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Dendritic cell deficiencies persist seven months after SARS-coV-2 infection

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cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé carmen Gasca-capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias cesar Sotomayor cristina Roca-Oporto Nuria Espinosa carmen Infante-Domínguez Juan carlos crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel cisneros Sonsoles Salto-Alejandre Judith Berastegui-cabrera Pedro camacho-Martínez carmen Infante-Domínguez Marta carretero-Ledesma Juan carlos crespo-Rivas Eduardo Márquez JoséManuel Lomas claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa cordero Javier Sánchez-céspedes Manuela Aguilar-Guisado Almudena Aguilera clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-wittel candela caballero-Eraso Macarena cabrera Enrique calderón Jesús carbajal-Guerrero Manuela cid-cumplido Yael corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-castillo Aurora González-Estrada Demetrio González carmen Gómez-González Rocío González-León carmen Grande-cabrerizo Sonia Gutiérrez carlos Hernández-Quiles Inmaculada concepción Herrera-Melero Marta Herrero-Romero Luis Jara carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado carmina López Isabel López Álvaro López-Barrios Luis F.López-cortés Rafael Luque-Márquez daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain cardiology and cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of clinical Investigation and clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome coronavirus(SARS-coV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(Dcs)play a key role in the defense against viral infections,for instance plasmacytoid Dcs(pDcs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In cOVID-19 there is a deficit in Dc numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the Dc deficiency,several Dc activation and homing markers were altered in acute cOVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of cD1c+myeloid Dcs and pDcs seven months after SARS-coV-2 ***,the expression of Dc markers such as cD86 and cD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of cOVID-19.

关键词： SARS-coV-2 cOVID-19 Dendritic cell Long-cOVID

2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联盟的联合倡议

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2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联...

贵州省医学会风湿病学分会第四届学术年会

作者： daniel Aletaha Tuhina Neogi Alan J Silman Julia Funovits David T Felson clifton O Bingham Ⅲ Neal S Birnbaum Gerd R Burmester Vivian P Bykerk Marc D cohen Bernard combe Karen H costenbader Maxime Dougados Paul Emery Gianfranco Ferraccioli Johanna Mw Hazes Kathryn hobbs Tom wJ Huizinga Arthur Kavanaugh Jonathan Kay Tore K Kvien Timothy Laing Philip Mease Henri A Menard Larry w Moreland Raymond L Naden Theodore Pincus Josef S Smolen Ewa Stanislawska-Biernat Deborah Symmons Paul P Tak Katherine S Upchurch Jiri Vencovsky Frederick wolfe Gillian Hawker 季兰岚邓雪蓉赵明田真张卓莉 Medical University of Vienna ViennaAustria Boston University School of Medicine BostonMassachusettsUSA

目的 :在早期类风湿关节炎(rheumatoid arthritis,RA)的诊断中,1987年美国风湿病学会(Americancollege of Rheumatology,AcR;旧称AmericanRheumatism Association,ARA)的诊断标准因为缺乏敏感度而受到质疑。本研究的目的是建立新的RA分类标准。方法 :由AcR和欧洲抗风湿病联盟(EuropeanLeague Against Rheumatism,EULAR)共同组成的工作小组,分三个阶段建立RA新的分类标准。研究的目标人群是初发的未分化关节炎患者,主要研究目的是寻找能够预测这些病人发展为RA的危险因素,并将RA疾病特点定义为持续性和/或侵蚀性关节炎。结果 :在新的分类标准中,确诊RA至少需要一个关节有明确的滑膜炎表现,除外其他可能导致滑膜炎症的疾病,同时以下四项评分的总分≥6分(最高10分):受累关节的数量和部位(0-5分)、血清学自身抗体异常(0-3分)、急性期反应物升高(0-1分)和症状持续时间(共分两级;0-1分)。结论 :既往诊断RA比较依赖骨破坏这一RA晚期表现,而新的分类标准着重于疾病早期表现而不是晚期特点,将疾病特点重新定义为持续性和/或侵蚀性滑膜炎。这一新标准的推出将再次强调了RA早期诊断的必要性以及早期有效治疗对于预防或减少不良后遗症的发生具有重要意义。

