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Detection of Stage I nasopharyngeal carcinoma by serologicscreening and clinical examination

Chinese Journal of Cancer 2011年第2期30卷 120-123页

作者： Ming-Fang Ji Yuan-Long Yu Wei-Ming Cheng Yong-Sheng Zong Park Sze-Park Ng daniel tsin-tien chua Mun-Hon Ng Cancer Research Institute of Zhongshan City Zhongshan Guangdong 528403 P R China Department of Pathology Sun Yat-sen Medical College Sun Yat-sen University Guangzhou Guangdong 510080 P. R. China Department of Microbiology Faculty of Medicine The University of Hong Kong Hong Kong SAR P. R. China Department of Clinical Oncology Faculty of Medicine The University of Hong Kong Hong Kong SAR P. R. China

In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed nasopharyngeal carcinoma (NPC). Although Epstein-Barr virus (EBV) antibody levels of the cohort fluctuated, the antibody levels of 93% of the patients with NPC were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor tumor progression during the preclinical stage of NPC development, facilitating early NPC detection. We reviewed the clinical records of the 171 patients with NPC in the prospective study to assess the efficacy of early NPC detection by serologic screening and clinical examination. Of the 171 patients, 51 had Stage I tumor (44 were among the 73 patients detected by clinical examination and 7 were among the 98 patients presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 patients detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I tumor. The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I tumors among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of NPC can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect tumors before the symptoms develop.

关键词：血清学检测临床检查鼻咽癌筛查一阶全国人民代表大会抗体水平 EB病毒

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Barriers and facilitators of peer support work in a large psychiatric hospital:a thematic analysis

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General Psychiatry 2021年第3期34卷 154-162页

作者： Jonathan Han Loong Kuek Hong Choon chua daniel Poremski Health Intelligence Unit Institute of Mental HealthSingapore

Background Peer support workers are an important addition to the mental healthcare ***,much of the literature and knowledge of the peer support role is derived from western *** concept is relatively new in Asian *** The study sought to improve the understanding of the barriers and facilitators of peer support work in a large psychiatric hospital in *** This study used qualitative data from a larger mixed-methods *** analysis was conducted based on the five steps recommended by Braun and Clarke(2006):(1)familiarisation of data whereby transcripts were read and reread,(2)generating initial codes,(3)searching for themes by gathering relevant codes,(4)reviewing themes and(5)defining and naming *** Four subthemes under the broader notion of facilitators(supportive figures,defined role,opportunities for personal growth and identifying personalised coping strategies)and three subthemes under the concept of barriers(unclear role,hostility from non-peer-support specialist staff and unsupportive working environments)were *** Our findings echoed those of previous studies conducted in western countries providing some evidences for the cross-cultural nature of these barriers and ***,the way their impact can be mitigated or enhanced is likely to be different owing to cultural barriers,such as the general consensus and acceptance of larger personal recovery *** research is required in community settings to better understand the boundaries and limitations of our *** information will allow us to continue improving peer support worker integration in diverse mental healthcare settings.

关键词： finding analysis gathering

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Optimization Strategies Toward Functional Sodium-Ion Batteries

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Energy & Environmental Materials 2023年第4期6卷 332-354页

作者： Jingwei Chen Gupta Adit Lun Li Yingxin Zhang daniel H.C.chua Pooi See Lee School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China School of Materials Science and Engineering Nanyang Technological UniversitySingapore City 639798Singapore Department of Materials Science and Engineering National University of SingaporeSingapore City 117575Singapore

Exploration of alternative energy storage systems has been more than necessary in view of the supply risks haunting lithium-ion *** various alternative electrochemical energy storage devices,sodium-ion battery outstands with advantages of cost-effectiveness and comparable energy density with lithium-ion *** to the similar electrochemical mechanism,the research and development of lithium-ion batteries have forged a solid foundation for sodium-ion battery *** in sodium-ion batteries have been witnessed in terms of superior electrochemical performance and broader application ***,the strategies adopted to optimize the battery components(cathode,anode,electrolyte,separator,binder,current collector,etc.)and the cost,safety,and commercialization issues in sodium-ion batteries are summarized and *** on these optimization strategies,assembly of functional(flexible,stretchable,self-healable,and self-chargeable)and integrated sodium-ion batteries(−actuators,−sensors,electrochromic,etc.)have been *** these achievements,challenges including energy density,scalability,trade-off between energy density and functionality,cost,*** to be addressed for sodium-ion battery *** review aims at providing an overview of the up-to-date achievements in sodium-ion batteries and serves to inspire more efforts in designing upgraded sodium-ion batteries.

