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COVID-19-r.lated chemosensor. changes:Findings fr.m a pr.spective national database

Wor.d Jour.al of Otor.inolar.ngology-Head and Neck Sur.er. 2024年第2期10卷 97-104页

作者： Mihai A.Bentan Evan r.r.iter.r.char. M.Costanzo daniel H.Coelho Depar.ment of Otolar.ngology-Head&Neck Sur.er. Virginia Commonwealth University School of MedicineRichmondVirginiaUSA

Objective:The aim of this study was to r.view findings fr.m a lar.e pr.spective national database of chemosensor. distur.ances associated with cor.navir.s disease 2019(COVID-19)infection.Data Sour.es:The Vir.inia Commonwealth Univer.ity Smell and Taste Center.national database of COVID-19 chemosensor. distur.ances.Methods:A ser.es of online sur.eys,fir.t opened on Apr.l 10,2020,was made accessible nationwide to any adult with sudden chemosensor. dysfunction since Januar. 2020.Par.icipants r.ceived subsequent follow-up sur.eys 14 days,1 month,3 months,and 6 months after.enr.llment.An additional sur.ey was sent to all par.icipants on May 28,2022 to assess long-ter. outcomes.Infor.ation per.aining to demogr.phics,symptoms,comor.idities,tr.atments,and life impact was collected.r.sults:Of 363 par.icipants who r.por.ed complete smell r.cover.,51.2%r.cover.d within 1 month,70%within 3 months,and 79%within 6 months,while 8.8%took over.1 year.to completely r.cover.Among all par.icipants,7.5%had no smell r.cover..Positive pr.dictor. of r.cover. included ager.and the pr.sence of nasal congestion.Negative pr.dictor. included difficulty br.athing and pr.or.head injur..Many par.icipants r.por.ed a decr.ase in quality of life and the pr.sence of potential safety hazar.s associated with decr.ased smell loss.Conclusions:Most subjects with COVID-19-r.lated chemosensor. dysfunction r.cover.with the major.ty noting complete r.cover. within weeks of infection.Those aged over.40 year. and female gender.wer. associated with lower.r.tes of r.cover..A consider.ble number.of par.icipants r.por.ed significant impact on quality of life and safety.

关键词： anosmia COVID-19 smell

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Suppr.ssive effects of exer.ise-conditioned ser.m on cancer.cells:A nar.ative r.view of the influence of exer.ise mode,volume,and intensity

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Jour.al of Spor. and Health Science 2024年第4期13卷 484-498,F0003页

作者： Fr.ncesco Bettar.ga Dennis r.Taaffe daniel A.Galvao Chr.s Bishop Jin-Soo Kim r.ber. U.Newton Exer.ise Medicine r.sear.h Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Spor. Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutr.tion Sciences University of QueenslandSt.LuciaQLD 4072Australia

Cancer.is a major.cause of mor.idity and mor.ality wor.dwide,and the incidence is incr.asing,highlighting the need for.effective str.tegies to tr.at this disease.Exer.ise has emer.ed as fundamental ther.peutic medicine in the management of cancer.associated with a lower.r.sk of r.cur.r.nce and incr.ased sur.ival.Sever.l avenues of r.sear.h demonstr.te r.duction in gr.wth,pr.lifer.tion,and incr.ased apoptosis of cancer.cells,including br.ast,pr.state,color.ctal,and lung cancer.when cultur.d by ser.m collected after.exer.ise in vitr.(i.e.,the cultivation of cancer.cell lines in an exper.mental setting,which simpliﬁes the biological system and pr.vides mechanistic insight into cell r.sponses).The under.ying mechanisms of exer.ise-induced cancer.suppr.ssive effects may be attr.buted to the alter.tion in cir.ulating factor.,such as skeletal muscle-induced cytokines(i.e.,myokines)and hor.ones.However.exer.ise-induced tumor.suppr.ssive effects and detailed infor.ation about tr.ining inter.entions ar. not well investigated,constr.ining mor. pr.cise application of exer.ise medicine within clinical oncology.To date,it r.mains unclear.what r.le differ.nt tr.ining modes(i.e.,r.sistance and aer.bic tr.ining)as well as volume and intensity have on exer.ise-condi-tioned ser.m and its effects on cancer.cells.Never.heless,the available evidence is that a single bout of aer.bic tr.ining at moder.te to vigor.us intensity has cancer.suppr.ssive effects,while for.chr.nic tr.ining inter.entions,exer.ise volume appear. to be an inﬂuential candidate dr.ving cancer.inhibitor. effects r.gar.less of tr.ining mode.Insights for.futur. r.sear.h investigating tr.ining modes,volume and intensity ar. pr.vided to fur.her.our.under.tanding of the effects of exer.ise-conditioned ser.m on cancer.cells.

