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定位,让营销更富有意义

广告大观（综合版） 2014年第3期 87-88页

作者： Rori Duboff David Potin daniel rodrigo

从第一个为了吸引顾客而竖起商店路标的店主开始，定位广告就已经存在了。不过最近，无论国际品牌，还是地区和本土品牌都愈发依赖基于地理位置的媒介平台，它们以此与人们建立个性化、富有意义及有效的实时联系，因此，“定位”这个概... 详细信息

从第一个为了吸引顾客而竖起商店路标的店主开始，定位广告就已经存在了。不过最近，无论国际品牌，还是地区和本土品牌都愈发依赖基于地理位置的媒介平台，它们以此与人们建立个性化、富有意义及有效的实时联系，因此，“定位”这个概念又重新焕发生机。

关键词：意义营销国际品牌地理位置本土品牌个性化店主商店

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定位营销:品牌新的沟通方式

声屏世界（广告人） 2014年第4期 155-156页

作者： Rori Duboff David Potin daniel rodrigo 汉威士媒体

最近,基于地理位置的媒介平台投放——定位营销,越来越受到国际品牌和区域性本土品牌的依赖。从第一个为了吸引顾客而竖起的商店路标开始,定位广告就已经存在了,随着消费者对市场和消费需求的重新细分,品牌通过定位营销与消费者建立个... 详细信息

最近,基于地理位置的媒介平台投放——定位营销,越来越受到国际品牌和区域性本土品牌的依赖。从第一个为了吸引顾客而竖起的商店路标开始,定位广告就已经存在了,随着消费者对市场和消费需求的重新细分,品牌通过定位营销与消费者建立个性化、富有意义及有效的实时联系的需求愈加明显,＂定位＂这个概念又重新焕发新的生机。

关键词：国际品牌过定位营销地理位置消费需求消费者区域性个性化

Sm-Nd systematics of metaultramafic-mafic rocks from the Arroio Grande Ophiolite(Brazil): Insights on the evolution of the South Adamastor paleo-ocean

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Geoscience Frontiers 2020年第6期11卷 2287-2296页

作者： rodrigo Chaves Ramos Edinei Koester daniel Triboli Vieira Programa de Pòs-Graduação Em Geociências Instituto de GeociênciasUniversidade Federal Do Rio Grande Do Sul.PO Box 1500191501-970Porto AlegreRSBrazil Departamento de Geologia Universidade Federal Do Rio Grande Do Sul.Bento Gonçalves Avenue950091540-000Porto AlegreRSBrazil

In this contribution we present new insights on the evolution of the Dom Feliciano Belt,southernmost Mantiqueira Province,integrating new whole-rock Sm-Nd isotopic data for the Arroio Grande Ophiolite(Punta del Este Terrane,Brazil/Uruguay border)with previously published bulk-rock and isotope geochemistry of the South Adamastor paleo-ocean metamafic rocks located in Uruguay(Paso del Dragon Complex,Punta del Este Terrane)and Namibia(Chameis Subterrane,Marmora Terrane,Gariep Belt).For the regional geology,the new data corroborate previous hypothesis and demonstrate the depleted mantle features of the amphibolites and metagabbros of the studied *** Arroio Grande Ophiolite rocks are compared with its Uruguayan and Namibian counterparts,demonstrating their isotopic and geochemical similarities and differences,and the backarc affinity of the South Adamastor *** MORB-affinity amphibolites from the Arroio Grande Ophiolite-Paso del Dragon Complex are,so far,the most juvenile rocks in the eastern sector of the Dom Feliciano Belt,yielding εNd(640)Ma)between+7.3 and+9,and high 147Sm/144Nd(>0.169)and 143Nd/144Nd(640 Ma)ratios(0.51219-0.51229).The South Adamastor is interpreted in this paper as an internal back-arc ocean,with limited lateral extension,opened at around 750-650 Ma as the result of the closure of the older Charrua-Goianide paleoocean during the Brasiliano/Pan-African orogenic cycle and final configuration of the West Gondwana paleocontinent.

