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Corel Lumiere向Premiere提出挑战

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电子与电脑 1997年第6期4卷 41-41页

作者： daniel b.levine 丁江峰

那些初露头脚的导演们终于可以实现他们的梦想了,他们都希望有“侏罗纪公园”那样宏大的场面和“杀手托马托斯的攻击”那样的预算。在价值99美元的软件包Lumiere Suite中,Corel把其新的非线性数字视频编辑程序Lumiere与三维透视以及图... 详细信息

那些初露头脚的导演们终于可以实现他们的梦想了,他们都希望有“侏罗纪公园”那样宏大的场面和“杀手托马托斯的攻击”那样的预算。在价值99美元的软件包Lumiere Suite中,Corel把其新的非线性数字视频编辑程序Lumiere与三维透视以及图像编辑软件包CorelMotion 3D和CorelPhoto-Paint 6组合在一起。我们对Lumiere的β版本进行了测试。

关键词： CorelLumiere Premiere 应用软件视频编辑器

Qualcomm Eudora Pro 3.0——第一流的Internet E-mail

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电子与电脑 1997年第2期4卷 20-20页

作者： daniel b.levine 高亚林

很难想象没有e-mail的生活是什么样子。如果你是经商的,则很可能已经有了一套安装好的e-mail系统,尤其是如果你使用Windows 95或Windows NTWorkstation和MicrosoftExchange的话。

关键词： Internet E-mail EudoraPro3.0

Mechanical circulatory support in cardiogenic shock and post-myocardial infarction mechanical complications

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Journal of Geriatric Cardiology 2022年第2期19卷 130-136页

作者： daniel Rob Jan bělohlávek nd Department of Medicine-Department of Cardiovascular Medicine First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic

Despite advanced therapies,the mortality of patients with myocardial infarction(MI)complicated by cardiogenic shock(CS)remains around 50%.Mechanical complications of MI are rare nowadays but associated with high mortality in patients who present with *** treatment strategies and mechanical circulatory support(MCS)devices have been increasingly used to improve the grim prognosis of refractory *** article discusses current evidence regarding the use of MCS in MI complicated by CS,ventricular septal rupture,free wall rupture and acute mitral *** selection should be tailored according to the cause and severity of *** MCS initiation and multidisciplinary team cooperation is mandatory for good *** associated bleeding remains a major complication and an obstacle to better *** prospective randomized trials will improve current knowledge regarding MCS indications,timing,and patient selection in the coming years.

关键词： mortality infarction rupture

Design of synthetic materials for intracellular delivery of RNAs： From siRNA-mediated gene silencing to CRISPR/Cas gene editing

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Nano Research 2018年第10期11卷 5310-5337页

作者： Jason b. Miller daniel J. Siegwart Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX 75390 USA Department of biochemistry University of Texas Southwestern Medical Center Dallas TX 75390 USA

Ribonucleic acids （RNAs） possess great therapeutic potential and can be used to treat a variety of diseases. The unique biophysical properties of RNAs, such as high molecular weight, negative charge, hydrophilicity, low stability, and potential immunogenicity, require chemical modification and development of carriers to enable intracellular delivery of RNAs for clinical use. A variety of nanornaterials have been developed for the effective in vivo delivery of short/ small RNAs, messenger RNAs, and RNAs required for gene editing technologies including clustered regularly interspaced palindromic repeat （CRISPR）/Cas. This review outlines the challenges of delivering RNA therapeutics, explores the chemical synthesis of RNA modifications and carriers, and describes the efforts to design nanomaterials that can be used for a variety of clinical indications.

关键词： nucleic acid therapeutics nanoparticles synthetic nanomaterials RNA interference (RNAi) messenger RNA (mRNA) clustered regularly inter-spaced palindromic repeat(CRISPR)/Cas

Subchronic Oral Toxicity of Pyridostigmine bromide in Rats

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biomedical and Environmental Sciences 1991年第3期4卷 283-289页

作者： b.S.levine R.LONG H.CHUNG Department of Pharmacology University of Illinois at Chicago Chicago IL 60680Pathology Associates Inc. Chicago IL 60616Walter Reed Army Institute of Research WashingtonDC 20307

This study evaluated the oral toxicity of pyridostigmine bromide in Sprague-Dawley rats when administered for 13 weeks by daily gavage. Groups of 10 rats/sex received doses of 0, 5, 15, 30, or 60 mg/kg/day. Toxicity was limited to exaggerated cholinergic stimulation at doses of 15 mg/kg/day or greater. Significant findings included tremors and inhibition of RbC acetylcholinesterase. Thus, 5 mg/kg/day of pyridostigmine bromide appears to be the no observed toxic effect level under the conditions of the present investigation.

