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Temporal trends in concentrations of legacy and novel brominated flame retardants in house dust from Birmingham in the United Kingdom

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Emerging Contaminants 2020年第1期6卷 323-329页

作者： daniel simon Drage Sonthinee Waiyarat Stuart Harrad Mohamed Abou-Elwafa Abdallah Suwanna Kitpati Boontanon School of Geography Earth&Environmental SciencesUniversity of BirminghamBirminghamB152TTUK Department of Civil and Environmental Engineering Faculty of EngineeringMahidol UniversityNakhon PathomThailand

Concentrations of polybrominated diphenyl ethers(PBDEs),hexabromocyclododecane(HBCDD),tetrabromobisphenol-A(TBBPA)and two potential replacements decabromodiphenylethane(DBDPE)and 1,2-bis(2,4,6-tribromophenoxy)ethane(BTBPE)were measured in dust samples collected from 14 homes across Birmingham(UK).Concentrations were compared with those from the same city in previous studies to ascertain any temporal changes and to assess the effects of legislative *** average PHBCDDs concentration(46,000 ng/g;median=280 ng/g)included the highest dust concentration recorded globally(570,000 ng/g).This is despite the listing of HBCDD under the Stockholm Convention in 2013,demonstrating that decreases in indoor contamination will likely be slow as existing sources are gradually *** contrast,concentrations of BDE-47(mean=5.7 ng/g;median=0.93 ng/g)and BDE-99(mean=11 ng/g;median=2.9 ng/g)were significantly lower than in all previous(p<0.01)studies in the same city since 2006,suggesting restrictions on the Penta-BDE formulation have been *** average BDE-209 concentration(4800 ng/g;median=1600 ng/g)is lower than the peak average concentration,which was observed in 2007(280,000 ng/g),however this is not a significant decline,probably due to the later imposition of Deca-BDE restrictions compared to those on *** in PBDE concentrations have coincided with a significant(p<0.01)increase in DBDPE concentrations(average=1500 ng/g;median=660 ng/g)since 2014,suggesting its use as a replacement flame retardant for *** no significant change was detected for BTBPE(average 11 ng/g;median=0.84 ng/g in this study);concentrations of TBBPA(average=34 ng/g;median=35 ng/g)were significantly lower(p<0.05)than in 2007(average 62 ng/g).The decreases observed in PBDE concentrations,demonstrates that legislation has been effective in reducing the commercial use of PBDEs,however this has coincided with increases of alternative flame retardants such as DBDPE.

关键词： Brominated Flame Retardants(BFRs) Polybrominated diphenyl ethers(PBDEs) Hexabromocyclododecane(HBCDD) Decabromodiphenyl ethane(DBDPE) Stockholm convention Tetrabromobisphenol A(TBBPA) BTBPE

Fully 3D-printed organic electrochemical transistors

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npj Flexible Electronics 2023年第1期7卷 453-463页

作者： Matteo Massetti Silan Zhang Padinhare Cholakkal Harikesh Bernhard Burtscher Chiara Diacci daniel T.simon Xianjie Liu Mats Fahlman Deyu Tu Magnus Berggren simone Fabiano Laboratory of Organic Electronics Department of Science and TechnologyLinköping UniversityNorrköpingSweden.2Wallenberg Wood Science CenterLinköping UniversityNorrköpingSweden

Organic electrochemical transistors(OECTs)are being researched for various applications,ranging from sensors to logic gates and neuromorphic *** meet the requirements of these diverse applications,the device fabrication process must be compatible with flexible and scalable digital ***,we report a direct-write additive process to fabricate fully 3D-printed OECTs,using 3D printable conducting,semiconducting,insulating,and electrolyte *** 3D-printed OECTs,which operate in the depletion mode,can be fabricated on flexible substrates,resulting in high mechanical and environmental *** 3D-printed OECTs have good dopamine biosensing capabilities(limit of detection down to 6μM without metal gate electrodes)and show long-term(~1 h)synapse response,indicating their potential for various applications such as sensors and neuromorphic *** manufacturing strategy is suitable for applications that require rapid design changes and digitally enabled direct-write techniques.

关键词： electrochemical hardware printed

Resistance mechanism to cisplatin in NCI-H460 non-small cell lung cancer cell line:investigating apoptosis,autophagy,and cytogenetic damage

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Cancer Drug Resistance 2018年第1期1卷 72-81页

作者： Érica Ballestreri daniel simon Ana Paula de Souza Camila Schultz Grott Débora Dreher Nabinger Rafael Rodrigues Dihl Ivana Grivicich Laboratory of Cancer Biology Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Human Molecular Genetics Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Genetic Toxicity Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil

Aim:To investigate the effects of cisplatin on the human non-small cell lung carcinoma(NCI-H460)cell line regarding cytotoxicity,genotoxicity,and expression of genes associated with apoptosis(BIRC5)and autophagy(BECN1).Methods:Cell cultures were treated with cisplatin concentrations(0.16-33.3μmol/L)for 48 *** and acute and chronic cytotoxicities were assessed using the MTT,clonogenic,and cytokinesis-block micronucleus *** expression of BIRC5 and BECN1 was evaluated by reverse transcription-polymerase chain ***:Cisplatin IC50(0.33μmol/L)increased micronucleus frequency 2.50 *** was also cytotoxic in the 0.6-33.3μmol/L range,with reduced expression of the BIRC5 gene,suggesting induction of *** reducing the expression of the BIRC5 gene,33.3μmol/L cisplatin increased the expression of the BECN1 gene,suggesting that autophagy can be related to cisplatin ***:Cisplatin inhibited NCI-H460 growth,and cisplatin IC50 induced genotoxic *** higher cisplatin concentrations are used,the expression of genes associated with apoptosis and autophagy was *** results points to a further investigation of the role of autophagy in cisplatin resistance.

关键词： BECN1 BIRC5 cisplatin cytotoxicity lung cancer

Association of interferon lambda-4 rs12979860 polymorphism with hepatocellular carcinoma in patients with chronic hepatitis C infection

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World Journal of Hepatology 2021年第1期13卷 109-119页

作者： Jóice Teixeira de Bitencorte Tássia Flores Rech Vagner Ricardo Lunge Deivid Cruz dos Santos Mário ReisÁlvares-da-Silva daniel simon PPG Biologia Celular e Molecular AplicadaàSaúde Universidade Luterana do BrasilCanoas 92425-900Rio Grande do SulBrazil Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil

BACKGROUND Hepatitis C virus(HCV)infection is a public health concern *** factors,including genetic polymorphisms,may be evolved in the progression of HCV infection to liver *** lambdas(IFNLs)modulate the immune response during viral *** induce antiviral activity,interfering in the viral replication by promoting the expression of several genes that regulate immunological *** interferon lambda-4(IFNL4)rs12979860 polymorphism,which is characterized by a C to T transition in intron 1,is associated with spontaneous and treatment-induced clearance of HCV infection and may play a role in the development of HCV-associated liver diseases,including hepatocellular carcinoma(HCC).AIM To investigate the association of IFNL4 rs12979860 polymorphism with fibrosis,cirrhosis,and HCC in patients with chronic HCV *** This study was comprised of 305 chronic HCV-infected patients(53 fibrosis,154 cirrhosis,and 98 HCC cases).The control group was comprised of 260 HCVnegative healthy *** IFNL4 rs12979860 polymorphism was genotyped using the TaqMan *** was diagnosed based on liver biopsy findings,while cirrhosis was diagnosed through clinical,laboratory,anatomopathological,and/or imaging *** was diagnosed through imaging tests,tumor,and/or anatomopathological *** The T allele was observed in the three groups of patients(fibrosis,cirrhosis,and HCC)at a significantly higher frequency when compared with the control group(P=0.047,P<0.001,and P=0.01,respectively).Also,genotype frequencies presented significant differences between the control group and cirrhosis patients(P<0.001)as well as HCC patients(P=0.002).The risk analysis was performed using the codominant and dominant T allele *** the codominant model,it was observed that the CT genotype showed an increased risk of developing cirrhosis in comparison with the CC genotype[odds ratio(OR)=2.53;95%confidence interval(CI):1.55-4.15;

关键词： Hepatitis C Hepatitis C virus Cirrhosis Hepatocellular carcinoma Genetic polymorphism Interferon-lambda

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未来幻境设计师

汽车生活 2013年第4期 46-51页

作者： daniel simon 张萌

danielsimon幼时生长于东德，多数时间里，这个小小少年都在画画。他的画笔随着自己无边的想象在画纸上流淌，勾勒出虚构的奇妙世界和那个世界里的各种机器。三十年后，他已在美国洛杉矶创办了自己的工作室并继续在那里描绘存在于他想... 详细信息

danielsimon幼时生长于东德，多数时间里，这个小小少年都在画画。他的画笔随着自己无边的想象在画纸上流淌，勾勒出虚构的奇妙世界和那个世界里的各种机器。三十年后，他已在美国洛杉矶创办了自己的工作室并继续在那里描绘存在于他想象中的奇幻世界。此外，他还是好莱坞顶尖汽车设计师，曾为影片《创：战纪》、《美国队长》、《遗落战境》等设计汽车。但他表示，作为一名汽车设计师，这些概念车只是他本职工作的分支。他大学毕业后加入大众公司，先后为大众、奥迪、布加迪等品牌设计概念车，随后开设了自己的咨询公司。

关键词：汽车设计师大众公司本职工作品牌设计咨询公司概念车世界工作室

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梦圆梦非梦

汽车测试报告 2013年第7期 106-111页

作者： Jason Barlow daniel simon(图)

请见过八零年代最精湛的勒芒赛车，唯此中有一玄机——它其实来自另一宇宙的八零年代。欢迎莅临daniel simon的不可思议世界。欢迎大家进入1916至2582年间整整横跨666年的赛车世界。此界能化不可能为可能，容许阁下自由进出另一红尘。... 详细信息

请见过八零年代最精湛的勒芒赛车，唯此中有一玄机——它其实来自另一宇宙的八零年代。欢迎莅临daniel simon的不可思议世界。欢迎大家进入1916至2582年间整整横跨666年的赛车世界。此界能化不可能为可能，容许阁下自由进出另一红尘。出现于在这个平行赛车宇宙的大部分事物，不管是赛车、赞助商标、人物、男女或发型，

关键词： simon 赛车年代宇宙世界

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跟顶级实验室学人才管理

商学院 2011年第8期 J0014-J0016页

作者： Wouter Aghina Marc de Jong daniel simon

6种关键做法可以推动研究机构获得成功。在这6种做法中，人才管理与高绩效的相关性最大，而且具有最大的改进机会。任何实验室都不应该忽视自己的员工绩效最高的实验室采用了最好的人才管理做法，这绝非巧合。

关键词：人才管理实验室员工绩效研究机构相关性

Exploration of the Seaweed Resources in Nigeria: A Case Study of Lagos Coastal Waters

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Open Journal of Marine Science 2025年第1期15卷 13-34页

作者： Esther U. Kadiene daniel Oluwaleke Biaoku Dunsin Abimbola Bolaji simon Ekele Edike Kaine Adewunmi Adeyemi Oluwatobi Olaolu Akerele Department of Animal and Environmental Biology Faculty of Science Delta State University Abraka Nigeria Centre for Research and International Programmes Delta State University Abraka Nigeria Nigerian Institute for Oceanography and Marine Research Victoria Island Lagos Nigeria AquaEarth Consulting Victoria Island Lagos Nigeria Adeyemi Golden Hatch Farm Abeokuta Nigeria African Seaweed Ventures Ltd London United Kingdom

This study provides an in-depth exploration of seaweed biodiversity in Nigeria’s coastal waters, a largely unexplored area for marine resources. There is a dearth of sufficient data on seaweed biodiversity in Nigeria. The research aimed to assess the diversity and distribution of seaweeds in this region. Seaweed samples were collected by hand, using scrapers, at low tide from four stations identified by local fisherfolk and commercial divers. These samples were analyzed in the laboratory for species identification. A total of 39 seaweed taxa were identified, with Rhodophyta (red algae) being the most abundant (74%), followed by Chlorophyta (green algae) (21%) and Heterokontophyta (brown algae) (5%). The highest biomass species included Grateloupia sp., Chaetomorpha antennina, Gracilaria sp., Ceratodictyon variabile, Cladophora sp., Gelidium pusillum, Ulva sp., Blidingia minima, and Caloglossa leprieurii. Species abundance was highest on breakwater rocks and on the bodies of anchored or sunken vessels, while sandy beaches exhibited lower abundance. The findings reveal significant potential for Nigeria’s seaweed in aquaculture, climate change mitigation, and biotechnology. The study recommends further molecular research, expansion of sampling areas, and the development of sustainable seaweed cultivation practices to support Nigeria’s blue economy.

关键词： Seaweed Biodiversity Lagos Coastal Waters Marine Ecology Macroalgae Blue Economy Aquaculture

LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders？

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Neural Regeneration Research 2017年第8期12卷 1247-1251页

作者： simon Foale Martin Berry Ann Logan daniel Fulton Zubair Ahmed Neuroscience and Ophthalmology Institute of Inflammation and Ageing University of Birmingham Birmingham UK

Leucine rich repeat proteins have gained considerable interest as therapeutic targets due to their expression and biological activity within the central nervous system. LINGO-1 has received particular attention since it inhibits axonal regeneration after spinal cord injury in a Rho A dependent manner while inhibiting leucine rich repeat and immunoglobulin-like domain-containing protein 1（LINGO-1） disinhibits neuron outgrowth. Furthermore, LINGO-1 suppresses oligodendrocyte precursor cell maturation and myelin production. Inhibiting the action of LINGO-1 encourages remyelination both in vitro and in vivo. Accordingly, LINGO-1 antagonists show promise as therapies for demyelinating diseases. An analogous protein to LINGO-1, amphoterin-induced gene and open reading frame-3（AMIGO3）, exerts the same inhibitory effect on the axonal outgrowth of central nervous system neurons, as well as interacting with the same receptors as LINGO-1. However, AMIGO3 is upregulated more rapidly after spinal cord injury than LINGO-1. We speculate that AMIGO3 has a similar inhibitory effect on oligodendrocyte precursor cell maturation and myelin production as with axogenesis. Therefore, inhibiting AMIGO3 will likely encourage central nervous system axonal regeneration as well as the production of myelin from local oligodendrocyte precursor cell, thus providing a promising therapeutic target and an area for future investigation.

关键词： multiple sclerosis demyelination oligodendrocyte AMIGO3 LINGO1 oligodendrocyte precursor cell