关键词： West Gondwana Brasiliano orogenic cycle Adamastor ocean

Unraveling biochar surface area on structure and heavy metal removal performances of carbothermal reduced nanoscale zero-valent iron

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Journal of Bioresources and Bioproducts 2023年第4期8卷 388-398页

作者： Tharindu N.Karunaratne Prashan M.rodrigo daniel O.Oguntuyi Todd E.Mlsna Jilei Zhang Xuefeng Zhang Department of Sustainable Bioproducts Mississippi State UniversityMississippi StateMS 39762USA Department of Chemistry Mississippi State UniversityMississippi StateMS 39762USA

Carbothermal reduction using biochar(BC)is a green and effective method of synthesizing BCsupported nanoscale zero-valent iron(nanoFe^(0))***,the effect of BC surface area on the structure,distribution,and performance such as the heavy metal uptake capacity of nanoFe^(0)particles remains *** stover-based BCs with different surface areas(1.7−1472 m^(2)/g)were prepared in this *** have been used for in-situ synthesis BCs-supported nanoFe^(0)particlesthrough carbothermal reduction of ferrous *** BCs-supported nanoFe^(0)particles were found to be covered with graphene shells and dispersed onto BC surfaces,forming the BC-supported graphene-encapsulated nanoFe^(0)(BC-G@Fe^(0))*** graphene shells covering the nanoFe^(0)particles were formed because of gaseous carbon evolved from biomass carbonization reacting with iron oxides/iron *** BC surface area decreased the average diameters of nanoFe^(0)particles,indicating a higher BC surface area alleviated the aggregation of nanoFe^(0)particles,which resulted in higher heavy metal uptake *** the optimized condition,BC-G@Fe^(0)composite exhibited uptake capacities of 124.4,121.8,254.5,and 48.0 mg/g for Cu^(2+),Pb^(2+),Ag^(+),and As^(3+),respectively(pH 5,25℃).Moreover,the BC-G@Fe^(0)composite also demonstrated high stability for Cu^(2+)removal from the fixed-bed continuous flow,in which 1 g of BC-G@Fe^(0)can work for 120 h in a 4 mg/L Cu^(2+)flow continually and clean 28.6 L Cu^(2+)contaminated ***,the BC-G@Fe^(0)composite can effectively immobilize the bioavailable As^(3+)from the contaminated soil,i.e.,5%(w)of BC-G@Fe^(0)composite addition can immobilize up to 92.2%bioavailable As^(3+)from the contaminated soil.

关键词： Carbothermal reduction Nanoscale zero-valent iron Heavy metal Fix-bed sorption Soil remediation

Heart failure as an adverse effect of infliximab for Crohn's disease: A case report and review of the literature

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World Journal of Clinical Cases 2021年第33期9卷 10382-10391页

作者： Thais Gagno Grillo Luciana Rocha Almeida rodrigo Fedatto Beraldo Mariana Barros Marcondes Diego Aparecido Rios Queiróz daniel Luiz da Silva rodrigo Quera Julio Pinheiro Baima Rogerio Saad-Hossne Ligia Yukie Sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Department of Pathology São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Inflammatory Bowel Disease Program Digestive Disease Center Clínica Universidad de los AndesSantiago 7550000Chile

BACKGROUND Anti-tumor necrosis factor agents were the first biologic therapy approved for the management of Crohn's disease(CD).Heart failure(HF)is a rare but potential adverse effect of these *** objective of this report is to describe a patient with CD who developed HF after the use of *** SUMMARY A 50-year-old woman with a history of hypertension and diabetes presented with abdominal pain,diarrhea,and weight *** and enterotomography showed ulcerations,areas of stenosis and dilation in the terminal ileum,and thickening of the intestinal *** patient underwent ileocolectomy and the surgical specimen confirmed the diagnosis of stenosing *** patient started infliximab and azathioprine treatment to prevent post-surgical *** 6 mo after initiating infliximab therapy,the patient complained of dyspnea,orthopnea,and paroxysmal nocturnal dyspnea that gradually *** revealed biventricular dysfunction,moderate cardiac insufficiency,an ejection fraction of 36%,and moderate pericardial effusion,consistent with *** cardiac disease was considered an infliximab adverse effect and the drug was *** patient received treatment with diuretics for HF and showed improvement of symptoms and cardiac ***,the patient is using anti-interleukin for CD and is *** This reported case supports the need to investigate risk factors for HF in inflammatory bowel disease patients and to consider the risk-benefit of introducing infliximab therapy in such patients presenting with HF risk factors.