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神经损伤与功能重建 2024年第8期19卷 F0003-F0003页

作者： Adina N MacMahon copas Sarah F Mccomish Andreea Petrasca Rachel Mccormack daniel Ivers Anna Stricker Jean M Fletcher Maeve A caldwell 唐颖馨 Discipline of Physiology School of MedicineTrinity Biomedical Sciences InstituteTrinity College DublinDublinIreland Trinity college Institute for Neuroscience Trinity CollegeDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinDublinIreland School of Medicine Trinity Biomedical Sciences InstituteTrinity College DublinDublinIreland 不详

星形胶质细胞是维持稳态的介质,但在帕金森病(Parkinson’s disease,PD)中参与神经炎症。越来越多的证据表明外周免疫细胞参与了PD的发病机制。因此,本研究旨在确定外周免疫细胞分泌的细胞因子在调节中脑星形胶质细胞反应性中的潜在作... 详细信息

星形胶质细胞是维持稳态的介质,但在帕金森病(Parkinson’s disease,PD)中参与神经炎症。越来越多的证据表明外周免疫细胞参与了PD的发病机制。因此,本研究旨在确定外周免疫细胞分泌的细胞因子在调节中脑星形胶质细胞反应性中的潜在作用。人类诱导性多能干细胞(iPSc)衍生的中脑星形胶质细胞暴露于5%和10%的cD4^(+)T细胞条件培养基(cD4cM)24小时、72小时和7天,以评估长期暴露的影响。此外,星形胶质细胞还暴露于Th17细胞细胞因子IL-17A(10 ng/mL),单独或与TNF-α(0.3 ng/mL)结合,在24小时、72小时和7天评估2种细胞因子可能的协同效应。cD4cM在中脑星形胶质细胞中引起了急性及长期的变化。观察到了NFκB向细胞核的转移增加,以及在24小时时促炎基因IL-1β和cXcL10的表达增加;在24小时和48小时时c3、LcN2和IL-6的表达增加;同时在这些时间点促炎细胞因子IL-6和cXcL10的释放也有所增加。IL-17A和TNF-α的组合对增加促炎基因表达和细胞因子释放产生了协同效应。IL-17A和TNF-α在24小时时增加了S100β的强度,在72小时时减少了细胞核面积并增加了星形胶质细胞的圆度。在72小时时观察到了γH2AX强度的协同效应,并且在7天时观察到了乳酸脱氢酶(LDH)释放的增加。我们的结果表明,IL-17A和TNF-α协同作用,增强了中脑星形胶质细胞的反应性,其程度类似于cD4cM。这突出了外周免疫细胞分泌的细胞因子在增强中脑星形胶质细胞反应状态方面的重要性,并提示了它们在PD发病机制中的可能作用。

关键词：帕金森病星形胶质细胞细胞因子诱导性多能干细胞神经炎症反应性星形胶质细胞

Decline in subarachnoid haemorrhage volumes associated with the first wave of the cOVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo c Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M cervantes-Arslanian hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi chandril chugh charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke watanabe Dong Hun Shin Pedro Sc Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne weeks Elena A cora Rotem Sivan-hoffmann Roberto crosa Markus Möhlenbruch Simon Nagel hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi daniel G Abud Octavio M Pontes-Neto Ajay K wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man hong Robert Fahed Gregory walker Eiji Hagashi Steve M cordina hong Gee Roh Ken wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y wu Simon John Alex Brehm Marios Psychogios william J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen winters Johnny wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the cOVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** we conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and cOVID-19 were identified by prospective aneurysm databases or by International classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%cI−24.3%to−20.7%,pclined with 1170-1035 procedures,respectively,representing an 11.5%(95%cI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%cI−28.0%to−22.1%,pcrease in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%cI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the cOVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

将卒中纳入心血管风险预测工具美国心脏协会／美国卒中协会对医疗卫生专业人员的声明

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国际脑血管病杂志 2012年第11期20卷 801-828页

