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Perspective: Limiting Antimicrobial Resistance with Artificial Intelligence/Machine Learning

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Biomedical Engineering Frontiers 2023年第1期4卷 1-2页

作者： daniel Amsterdam Jacobs School of Medicine&Biomedical Sciences State University of New YorkBuffaloNYUSA.Departments of Microbiology and ImmunologyMedicineand Pathology at the Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA.Department of Laboratory MedicineECMCBuffaloNYUSA

The author traces his experience with the application of computers in clinical microbiology over the past 60 years,specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the antibacterial agent(s)that could be used to treat those *** use of antibiotics will result in reduced antimicrobial resistance,which is increasing *** early form of AI,Mycin(1976),a system based on rules provided by experts designed to propose antibiotic regimens for central nervous system infections,was never applied due to the limitations in the number of rules that could be incorporated into the clinical *** learning(ML)was developed to overcome the limitations of expert *** variables that influence the outcome bacteria/drug interaction,such as the source of the infection,absence of antimicrobial resistance markers,patients’health profile,and the historical susceptibility within the hospital and the local area are incorporated in the proposed comprehensive AI/ML *** role of AI in the discovery of new antimicrobial agents is also addressed.

关键词： computer agent limitations

Round Top Mountain rhyolite(Texas, USA), a massive, unique Y-bearing-fluorite-hosted heavy rare earth element(HREE) deposit

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Journal of Rare Earths 2014年第1期32卷 90-96页

作者： PINGITORE Nicholas CLAGUE Juan GORSKI daniel Department of Geological Sciences The University of Texas at El Paso Texas Rare Earth Resources

Round Top Mountain in Hudspeth County, west Texas, USA is a surface-exposed rhyolite intrusion enriched in Y and heavy rare earth elements （HREEs）, as well as Nb, Ta, Be, Li, F, Sn, Rb, Th, and U. The massive tonnage, estimated at well over 1 billion tons, of the deposit makes it a target for recovery of valuable yttrium and HREEs （YHREEs）, and possibly other scarce ele-ments. Because of the extremely fine grain size of the mineralized rhyolite matrix, it has not been clear which minerals host the YHREEs and in what proportions. REE-bearing minerals reported in the deposit included bastn？site-Ce, Y-bearing fluorite, xeno-time-Y, zircon, aeschynite-Ce, a Ca-Th-Pb fluoride, and possibly ancylite-La and cerianite-Ce. Extended X-ray absorption fine struc-ture （EXAFS） indicated that virtually all of the yttrium, a proxy for the HREEs, resided in a coordination in the fluorite-type crystal structure, rather than those in the structures of bastn？site-Ce and xenotime-Y. The YREE grade of the Round Top deposit was just over 0.05%, with 72%of this consisting of YHREEs. This grade was in the range of the South China ionic clay deposits that supply essentially all of the world’s YHREEs. Because the host Y-bearing fluorite is soluble in dilute sulfuric acid at room temperature, a heap leaching of the deposit appeared feasible, aided by the fact that 90%-95%of the rock consists of unreactive and insoluble feld-spars and quartz. The absence of overburden, remarkable consistency of mineralization grade throughout the massive rhyolite, prox-imity （a few km） to a US interstate highway, major rail systems and gas and electricity, temperate climate, and stable political location in the world’s largest economy all enhanced the potential economic appeal of Round Top.

关键词： heavy rare earth elements yttrium-beating fluorite yttrofluorite heap leaching rhyolite Round Top deposit

New opportunities for light-based tumor treatment with an“iron fist”

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Light(Science & Applications) 2022年第4期11卷 457-459页

作者： Riccardo Marin Erving Ximendes daniel Jaque Nanomaterials for Bioimaging Group(NanoBIG) Departamento de Ffsica de MaterialesFacultad de CienciasUniversidad Aut6noma de MadridMadrid 28030Spain

The efficacy of photodynamic treatments of tumors can be significantly improved by using a new generation of nanoparticles that take advantage of the unique properties of the tumor microenvironment.