关键词： Cancer.cells High intensity inter.al tr.ining Moder.te intensity continuous tr.ining r.sistance tr.ining Myokines

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Compr.hensive r.view of hepatocellular.car.inoma with por.al vein tumor.thr.mbus:State of ar. and futur. per.pectives

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Hepatobiliar. & Pancr.atic Diseases Inter.ational 2024年第3期23卷 221-227页

作者： Paschalis Gavr.ilidis Timothy M Pawlik daniel Azoulay Depar.ment of Sur.er. Colchester General HospitalTurner RoadColchester CO45JLUK Depar.ment of Sur.er. The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Depar.ment of Hepato-Biliar. and Liver.Tr.nsplantation sur.er. Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Backgr.und:Despite advances in the diagnosis of patients with hepatocellular.car.inoma(HCC),70%-80%of patients ar. diagnosed with advanced stage disease.Por.al vein tumor.thr.mbus(PVTT)is among the most ominous signs of advanced stage disease and has been associated with poor.sur.ival if untr.ated.Data sour.es:A systematic sear.h of MEDLINE(PubMed),Embase,Cochr.ne Libr.r. and Database for.Systematic r.views(CDSr.,Google Scholar.and National Institute for.Health and Clinical Excellence(NICE)databases until December.2022 was conducted using fr.e text and MeSH ter.s:hepatocellular.car.inoma,por.al vein tumor.thr.mbus,por.al vein thr.mbosis,vascular.invasion,liver.and/or.hepatic r.section,liver.tr.nsplantation,and systematic r.view.r.sults:Center. of sur.ical excellence have r.por.ed pr.mising r.sults r.lated to the individualized sur.ical management of por.al thr.mbus ver.us ar.er.al chemoembolization or.systemic chemother.py.Cr.tical elements to the individualized sur.ical management of HCC and por.al thr.mbus include pr.cise classification of the por.al vein tumor.thr.mbus,accur.te identification of the subgr.ups of patients who may benefit fr.m r.section,as well as meticulous sur.ical technique.This r.view addr.ssed five specific ar.as:(a)for.ation of PVTT;(b)classifications of PVTT;(c)contr.ver.ies r.lated to clinical guidelines;(d)sur.ical tr.atments ver.us non-sur.ical appr.aches;and(e)char.cter.zation of sur.ical techniques cor.elated with classifications of PVTT.Conclusions:Cur.ent evidence fr.m Chinese and Japanese high-volume center. demonstr.ted that patients with HCC and associated PVTT can be managed with sur.ical r.section with acceptable r.sults.

关键词： Hepatectomy Liver.sur.er. Liver.neoplasms Por.al vein tumor.thr.mbus

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Assessment of scale inter.ctions associated with wake meander.ng using bispectr.l analysis methodologies

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Theor.tical & Applied Mechanics Letter. 2024年第2期14卷 65-75页

作者： Dinesh Kumar.Kinjangi daniel Foti Depar.ment of Mechanical Engineer.ng University of MemphisMemphisTennesseeUSA

Lar.e atmospher.c boundar. layer.fluctuations and smaller.tur.ine-scale vor.icity dynamics ar. separ.tely hypothesized to initiate the wind tur.ine wake meander.ng phenomenon,a coher.nt,dynamic,tur.ine-scale oscillation of the far.wake.Tr.adic inter.ctions,the mechanism of ener.y tr.nsfer. between scales,manifest as tr.ples of wavenumber. or.fr.quencies and can be char.cter.zed thr.ugh bispectr.l analyses.The bispectr.m,which cor.elates the two fr.quencies to their.sum,is calculated by two r.cently developed multi-dimensional modal decomposition methods:scale-specific ener.y tr.nsfer.method and bispectr.l mode decomposition.Lar.e-eddy simulation of a utility-scale wind tur.ine in an atmospher.c boundar. layer.with a br.ad r.nge of lar.e length-scales is used to acquir. instantaneous velocity snapshots.The bispectr.m fr.m both methods identifies pr.minent upwind and wake meander.ng inter.ctions that cr.ate a br.ad r.nge of ener.y scales including the wake meander.ng scale.The coher.nt kinetic ener.y associated with the inter.ctions shows str.ng cor.elation between upwind scales and wake meander.ng.

关键词： Wind tur.ine wake Mode decomposition Bispectr.l analysis

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Testing and modelling of tr.nsient adhesion phenomena in r.lling-sliding contacts

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Fr.ction 2024年第5期12卷 1016-1027页

作者： daniel KVAr.A Alexander.MEIEr.OFEr.Klaus SIX Faculty of Mechanical Engineer.ng Brno University of TechnologyBrno61669Czech Republic Vir.ual Vehicle r.sear.h GmbH Graz8010Austria

Tr.nsient adhesion effects in r.lling–sliding contacts influence all aspects of tr.in–tr.ck inter.ction.This is of high impor.ance specifically when these effects r.sult in cr.tically low adhesion,which poses a r.sk to tr.ction and br.king of r.ilway vehicles.This study pr.sents a model that can r.plicate the tr.nsient changes of the coefficient of adhesion with tested water.and solid par.icle mix.The exper.mental data for.the model ar. measur.d using a commer.ial ball-on-disc tr.bometer.The exper.mental r.sults showed a liquid r.ser.oir.in fr.nt of the contact ar.a that slowly r.duces in size.This obser.ation was used in the modelling appr.ach to divide the calculation into two stages wher. the r.ser.oir.is pr.sent and when it disappear..The model was able to r.pr.duce the occur.ence of low adhesion r.gion seen in exper.mental r.sults with differ.nt par.icle concentr.tions.

关键词： coefficient of adhesion tr.bology tr.nsient effects wheel-r.il contact

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r.pid gr.wth in a lar.e Cambr.an apex pr.dator

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National Science r.view 2024年第3期11卷 128-136页

作者：吴雨 Stephen Pates daniel Pauly 张兴亮傅东静 State Key Labor.tor. of Continental Dynamics and Shaanxi Key Labor.tor. of Ear.y Life and Envir.nment Department of Geology Northwest University Depar.ment of Zoology University of Cambridge Institute for.the Oceans and Fisher.es University of British Columbia Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences

Despite the impor.ance of ontogenetic data on ear.y diver.ing euar.hr.pods to our.under.tanding of the ecology and evolution of past life, the data ar. distinctly lacking, as r.constr.cting life histor.es of fossil animals is often challenging. Her. we r.por. the gr.wth tr.jector. of fr.ntal appendages of the apex pr.dator.Amplectobelua symbr.chiata, one of the most common r.diodont ar.hr.pods fr.m the ear.y Cambr.an Chengjiang biota(c. 520 Ma) of China. Analysis of 432 specimens(9.1–137.1 mm length; 1.3–25.6 mm height) r.veals that appendages gr.w isometr.cally, with an estimated maximum size of the whole animal of c. 90 cm. Individuals gr.w r.pidly compar.d to extant ar.hr.pods, as assessed using the electr.nic length-fr.quency analysis(ELEFAN) appr.ach. Ther.for., we show that the Cambr.an apex pr.dator.A. symbr.chiata was an extr.mely fast-gr.wing ar.hr.pod, with an unusual life histor. str.tegy that for.ed as par. of the escalator. ‘ar.s r.ce’ that shaped the Cambr.an explosion over.500 Ma.