关键词： energy storage integration multifunctional optimization strategies sodiumion batteries

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联营电力市场中需求侧的直接参与(英文)

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电网技术 2007年第20期31卷 7-15页

作者： chua-Liang Su daniel Kirschen 曼彻斯特大学电气与电子工程学院

在现有的允许需求侧竞标的日前联营市场中,每当某个时段的市场清算电价高于投标报价时,需求侧的兆瓦级购电竞标就被拒绝。由于用户不参与通过削减供电量来牟利的商业运作,因此未得到满足的用户需求只能从平衡市场中在更接近于预期用电... 详细信息

在现有的允许需求侧竞标的日前联营市场中,每当某个时段的市场清算电价高于投标报价时,需求侧的兆瓦级购电竞标就被拒绝。由于用户不参与通过削减供电量来牟利的商业运作,因此未得到满足的用户需求只能从平衡市场中在更接近于预期用电的时段中获得。这就使用户遭受更大的不能以所希望的价格来满足其对电能的需要的风险。文章介绍了一种新的市场概念,它能在日前市场对需求侧的竞标者关闭后,以合并拍卖规则中需求移动机制的方法来降低其需求不平衡的风险。

关键词：市场清算工具最大社会福利允许需求侧参与需求移动基于联营的电力市场完全竞争混合整数线性规划

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Living Earth:Implementing national standardised land cover classification systems for Earth Observation in support of sustainable development

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Big Earth Data 2021年第3期5卷 368-390页

作者： Christopher J.Owers Richard M.Lucas daniel Clewley Carole Planque Suvarna Punalekar Belle Tissott Sean M.T.chua Pete Bunting Norman Mueller Graciela Metternicht Department of Geography and Earth Sciences Aberystwyth UniversityAberystwythCeredigionWalesUK Centre for Geospatial Applications Plymouth Marine LaboratoryPlymouthDevonEnglandUK Geoscience Australia SymonstonACTAustralia Earth and Sustainability Science Research Centre School of BiologicalEarth and Environmental SciencesUniversity of New South WalesSydneyAustralia

Earth Observation(EO)has been recognised as a key data source for supporting the United Nations Sustainable Development Goals(SDGs).Advances in data availability and analytical capabilities have provided a wide range of users access to global coverage analysis-ready data(ARD).However,ARD does not provide the information required by national agencies tasked with coordinating the implementation of ***,standardised,scalable mapping of land cover and its change over time and space facilitates informed deci-sion making,providing cohesive methods for target setting and reporting of *** aim of this study was to implement a global framework for classifying land *** Food and Agriculture Organisation’s Land Cover Classification System(FAO LCCS)provides a global land cover taxonomy suitable to comprehensively support SDG target setting and *** present a fully implemented FAO LCCS optimised for EO data;Living Earth,an open-source software package that can be readily applied using existing national EO infrastructure and satellite *** resolve several semantic challenges of LCCS for consistent EO implementation,including modifications to environmental descriptors,inter-dependency within the mod-ular-hierarchical framework,and increased flexibility associated with limited data *** ensure easy adoption of Living Earth for SDG reporting,we identified key environmental descriptors to provide resource allocation recommendations for generating routinely retrieved input *** Earth provides an optimal platform for global adoption of EO4SDGs ensuring a transparent methodology that allows monitoring to be standardised for all countries.

关键词： Land cover FAO LCCS open data cube sustainable development goals environmental descriptors

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Intensity modulated radiotherapy （IMRT） and combined chemotherapy for nasopharyngeal carcinoma

Intensity modulated radiotherapy （IMRT） and combined chemo...