关键词： protective light treatment

Analysis of drop deformation dynamics in turbulent flow

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Chinese Journal of Chemical Engineering 2016年第2期24卷 264-277页

作者： Stephanie Nachtigall daniel Zedel Matthias Kraume Chair of Chemical and Process Engineering Technische Universitat Berlin

Drop breakage and coalescence influence the particle formation in liquid-liquid dispersions. In order to reduce the influencing factors of the whole dispersion process, single drops where coalescence processes can be neglected were analyzed in this work. Drops passing the turbulent vicinity of a single stirrer blade were investi- gated by high-speed imaging. In order to gain a statistically relevant amount of drops passing the area of interest and corresponding breakage events, at least 1600 droplets were considered for each parameter set of this work. A specially developed fully automatic image analysis based on Matlab was used for the evaluation of the resulting high amount of image data. This allowed the elimination of the time-consuming manual analysis and further- more, allowed the objective evaluation of the drops＇ behavior. Different deformation parameters were consid- ered in order to describe the drop deformation dynamics properly. Regarding the ratio of both main particle axes （0axes）, which was therefore approximated through an ellipse, allowed the determination of very small de- viations from the spherical shape. The perimeter of the particle （0peri） was used for the description of highly de- formed shapes. In this work the results of a higher viscosity paraffin oil （ηd =127 mPa. s） and a low viscosity solvent （petroleum, ηd = 1.7 mPa-s） are presented with and without the addition of SDS to the continuous water phase. All results show that the experimentally determined oscillation but also deformation times underlie a wide spreading. Drop deformations significantly increased not only with increasing droplet viscosity, but also with decreasing interfacial tension. Highly deformed particles of one droplet species were more likely to break than more or less spherical particles. As droplet fragmentation results from a variety of different macro-scale de- formed particles, it is not assumed that a critical deformation value must be reached for the fragmentati

关键词： Drop deformation Drop breakage Liquid-liquid system Turbulent mixing Image analysis High-speed imaging

Engineering the Smart Factory

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1046-1051页

作者： HARRISON Robert VERA daniel AHMAD Bilal Warwick Manufacturing Group University of Warwick

The fourth industrial revolution promises to create what has been called the smart factory. The vision is that within such modular structured smart factories, cyber-physical systems monitor physical processes, create a virtual copy of the physical world and make decentralised decisions. This paper provides a view of this initiative from an automation systems perspective. In this context it considers how future automation systems might be effectively configured and supported through their lifecycles and how integration, application modelling, visualisation and reuse of such systems might be best achieved. The paper briefly describes limitations in current engineering methods, and new emerging approaches including the cyber physical systems （CPS） engineering tools being developed by the automation systems group （ASG） at Warwick Manufacturing Group, University of Warwick, UK.

关键词： index terms--smart factory Industry 4.0 automation systems cyber-physical systems engineering lifecycle

A CALCULUS FOR SERVICES INNOVATION

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Journal of Systems Science and Systems Engineering 2007年第2期16卷 129-165页

作者： James M. TIEN daniel BERG Department of Decision Sciences and Engineering Systems Rensselaer Polytechnic Institute Troy New York USA

Innovation in the services area - especially in the electronic services （e-services） domain - can be systematically developed by first considering the strategic drivers and foci, then the tactical principles and enablers, and finally the operational decision attributes, all of which constitute a process or calculus of services innovation. More specifically, there are four customer drivers （i.e., collaboration, customization, integration and adaptation）, three business foci （i.e., creation-focused, solution-focused and competition-focused）, six business principles （i.e., reconstruct market boundaries, focus on the big picture not numbers, reach beyond existing demand, get strategic sequence right, overcome organizational hurdles and build execution into strategy）, eight technical enablers （i.e., software algorithms, automation, telecommunication, collaboration, standardization, customization, organization, and globalization）, and six attributes of decision informatics （i.e., decision-driven, information-based, real-time, continuously-adaptive, customer-centric and computationally-intensive）. It should be noted that the four customer drivers are all directed at empowering the individual - that is, at recognizing that the individual can, respectively, contribute in a collaborative situation, receive customized or personalized attention, access an integrated system or process, and obtain adaptive real-time or just-in-time input. The developed process or calculus serves to identify the potential white spaces or blue oceans for innovation. In addition to expanding on current innovations in services and related experiences, white spaces are identified for possible future innovations; they include those that can mitigate the unforeseen consequences or abuses of earlier innovations, safeguard our rights to privacy, protect us from the always-on, interconnected world, provide us with an authoritative search engine, and generate a GDP metric that can adequately measure the gro

关键词： Services innovation decision informatics software algorithms automation globalization collaboration customization integration adaptation standardization telecommunication organization business principles

Forecasting complex group behavior via multiple plan recognition

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Frontiers of Computer Science 2012年第1期6卷 102-110页

作者： Xiaochen LI Wenji MAO daniel ZENG State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Group behavior forecasting is an emergent re- search and application field in social computing. Most of the existing group behavior forecasting methods have heavily re- lied on structured data which is usually hard to obtain. To ease the heavy reliance on structured data, in this paper, we pro- pose a computational approach based on the recognition of multiple plans/intentions underlying group behavior. We fur- ther conduct human experiment to empirically evaluate the effectiveness of our proposed approach.

关键词： group behavior forecasting multiple planrecognition graph search

Mining Frequent Generalized Itemsets and Generalized Association Rules Without Redundancy

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Journal of Computer Science & Technology 2008年第1期23卷 77-102页

作者： daniel Kunkle 张冬晖 Gene Cooperman College of Computer and Information Science Northeastern UniversityBoston

This paper presents some new algorithms to efficiently mine max frequent generalized itemsets （g-itemsets） and essential generalized association rules （g-rules）. These are compact and general representations for all frequent patterns and all strong association rules in the generalized environment. Our results fill an important gap among algorithms for frequent patterns and association rules by combining two concepts. First, generalized itemsets employ a taxonomy of items, rather than a flat list of items. This produces more natural frequent itemsets and associations such as （meat, milk） instead of （beef, milk）, （chicken, milk）, etc. Second, compact representations of frequent itemsets and strong rules, whose result size is exponentially smaller, can solve a standard dilemma in mining patterns： with small threshold values for support and confidence, the user is overwhelmed by the extraordinary number of identified patterns and associations; but with large threshold values, some interesting patterns and associations fail to be identified. Our algorithms can also expand those max frequent g-itemsets and essential g-rules into the much larger set of ordinary frequent g-itemsets and strong g-rules. While that expansion is not recommended in most practical cases, we do so in order to present a comparison with existing algorithms that only handle ordinary frequent g-itemsets. In this case, the new algorithm is shown to be thousands, and in some cases millions, of the time faster than previous algorithms. Further, the new algorithm succeeds in analyzing deeper taxonomies, with the depths of seven or more. Experimental results for previous algorithms limited themselves to taxonomies with depth at most three or four. In each of the two problems, a straightforward lattice-based approach is briefly discussed and then a classificationbased algorithm is developed. In particular, the two classification-based algorithms are MFGI_class for mining max frequent g-itemsets and EGR_cl

关键词： generalized association rules frequent generalized itemsets redundancy avoidance

Nanosphere molecularly imprinted polymers doped with gold nanoparticles for high selectivity molecular sensors

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Nano Research 2017年第3期10卷 1056-1063页

作者： Tehila Shahar Tama Sicron daniel Mandler Institute of Chemistry The Hebrew University of Jerusalem Jerusalem 9190401 Israel

We report the first attempt of using molecularly imprinted polymers （MIPs） in the shape of nanoparticles that were doped with gold nanoparticles （AuNPs） for surface enhanced Raman scattering （SERS）-based sensing of molecular spedes. Specifically, AuNPs doped molecularly imprinted nano-spheres （AuNPs@nanoMIPs） were synthesized by one-pot precipitation polymerization using Sudan IV as the template for the SERS sensing. The AuNPs@nanoMIPs were characterized by various modes of scanning transmission electron microscopy （STEM） that showed the exact location of the AuNPs inside the MIP particles. The effects of Au concentration and solution stirring on the shape and the polydispersity of the particles were studied. Significant enhancement of the Raman signals was observed only when the MIP particles were doped with the AuNPs. The SERS signal improved significantly with increase in the Au concentration inside the AuNPs@nanoMIPs. Selectivity measurements of the Sudan IV imprinted AuNPs@nanoMIPs carried out with different Sudan derivatives showed high selectivity of the AuNPs-doped MIP particles.

关键词： molecularly imprintedpolymers surface enhanced Ramanscattering (SERS) gold nanoparticles Sudan IV doping