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Re-evaluation of classical prognostic factors in resectable ductal adenocarcinoma of the pancreas

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World Journal of Gastroenterology 2016年第28期22卷 6424-6433页

作者： daniel Akerberg daniel Ansari Roland Andersson Department of Surgery Clinical Sciences Lund Lund University and Skane University Hospital SE-221 85 Lund Sweden

Pancreatic ductal adenocarcinoma carries a poor prognosis with annual deaths almost matching the reported incidence rates. Surgical resection offers the only potential cure. Yet, even among patients that undergo tumor resection, recurrence rates are high and long-term survival is scarce. Various tumorrelated factors have been identified as predictors of survival after potentially curative resection. These factors include tumor size, lymph node disease, tumor grade, vascular invasion, perineural invasion and surgical resection margin. This article will re-evaluate the importance of these factors based on recent publications on the topic, with potential implications for treatment and outcome in patients with pancreatic cancer.

关键词： Pancreatic cancer Survival Prognostic factors

Two-tiered reconstruction of Late Pleistocene to Holocene changes in the freezing level height in the largest glacierized areas of the Colombian Andes

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Journal of Mountain Science 2022年第3期19卷 615-636页

作者： daniel RUIZ-CARRASCAL daniel GONZALEZ-DUQUE Isabel RESTREPO-CORREA Department of Ecology Evolution and Environmental BiologyColumbia University in the City of New YorkNew YorkNY 10027USA Department of Civil and Environmental Engineering Vanderbilt University40024th Avenue South269 Jacobs HallNashville TN 3720USA Department of Earth Sciences Universidad EAFITCarrera 49 No.7Sur-50MedellínColombia

One way of deducing vertical shifts in the altitudinal distribution of Colombian high-altitude páramo environments is by inferring fluctuations in the height of the local freezing *** our research,we are implementing two complementary approaches to reconstruct Late Pleistocene to Holocene changes in the freezing level height(FLH)in two of the most extensively glacier-covered areas of the northern *** combined remote sensing and field-based geomorphological mapping with time-series reconstruction of changes in the altitude of the 0°C *** in the FLH were based on alreadypublished~30 kyr paleo-reconstructions of sea surface temperatures(SSTs)of the eastern tropical Pacific and the western tropical Atlantic,as well as on reconstructed long-term sea level changes and empirical orthogonal functions of present-day(historical)Indo-Pacific and tropical Atlantic SST *** also analyzed the probability distribution of air-sea temperature differences and the spatial distribution of grid points with SSTs above the minimum threshold necessary to initiate deep *** considered available historical nearsurface and free air temperature data of ERA-Interim reanalysis products,General Circulation Model(GCM)simulations,weather stations,and(deployed by our group)digital sensors,to assess the normal Environmental Lapse Rates(ELRs)at the regional to local *** combined maps of glacial landforms and our reconstructed FLHs provided us with a wellfounded inference of potential past glacier advances,narrowing down the coarse resolution of ice margins suggested by previous research *** extent of the areas with temperatures below the freezing point suggested here for the summits of our main study site exceeds in magnitude the corresponding glacier icecaps and front advances proposed by previous ***,our average lowest altitudes of the FLH for our comparative site are consistently above the main glacier-front advances previously su

关键词： Glacial events Colombian Andes Climate reconstruction Geomorphology Mountain glaciers Freezing level height

AIdeal:Sentience and Ideology

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Journal of Social Computing 2023年第4期4卷 275-325页

作者： daniel Estrada the Department of Humanities and Social Sciences New Jersey Institute of TechnologyNewarkNJ 07102USA

This paper addresses a set of ideological tensions involving the classification of agential kinds,which I see as the methodological and conceptual core of the sentience ***,I consider ideals involved in the classification of biological and artifactual kinds,and ideals related to agency,identity,and *** ideals frame the background against which sentience in Artificial Intelligence(AI)is theorized and debated,a framework I call the *** make this framework explicit,I review the historical discourse on sentience as it appears in ancient,early modern,and the 20th century philosophy,paying special attention to how these ideals are projected onto artificial agents.I argue that tensions among these ideals create conditions where artificial sentience is both necessary and impossible,resulting in a crisis of *** past this crisis does not require a satisfying resolution among competing ideals,but instead requires a shift in focus to the material conditions and actual practices in which these ideals *** Charles Mills,I sketch a nonideal approach to AI and artificial sentience that seeks to loosen the grip of ideology on the ***,I propose a notion of participation that deflates the sentience discourse in AI and shifts focus to the material conditions in which sociotechnical networks operate.