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第三届中国肿瘤学术大会

作者： Jonathan Sham Dora Kwong daniel chua Department of Clinical Oncology Queen Mary HospitalUniversity of Hong Kong Department of Clinical Oncology Queen Mary HospitalUniversity of Hong Kong Department of Clinical Oncology Queen Mary HospitalUniversity of Hong Kong

＜正＞ The adoption of the 1997 stage classification of AJC for nasopharyngeal carcinoma（NPC）has allowed not only betterprediction of prognosis,but also allowed grouping of patients with different patterns of failure after treatment. chua et al had analyzed the different stage sub—groups and the pattern of *** information,together with theadvances in radiotherapy and combination chemotherapy,allowed the adoption of different strategies to deal with the differentpatterns of failure.

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Operational continental-scale land cover mapping of Australia using the Open Data Cube

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International Journal of Digital Earth 2022年第1期15卷 1715-1737页

作者： Christopher J.Owers Richard M.Lucas daniel Clewley Belle Tissott Sean M.T.chua Gabrielle Hunt Norman Mueller Carole Planque Suvarna M.Punalekar Pete Bunting Peter Tan Graciela Metternicht School of Environmental and Life Sciences University of NewcastleCallaghanAustralia Department of Geography and Earth Sciences Aberystwyth UniversityAberystwythUK Commonwealth Scientific and Industrial Research Organisation Land and WaterCanberraAustralia Centre for Geospatial Applications Plymouth Marine LaboratoryPlymouthUK Geoscience Australia SymonstonAustralia Earth and Sustainability Science Research Centre University of New South WalesSydneyAustralia School of Science Western Sydney UniversityRichmondAustralia

To comprehensively support national and international initiatives for sustainable development,land cover products need to be reliably and routinely generated within operational *** with consistent semantics and taxonomies,ensuring confidence in mapping land cover for multiple time periods,facilitates informed decision-making at scales appropriate to multiple policy *** United Nations Food and Agriculture Organisation(FAO)Land Cover Classification System(LCCS)provides a taxonomy that comparable at different scales,level of detail and geographic *** Open Data Cube(ODC)initiative offers a framework for operational continental-scale land cover mapping using analysis-ready Earth Observation *** study utilised the FAO LCCS framework and the Landsat sensor data through Digital Earth Australia(DEA;Australia’s ODC instance)to generate consistent and continent-wide land cover mapping(DEA Land Cover)of the Australian *** Land Cover provides annual maps from 1988 to 2020 at 25 m *** maps were validated with∼12,000 independent validation points,giving an overall map accuracy of 80%.DEA Land Cover provides Australia with a nationally consistent picture of land cover,with an open-source software package using readily available global coverage data and demonstrates a pathway of adoption for national implementations across the world.

关键词： DEA land cover digital earth Australia FAO LCCS landsat sustainable development goals

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Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer:efficacy,safety,and biomarker results from Chinese patients

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Chinese Journal of Cancer 2011年第5期30卷 327-335页

作者： Bing-He Xu Ze-Fei Jiang daniel chua Zhi-Min Shao Rong-Cheng Luo Xiao-Jia Wang Dong-Geng Liu Winnie Yeo Shi-Ying Yu Beth Newstat Alka Preston Anne-Marie Martin Hai-Dong Chi Li wang Department of Medical Oncology Cancer Hospital Chinese Academy of Medical Sciences Beijing 100021 P. R. China Breast Cancer Department PLA 307 Hospital Beijing 100071 P. R.China Queen Mary Hospital Hong Kong P. R. China Breast Cancer Surgical Department Shanghai Cancer Hospital Shanghai 200032 P. R.China Department of Medical Oncology Nanfang Hospital GuangzhouGuangdong 510515 P. R. China Department of Medical Oncology Zhejiang Provincial Cancer Hospital Hangzhou Zhejiang 310022 P. R.China Sun Yat-sen University Cancer Center GuangzhouGuangdong 510060P.R.China Prince of Wales Hospital Shatin New TerritoryHong Kong P. R. China Tongji Hospital Huazhong University of Scienceand Technology Tongji Medical College Wuhan Hubei 430030 P. R. China GlaxoSmithKline Company Collegeville PA USA GlaxoSmithKline Company Ltd Shanghai 200001 P. R. China