关键词： Heart failure Infliximab Anti-tumor necrosis factor therapy Crohn's disease Inflammatory bowel disease Case report

Can small-scale altitudinal gradients predict spatial and temporal patterns in tropical forests?

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Journal of Forestry Research 2021年第5期32卷 1854-1865页

作者： Mariana Caroline Moreira Morelli Cléber rodrigo de Souza Jean daniel Morel Vinícius Andrade Maia Alisson Borges Miranda Santos Kaline Fernandes Miranda Rubens Manoel dos Santos Forest Sciences Department Federal University of LavrasCampus UniversitárioCx.P.3037LavrasMGCEP 37200-000Brazil Department of Biology Federal University of LavrasCampus UniversitárioLavrasMGCEP 37200-000Brazil

In tropical montane forests,compositional and structural changes are commonly driven by broad-scale altitudinal ***,given the lack of knowledge on small-scale vegetation changes and temporal dynamics,we address the effects of small-scale variations in soil and altitude on tree community structure,temporal dynamics and phylogenetic diversity in a semi-deciduous tropical forest of the Atlantic Forest Domain,southeastern *** 2010 and 2015 we sampled thirty plots of 400 m^(2),set up along an altitudinal gradient between 1000 and 1500 m a.s.I..In each plot,we collected soil samples for chemical and textural *** fitted linear models to test the effects of altitude and soil on community dynamics and phylogenetic *** and soil explained the spatial variation in number of individuals and phylogenetic diversity *** lower to higher altitudes,we found decreasing fertility,increasing tree density and decreasing phylogenetic *** significantly influenced the increases in total biomass(from 240.9 to 255.4 t ha^(-1))and individual biomass(from 0.15 to 0.17 t)recorded in the *** while community temporal dynamics had rates of 1.96%for mortality,1.02%for recruitment,1.61%for biomass loss and 2.81%for biomass gain,none of them were explained by altitude or *** species substitution averaged0.1 in the ***,these results suggest that the small-scale variations in altitude and soil likely determine the conditions and resources that drive community assembly and structure,which are expressed by spatial variations along the altitudinal *** the same time,temporal patterns were not influenced by altitude-related environmental variation,resulting in a similar dynamic behaviour across the gradient,suggesting that broad-scale factors may play a more important role than local ones.

关键词： Fine-scale Semideciduous forests Montane forests Dynamic patterns

Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro rodrigo Vieira Costa Lima daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa Departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCFMUSP Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil Laboratório de Carboidratos e Radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em Medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in ***: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of ***: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

Small-scale edaphic heterogeneity as a floristic-structural complexity driver in Seasonally Dry Tropical Forests tree communities

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Journal of Forestry Research 2020年第6期31卷 2347-2357页

作者： Cle´ber rodrigo de Souza Jean daniel Morel Alisson Borges Miranda Santos Wilder Bento da Silva Vinı´cius Andrade Maia Polyanne Aparecida Coelho Vanessa Leite Rezende Rubens Manoel dos Santos Forest Sciences Departament Federal University of LavrasCx.P.3037Lavras 37200-000Brazil Biology Department Federal University of LavrasCx.P.3037Lavras 37200-000Brazil

Our work aimed to test the hypothesis that soil microscale heterogeneity act as a community ecological driver,increasing diversity and promoting structural shifts on the Seasonally Dry Tropical Forest(SDTF)tree *** evaluated the relationship between microscale edaphic variations and floristic–structural patterns of tree communities in a SDTF fragment located in the southern end of the Brazilian Caatinga *** and soil data were obtained through 27 sample units of 400 m2(20 m 920 m),within each one we measured and identified at species level all arboreal individuals with Circumference at the Breast Height greater or equal to 10 cm,and also collected the soil *** the data we evaluated soil variation influence on the tree community structural and floristic patterns trough generalized linear *** explained the small-scale structural and floristic variations,contributing significantly to biomass,sprouting and to floristic relationships between sample *** was also observed a possible relation of the result with the Caatinga domain biogeographic history,due the presence of Sedimentary Caatinga species,which are not expected for the study *** plays an important role in driving small-scale complexity and diversity of SDTF,but we also suggest that Caatinga biogeographic events have influence on the high heterogeneity patterns.

关键词： Caatinga domain Edaphic variables Sprouting Sedimentary Caatinga

Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo Arantes Vinicius Rocha Santos rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms