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Lineament analysis as a seismic precursor:The El Mayor Cucapah earthquake of April 4,2010(MW7.2),Baja California,Mexico

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Geodesy and Geodynamics 2023年第2期14卷 121-129页

作者： Rosendo Romero-Andrade Manuel E.Trejo-soto Karan Nayak daniel Hernández-Andrade Naccieli Bojorquez-pacheco Faculty of Earth and Space Sciences Autonomous University of Sinaloa80013Culiacan RosalesSinaloaMexico

An earthquake called the MW7.2“El Mayor Cucapah”earthquake on April 4,2010 has been analyzed for seismic precursor.The changes in the lineament system concerning its pattern and time intervals were analyzed during the earthquake preparation period and occurrence using the automated lineament detection method.The Landsat 5 TM images were processed using LESSA and ADALGEO software obtaining similar results.The statistical analysis revealed the stress accumulation due to plate interaction during earthquake formation.The study shows that the number of extracted lineaments changes rapidly about 23 months before the earthquake,and the systems return to the initial stage after 23 months.Most lineaments coincide with the extension of the San Andreas Fault as NW direction is the dominant trend.Thus,it can be concluded that the featural changes within the Rose diagram corresponding to the different strokes direction along with oriented elongation lines as disclosed in the present study using satellite images could be identified as a mid-term and/or short-term precursors of the earthquake.However,even though the dynamism of the El Mayor Cucapah earthquake is found in the extracted lineaments,it is possible to isolate more significant earthquakes even if new ones appear near the zone.Moreover,using two algorithms for lineament detection allows for the tectonics to corroborate the obtained lineaments and dynamism.

关键词： Lineament analysis Earthquake Landsat images Seismic precursor

Simulation of consumers decision-making process using agent-based model approach

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第6期10卷 30-47页

作者： daniel soto Forero Yony F.Ceballos German Sanchez Torres Engineer Faculty University of Antioquia Calle 67 No.53-108Medell`inColombia Engineer Faculty University of Magdalena Carrera 32 No.22-08Santa MartaColombia

This paper describes a model to simulate the decision-making process of consumers that adopts technology within a dynamic social network.The proposed model use theories and tools from the psychology of consumer behavior,social networks and complex dynamical systems like the Consumat framework and fuzzy logic.The model has been adjusted using real data,tested with the automobile market and it can recreate trends like those described in the world market.

关键词： Decision-making process bounded rationality agent-based models social networks fuzzy logic model consumers

Quality assessment of Continuous Operating Reference Stations(CORS)-GpS stations in Mexico

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Geodesy and Geodynamics 2022年第3期13卷 275-287页

作者： daniel Hernández-Andrade Rosendo Romero-Andrade Gopal Sharma Manuel E.Trejo-soto Juan L.Cabanillas-Zavala Faculty of Earth and Space Sciences Autonomous University of Sinaloa80013Culiacán RosalesSinaloaMexico North Eastern Space Applications Centre Umiam793103MeghalayaIndia

The present analysis provided the quality assessment of 65 Continuous Operating Reference Stations(CORS) situated in and around Mexico using the data of about ten years(January 2010 to January 2020).To accomplish the assessment,we considered 4 quality indexes for performing the quality check,incluing the multipath effect on L1 and L2 bands,signal-to-noise ratio in both bands,cycle slips,and integrity.Meanwhile,a new reference parameter named regio nal values for Mexico(RVM) was calculated for the stations situated in Mexico.Additionally,an exhaustive analysis of the quality indicators in the worst and best cases was performed.The signal degradation was proved by a long-term time series and cru stal defo rmation analysis in GAMIT/GLOBK platform.The results showed a stro ng correlation between integrity,cycle slips and daily observations time,and the multipath effect is strong in the case of outdated systems.The study indicates that the estimated quality indexes and values could be the basis for establishing new CORS in Mexico,and the errors corrections which cannot be mitigated in the postprocessing stage would greatly help utilize the data for different scientific applications.The results were supported by deformation analysis in part of Baja California peninsula in Mexico indicating northern and eastern velocity vector of -3.08±0.02 mm/yr,-7.85±0.02 mm/yr and-0.07±0.03 mm/yr,-9.33±0.02 mm/yr respectively at MpR1 and INEG stations.