关键词： Subchronic Oral Toxicity of Pyridostigmine bromide in Rats

Energy Dissipation Within the Wave Run-Up at Stepped Revetments

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Journal of Ocean University of China 2017年第4期16卷 649-654页

作者： KERPEN Nils b bUNG daniel b VALERO Darnel SCHLURMANN Torsten Ludwig-Franzius-lnstitute Leibniz Universitat Hannover30167 HannoverGermany Hydraulic Engineering Section Fachhochschule Aachen52066 AachenGermany

To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment,hydraulic model tests with steady flow conditions are conducted and correlated with unsteady flow conditions of the wave run-up within a short time *** irregular waves,the run-up reduction over a stepped revetment is dependent on the Iribarren number and decreases for decreasing Iribarren *** gradients are found to be similar in a steady and unsteady flow regime near the pseudo-bottom.

关键词： run-up stepped revetment roughness: energy dissipation

Stability and scour development of bed material on crossbar block ramps

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International Journal of Sediment Research 2015年第04期30卷 344-350页

作者： Mario Oertel daniel b.bung Hydraulic Engineering Section Lbeck University of Applied Sciences Hydraulic Engineering Section Aachen University of Applied Sciences

block ramps are ecologically oriented drop structures with adequate energy dissipation and partially moderate flow velocities.A special case is given with crossbar block ramps,where the upstream and downstream level difference is reduced by a series of *** prevent the total structure from failing,the stability of single boulders within the crossbars and the bed material in between must be *** present paper addresses the stability of bed material and scour development for various flow *** bed material erosion may affect the stability of the crossbar boulders,which in turn can result in major damages of the *** new design approaches are developed to choose an appropriate bed material size and to avoid failures of crossbar block ramp structures.

关键词： Crossbar block ramp Scouring bed material erosion Particle densimetric Froude number

Contributors’enrollment in collaborative online communities:the case of OpenStreetMap

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Geo-Spatial Information Science 2017年第3期20卷 282-295页

作者： daniel bégin Rodolphe Devillers Stéphane Roche Department of Geography Memorial University of NewfoundlandSt.John’sCanada Centre de Recherche en Géomatique UniversitéLavalQuébecCanada

The number of people registering in an online community depends on two main factors:interest in,and awareness of,the *** to a project does not,however,imply contributing to it,as lacking the knowledge and skills can be a barrier to *** order to identify the nature of events that might have facilitated or hindered enrollments in the OpenStreetMap(OSM)project over time,we analyzed the correlations between the number of new participants and the events that dotted its *** different metrics were defined to characterize participants’behaviors:the daily number of registrations,the daily number of participants that made a first contribution,the delays between contributors’registration and their first edits,and a daily contribution ratio built from the number of new contributors and the number of new registered *** series analyses were used to identify trends,and outstanding variations of the number of *** inventory of events that took place along the OSM project’s history was created and appreciable variations of the metrics have been linked to events that seemed to be *** a correlation does not imply causality,many of the explanations these correlations suggest are supported by the results of other studies,either directly or *** instance,when considering the time participants spend as“lurker”,as well as on the nature of the contribution of early *** other cases,they suggest new explanations for the origin of the spam accounts that affect registration statistics,or the decline in the proportion of registered members who actually become contributors.

关键词： OpenStreetMap(OSM) contributors lurkers participation knowledge motivation

Iron regulatory protein 1: the deadly switch of ferroptosis

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Neural Regeneration Research 2024年第3期19卷 477-478页

作者： daniel A.bórquez Pamela J.Urrutia Center for biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Institute of Nutrition&Food Technology(INTA) Universidad de ChileSantiagoChile Geroscience Center for brain Health and Metabolism SantiagoChile

Ferroptosis,an iron-dependent cell death:Ferroptosis is a type of regulated necrosis,characterized by redox-active iron accumulation and increased free radical production derived by Fenton chemistry,that triggers oxidation of polyunsaturated fatty acids in phospholipids,loss of cellular membranes integrity,and leakage of intracellular contents.

关键词： integrity switch Iron