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Comprehensive review of hepatocellular carcinoma with portal vein tumor thrombus:State of art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis Timothy M Pawlik daniel Azoulay Department of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Department of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Department of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinoma(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tumor thrombus(PVTT)is among the most ominous signs of advanced stage disease and has been associated with poor survival if *** sources:A systematic search of MEDLINE(PubMed),Embase,Cochrane Library and Database for Systematic Reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases until December 2022 was conducted using free text and MeSH terms:hepatocellular carcinoma,portal vein tumor thrombus,portal vein thrombosis,vascular invasion,liver and/or hepatic resection,liver transplantation,and systematic ***:Centers of surgical excellence have reported promising results related to the individualized surgical management of portal thrombus versus arterial chemoembolization or systemic *** elements to the individualized surgical management of HCC and portal thrombus include precise classification of the portal vein tumor thrombus,accurate identification of the subgroups of patients who may benefit from resection,as well as meticulous surgical *** review addressed five specific areas:(a)formation of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatments versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from Chinese and Japanese high-volume centers demonstrated that patients with HCC and associated PVTT can be managed with surgical resection with acceptable results.

关键词： Hepatectomy Liver surgery Liver neoplasms Portal vein tumor thrombus

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Can rarefaction be used to estimate song repertoire size in birds？

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Current Zoology 2011年第3期57卷 300-306页

作者： Kathleen R. PESHEK daniel T. BLUMSTEIN The Rocky Mountain Biological Laboratory Box 519 Crested Butte CO 81224 USA Department of Ecology and Evolutionary Biology University of California Los Angeles CA 90095-1606 USA

Song repertoire size is the number of distinct syllables, phrases, or song types produced by an individual or population. Repertoire size estimation is particularly difficult for species that produce highly variable songs and those that produce many song types. Estimating repertoire size is important for ecological and evolutionary studies of speciation, studies of sexual selection, as well as studies of how species may adapt their songs to various acoustic environments. There are several methods to estimate repertoire size, however prior studies discovered that all but a full numerical count of song types might have substantial inaccuracies associated with them. We evaluated a somewhat novel approach to estimate repertoire size--rarefaction; a technique ecologists use to measure species diversity on individual and population levels. Using the syllables within American robins＇ Turdus migratorius repertoire, we compared the most commonly used techniques of estimating repertoires to the results of a rarefaction analysis. American robins have elaborate and unique songs with few syllables shared between individuals, and there is no evidence that robins mimic their neighbors. Thus, they are an ideal system in which to compare techniques. We found that the rarefaction technique results resembled that of the numerical count, and were better than two alternative methods （behavioral accumulation curves, and capture-recapture） to estimate syllable repertoire size. Future estimates of repertoire size, particularly in vocally complex species, may benefit from using rarefaction techniques when numerical counts are unable to be performed [Current Zoology 57 （3）： 300-306, 2011].

关键词： Behavioral accumulation curve Bioacoustics Capture-recapture Numerical count Rarefaction Song repertoire size

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Potential of roots and shoots of Napier grass for arresting soil erosion and runoff of mollisols soils of Himalayas

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International Soil and Water Conservation Research 2023年第3期11卷 538-548页

作者： Sushma Tamta Akhilesh Kumar daniel Prakash Kushwaha Krishi Vigyan Kendra Khodawandpur848202BegusaraiBiharIndia Department of Soiland Water Conservation Engineering G.B.Pant University of Agriculture and TechnologyPantnagar263145India

In this study, a soil filled Hydraulic Tilting Flume (HTF) was used as a test plot under simulated rainfallconditions. This flume was flled with mollisols soils (sandy loam in texture) collected from tarai regionof Himalayas. The effects of root and shoot characteristics of Napier grass in terms of leaf area index (LAI),shoot length (SL), number of leaves (NL), number of tillers (NT), shoot biomass (SB), root density (RD),root length (RL), root biomass (RB), and total biomass (TB) were investigated on runoff and sedimentoutflow at 90, 120 and 150 days after planting (DAP). Four simulated rainfall intensities namely 4.0, 6.5,8.3 and 9.4 cm/h over three land slopes of 1, 2 and 3% were selected. Runoff samples collected fromwhole plant plot and only root plot were analyzed for runoff and sediment outflow. Findings revealedthat Napier grasses were very effective to reduce runoff and sediment outflow and its efficacy increasedwith the extended growth stages. The reduction in runoff and sediment outflow at 90, 120 and 150 DAPwas obtained as 56% and 85%, 68% and 90%, and 74% and 96%, respectively, as compared to bare plotconditions. It was observed that the comparative contribution of shoots in runoff rate reduction washigher than the roots. On the contrary, the root part of the plant showed more contribution in sedimentrate reduction as compared to the shoot part. Step wise regression was attempted for the selection ofeffective input parameters to establish authentic runoff and sediment outflow models. Power form ofmultiple non-linear regression (MNLR) showed very satisfactory results for predicting runoff and sedimentoutflow with coefficient of determination (R^(2)) as 97.4% and 99.0%, respectively, root mean squareerror (RMSE) as 38.8 cc/m^(2)/min and 0.126 g/m^(2)/min, respectively, and coefficient of efficiency (CE) as93.9% and 96.7%, respectively, during testing period.