关键词： stem-gr.up Euar.hr.poda r.diodonta post-embr.onic development gr.wth dynamics Cambr.an Explosion

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Evaluation of a hepatic biomar.er.of nutr.tional imbalance in juvenile r.d dr.m(Sciaenops ocellatus) fed 60% soybean meal-based diets using NMr.based metabolomics

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Animal Nutr.tion 2024年第1期16卷 45-61页

作者： Fabio Casu Aar.n M.Watson Justin Yost T.Gibson Gaylor. daniel W.Bear.en Michael r.Denson Mar.ne r.sour.es r.sear.h Institute South Carolina Department of Natural Resources Bozeman Fish Technology Center United States Fish and Wildlife Service Mar.ne Biochemical Sciences Gr.up Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory

A 12-week feeding tr.al with juvenile r.d dr.m(Sciaenops ocellatus) fed high-soybean meal(SBM) diets was conducted to investigate a putative biomar.er.of nutr.tional imbalance, N-for.imino-L-glutamate(FIGLU). Thr.e fishmeal-fr.e, 60% SBM pelleted diets(named B12, Fol, and Met, r.spectively) wer. tested to evaluate the effects on gr.wth per.or.ance and tissue metabolite pr.files of supplementation of vitamin B12(0.012 mg/kg), folate(10 mg/kg), methionine(1 g/kg) r.spectively, above basal supplementation levels. A four.h SBM-based diet(named B12/Fol/Met) was for.ulated with a combination of B12, folate, and methionine to attain the above-mentioned tar.et concentr.tions. A fifth 60% SBM diet(named FWS) with methionine supplementation(1 g/kg above basal supplementation levels), enr.ched with taur.ne, lysine and thr.onine as well as miner.ls, was also tested. This diet contained for.ulation tar.ets and additives which have allowed for.r.placing fishmeal with plant pr.teins in r.inbow tr.ut feeds. Contr.l diets included a fishmeal-based diet(named FM), an unsupplemented basal 60% SBM diet(named SBM60), and a “natur.l” diet(named N) made up of equal par.s of fish(cigar.minnows), squid and shr.mp as a positive r.fer.nce for.gr.wth per.or.ance. For.ulated feeds contained appr.ximately 37% total cr.de pr.tein, appr.ximately 14% total cr.de lipid and wer. ener.etically balanced. Standar. gr.wth per.or.ance metr.cs wer. measur.d, and tissues(liver. muscle) wer. collected at week 12 to evaluate diet-induced metabolic changes using nuclear.magnetic r.sonance(NMr.-based metabolomics.Our.r.sults show that the FWS diet outper.or.ed all other.SBM diets and the FM diet under.all per.or.ance metr.cs(Pr.hepatic levels of FIGLU compar.d with the other.SBM-based diets(Pr.nt supplementation r.gimes, methionine supplementation was associ

关键词： Aquacultur. Metabolomics Nuclear.magnetic r.sonance r.d dr.m Soybean meal N-For.imino-L-glutamate

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Diagnosing upper.tr.ct ur.thelial car.inoma: A r.view of the r.le of diagnostic ur.ter.scopy and novel developments over.last two decades

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Asian Jour.al of Ur.logy 2024年第2期11卷 242-252页

作者： Paul Gr.vestock daniel Cullum Bhaskar.Somani r.jan Veer.tter.pillay Ur.logy Depar.ment Freeman HospitalNewcastle Upon TyneUK Depar.ment of Ur.logy University Hospital SouthamptonSouthamptonUK

