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Fungal diversity notes 603–708: taxonomic and phylogenetic notes on genera and species

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Fungal Diversity 2017年第6期87卷 1-235页

作者： Kevin D.Hyde Chada Norphanphoun Vanessa P.Abreu Anna Bazzicalupo K.W.Thilini Chethana Marco Clericuzio Monika C.Dayarathne Asha J.Dissanayake Anusha H.Ekanayaka Mao-Qiang He Sinang Hongsanan Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Anuruddha Karunarathna Sirinapa Konta Ivana Kusan Hyun lee Junfu li Chuan-Gen lin Ning-Guo liu Yong-Zhong lu Zong-long luo Ishara S.Manawasinghe Ausana Mapook Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Igor Siedlecki Adriene Mayra Soares Danushka S.Tennakoon Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yuan-Pin Xiao Jing Yang Xiang-Yu Zeng Faten A.Abdel-Aziz Wen-Jing li Indunil C.Senanayake Qiu-Ju Shang Dinushani A.Daranagama Nimali Ide Silva Kasun M.Thambugala Mohamed A.Abdel-Wahab Ali H.Bahkali Mary l.Berbee Saranyaphat Boonmee D.Jayarama Bhat Timur S.Bulgakov Bart Buyck Erio Camporesi Rafael F.Castaneda-Ruiz Putarak Chomnunti Minkwan Doilom Francesco Dovana Tatiana B.Gibertoni Margita Jadan Rajesh Jeewon E.B.Gareth Jones Ji-Chuan Kang Samantha C.Karunarathna Young Woon lim Jian-Kui liu Zuo-Yi liu Helio longoni Plautz Jr Saisamorn lumyong Sajeewa S.N.Maharachchikumbura Neven Matocec Eric H.C.McKenzie Armin Mesic daniel Miller Julia Pawłowska Olinto l.Pereira Itthayakorn Promputtha Andrea I.Romero leif Ryvarden Hong-Yan Su Satinee Suetrong Zdenko Tkalcec Alfredo Vizzini Ting-Chi Wen Komsit Wisitrassameewong Marta Wrzosek Jian-Chu Xu Qi Zhao Rui-lin Zhao Peter E.Mortimer Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18Forlı`Italy Centre of Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China College of life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Botany University of British ColumbiaVancouverCanada Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityP.O.Box 34123 Al-KhodOman Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Department of Molecular Phylogenetics and Evolution Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsaw_Zwirki i Wigury 10102-089 WarsawPoland Departamento de Micologia Centro de BiocienciasUniversidade Federal de PernambucoAv.da Engenharia s/nRecifePernambuco 50760-600Brazil Dipartimento

This is the sixth in a series of papers where we bring collaborating mycologists together to produce a set of notes of several taxa of *** this study we introduce a new family Fuscostagonosporaceae in *** also introduce the new ascomycete genera Acericola,Castellaniomyces,Dictyosporina and longitudinalis and new species Acericola italica,Alternariaster trigonosporus,Amarenomyces dactylidis,Angustimassarina coryli,Astrocystis bambusicola,Castellaniomyces rosae,Chaetothyrina artocarpi,Chlamydotubeufia krabiensis,Colletotrichum lauri,Collodiscula chiangraiensis,Curvularia palmicola,Cytospora mali-sylvestris,Dictyocheirospora cheirospora,Dictyosporina ferruginea,Dothiora coronillae,Dothiora spartii,Dyfrolomyces phetchaburiensis,Epicoccum cedri,Epicoccum pruni,Fasciatispora calami,Fuscostagonospora cytisi,Grandibotrys hyalinus,Hermatomyces nabanheensis,Hongkongmyces thailandica,Hysterium rhizophorae,Jahnula guttulaspora,Kirschsteiniothelia rostrata,Koorchalomella salmonispora,longitudinalis nabanheensis,lophium zalerioides,Magnibotryascoma mali,Meliola clerodendri-infortunati,Microthyrium chinense,Neodidymelliopsis moricola,Neophaeocryptopus spartii,Nigrograna thymi,Ophiocordyceps cossidarum,Ophiocordyceps issidarum,Ophiosimulans plantaginis,Otidea pruinosa,Otidea stipitata,Paucispora kunmingense,Phaeoisaria microspora,Pleurothecium floriforme,Poaceascoma halophila,Periconia aquatica,Periconia submersa,Phaeosphaeria acaciae,Phaeopoacea muriformis,Pseudopithomyces kunmingnensis,Ramgea ozimecii,Sardiniella celtidis,Seimatosporium italicum,Setoseptoria scirpi,Torula gaodangensis and Vamsapriya *** also provide an amended account of Rhytidhysteron to include apothecial ascomata and a J?*** type species of Ascotrichella hawksworthii(Xylariales genera incertae sedis),Biciliopsis leptogiicola(Sordariomycetes genera incertae sedis),Brooksia tropicalis(Micropeltidaceae),Bryochiton monascus(Teratosphaeriaceae),Bryomyces scapaniae(Pseud