关键词： Multipath effect Signal-to-Noise ratio Cycle slip Integrity Regional quality indicators IGS indicators

Cold and Fertile: Cryopreservation as an Innovative Tool in Addressing Challenges in Teratozoospermia

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Journal of Biosciences and Medicines 2024年第2期12卷 274-281页

作者： Víctor Manuel soto-Márquez Jorge Mulia-Rodríguez daniel Osorio-González Molecular Biophysics Laboratory Faculty of Sciences Autonomous University of State of Mexico Toluca Mexico

Teratozoospermia is an infertility issue that affects a significant number of couples of reproductive age. One of the potential causes contributing to the global decline in seminal quality includes factors such as diet, alcohol and tobacco consumption, high levels of stress, and environmental influences. This underscores the need to preserve the fertility of these patients through cryopreservation techniques. In this review, we explore the latest methods for freezing seminal samples, highlighting their advancements and advantages in addressing the challenge of perpetuating animal species, particularly in the context of human infertility.

关键词： Cryopreservation Teratozoospermia Infertility

Inflammatory effect on the gastrointestinal system associated with COVID-19

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World Journal of Gastroenterology 2021年第26期27卷 4160-4171页

作者： paulina Delgado-Gonzalez Carlos A Gonzalez-Villarreal Jorge A Roacho-perez Adriana G Quiroz-Reyes Jose Francisco Islas Juan Luis Delgado-Gallegos daniel Arellanos-soto Kame A Galan-Huerta Elsa N Garza-Treviño Departamento de Bioquimica y Medicina Molecular UANLMonterrey 64610Nuevo LeónMexico Universidad de Monterrey UDEM Vicerrectoria de Ciencias de la SaludMonterrey 66238Nuevo LeonMexico

The severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)that causes coronavirus disease-2019(COVID-19)has provoked a global pandemic,mainly affecting the respiratory tract;however,a percentage of infected individuals can develop gastrointestinal(GI)symptoms.Some studies describe the development of GI symptoms and how they affect the progression of COVID-19.In this review,we summarize the main mechanisms associated with gut damage during infection by SARS-CoV-2 as well as other organs such as the liver and pancreas.Not only are host factors associated with severe COVID-19 but intestinal microbiota dysbiosis is also observed in patients with severe disease.

关键词： SARS-CoV-2 Gastrointestinal symptoms COVID-19 Gastrointestinal system

Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila porfirio Nava daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in parkinson's disease.The human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for parkinson's disease therapy.This study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral alterations.Three independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in vitro.Their injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and striatum.Compared with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF transfection.An increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAp43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite levels.partial reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were achieved.Brain-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic effects.These findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against parkinson's disease.The Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy parkinson's disease reinnervation substantia nigra

Optimized Convolutional Neural Network Models for Skin Lesion Classification

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Computers, Materials & Continua 2022年第2期70卷 2131-2148页

作者： Juan pablo Villa-pulgarin Anderson Alberto Ruales-Torres daniel Arias-GarzónMario Alejandro Bravo-Ortiz Harold Brayan Arteaga-Arteaga Alejandro Mora-RubioJesus Alejandro Alzate-Grisales Esteban Mercado-Ruiz M.Hassaballah Simon Orozco-Arias Oscar Cardona-Morales Reinel Tabares-soto Department of Electronics and Automation Universidad Autónoma deManizalesManizales170001Colombia SEDMATEC Corporación Universitaria Autónoma de Nari駉Pasto520002Colombia Department of Computer Science Faculty of Computers and InformationSouth Valley UniversityQena83523Egypt Department of Computer Science Universidad Autónoma de ManizalesManizales170001Colombia Department of Systems and Informatics Universidad de CaldasManizales170001Colombia