作者： daniel T. Lackland Mitchell S.V. Elkind Ralph D'Agostino Sr Mandip S. Dhamoon David c. Goff Jr Randall T. Higashida Leslie A. Mcclure Pamela H. Mitchell Ralph L. Sacco cathy A. Sila Sidney c. Smith Jr David Tanne David L. Tirschwell Emmanuel Touze Lawrence R. wechsler 4:~ 尤寿江(译) 于海龙(译) 刘慧慧(译) 张霞(译) 刘春风(译) 代表美国心脏协会卒中委员会、流行病学和预防委员会、心血管放射学和介入委员会、心血管护理委员会、周围血管病委员会以及医疗质量和转归研究委员会苏州大学附属第二医院神经内科 215004

背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而，这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支... 详细信息

背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而，这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支持：（1）将卒中（尤其是动脉粥样硬化性卒中）患者纳入心血管病绝对风险增高的患者群体；（2）将卒中纳入血管性疾病风险预测工具的转归预测因素。方法和结果写作组成员由委员会联合主席基于先前在相关领域的研究成果来提名，并得到美国心脏协会（American Heart Association，AHA）卒中委员会科学声明监督委员会以及文稿监督委员会的批准。作者采用系统文献回顾（覆盖1980年1月至2010年3月期间的文献）并参考以往公布的指南、个人资料以及专家观点，以归纳现有证据，提出当前知识的不足，并根据AHA标准对适当的问题制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并批准了最终版本。经广泛的AHA内部同行评议以及卒中委员会领导阶层和科学声明监督委员会的审阅后，最终获得AHA科学咨询和协调委员会的批准。将卒中患者（尤其是动脉粥样硬化性卒中患者）纳入冠状动脉和心血管病绝对高危人群的原因如下。首先，有证据显示，缺血性卒中患者发生致死性和非致死性心肌梗死或猝死的绝对风险增高，10年绝对风险≥20％，这一风险阈值已被一些指南用于定义冠状动脉疾病风险等危症。其次，纳入动脉粥样硬化性卒中的原因与纳入糖尿病、周围血管病、慢性肾脏病以及其他动脉粥样硬化性疾病的原因相同，尽管尚缺乏在所有人群或患者中风险增高的统一证据。再次，缺血性卒中的大动脉粥样硬化性卒中亚型与其他这些疾病的病理生理学机制相同。将卒中纳入高危因素将导致高危人群的数量扩大约10％。然而，由于卒中的异质性，尚不确定其他卒中亚型，包括出血性卒中以及非动脉粥样硬化性卒中亚型，是否应被视为具有相同水平的风险，因此有待进一步研究。鉴于卒中对残疾和死亡的影响、卒中与其他血管性疾病预防措施的相似性以及卒中在某些人群中较冠状动脉疾病更高的重要性，将卒中、心肌梗死和猝死纳入心血管事件风险预测工具的转归预测因素是合适的。美国以外的指南常常将卒中患者纳入心血管高危人群，并将卒中作为心脏终点的一个相关转归事件。结论动脉粥样硬化性卒中患者应被纳入会进一步发生冠状动脉粥样硬化事件的高危患者（10年≥20％）。是否应纳入非动脉粥样硬化卒中亚型尚不确定。对于一级预防，缺血性卒中应被纳入绝对风险评估方案的心血管疾病转归事件。将动脉粥样硬化性卒中作为一个高危因素或者更宽泛地将缺血性卒中视作一种转归事件纳入，可能对心血管病的预防具有重要意义，因为被评定为高危风险的患者数量将大幅增加。

关键词： AHA科学声明心血管疾病危险性评估风险预测卒中

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定位于内质网膜的转录因子MYRF经剪切后入核以调控秀丽线虫神经元突触发育重塑

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科学新闻 2018年第4期 105-105页

作者： Jun Meng Xiaoxia Ma Huaping Tao Xia Jin daniel witvliet James Mitchell Ming Zhu Meng-Qiu Dong Mei Zhen Yishi Jin 齐瀛川上海科技大学生命科学与技术学院

文章简介本研究以遗传筛选的方式鉴别到突变体具有突触重塑障碍,并鉴别出该突变是个单点突变,发生在MYRF-1上。进一步的研究发现,MYRF-1蛋白全长定位在内质网上,并能发生剪切,之后释放出蛋白的氮端,氮端具有结合DNA的功能域,它进入细胞... 详细信息