关键词： Ascomycota Basidiomycota Mucoromycota Phylogeny Taxonomy

含角质溶解剂和保湿剂的洗发水用于轻至中度头皮银屑病患者的功效性和安全性随机对照研究

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中华皮肤科杂志 2024年第11期57卷 1064-1064页

作者： Philippe Massiot PhD Pedro Contreiras Pinto MD Stephanie leclerc-Mercier MD Virginie Rasmont PhD Bianca Maria Piraccini MD lidia Rudnicka Pascal Reygagne MD daniel Fernandes Melo MD Sergio Vano-Galvan MD Wen-Yu Wu MD Delphine Kerob MD l'Oréal Research and Innovation Clichy France PhDTrials Lisbon Portugal laboratoires Vichy International Levallois-Perret France Division of Dermatology Department of Specialized Diagnostic and Experimental Medicine University of Bologna Bologna Italy Department of Dermatology Medical University of Warsaw Warsaw Poland Sabouraud Centre St Louis Hospital Paris France Department of Dermatology University of State of Rio de Janeiro (UERJ) Rio de Janeiro Brazil Ramon y Cajal University Hospital TricoHRC IRYCIS University of Alcala Madrid Spain Department of Dermatology Huashan Hospital Fudan University Shanghai China Cosmetic Active International Levallois-Perret France Delphine Kerob Cosmetic Active International Levallois-Perret France.

高达80%的银屑病患者同时受到头皮银屑病的困扰,头皮银屑病难以治疗,严重影响生活质量,临床应给予额外关注。目前,头皮银屑病的治疗常依赖局部外用糖皮质激素,短期使用可能引起皮肤刺激(尤其是含酒精制剂),长期使用可能导致局部不良反... 详细信息

高达80%的银屑病患者同时受到头皮银屑病的困扰,头皮银屑病难以治疗,严重影响生活质量,临床应给予额外关注。目前,头皮银屑病的治疗常依赖局部外用糖皮质激素,短期使用可能引起皮肤刺激(尤其是含酒精制剂),长期使用可能导致局部不良反应。已有功效性洗护产品(PSOlution,薇姿实验室,法国)通过添加角质溶解剂(2%水杨酸)和保湿剂(5%尿素、1%甘油)等成分,用于改善头皮银屑病的临床症状。本研究旨在评估该洗发产品用于轻至中度头皮银屑病患者的功效性和局部安全性。

关键词：头皮银屑病功效性随机对照研究短期使用保湿剂皮肤刺激外用糖皮质激素洗发水

欧亚大陆渐新世古气候时空演变及其驱动因子——基于植物大化石和气候模型的综合分析

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欧亚大陆渐新世古气候时空演变及其驱动因子——基于植物大化石和...

FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

中国古生物学会第十二次全国会员代表大会暨第29届学术年会

作者：李树峰星耀武 Paul J.Valdes 黄永江苏涛 Alex Farnsworth daniel J.lunt 唐赫 Alan T.Kennedy 周浙昆中国科学院西双版纳热带植物园热带森林生态学重点实验室 School of Geographical Sciences University of Bristol 中国科学院昆明植物研究所生物多样性与生物地理学重点实验室中国科学院大学

渐新世(33.9–23.03 Ma)是新生代地球演化历史中非常独特的一个时期,地球从始新世的"温室"气候快速转变为"冰室"气候。关于欧亚大陆渐新世气候的研究前人已做了不少相关工作,但是不同的古气候代理指标以及气候模型研究得到的结果有很大... 详细信息