Skin cancer is one of themost severe diseases,andmedical imaging is among themain tools for cancer diagnosis.The images provide information on the evolutionary stage,size,and location of tumor lesions.This paper focuses on the classification of skin lesion images considering a framework of four experiments to analyze the classification performance of Convolutional Neural Networks(CNNs)in distinguishing different skin lesions.The CNNs are based on transfer learning,taking advantage of ImageNet weights.Accordingly,in each experiment,different workflow stages are tested,including data augmentation and fine-tuning optimization.Three CNN models based on DenseNet-201,Inception-ResNet-V2,and Inception-V3 are proposed and compared using the HAM10000 dataset.The results obtained by the three models demonstrate accuracies of 98%,97%,and 96%,respectively.Finally,the best model is tested on the ISIC 2019 dataset showing an accuracy of 93%.The proposed methodology using CNN represents a helpful tool to accurately diagnose skin cancer disease.

关键词： Deep learning skin lesion convolutional neural network data augmentation transfer learning

Anthropometric Analysis of the Upper Eyelid and Eyebrow in patients Attended by the plastic and Reconstructive Surgery Service of the Hospital Central Sur De petróleos Mexicanos

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Journal of Biosciences and Medicines 2022年第8期10卷 47-56页

作者： Alejandro Costa-Dulché Jaime García-Espinoza daniel De-Luna-Gallardo Cuahutemoc Márquez-Espriella Rodrigo Dávila-Díaz Blanca Arámbula-Sánchez Marco Cuervo-Vergara David Flores-soto Hospital Central Sur de Alta Especialidad de petróleos Mexicanos Mexico City Mexico

Upper eyelid blepharoplasty is one of the most frequently performed surgeries by plastic surgeons worldwide. A prospective observational study was conducted to describe the anthropometric measurements of the upper eyelid and eyebrow in a Mexican population. The researcher measured the anthropometry of the eyelids and eyebrows to establish the diagnosis and surgical plan according to the checklist created and applied by the plastic and reconstructive surgery service. In anatomical position with a caliper instrument, the marginal reflex distance (MRD1), the tarsal thickness, the length of the vertical and horizontal slit, and finally the distance at which the external canthus is located with respect to the internal canthus were measured in millimeters. For the anthropometry of the eyebrows, the distance from the eyebrows to the hairline, the position in millimeters of the orbital rim with respect to the eyebrow, and the angle of its apex were measured. A sample of 210 patients was obtained, of which 65 were male and 145 females, divided by age groups. It was observed that in the three age groups, females presented a vertical palpebral fissure with a higher mean than males. Similar is the case of tarsal thickness, in which the difference was significantly greater in the female of the three age groups. On the other hand, it was observed that the horizontal slit in males was higher than that of females, while the MDR1 was similar in both sexes. Finally, it was identified that in the group of 41 to 50 years old significant decreases are observed both in the vertical cleft, tarsal thickness and the position of the external canthus compared to the group of 20 to 30 years old, this is due to the aging process. When evaluating the anthropometrics of the eyebrows, a greater distance from the trichion to the eyebrow was observed in males than in females, in contrast to the position of the eyebrow with respect to the supraorbital rim and its apex, in which it was shown that in females there is a greater distance. In the other

关键词： Eyelid Upper-Eyelid Eyebrow Anthropometrics Facial-Analysis

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-parrilla Juan U.Mascotte-Cruz Cp Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of parkinson’s disease,a typicalα-synucleinopathy.As Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection.This study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced neuropathology.Accordingly,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the striatum.In addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia nigra.These effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor behavior.Our results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor deficits.Increased neurotrophic astrocytes and brain-derived neurotrophic factor can mediate t

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates