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Hepatobiliary phases in magnetic resonance imaging using liverspecific contrast for focal lesions in clinical practice

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World Journal of Hepatology 2022年第7期14卷 1459-1469页

作者： daniel Alvarenga Fernandes Eduardo Andreazza Dal Lago Felipe Aguera Oliver Bruna Melo Coelho Loureiro daniel lahan martins Thiago José Penachim Ricardo Hoelz de Oliveira Barros José de ArimatéiaBatista Araújo Filho Larissa Bastos Eloy da Costa Áurea Maria Oliveira da Silva Elaine Cristina de Ataíde Ilka de Fátima Santana Ferreira Boin Nelson Marcio Gomes Caserta Department of Radiology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazi Department of Radiology Medical SchoolSão Paulo State University-UNESPBotucatu 18618-970São PauloBrazil Instituto de Radiologia Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo-InRad/HC-FMUSPSão Paulo 05403-010SPBrazil Department of Radiology Sírio-Libanês HospitalSão Paulo 05652-900SPBrazil Department of Pathology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil Liver Transplant Unit Department of SurgerySchool of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil

BACKGROUND Challenging lesions,difficult to diagnose through non-invasive methods,constitute an important emotional burden for each patient regarding a still uncertain diagnosis(malignant x benign).In addition,from a therapeutic and prognostic point of view,delay in a definitive diagnosis can lead to worse *** of the main innovative trends currently is the use of molecular and functional methods to *** liver-specific contrast agents havebeen developed and studied in recent years to improve the performance of liver magnetic resonance imaging(MRI).More recently,one of the contrast agents introduced in clinical practice is gadoxetic acid(gadoxetate disodium).AIM To demonstrate the value of the hepatobiliary phases using gadoxetic acid in MRI for the characterization of focal liver lesions(FLL)in clinical *** Overall,302 Lesions were studied in 136 patients who underwent MRI exams using gadoxetic acid for the assessment of *** radiologists independently reviewed the MRI exams using four stages,and categorized them on a 6-point scale,from 0(lesion not detected)to 5(definitely malignant).The stages were:stage 1-images without contrast,stage 2-addition of dynamic phases after contrast(analogous to usual extracellular contrasts),stage 3-addition of hepatobiliary phase after 10 min(HBP 10’),stage 4-hepatobiliary phase after 20 min(HBP 20’)in addition to stage *** The interobserver agreement was high(weighted Kappa coefficient:0.81-1)at all stages in the characterization of benign and malignant *** diagnostic weighted accuracy(Az)was 0.80 in stage 1 and was increased to 0.90 in stage *** of the hepatobiliary phase increased Az to 0.98 in stage 3,which was also 0.98 in stage *** The hepatobiliary sequences improve diagnostic *** growing potential in the era of precision medicine,the improvement and dissemination of the method among medical specialties can bring benefits in the management of patients w

关键词： Liver Liver neoplasms Liver transplantation Medical oncology Diagnostic imaging Magnetic resonance imaging

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Evolution of the 3.65-2.58 Ga Mairi Gneiss Complex,Brazil:Implications for growth of the continental crust in the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 110-128页

作者： Igor de Camargo Moreira Elson Paiva Oliveira daniel Francisco martins de Sousa Institute of Geosciences University of Campinas(UNICAMP)CampinasSPBrazil

The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the ***,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient *** this complexity,exposures of the Archean Mairi Gneiss Complex basement unit in the São Francisco Craton offer important information about the evolution of South America’s primitive ***,here we present field relationships,LA-ICP-SFMS zircon U-Pb ages,and LA-ICP-MCMS Lu-Hf isotope data for the recently identified Eoarchean to Neoarchean gneisses of the Mairi *** Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic *** new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarchean(ca.3.65–3.60 Ga),early Paleoarchean(ca.3.55–3.52 Ga),middle-late Paleoarchean(ca.3.49–3.33 Ga)and Neoarchean(ca.2.74–2.58 Ga),with no records of Mesoarchean ***-Hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over *** the Eoarchean,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarchean,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarchean.A different stage of crustal growth and recycling dominated the Neoarchean,probably owing to the thickening of the continental crust by collision,continental arc growth,and mantle differentiation.

关键词： São Francisco Craton Mairi Gneiss Complex Primitive continental crust Zircon U-Pb dating Lu-Hf isotope geochemistry

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Hepatic“pregnancy”:hepatocellular carcinoma with extensive extrahepatic growth

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 641-642页

作者： Ana Rita Ferreira Bárbara Castro Jose daniel martins João Varanda Alexandre Costa Bela Pereira Manuel Oliveira General Surgery Centro Hospitalar Vila Nova de Gaia/EspinhoVila Nova de GaiaPortugal

A female in her 50s,no previous personal history,presented to the Emergency Department with a 7 months history of progressively worsening abdominal diffuse pain associated with increasing abdominal *** physical examin... 详细信息

关键词： pregnancy Hepatic Figure

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Technical Evaluation of Hybrid Clones of Corymbia spp. to Produce Market Pulp

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Paper And Biomaterials 2022年第3期7卷 1-6页

作者： Marcelo Moreira da Costa Ricardo de Carvalho Bittencourt Thales Augusto Pinto Coelho Nogueira Larissa Soares Silva Weslley Henrique martins da Silva Sebastião Renato Valverde Gleison Augusto Dos Santos daniel Alexander Fernandes Coelho Claudilene Aparecida Alves Pena Department of Forest Sciences Federal University of VicosaVicosaMinas Gerais36570900Brazil Aperam BioEnergia Co. CapelinhaMinas Gerais39680000Brazil

This study presents hybrid clones of Corymbia *** by Aperam BioEnergia as potential substitutes for Eucalyptus wood in the pulp *** biomass of Eucalyptus *** compared with that of Corymbia *** performing modified kraft pulping and basic density *** were made by analyzing their respective mean annual increments of cellulose(MAI_(cel))and specific wood consumption(SWC),estimated using a kappa number of(19±1).The results showed that one of the hybrid clones(Corymbia citriodora×Corymbia torelliana,ID 4)had higher basic wood density,higher screened yield,better MAI_(cel#k19),and lower SWC than the other samples,reaching values of 0.608 t/m^(3),54.1%,24.6 ADt/ha/year(i.e.,air dry ton/hectare/year),and 2.74 m^(3)/ADt,***,clone ID 4 had the highest MAI_(cel)/SWC ratio score(8.98).Given its high forest productivity and low industrial cost compared with other samples,as well as its advantages over Eucalyptus ***,we concluded that clone ID 4 has great potential as an alternative biomass for pulp production.

关键词： Corymbia hybrids modified kraft pulping mean annual increments of cellulose(MAIcel) specific wood consumption(SWC)

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Far infrared-emitting ceramics decrease Freund's adjuvant-induced inflammatory hyperalgesia in mice through cytokine modulation and activation of peripheral inhibitory neuroreceptors

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Journal of Integrative Medicine 2018年第6期16卷 396-403页

作者： Ralph Fernando Rosas Aline Armiliato Emer Ana Paula Batisti daniela Dero Ludtke Bruna Lenfers Turnes Franciane Bobinski Francisco Jose Cidral-Filho daniel fernandes martins Experimental Neuroscience Laboratory(LaNEx) University of Southern Santa CatarinaPalhoca 88137-272Santa CatarinaBrazil Postgraduate Program in Health Sciences University of Southern Santa CatarinaPalhoca 88137-272Santa CatarinaBrazil Laboratory of Bioenergetics and Oxidative Stress(LABOX) Federal University of Santa CatarinaFlorianopolis 88049-000Santa CatarinaBrazil

Objective： The present study aimed to evaluate the analgesic and anti-inflammatory effects of far infrared-emitting ceramics （cFIRs） in a model of persistent inflammatory hyperalgesia and to elucidate the possible mechanisms of these effects. Methods： Mice were injected with complete Freund＇s adjuvant （CFA） and treated with cFIRs via place- ment on a pad impregnated with cFIRs on the bottom of the housing unit for different periods of time. Mice underwent mechanical hyperalgesia and edema assessments, and tumor necrosis factor-α （TNF-α）, interleukin-1β （IL-1β） and IL-10 levels were measured. Twenty-four hours after CFA injection and 30 min before cFIR treatment, mice were pretreated with a nonselective adenosinergic antagonist, caffeine, the selective adenosine receptor A antagonist, 1,3-dipropyl-8-cyclopentylxanthine （DPCPX）, the selective cannabinoid receptor type 1 antagonist, AM281, the selective cannabinoid receptor type 2 antagonist, AM630, or the nonselective opioid receptor antagonist, naloxone, and mechanical hyperalge- sia was assessed. Results： cFIRs statistically （P 〈 0.05） decreased CFA-induced mechanical hyperalgesia （82.86 ±5.21）% in control group vs （56.67±9.54）% in cFIR group） and edema （（1699.0 ± 77.8） gm in control group vs （988.7±107.6） gm in cFIR group）, cFIRs statistically （P 〈 0.05） reduced TNF-α （0.478± 0.072） pg/mg of protein in control group vs （0.273 ±0.055） pg/mg of protein in cFIR group） and IL-113 （（95.81 ± 3.95） pg/mg of protein in control group vs （80.61 ±4.71）pg/mg of protein in cFIR group） levels and statistically （P〈 0.05） increased IL-10 （（18.32 ±0.78） pg/mg of protein in control group vs （25.89 ±1.23） pg/mg of protein in cFIR group） levels in post-CFA-injected paws. Peripheral pre-administration of inhibitory neuroreceptor antagonists （caffeine, DPCPX, AM281, AM630 and naloxone） prevented the analgesic effects of cF1Rs （P 〈 0.05）.Conclusion： These data provide additional support for the use of cFIRs in the treatment of painful in

关键词： Adenosine Cannabinoid Far infrared-emitting ceramics Integrative therapy Inflammatory pain Opioid receptors

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Enamel microabrasion: An overview of clinical and scientific considerations

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World Journal of Clinical Cases 2015年第1期3卷 34-41页

作者： Núbia Inocencya Pavesi Pini daniel Sundfeld-Neto Flavio Henrique Baggio Aguiar Renato Herman Sundfeld Luis Roberto Marcondes martins José Roberto Lovadino Débora Alves Nunes Leite Lima Department of Restorative Dentistry Piracicaba Dental SchoolUniversity of CampinasPiracicabaSão Paulo 13414-903Brazil Department of Restorative Dentistry Araçatuba Dental SchoolSão Paulo State UniversityAraçatubaSão Paulo 16015-050Brazil

Superficial stains and irregularities of the enamelare generally what prompt patients to seek dental intervention to improve their smile. These stains or defects may be due to hypoplasia, amelogenesis imperfecta, mineralized white spots, or fluorosis, for which enamel microabrasion is primarily indicated. Enamel microabrasion involves the use of acidic and abrasive agents, such as with 37% phosphoric acid and pumice or 6% hydrochloric acid and silica, applied to the altered enamel surface with mechanical pressure from a rubber cup coupled to a rotatory mandrel of a lowrotation micromotor. If necessary, this treatment can be safely combined with bleaching for better esthetic results. Recent studies show that microabrasion is a conservative treatment when the enamel wear is minimal and clinically imperceptible. The most important factor contributing to the success of enamel microabrasion is the depth of the defect, as deeper, opaque stains, such as those resulting from hypoplasia, cannot be resolved with microabrasion, and require a restorative approach. Surface enamel alterations that result from microabrasion, such as roughness and microhardness, are easily restored by saliva. Clinical studies support the efficacy and longevity of this safe and minimally invasive treatment. The present article presents the clinical and scientific aspects concerning the microabrasion technique, and discusses the indications for and effects of the treatment, including recent works describing microscopic and clinical evaluations.

关键词： Dental bleaching Enamel microabrasion Enamel surface Esthetic treatment Fluorosis Hypoplasia

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Effects of the use of bioceramic wraps in patients with lower limb venous ulcers:A randomized double-blind placebo-controlled trial

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Journal of Integrative Medicine 2020年第1期18卷 26-34页

作者： Gerli E.G.Herr Fábio Goulart da Silva Francisco Jose Cidral-Filho Fabricia Petronilho Lucinéia Gainski danielski Mariana Pereira de Souza Goldim Afonso Shiguemi Inoue Salgado Franciane Bobinski daniel Fernandes martins Eliane R.Winkelmann Integral Health Care Regional University of the Northwest of the State of Rio Grande do Sul(UNIJUí)and University of Cruz Alta(UNICRUZ)Ijuí98700-000RSBrazil Experimental Neuroscience Laboratory(LaNEx) University of Southern Santa CatarinaPalhoca 88137-270SCBrazil Laboratory of Neurobiology of Inflammatory and Metabolic Processes University of Southern Santa CatarinaTubarao 88704-900SCBrazil Integrative Physical Therapy Residency Philadelphia University CenterLondrina 86020-000PRBrazil Laboratory of Exercise Physiopathology Department of Life Sciences(DCVida)Regional University of the Northwest of the State of Rio Grande do Sul(UNIJUí)Ijuí98700-000RSBrazil

Background:Venous ulcer represents the most advanced stage of chronic venous *** is an important public health problem and has a significant impact on patients’quality of life due to chronic pain,inability to work,need for hospitalization and frequent outpatient ***:We investigated the treatment benefits of far-infrared ceramic(cFIR),in a 90-day study of lower limb venous ulcers and looked at ulcer healing scores,quality of life,serum bio-markers of oxidative stress and antioxidant defense ***,setting,participants and interventions:This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul,*** included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 *** outcome measures:The following evaluations were conducted at baseline and after 15,30,60 and90 days:ulcer healing score,quality of life,and serum markers of oxidative stress and antioxidant enzyme ***:Patients(n=24)with lower limb venous ulcers were randomized into two treatment *** decreased the ulcer size on day 30(P=0.042)and 90(P=0.034)and the total ulcer healing scale scores on day 30(P=0.049)and 90(P=0.02)of the treatment,when compared to ***,cFIR improved tissue type(epithelial tissue)on day 60(P=0.022)when compared to baseline ***:cFIR clinically improved ulcer healing in patients with lower limb venous *** registration:RBR-8c7xzn on ReBEC.

关键词： Far-infrared radiation Quality of life Oxidative stress Wound healing Randomized controlled trial Bioceramic wrap

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Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

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Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio Gonçalves da Costa Sousa Gabriela Conceiçao de Almeida Danilo Cesar martins Mota Rosiane Andrade da Costa Simoni Campos Dias Samuel Nunes Limberger Frank Ko Li Ting Lin Evan FHaney Hashem Etayash Beverlie Baquir Michael J.Trimble Ya Shen Zheng Su Markus Haapasalo daniel Pletzer Letícia Chaves de Souza Glaucia Schuindt Teixeira Renato M.Silva Robert E.W.Hancock Octavio Luiz Franco Taia Maria Berto Rezende Post-Graduation Program in Genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-Graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials Engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of Endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-Graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

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Pyoderma gangrenosum affecting the mouth

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Open Journal of Stomatology 2013年第2期3卷 142-145页

作者： Marcos martins Curi Camila Lopes Cardoso daniel Henrique Koga Cristina Zardetto Sergio Rocha Araujo Department of Stomatology Hospital Santa CatarinaSao PauloBrazil Department of Stomatology Bauru School of DentistryUniversity of Sao PauloBauruSao PauloBrazil

Pyoderma gangrenosum is a rare ulcerative cutaneous disorder commonly associated with systemic diseases such as inflammatory bowel diseases. This paper reports a case of pyoderma gangrenosum affecting the mouth and the skin associated with ulcerative colitis. A Medline search in English literature from 1961 to 2012 revealed only 11 documented cases of pyoderma gangrenosum with oral involvement. Previous reported cases of oral cavity involvement have shown that the most common sites of manifestation are the tongue, palate, and tonsillar fauces. This case emphasizes the importance of including inflammatory bowel diseases and their manifestations in the differential diagnosis of ulcerative lesions in the oral cavity.

关键词： Pyoderma Gangrenosum Oral Manifestation Inflammatory Bowel Disease Ulcerative Colitis

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Antithrombotic treatment in chronic heart failure and sinus rhythm: Systematic review

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World Journal of Meta-Analysis 2015年第1期3卷 36-42页

作者： daniel Caldeira Inês Cruz Rita Calé Cristina martins Helder Pereira Joaquim J Ferreira Fausto J Pinto Joo Costa Cardiology Department Hospital Garcia de Orta Clinical Pharmacology Unit Instituto de Medicina Molecular Laboratory of Clinical Pharmacology Faculty of MedicineUniversity of Lisbon Cardiology Department CCUL CAML Faculty of Medicine Evidence Based Medicine Centre Faculty of Medicine University of Lisbon Portuguese Collaborating Centre of the Cochrane Iberoamerican Network Faculty of Medicine University of Lisbon

AIM: To assess the efficacy and safety of antithrombotic drugs(antiplatelet or anticoagulant drugs) compared to no antithrombotic treatment or placebo in patients with heart failure(HF) and sinus rhythm. METHODS: We searched Medline and Cochrane Library for randomized controlled trials evaluating antithrombotic treatment and no antithrombotic treatment in patients with HF and sinus rhythm. Risk ratio(RR) and 95%CIs were estimated performing meta-analysis with random effects method. RESULTS: Two studies met the inclusion criteria: Heart failure Long-term Antithrombotic Study and Warfarin/Aspirin Study in Heart failure, with 336 patients and mean follow-up 1.8-2.25 years. Stroke risk was not reduced by acetylsalicylic acid(RR = 1.18, 95%CI: 0.17-8.15), oral anticoagulation(RR = 0.30, 95%CI: 0.03-2.65) or overall antithrombotic drugs(RR = 0.52, 95%CI: 0.10-2.74). Acetylsalicylic acid showed a significant increased risk of worsening HF(RR = 1.78, 95%CI: 1.08-2.92), while oral anticoagulation had no impact in this outcome(RR = 1.03, 95%CI: 0.61-1.75). Overall antithrombotic drugs showed a significant risk increase of major bleeding(RR = 6.99, 95%CI: 0.89-54.64). CONCLUSION: Best available evidence does not support the routine use of antithrombotic drugs in patients with HF and sinus rhythm. These drugs, particularly oral anti-coagulation has the hazard of increase significantly major bleeding risk.

关键词： Heart failure Sinus rhythm Platelet aggregation inhibitors Anticoagulants

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