关键词： sentience agency artifacts artificial intelligence ideology nonideal theory natural kinds participation

Achieving Transparency:A Metadata Perspective

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Data Intelligence 2023年第1期5卷 261-273页

作者： daniel Gillman US Bureau of Labor Statistics 2 Massachusetts Ave NE Washington District of Columbia 20212United States

Transparency is vital to realizing the promise of evidenced-based policymaking,where"evidence-based"means including information as to what data mean and why they should be ***,in turn,requires that enough of this information is *** speaking then,transparency is achieved when sufficient documentation is *** is situation specific,both for the provider and consumer of the *** ideas are presented in two recent Us commissioned reports:The Promise of Evidence-Based Policymaking and Transparency in Statistical Information for the National Center for Science and Engineering Statistics and All Federal Statistical *** are a more formalized kind of documentation,and in this paper,we provide and demonstrate necessary,sufficient,and general conditions for achieving transparency from the metadata perspective:conforming to a specification,providing quality metadata,and creating a usable interface to the *** conditions are important for any metadata system,but here the specification is tied to our framework for metadata quality based on the situation-specific needs for *** ideas are described,and their interrelationships are explored.

关键词： Metadata Standards Conformance Usability Metadata quality

Stretching the limits of maximal voluntary eccentric force production in vivo

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Journal of Sport and Health Science 2018年第3期7卷 275-281页

作者： daniel Hahn Human Movement Science Faculty of Sport Science Ruhr-University Bochum School of Human Movement and Nutrition Sciences University of Queensland

During eccentric contractions,muscular force production capacity is enhanced compared to isometric *** this is well accepted in terms of muscle mechanics,maximal voluntary eccentric contractions are associated with neural inhibition that prevents increased force production of in vivo human ***,because it was shown that maximal voluntary eccentric forces can exceed maximum isometric forces by a factor of 1.2-1.4,this review focuses on the question of whether the absent eccentric force enhancement,as observed in many studies,can unambiguously be attributed to an inherent neural ***,we demonstrate that participant familiarization,preload,and fascicle behavior are crucial factors influencing maximal voluntary eccentric force ***,we show that muscle mechanics such as muscle length,lengthening velocity,and stretch amplitude interact when it comes to maximal voluntary eccentric force ***,we discuss the diverging findings on neural inhibition during maximal voluntary eccentric *** there was no inhibition of the major motor pathways in the presence of enhanced maximal voluntary eccentric forces,further research is needed to test the concept of neural inhibition and to understand why maximal voluntary force production is reduced compared to the force capacity of isolated muscle preparations.

关键词： Active lengthening Eccentric contraction Inhibition Muscle Neural control

Effects of longwall-induced stress and deformation on the stability and mechanical integrity of shale gas wells drilled through a longwall abutment pillar

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International Journal of Mining Science and Technology 2017年第1期27卷 115-120页

作者： daniel W.H.Su National Institute for Occupational Safety and Health Bruceton 15236PAUSA

This paper presents the results of a comprehensive study conducted by CONSOL Energy, Marcellus Shale Coalition, and Pennsylvania Coal Association to evaluate the effects of longwall-induced subsurface deformations on the mechanical integrity of shale gas wells drilled over a longwall abutment *** primary objective is to demonstrate that a properly constructed gas well in a standard longwall abutment pillar can maintain mechanical integrity during and after mining operations. A study site was selected over a southwestern Pennsylvania coal mine, which extracts 457-m-wide longwall faces under about 183 m of cover. Four test wells and four monitoring wells were drilled and installed over a 38-m by84-m centers abutment pillar. In addition to the test wells and monitoring wells, surface subsidence measurements and underground coal pillar pressure measurements were conducted as the 457-m-wide longwall panels on the south and north sides of the abutment pillar were mined by. To evaluate the resulting coal protection casing profile and lateral displacement, three separate 60-arm caliper surveys were conducted. This research represents a very important step and initiative to utilize the knowledge and science obtained from mining research to improve miner and public safety as well as the safety and health of the oil and gas industries.