文章简介本研究以遗传筛选的方式鉴别到突变体具有突触重塑障碍,并鉴别出该突变是个单点突变,发生在MYRF-1上。进一步的研究发现,MYRF-1蛋白全长定位在内质网上,并能发生剪切,之后释放出蛋白的氮端,氮端具有结合DNA的功能域,它进入细胞核并参与转录调控,而其氮端在核内的功能恰恰对突

关键词：突触重塑神经元

美国俄亥俄州中部大德尔比支流上游的水文、水质和恢复潜力研究(摘要)(英文)

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四川林业科技 2007年第1期28卷 55-55页

作者：张立威廉.杰.米奇丹尼尔.弗.芬克 Olentangy River wetland Research Park School of Natural Resources and Environmental Science Graduate Program352 W.Dodridge StreetThe Ohio State UniversityColumbusOH 43202

The restoration of riparian buffers as well as the creation and restoration of wetlands along streams are practices that can be used to control point and non-point source *** study provides hydrology and water quality data from 2000～2002 in anticipation of recommending restoration of the headwaters of the Big Darby creek watershed in central *** tributary of concern in the headwaters,Flat Branch,contributed 11% of the total river flow during April 2002 flooding and 56 and 88% of the flow in the headwater study area during non-growing(winter and early spring) and growing(summer and early fall)seasons,*** were significant differences in water chemistry,both temporally and spatially,at each sampling station within the upper *** Branch was seasonally or continuously higher in temperature,pH,and turbidity,and lower in dissolved ions and oxygen than Darby *** dissolved oxygen at dawn during the summer months caused by diurnal metabolism in the water column is also a concern in Darby *** propose the creation/restoration of riparian wetlands at the confluence of the Big Darby and Flat Branch as one solution to degrading water quality in the upper Big Darby *** pulses,particularly from the Flat Branch,could be directed to riparian wetlands,which would minimize downstream erosion and capture the water exactly when several pollutants(sediments,nitrates,and so forth) are in higher *** restoration area could have flood control,habitat,and ecotourism values as well.

关键词：美国俄亥俄州中部上游水文水质 water quality dissolved oxygen water chemistry flood control water column quality data

correction:clinical outcome measures in dementia with Lewy bodies trials:critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 588-588页

作者： Federico Rodriguez-Porcel Kathryn A.wyman-chick carla Abdelnour Ruiz Jon B.Toledo daniel Ferreira Prabitha Urwyler Rimona S.weil Joseph Kane Andrea Pilotto Arvid Rongve Bradley Boeve John-Paul Taylor Ian McKeith Dag Aarsland Simon J.G.Lewis the Lewy Body Dementias clinical Trials workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment(ISTAART) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of Radiology Mayo ClinicRochesterMNUSA ARTORG center for Biomedical Engineering Research University of BernBernSwitzerland Dementia Research centre University College LondonLondonUK centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of Research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and clinical Research Institute Newcastle University Newcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease Research clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

correction to:Translational Neurodegeneration(2022)11:24 https://***/10.1186/s40035-022-00299-w Following publication of the original article[1],the authors identified some errors in the Additional files *** original ... 详细信息

关键词： degeneration clinical measures

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大熊猫保护区的生态系统服务价值

科学新闻 2019年第2期 120-120页

作者：魏辅文 Robert costanza Qiang Dai Natalie Stoeckl Xiaodong Gu Stephen Farber Yonggang Nie Ida Kubiszewski Yibo Hu Ronald Swaisgood Xuyu Yang Michael Bruford Youping chen Alexey Voinov Dunwu Qi Megan Owen Li Yan daniel c.Kenny Zejun Zhang Rong hou Shiwei Jiang hongbo Liu Xiangjiang Zhan Li Zhang Biao Yang Lianjun Zhao Xiaoguang Zheng wenliang Zhou Yali wen Heran Gao wen Zhang 中国科学院中国科学院动物研究所

文章简介全球生态系统服务价值估计每年为125万亿美元,相似的国家和区域层面的评估也显示生态系统服务价值足以支撑我们的生活。所有的生态系统服务价值评估都肯定了生物多样性的重要作用,尽管全球的生物多样性

关键词：大熊猫保护区生态系统服务价值生物多样性