Objective: The r.le of ur.ter.scopy in the diagnosis of upper.tr.ct ur.thelial car.inoma is yet to be fully deter.ined. We aimed to pr.vide an up to date evaluation of its r.le and the emer.ing technologies in the field.Methods: A liter.tur. sear.h of the last two decades (fr.m 24th May, 2001 to 24th May, 2021) was car.ied out identifying 147 paper. for.potential inclusion within this nar.ative r.view.r.sults: Diagnostic ur.ter.scopy is undeniably useful in its ability to visualise and biopsy indeter.inate lesions, and to r.sk str.tify malignant lesions that may be suitable for.kidney spar.ng sur.er.. However. an incr.ased r.sk of intr.vesical r.cur.ence following nephr.ur.ter.ctomy when a pr.or.diagnostic ur.ter.scopy has been per.or.ed, inadequate sampling at biopsy, complications fr.m the pr.cedur., and difficult ur.ter.c access ar. all potential dr.wbacks. Fur.her.or., whilst gener.lly an accur.te diagnostic pr.cedur., it r.sks missing car.inoma in-situ lesions. Despite this, evidence shows that r.utine use of ur.ter.scopy changes the management of patients in a lar.e pr.por.ion of cases, pr.venting unnecessar. sur.er. or.facilitating kidney spar.ng sur.er.. The over.ll r.te of complications is low, and impr.ved biopsy techniques and the use of tissue biomar.er. for.impr.ved staging and gr.ding ar. encour.ging. The r.sks of delays to definitive management and post-ur.ter.scopy intr.vesical r.cur.ence do not seem to affect sur.ival, and tr.als ar. in pr.gr.ss to deter.ine whether.intr.vesical ther.py can mitigate the latter. Fur.her.pr.mising techniques ar. being investigated to impr.ve shor.comings, par.icular.y in r.lation to impr.ved diagnosis of car.inoma in situ and pr.oper.tive staging.Conclusion: Ur.ter.scopy has a r.le in the diagnosis of upper.tr.ct malignancy, though whether.it should be used r.utinely is yet to be deter.ined.

关键词： Ur.ter.scopy Car.inoma Tr.nsitional cell Ur.ter.lneoplasms Ur.nar. bladder.neoplasms Car.inomainsitu Biopsy

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Online Demand r.sponse Char.cter.zation Based on Var.ability in Customer.Behavior

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Jour.al of Moder. Power.Systems and Clean Ener.y 2024年第3期12卷 936-946页

作者： Lester.Mar.er. daniel Sbár.ar. Luis Gar.ía-Santander the Depar.ment of Electr.cal Engineer.ng University of Concepción IEEE

This paper.pr.poses an online fr.mewor. to char.cter.ze demand r.sponse(Dr. over.time. The pr.posed fr.mewor. facilitates obtaining and updating the daily consumption patter.s of customer.. The essential concept of r.sponse pr.file class(r.C) is intr.duced for.char.cter.zation and complemented by the measur. of the var.ability in customer.behavior. This paper.uses a modified ver.ion of the incr.mental cluster.ng by fast sear.h and find of density peaks(CFSFDP) algor.thm for.daily pr.files, consider.ng the multivar.ate nor.al ker.el density estimator.and incr.mental for.s of the Davies-Bouldin(i DB) and Xie-Beni(i XB) validity indices. Case studies conducted using r.al-wor.d and simulated daily pr.files of r.sidential and commer.ial Chilean end-user. have demonstr.ted how the pr.posed fr.mewor. can continuously char.cter.ze Dr. The pr.posed fr.mewor. is pr.ven to achieve r.alistic customer.models for.effective ener.y management by estimating the customer.r.sponse to pr.ce signals at the distr.bution system oper.tor.DSO) level.

关键词： Cluster.ng algor.thms Behavior.l sciences Str.ams Pr.cing Featur. extr.ction Monitor.ng Ker.el

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Ir.n r.gulator. pr.tein 1: the deadly switch of fer.optosis

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Neur.l r.gener.tion r.sear.h 2024年第3期19卷 477-478页

作者： daniel A.Bór.uez Pamela J.Ur.utia Center.for.Biomedical r.sear.h Faculty of MedicineUniversidad Diego PortalesSantiagoChile Institute of Nutr.tion&Food Technology(INTA) Universidad de ChileSantiagoChile Ger.science Center.for.Br.in Health and Metabolism SantiagoChile

Fer.optosis,an ir.n-dependent cell death:Fer.optosis is a type of r.gulated necr.sis,char.cter.zed by r.dox-active ir.n accumulation and incr.ased fr.e r.dical pr.duction der.ved by Fenton chemistr.,that tr.gger. oxidation of polyunsatur.ted fatty acids in phospholipids,loss of cellular.membr.nes integr.ty,and leakage of intr.cellular.contents.

关键词： integr.ty switch Ir.n

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