关键词： Rootand shoot characteristics Runoff and sedimentreduction Simulated rainfall conditions Hydraulic tilting flume Step wise regression analysis

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Disaster Risk Resilience:Conceptual Evolution,Key Issues,and Opportunities

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International Journal of Disaster Risk Science 2022年第3期13卷 330-341页

作者： Marie-Hélène Graveline daniel Germain Institut des Sciences de l’Environnement(ISE) Universitédu QuébecàMontréalMontréalH3C 3P8Canada Department of Geography Universitédu QuébecàMontréalMontréalH3C 3P8Canada

Resilience has become a cornerstone for risk management and disaster ***,it has evolved extensively both etymologically and conceptually in time and across scientific *** concept has been(re)shaped by the evolution of research and practice *** the opposite of vulnerability for a long time,resilience was first defined as the ability to resist,bounce back,cope with,and recover quickly from the impacts of *** avoid the possible return to conditions of vulnerability and exposure to hazards,the notions of post-disaster development,transformation,and adaptation(build back better)and anticipation,innovation,and proactivity(bounce forward)were then ***,resilience is characterized by a multitude of components and several *** present a selection of 25 components used to define resilience,and an interesting linkage emerges between these components and the dimensions of risk management(prevention,preparedness,response,and recovery),offering a perspective to strengthen resilience through the development of *** its potential,resilience is subject to challenges regarding its operationalization,effectiveness,measurement,credibility,equity,and even its ***,it offers applicability and opportunities for local communities as well as an interdisciplinary look at global challenges.

关键词： Community Disaster risk Resilience Sustainable development

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Human Interaction Dynamics for Its Use in Mobile Robotics:Impedance Control for Leader-follower Formation

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 696-703页

作者： daniel Herrera Flavio Roberti Marcos Toibero Ricardo Carelli Instituto de Automatica Universidad Nacional de San Juan-CONICET IEEE

A complete characterization of the behavior in human-robot interactions(HRI) includes both: the behavioral dynamics and the control laws that characterize how the behavior is regulated with the perception data. In this way, this work proposes a leader-follower coordinate control based on an impedance control that allows to establish a dynamic relation between social forces and motion error. For this, a scheme is presented to identify the impedance based on fictitious social forces, which are described by distance-based potential *** part of the validation procedure, we present an experimental comparison to select the better of two different fictitious force structures. The criteria are determined by two qualities: least impedance errors during the validation procedure and least parameter variance during the recursive estimation ***, with the best fictitious force and its identified impedance,an impedance control is designed for a mobile robot Pioneer 3AT,which is programmed to follow a human in a structured *** to results, and under the hypothesis that moving like humans will be acceptable by humans, it is believed that the proposed control improves the social acceptance of the robot for this kind of interaction.

关键词： Human modeling human-machine interaction impedance control robot dynamics social robotics

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Design of synthetic materials for intracellular delivery of RNAs： From siRNA-mediated gene silencing to CRISPR/Cas gene editing

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Nano Research 2018年第10期11卷 5310-5337页

作者： Jason B. Miller daniel J. Siegwart Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX 75390 USA Department of Biochemistry University of Texas Southwestern Medical Center Dallas TX 75390 USA

Ribonucleic acids （RNAs） possess great therapeutic potential and can be used to treat a variety of diseases. The unique biophysical properties of RNAs, such as high molecular weight, negative charge, hydrophilicity, low stability, and potential immunogenicity, require chemical modification and development of carriers to enable intracellular delivery of RNAs for clinical use. A variety of nanornaterials have been developed for the effective in vivo delivery of short/ small RNAs, messenger RNAs, and RNAs required for gene editing technologies including clustered regularly interspaced palindromic repeat （CRISPR）/Cas. This review outlines the challenges of delivering RNA therapeutics, explores the chemical synthesis of RNA modifications and carriers, and describes the efforts to design nanomaterials that can be used for a variety of clinical indications.

关键词： nucleic acid therapeutics nanoparticles synthetic nanomaterials RNA interference (RNAi) messenger RNA (mRNA) clustered regularly inter-spaced palindromic repeat(CRISPR)/Cas

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Assembly and electrochemical testing of renewable carbon-based anodes in SIBs:A practical guide

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Journal of Energy Chemistry 2022年第12期75卷 457-477,I0012页

作者： Darío Alvira daniel Antorán Joan JManyà Aragón Institute of Engineering Research(I3A) Thermochemical Processes GroupUniversity of ZaragozaEscuela Politécnica Superior22071 HuescaSpain

Sodium-ion batteries(SIBs)are considered as a promising candidate to replace lithium-ion batteries(LIBs)in large-scale energy storage *** sodium resources and similar working principles make this technology attractive to be implemented in the near ***,the development of high-performance carbon anodes is a focal point to the upcoming success of SIBs in terms of power density,cycling stability,and *** knowledge in electrochemical and physicochemical techniques is required to properly evaluate the anode performance and move it in the right *** review aims at providing a comprehensive guideline to help researchers from different backgrounds(e.g.,nanomaterials and thermochemistry)to delve into this *** main components,lab configurations,procedures,and working principles of SIBs are ***,a detailed description of the most used electrochemical and physicochemical techniques to characterize electrochemically active materials is provided.