渐新世(33.9–23.03 Ma)是新生代地球演化历史中非常独特的一个时期,地球从始新世的"温室"气候快速转变为"冰室"气候。关于欧亚大陆渐新世气候的研究前人已做了不少相关工作,但是不同的古气候代理指标以及气候模型研究得到的结果有很大差异,尤其是在中高纬度地区,因此有必要对渐新世的气候变化进行深入研究。本文综合整理了渐新世欧亚大陆中高纬度地区149个大化石数据点,通过共存法重建了化石点的古气候数据(其中整合了已发表的35个点的古气候)。通过对不同时期和地区的古气候进行对比,分析了早、晚渐新世欧亚大陆不同地区的气候差异,以及和现代气候的对比分析。同时,本研究将化石数据英国布里斯托大学一系列HadCM3l模型模拟的渐新世气候数据进行对比,进一步揭示了欧亚大陆渐新世气候的主要驱动因子。古气候重建的结果表明:渐新世欧亚大陆中高纬度地区的年均温范围为5.4–25.5°C,年降雨量范围是338–2453 mm,该时期大部分地区的气候类型和现代的亚热带季风性湿润气候相似。研究表明早渐新世(33.9–28.1 Ma)和晚渐新世(28.1-23.03 Ma)气候较为相似;渐新世欧洲的气候整体上比中亚和东亚更为温暖湿润,中亚是其中最为干冷的地区。通过对渐新世和现代气候的对比分析,结果表明地质构造运动(如副特提斯海退却),是影响欧亚大陆渐新世以来的气候演变的重要作用。通过和不同边界条件(如CO2和古地理)的HadCM3l古气候模型对比,表明气候模型和大化石数据在大的空间尺度上大体一致,但是气候模型重建的温度季节性差异明显比化石数据要大(模拟的夏季温度比化石数据高,冬季温度低),尤其是在高纬度地区。另外基于年均温的分析表明:CO2在560 ppmv以及1120 ppmv的模型和化石数据较为吻合。本研究揭示了古气候模拟诸多边界条件的不确定性,为气候模拟提供重要参考价值。

关键词：渐新世古气候植物化石气候模拟副特提斯海

来源： cnki会议评论

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Fungal Diversity 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks laszlo Irinyi lászlóGNagy liina Soonvald li-Wei Zhou lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato l.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de lima Vladimir S.Mikryukov Yongzhong lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GlOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNlAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

以人群为基础的生物监测:纽约市有机磷和拟除虫菊酯类杀虫剂暴露

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环境与职业医学 2014年第4期31卷 329-329页

作者： Wendy McKelvey J.Bryan Jacobson daniel Kass Dana Boyd Barr Mark Davis Antonia M.Calafat Kenneth M.Aldous

[背景]有机磷类和拟除虫菊酯类是两类美国最常见的杀虫剂。这些杀虫剂广泛用于控制纽约市建筑物里的虫害,所导致的杀虫剂暴露可能比比在欠城市化的环境中更高。[目的]估计纽约市杀虫剂暴露的参考值,并确定人口学特征和行为特征以预测暴... 详细信息

[背景]有机磷类和拟除虫菊酯类是两类美国最常见的杀虫剂。这些杀虫剂广泛用于控制纽约市建筑物里的虫害,所导致的杀虫剂暴露可能比比在欠城市化的环境中更高。[目的]估计纽约市杀虫剂暴露的参考值,并确定人口学特征和行为特征以预测暴露。[方法]2004年纽约市健康与营养调查是一项在人群基础上的横断面研究,研究对像为≥20岁的成年人。检测883名参加者的尿中有机磷代谢产物[二甲基磷酸酯(DMP)、二甲基硫代磷酸酯(DMTP)、二甲基二硫代磷酸酯、二乙基磷酸酯、二乙基硫代磷酸酯和二乙基二硫代磷酸酯]的浓度,以及1 452名参加者的尿中拟除虫菊酯类代谢产物[3-苯氧基苯甲酸(3-PBA)、反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(反式DCCA)、4-氟-3-苯氧基苯甲酸和顺式-3-(2,2-二溴乙烯基)-2,2-二甲基环丙烷-1-羧酸]的浓度。使用多元线性回归在不同的预测因子类别中估计总二烃基磷酸盐(ΣDAP)的最小二乘几何平均值和3-PBA浓度。[结果]二甲基有机磷代谢产物的第95百分位浓度最高(DMP和DMTP分别为87.4μg/l和74.7μg/l)。拟除虫菊酯类代谢物中测得的最高第95百分位浓度分别为3-PBA和反式-DCCA(分别为5.23μg/l和5.94μg/l)。ΣDAP浓度随着年龄增加而增加,在非西班牙裔白人或黑人中较西班牙裔/族裔高,在专业使用杀虫剂者中较高,也随水果的消费频率增加而增加;ΣDAP浓度随非绿色蔬菜消费增加而下降。在各预测因子类别中尿3-PBA浓度几何均数的绝对差值都太小而无意义。[结论]纽约市拟除虫菊酯类和有机磷二甲酯类暴露水平估值均高于美国的整体水平,因此在制定杀虫剂的使用法规时,一定要考虑城市中虫害与杀虫剂负荷。

