology and Hepatology Mayo Clinic RochesterMinnesotaMN 55905United States

BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the *** on hepatic histopathological findings in COVID-19 is *** To characterize hepatic pathological findings in patients with *** We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA *** trials were those including patients of any age and COVID-19 diagnosis based on a molecular *** reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were *** including less than ten patients were *** were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,*** We identified 18 studies from 7 countries;all were case reports and case series from *** the patients were over 15 years old,and 67.2%were *** performed a meta-analysis of 5 studies,including 116 *** prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and *** We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver *** frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or *** studies are needed to establish the mechanisms and implications of these findings.

关键词： Pathology SARS-CoV-2 COVID-19 Autopsies Liver Liver biopsies

Anchoring of 10-phenylphenothiazine to mesoporous silica materials:A water compatible organic photocatalyst for the degradation of pollutants

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Journal of Materials Science & Technology 2022年第8期103卷 134-143页

作者： daniel González-Muñoz Almudena Gómez-Avilés Carmen B.Molina Jorge Bedia Carolina Belver Jose Alemán Silvia cabrera Organic Chemistry Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Chemical Engineering Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autónoma de Madrid28049 MadridSpain Inorganic Chemistry Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain

The application of organic photocatalysts towards the oxidation of pollutants in water is hampered by different limitations such as their insolubility in the ***,we report that the grafting of a photoorganocatalyst into mesoporous silica materials is an ideal approach to obtain effective ***,the photocatalyst 10-phenylphenothiazine(PTH)was easily anchored into three different mesoporous silica-based materials(MSN,MSU-2 and SBA-15)with different particle sizes and pore sizes through an amide bond *** materials were characterized using IR analysis,solid-state X-ray diffraction,porosity and microscopy(SEM and TEM)techniques,showing that PTH is immobilized inside the pores of the materials and its optical properties are maintained after the *** homogeneous PTH was inactive in water media,the three photocatalytic materials were active for the degradation of ***-15-AP-PTH exhibited the highest catalytic performance towards the degradation of acetaminophen and diclofenac under solar irradiation,finding in this manner a new strategy for the decontamination of pollutants.

关键词： Organic semiconductors Silica support Solar photocatalysis Water treatment Pharmaceuticals

On the wavelet analysis of cutting forces for chatter identification in milling

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Advances in Manufacturing 2017年第2期5卷 130-142页

作者： Cesar Giovanni cabrera Anna Carla Araujo daniel Alves Castello Department of Mechanical Engineering UniversidadeFederal do Rio de Janeiro Rio de Janeiro Brazil

Chatter vibrations in machining operations affect surface finishing and tool behaviour, particularly in the end-milling of aluminum parts for the aerospace industry. This paper presents a methodological approach to identify chatter vibrations during manufacturing processes. It relies on wavelet analyses of cutting force signals during milling operations. The cutting-force signal is first decomposed into an approximation/trend sub-signal and detailed subsignals, and it is then re-composed using modified subsignals to reduce measurement noise and strengthen the reference peak forces. The reconstruction of the cuttingforce signal is performed using a wavelet denoising pro- cedure based on a hard-thresholding method. Four experimental configurations were set with specific cutting parameters using a workpiece specifically designed to allow experiments with varying depths of cut. The experimental results indicate that resultant force peaks （after applying the threshold to the detailed sub-signals） are related to the presence of chatter, based on the increased correlation of such peaks and the surface roughness profiles, thereby reinforcing the applicability of the proposed method. The results can be used to control the online occurrence of chatter in end-milling processes, as the method does not depend on the knowledge of cutting geometry nor dynamic parameters.

关键词： Cutting force End milling Chatter Waveletfilter

A Fragmentation Mechanism of Homemade Explosive TMDD Using DART-MS and Isotopic Labeling

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火炸药学报 2018年第1期41卷 16-20,30页

作者： Alexander Pedroza Zarate Fredy Colpas-Castillo daniel J.Alcazar Franco Wilman A.cabrera-Lafaurie Eduardo A.Espinosa-Fuentes Department of Chemistry Universidad de Cartagena Facultad de Ciencias Exactas Cartagena Colombia Department of Natural and Exact Science Corporación Universidad de la Costa (CUC) Barranquilla Colombia Department of Civil and Environmental Sciences Corporación Universidad de la Costa (CUC) Barranquilla Colombia

A fragmentation mechanism and characterization for the first time using Direct Analysis in Real Time- Time of Flight-Mass Spectrometry(DART-TOF-MS)of the tetramethylene diperoxide dicarbamide(TMDD)compound were *** MS-spectrum may support other research about devices and detection in real *** mass spectrum of TMDD obtained using DART ionization in the positive-ion detection mode exhibited a strong peak at m/z254representing an ammonium adduct([TMMD·NH_4]~+).There was another peak at m/z237,which represented the protonated molecule([TMDD·H]~+)of *** two peaks corroborated the identity of the *** DART-MS spectra of the TMDD-isotopomer successfully corroborated the respective molecular tails. The principal fragmentation residues also showed coherence according to the number of isotopically labeled atoms on the TMDD *** contrast with other organic peroxides analyzed by this technique,TMDD exhibited substantial *** theoretical modeling results showed that the fragmentation mechanism of the TMDD ion adduct is strongly dependent of the TMDD ring flexibility and the hydrogen bonding formed between the nitrogen and oxygen atoms and the atmospheric proton.