Overexpression of human epidermal growth factor receptor-2(HER2) in metastatic breast cancer(MBC) is associated with poor *** single-arm open-label trial(EGF109491;NCT00508274) was designed to confirm the efficacy and safety of lapatinib in combination with capecitabine in 52 heavily pretreated Chinese patients with HER2-positive *** primary endpoint was clinical benefit rate(CBR).Secondary endpoints included progression-free survival(PFS),time to response(TTR),duration of response(DoR),central nervous system(CNS) as first site of relapse,and *** results showed that there were 23 patients with partial responses and 7 patients with stable disease,resulting in a CBR of 57.7%.The median PFS was 6.34 months(95% confidence interval,4.93-9.82 months).The median TTR and DoR were 4.07 months(range,0.03-14.78 months) and 6.93 months(range,1.45-9.72 months),***(25.0%) patients had new lesions as disease *** them,2(3.8%) patients had CNS disease reported as the first *** most common toxicities were palmar-plantar erythrodysesthesia(59.6%),diarrhea(48.1%),rash(48.1%),hyperbilirubinemia(34.6%),and fatigue(30.8%).Exploratory analyses of oncogenic mutations of PIK3CA suggested that of 38 patients providing a tumor sample,baseline PIK3CA mutation status was not associated with CBR(P = 0.639) or PFS(P = 0.989).These data confirm that the lapatinib plus capecitabine combination is an effective and well-tolerated treatment option for Chinese women with heavily pretreated MBC,irrespective of PIK3CA status.

关键词：治疗方案安全性乳腺癌生物标志物患者中国疗效阳性

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贝多芬的空白美学

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中央音乐学院学报 2020年第4期 89-106页

作者： [英]蔡宽量孙月(译) 香港大学人文学院国际音乐学会(IMS) 上海音乐学院

自由在贝多芬音乐中的关键能指是“空白符号”,这个符号呈现出多种形式。本文从音乐和哲学两方面追溯了这些空白,以此探索它们的作用和意义。特别是将贝多芬的《合唱幻想曲》视作这种空白的注解,集中阐述作曲家自己将这一符号作为表征... 详细信息

自由在贝多芬音乐中的关键能指是“空白符号”,这个符号呈现出多种形式。本文从音乐和哲学两方面追溯了这些空白,以此探索它们的作用和意义。特别是将贝多芬的《合唱幻想曲》视作这种空白的注解,集中阐述作曲家自己将这一符号作为表征自由与进步的创作手法。

关键词：绝对音乐贝多芬合唱幻想曲自由黑格尔康德

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局部晚期鼻咽癌同期放化疗的疗效分析

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中华肿瘤杂志 2005年第7期27卷 429-431页

作者：田野蔡清淟岑信棠苏州大学附属第二医院放疗科 215004 香港大学医学院临床肿瘤学系

目的评估同期放化疗方案对局部晚期鼻咽癌患者的疗效、急性毒性反应、依从性和晚期损伤情况。方法74例Ⅲ、Ⅳ期中国人种局部晚期鼻咽癌患者,按照北美Intergroup0099方案接受了同期放疗加辅助化疗的治疗,其急性与晚期毒性反应采用美国放... 详细信息

目的评估同期放化疗方案对局部晚期鼻咽癌患者的疗效、急性毒性反应、依从性和晚期损伤情况。方法74例Ⅲ、Ⅳ期中国人种局部晚期鼻咽癌患者,按照北美Intergroup0099方案接受了同期放疗加辅助化疗的治疗,其急性与晚期毒性反应采用美国放射治疗协作组织(RTOG)的标准进行评价。结果74例患者的5年生存率和无瘤生存率分别为71.3%和43.5%。无5级毒性反应发生,3,4级急性毒性反应主要为造血系统25例,占33.8%;咽部黏膜19例,占25.7%;放疗区皮肤损伤6例,占8.1%。完成放疗、同期放化疗和全部化疗者分别为100.0%、75.7%和47.3%;3～4级晚期并发症主要为唾液腺损伤(17例)、听力损伤(13例)、皮肤及皮下组织损伤(7例),晚期损伤的5年累积发生率为44.3%。结论与常规放射治疗相比,同期放化疗方案有助于中国人种局部晚期鼻咽癌患者疗效的提高,其急性毒性反应有所增加,晚期损伤基本相同。

关键词：鼻咽癌药物疗法放射疗法唾液腺损伤

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