关键词：拟除虫菊酯类杀虫剂有机磷类纽约市生物监测人群硫代磷酸酯人口学特征行为特征

Gammasphere上裂变丰中子核核结构若干前沿领域的新进展(Ⅱ:第三和第四部分)(英文)

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原子核物理评论 2010年第3期27卷 363-389页

作者：罗亦孝 J.H.Hamilton J.O.Rasmussen A.V.Ramayya C.Goodin A.V.daniel N.J.Stone 朱胜江 J.K.Hwang 刘少华 C.J.Beyer 李科 H.l.Crowell D.Al mehed S.Frauendorf A.Covello V.Di mitrov 张敬业车兴来姜卓 D.Fong A.Gelberg I.Stefanescu A.Gargano E.F.Jones P.M.Gore I.Y.lee G.M.Ter-Akopian Yu.Ts.Oganessian M.A.Stoyer R.Donangelo 马文超 J.D.Cole J.Kormicki 张学谦 S.C.Wu J.Gilat T.N.Ginter S.J.Asztalos Physics Department Vanderbilt University Nashville TN 37235 USA lawrence Berkeley National laboratory Berkeley CA 94720 USA Flerov laboratory for Nuclear Reactions JINR Dubna Russia Joint Institute for Heavy Ion Research Oak Ridge TN 37831 USA Department of Physics Oxford University Oxford OX1 3PU United Kingdom Department of Physics and Astronomy University of Tennessee Knoxville Tennessee 37996 USA Physics Department Tsinghua University Beijing 100084 China Department of Physics University of Notre Dame Notre Dame IN 46556 USA Institut far Strahlenphysik FZD-Rossendorf Postfach 510119 D-01314 Dresden Germany Dipartimento di Scienze Fisiche Universita di Napoli Federico II and Istituto Nazionale di Fisica Nuclear Complesso Universitario di Monte S. Angelo Via Cintia 80126 Napoli Italy Idaho Accelerator Center Idaho State University Pocatello ID-83209-8263 USA Institut fur Kernphysik Universitat zu Koln 50937 Kdln Germany Department of Chemistry and Biochemistry University of Maryland MD 20742 USA lawrence livermore National laboratory Livermore CA 94550 USA Instituto de Fisica Facultad de Ingenieria C. C. 30 11300 Montevideo Uruguay Mississippi State University Drawer 5167 Mississippi State MS 39762 USA Idaho National laboratory Bldg. IRCPL MS2114 Idaho Falls ID 83415 USA Department of Physics National Tsing Hua University Hsinchu Taiwan 30013 China National Superconducting Cyclotron laboratory Michigan State University East Lansing Michigan 48824 USA Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大... 详细信息

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大四极形变到Z=43(Tc),44(Ru)和45(Rh)同位素中具有中等四极形变之大三轴形变的过渡。Nb(Z=41)同位素具有过渡核的特征。根据邻近同位素和同中素带交叉信息的系统性及推转壳模型(CSM)计算,Tc和Rh偶-N同位素中观察到的带交叉产生于一对h11/2中子的转动顺排。首次观察到100Nb(Z=41,N=59)的高自旋能级纲图和形变态,从而证实了100Nb中的形状共存,并确认,在Nb同位素链上,基态形状突变发生于N=58(球形)到N=59(大形变);而在Sr(Z=38),Y(Z=39)和Zr(Z=40)各同位素链上,基态形状突变均发生于N=59(球形)到N=60(大形变)。100Nb具有大形变基态,同现有理论预言相矛盾,其大形变的基态及转动带所具有的很大的和不规则的转动惯量具有重要的理论意义。对奇-质子Cs(Z=55)和la(Z=57)丰中子同位素八极激发的详细研究,发现了141,143,144Cs同位素链上电二极矩D0随中子数增加而减小的急剧变化,此前在145,147la中观察到的电二极矩D0的较缓和的减小似乎亦很陡地下延至148la。在Cs和la同位素中观察到的电二极矩D0的急剧下降很可能同偶-质子核146Ba和224Ra中观察到的电二极矩D0的急剧下降相类似,后者已获反射非对称平均场壳修正理论的成功解释。实验证明,141Cs具有很大电二极矩D0。141Cs和142Xe中观测到的很大的电二极矩D0和仅在141Cs中观察到的电二极矩D0的simplex量子数相关性需要进一步的理论研究。根据转动频率比值ω-(I)/ω+(I)的检定,同Xe同位素一样,认定Cs同位素中包括号143Cs的八极激发为八极振动,而在la同位素中存在八极形变。