关键词： direct analysis in real time Time of Flight-Mass Spectrometry TMDD isotopomers

Potential and Limits of a High-Density Hemispherical Array of Loudspeakers for Spatial Hearing and Auralization Research

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Journal of Applied Mathematics and Physics 2015年第2期3卷 240-246页

作者： William L. Martens Densil cabrera Luis Miranda daniel Jimenez The Faculty of Architecture Design and Planning The University of Sydney Sydney Australia

A hemispherical array of 196 independent loudspeakers has been constructed for laboratory research on spatial hearing, auralization, sound-field quality and spatial audio signal processing. The array of small loudspeakers is supported by a geodesic frame with a radius is 2.4 m. With this relatively high spatial density of sound sources, spatially quantized rendering of sound fields should be viable for a variety of applications, and this paper considers the potential and limits of this approach in relation to human spatial hearing capacities. The paper also considers the combined use of multiple loudspeakers for the rendering low-frequency components of sound sources in order to extend the low-frequency response of the system.

关键词： Loudspeaker Array Sound Field Control Auralization Spatial Hearing

Molecular Modeling of Quinoline-Based Compounds as Potential Dual Inhibitors of Reverse Transcriptase and Integrase of HIV

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Computational Molecular Bioscience 2018年第3期8卷 122-148页

作者： Alberto cabrera Leonor Huerta Hernández daniel Chávez José L. Medina-Franco Departamento de Farmacia Facultad de Química Universidad Nacional Autónoma de México México City México Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México México City México Centro de Graduados e Investigación en Química del Instituto Tecnológico de Tijuana Tijuana México

As follow-up of our past publication?[1], we propose that quinolones (as part of the pyridinone family) are capable to increase the number of interactions with HIV reverse transcriptase (RT) or integrase (IN) by adding a halogen in position C-8 of aromatic portion of the quinolones. This addition could help with the activity of dual inhibitors of RT and IN. In this work, we add a chlorine atom with the rationale to identify in the docking simulations a halogen interaction with the oxygen in the near aminoacids in the binding pockets of RT and IN enzymes. Our docking studies started with RT and 320 structures. Later, we took 73 structures with good results in docking with RT. The structures that we choose contain ester or acids groups in C-3 due the structural similarity with groups in charge to interact with the Mg++ ions in Elvitegravir. In conclusion, we obtained 14 structures that could occupy the allosteric pocket of RT and could inhibit the catalytic activity of IN, for this reason could be dual inhibitors. A major perspective of this work is the synthesis and testing of the potential dual inhibitors designed.

关键词： Reverse Transcriptase Integrase Quinolone Dual Inhibitor Docking

Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase

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Computational Molecular Bioscience 2018年第1期8卷 1-41页

作者： Alberto cabrera Leonor Huerta Hernández daniel Chávez José L. Medina-Franco Departamento de Farmacia Facultad de Química Universidad Nacional Autónoma de México Mexico City Mexico Instituto de Investigaciones Biomedicas Universidad Nacional Autónoma de México Mexico City Mexico Centro de Graduados e Investigaciónen Químicadel InstitutoTecnológico de Tijuana Tijuana B.C. Mexico

With the goal of suggesting dual inhibitors of HIV reverse transcriptase (RT) and integrase (IN), herein we report the molecular docking of an initial set of 556 compounds related to the pyridinone class. Docking with multiple crystallographic structures of HIV-1 RT led to 160 potential binders of RT interacting with key amino acid residues at the enzyme’s allosteric site. Compounds selected from the docking with RT were further docked with a crystallographic structure of HIV-1 IN. A total of 31 structures had the potential to make contacts with Mg2+ ions located in a small space between DNA and IN. Interactions with Mg2+ ions are relevant because they participate in the stabilization of the IN-DNA complex. In conclusion, 31 compounds synthetically accessible are proposed as dual inhibitors of RT and IN. It is hypothesized that the suggested compounds will inhibit RT by occupying the allosteric site for NNRTIs and will inhibit the catalytic activity of IN by destabilizing the IN-DNA complex. The main perspective of this work is the synthesis and biological testing of the candidate molecules.

关键词： AIDS Antiviral Computer-Aided Drug Design Docking Polypharmacology