关键词： Sodium-ion battery Anode Hard carbon Electrochemical techniques Carbon characterization

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Shear Band Formation in AISI 4340 Steel Under Dynamic Impact Loads:Modeling and Experiment

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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 378-384页

作者： daniel Odoh Gbadebo Owolabi Akindele Odeshi Horace Whitworth Department of Mechanical Engineering Howard University Department of Mechanical Engineering University of Saskatchewan57 Campus DriveSaskatoonSKS7N 5A9Canada

In this study, the occurrence of the adiabatic shear bands in AISI 4340 steel under high velocity impact loading was investigated using finite element analysis and experimental tests. The cylindrical specimen subjected to the impact load was divided into different regions separated by nodes using finite element method in ABAQUS environment with boundary conditions specified. The material properties were assumed to be lower in the region where the probability of strain localization is high based on prior experimental results in order to initialize the formation of the adiabatic shear bands. The finite element model was used to determine the maximum flow stress, the strain hardening, the thermal softening, and the time to reach the critical strain for the formation of adiabatic shear bands. Experimental results show that deformed bands were formed at low strain rates and there was a minimum strain rate required for the formation of the transformed band in the alloy and the cracks were initiated and propagated along the transformed bands leading to fragmentation under the impact loading. The susceptibility of the adiabatic shear bands to cracking was markedly influenced by the strain-rates and the initial material microstructure. The simulation results obtained were compared with the experimental results obtained from the AISI 4340 steel under high strain-rate loading in compression using split impact Hopkinson bars. A good agreement between the experimental and simulation results was obtained.

关键词： Adiabatic shear bands Finite element model Strain hardening Thermal softening Johnson-Cook model AISI 4340 steel

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Crystal Plasticity Finite Element Process Modeling for Hydro-forming Micro-tubular Components

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Chinese Journal of Mechanical Engineering 2011年第1期24卷 78-83页

作者： ZHUANG Weimin WANG Shiwen BALINT daniel LIN Jianguo State Key Laboratory of Automotive Dynamic Simulation Jilin University Changchun 130022 China Department of Mechanical Engineering lmperial College London SW7 2AZ UK

Micro-tubes manufactured by hydro-forming techniques have now been widely used in medical and microelectronics applica- tions. One of the difficulties in forming such parts is the control of localized necking in the initial stages of the deformation/forming process. A lack of microstructural information causes conventional macro-mechanics finite element（FE） tools to break down when used to investigate the localized microstructure evolution and necking encountered in micro-forming. An effort has been made to create an integrated crystal plasticity finite element（CPFE） system that enables micro-forming process simulations to be carried out easily, with the important features in forming micro-parts captured by the model. Based on Voronoi tessellation and probability theory, a virtual GRAIN（VGRAIN） system is created for generating grains and grain boundaries for micro-materials. Numerical procedures are devel- oped to link the physical parameters of a material to the control variables in a Gamma distribution. A script interface is developed so that the virtual microstructure can be input to the commercial FE code, ABAQUS, for mesh generation. A simplified plane strain CPFE modeling technique is developed and used to capture localized thinning and failure features for hydro-forming of micro-tubes. Grains within the tube workpiece, their distributions and orientations are generated automatically by using the VGRAIN system. A set of crystal viscoplasticity constitutive equations are implemented in ABAQUS/Explicit by using the user-defined material subroutine, VUMAT. Lo- calized thinning is analyzed for different microstructures and deformation conditions of the material using the CPFE modeling technique. The research results show that locations of thinning in forming micro-tubes can be random, which are related to microstructure and grain orientations of the material. The proposed CPFE technique can be used to predict the locations of thinning in forming micro-tubes.

关键词： micro-mechanics modeling micro-forming hydro-forming

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Closed-loop subspace identification algorithm based on correlation function estimates

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Science China(Information Sciences) 2015年第3期58卷 173-182页

作者： WANG Jia MILLER daniel WANG HongWei GU Hong Department of Biotechnology Dalian Medical University School of Control Science and Engineering Dalian University of Technology Department of Mechanical Engineering University of California San Diego

A novel subspace identification method based on correlation function which estimates a state-space system dynamics of unknown plant operating in closed-loop experimental condition is proposed in this *** is shown that the cross-correlation function of the output and external input signals are equal to the crosscorrelation function of the input and external signals filtered through the system dynamics since noise signal has no correlation with the external *** proposed algorithm is developed to obtain unbiased estimates of system matrices based on time-shifted invariance of the correlation function *** the algorithm is compared to other popular subspace methods in the simulation study and the results show the effectiveness of our method in the presence of colored noise and low signal-to-noise ratios.

关键词： subspace identification method correlation function estimates closed-loop system asymptotic properties the system dynamics

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