关键词：形状过渡轴对称形状三轴形变形状突变带交叉奇-质子八极激发 B(E1)/B(E2)比值电二极矩D0 二极矩的下降八极振动 Cs,la同位素

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Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, lynette Brown, James M. Caddle, l. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, lance C. lanoue, louise lawson, Thomas N. lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa l. Newbigging, Susan Nutter, lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, leeyean Yoshiki, Atsushi MacArthur, daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen l. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur l. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

氯吡格雷的使用与药物洗脱支架植入后远期临床结果

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美国医学会杂志（中文版） 2007年第3期26卷 131-139页

作者： Eric l Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD linda K. Shaw, MS Robert H. Tuttle, MSPH daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿（译） David E. Kandzari, MD Department of Medicine Duke Clinical Research Institute Biostatistics and Bioinformatics Duke Clinical Research Institute Duke University Medical Center Duke Clinical Research Institute Duke Translational Medicine Institute Durham NC the Duke Center for Clinical Health Policy Research Durham NC 不详

背景：近来的冠状动脉内药物洗脱支架研究提示，现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的：于接受药物洗脱支架（drug-eluting stents，DESs）和裸金属支架（bare-metal stents，BMSs）治疗的冠状动脉病患者中... 详细信息

背景：近来的冠状动脉内药物洗脱支架研究提示，现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的：于接受药物洗脱支架（drug-eluting stents，DESs）和裸金属支架（bare-metal stents，BMSs）治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者：于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心（一家位于北卡罗来纳州达累姆市的三级治疗中心）接受冠状动脉内支架治疗。于6、12、24个月时进行随访，直至2006年9月7日。研究人群包括4666例最初接受BMS（n=3165）或DES（n=1501）经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件（没有死亡、心肌梗死或血管重建手术）的患者进行界标分析（landmark analysis）。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组：DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标：随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果：在6个月时没有事件发生的DES组患者（637例使用、579例未使用氯吡格雷）中，氯吡格雷的使用是随访24个月校正死亡率较低（使用2．0％比未使用5．3％；差异，-3．3％；95％CI，-6．3％至-0．3％；P=0．03）以及死亡或心肌梗死发生率较低（3．1％比7．2％；差异，-4．1％；95％CI，-7．6％至-0．6％；P=0．02）的显著预测指标。然而，在BMS组患者中（417例使用、1976例未用氯吡格雷），死亡（3．7％比4．5％；差异，-0．7％；95％CI，-2．9％至1．4％；P=0．50）以及死亡或心肌梗死发生率（5．5％比6．0％；差异，-0．5％；95％CI，-3．2％至2．2％；P：0．70）没有差异。在12个月随访没有事件发生的DES组患者（252例使用、276例未用氯吡格雷）中，氯吡格雷的使用依然可以预测24个月死亡（0％比3．5％；差异，-3．5％；95％CI，-5．9％至-1．1％；P=0．004）以及死亡或心肌梗死发生率（0％比4．5％；差异，-4．5％；95％CI，-7．1％至-1．9％；P〈0．001）较低。然而，在BMS组患者中（346例使用、1644例未用氯吡格雷），在死亡（3．3％比2．7％；差异，0．6％；95％CI，1．5％至2．8％；P=0．57）以及死亡或心肌梗死（4．7％比3．6％；差异，1．0％；95％CI，-1．6％至3．6％；P=0．44）发生方面，依然没有差异。结论：在接受DES治疗的患者中，延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而，使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。

关键词：药物洗脱支架氯吡格雷临床结果经皮冠状动脉介入治疗植入后冠状动脉内心肌梗死支架内血栓形成

miR-182参与调节胶质母细胞瘤的凋亡、生长和分化（英文）

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中华神经外科疾病研究杂志 2015年第2期14卷 163-163页

作者： Kouri FM Hurley lA daniel Wl Day ES Hua Y Hao l Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin l Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH

Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to ***,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient *** of Bcl2-like12(Bcl2l12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in *** evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 *** administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal *** results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM.

关键词： miR-182 神经外科疾病临床 GICs