关键词： Gas well Casing Abutment pillar Stability Safety and health Instrumentation Numerical simulation

Effects of Navier slip on unsteady flow of a reactive variable viscosity non-Newtonian fluid through a porous saturated medium with asymmetric convective boundary conditions

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Journal of Hydrodynamics 2015年第6期27卷 934-944页

作者： RUNDORA Lazarus MAKINDE Oluwole daniel Department of Mathematics and Applied Mathematics University of LimpopoTurfloop Campus Faculty of Military Science Stellenbosch University

A study on the effects of Navier slip, in conjunction with other flow parameters, on unsteady flow of reactive variable viscosity third-grade fluid through a porous saturated medium with asymmetric convective boundary conditions is presented. The channel walls are assumed to be subjected to asymmetric convective heat exchange with the ambient, and exothermic chemical reactions take place within the flow system. The heat exchange with the ambient obeys Newton＇s law of cooling. The coupled equations, arising from the law of conservation of momentum and the first law of thermodynamics, then the derived system are non- dimensionalised and solved using a semi-implicit finite difference scheme. The lower wall slip parameter is observed to increase the fluid velocity profiles, whereas the upper wall slip parameter retards them because of backflow at the upper channel wall. Heat pro- duction in the fluid is seen to increase with the slip parameters. The wall shear stress increases with the slip parameters while the wall heat transfer rate is largely unaltered by the lower wall slip parameter but marginally increased by the upper wall slip parameter.

关键词： Navier slip saturated porous medium third-grade fluid temperature dependent viscosity convective boundary condi-tions

Leveraging Hazard,Exposure,and Social Vulnerability Data to Assess Flood Risk to Indigenous Communities in Canada

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International Journal of Disaster Risk Science 2021年第6期12卷 821-838页

作者： Liton Chakraborty Jason Thistlethwaite Andrea Minano daniel Henstra daniel Scott Public Safety Canada.Ottawa.ON K1A OPS.Canada Department of Geography and Environmental Management.Faculty of En\imnmcnt.University of Waleiioo Waicrloo.ON N2A 0E9.Canada School of En\imnmcnt.Enterprise and De\elopmont.Faculty of Environment University of WaterlooWaterloo.ON N2L 3GICanada Department of Political Science University of Waterloo.Waterloo.ON N2L 3GL Canada

This study integrates novel data on 100-year flood hazard extents,exposure of residential properties,and place-based social vulnerability to comprehensively assess and compare flood risk between Indigenous communities living on 985 reserve lands and other Canadian communities across 3701 census ***-scale exposure of residential properties to fluvial,pluvial,and coastal flooding was estimated at the 100-year return period.A social vulnerability index(SVI)was developed and included 49 variables from the national census that represent demographic,social,economic,cultural,and infrastructure/community indicators of *** information system-based bivariate choropleth mapping of the composite SVI scores and of flood exposure of residential properties and population was completed to assess the spatial variation of flood *** found that about 81%of the 985 Indigenous land reserves had some flood exposure that impacted either population or residential *** analysis indicates that residential property-level flood exposure is similar between non-Indigenous and Indigenous communities,but socioeconomic vulnerability is higher on reserve lands,which confirms that the overall risk of Indigenous communities is *** suggest the need for more local verification of flood risk in Indigenous communities to address uncertainty in national scale analysis.

关键词： Canada Flood risk assessment Indigenous communities Social vulnerability

Testing and modelling of transient adhesion phenomena in rolling-sliding contacts

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Friction 2024年第5期12卷 1016-1027页

作者： daniel KVARDA Alexander MEIERHOFER Klaus SIX Faculty of Mechanical Engineering Brno University of TechnologyBrno61669Czech Republic Virtual Vehicle Research GmbH Graz8010Austria

Transient adhesion effects in rolling–sliding contacts influence all aspects of train–track *** is of high importance specifically when these effects result in critically low adhesion,which poses a risk to traction and braking of railway *** study presents a model that can replicate the transient changes of the coefficient of adhesion with tested water and solid particle *** experimental data for the model are measured using a commercial ball-on-disc *** experimental results showed a liquid reservoir in front of the contact area that slowly reduces in *** observation was used in the modelling approach to divide the calculation into two stages where the reservoir is present and when it *** model was able to reproduce the occurrence of low adhesion region seen in experimental results with different particle concentrations.

关键词： coefficient of adhesion tribology transient effects wheel-rail contact