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Cardiac functional magnetic resonance imaging at 7T:Image quality optimization and ultra-high field capabilities

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World Journal of Radiology 2020年第10期12卷 231-246页

作者： El-Sayed H Ibrahim V Emre Arpinar l Tugan Muftuler Jadranka Stojanovska Andrew S Nencka Kevin M Koch Department of Radiology Medical College of WisconsinMilwaukeeWI 53226United States Department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226United States Department of Radiology University of MichiganAnn ArborMI 48109United States

BACKGROUND 7T cardiac magnetic resonance imaging(MRI)introduces several advantages,as well as some limitations,compared to lower-field *** capabilities of ultra-high field(UHF)MRI have not been fully exploited in cardiac functional *** To optimize 7T cardiac MRI functional imaging without the need for conducting B1 shimming or subject-specific tuning,which improves scan *** this study,we provide results from phantom and in vivo scans using a multi-channel transceiver modular *** We investigated the effects of adding a dielectric pad at different locations next to the imaged region of interest on improving image quality in subjects with different body *** also investigated the effects of adjusting the imaging flip angle in cine and tagging sequences on improving image quality,B1 field homogeneity,signal-to-noise ratio(SNR),blood-myocardium contrast-to-noise ratio(CNR),and tagging persistence throughout the cardiac *** The results showed the capability of achieving improved image quality with high spatial resolution(0.75 mm×0.75 mm×2 mm),high temporal resolution(20 ms),and increased tagging persistence(for up to 1200 ms cardiac cycle duration)at 7T cardiac MRI after adjusting scan set-up and imaging *** the imaging flip angle was essential for achieving optimal SNR and myocardium-toblood *** a dielectric pad at the anterior left position of the chest resulted in improved B1 homogeneity compared to other positions,especially in subjects with small chest *** Improved regional and global cardiac functional imaging can be achieved at 7T MRI through simple scan set-up adjustment and imaging parameter optimization,which would allow for more streamlined and efficient UHF cardiac MRI.

关键词： Magnetic resonance imaging High-field Cardiac function Cine Tagging Strain

贮藏于4℃的家制酸奶中低浓度大肠杆菌O157:H7的存活研究

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食品科学 2010年第5期31卷 252-255页

作者：赖卫华冯贻泽 Beth Ann Crozier-Dodson 南昌大学食品科学与技术国家重点实验室江西南昌330047 堪萨斯州立大学动物科学与工业系

牛奶预热后分装并分别接种体积分数3%的酸奶和2.15(lg(CFU/ml))的大肠杆菌O157:H7,在45℃下发酵5h后贮藏于4℃的冰箱中。利用Pathatrix大体积循环系统中偶联了抗体的免疫磁珠特异性地捕获这些酸奶中的大肠杆菌O157:H7。免疫磁珠重悬于1... 详细信息

牛奶预热后分装并分别接种体积分数3%的酸奶和2.15(lg(CFU/ml))的大肠杆菌O157:H7,在45℃下发酵5h后贮藏于4℃的冰箱中。利用Pathatrix大体积循环系统中偶联了抗体的免疫磁珠特异性地捕获这些酸奶中的大肠杆菌O157:H7。免疫磁珠重悬于1%的蛋白胨水后涂布于添加了新生霉素(5mg/l)的山梨醇麦康凯固体培养基中,培养基在37℃恒温培养箱中放置24h。实验结果表明,酸奶中大肠杆菌O157:H7的数量逐渐减少,12d后才检测不到。因此乳制品加工及保存过程中,需要加强对大肠杆菌O157:H7污染的监测,以保证乳制品的安全性。

关键词：大肠杆菌O157:H7 酸奶 Pathatrix系统

Memory AND effector cells in children with bacterial infections of the gastrointestinal and respiratory tracts

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Open Journal of Immunology 2012年第4期2卷 202-209页

作者： Monika Palacios-Martínez María Cristina González-Torres leonor Rodríguez-Cruz Rubén D. Martínez-Pérez Consuelo del Carmen Cortés-Bejar Fernando Valencia-Chavarria daniel Martínez-Gómez Oralia Nájera-Medina Departamento de Atención a la Salud Universidad Autónoma Metropolitana-Xochimilco Departamento de Ciencias de la Salud Universidad Autónoma Metropolitana-Iztapalapa Departamento de Producción Agrícola y Animal Facultad de Medicina-Universidad Nacional Autónoma de México Hospital Materno-Pediátrico Xochimilco del Gobierno del DF

Infections in infants and children under five years of age are a public health in México and are one of the major causes of death. Methods In this study, lymphocyte immunophenotyping for CD3+ (T-cells), CD3+CD4+, CD3+CD8+, CD3+CD19+, CD3+CD16/56+, CD45RA+, CD45RO+, CD62l- and CD28- were determined in the whole blood of gastrointestinal and respiratory bacterial infected children, using a four-color flow cytometry technique. Results: Our data showed that the percentages and the absolute numbers of monocytes and granulocytes are increased in infected children, when compared to the control group. Similarly, we observed increases in the percentages of B lymphocytes, CD8+ cells, memory T cells (CD4+CD45RO+ and CD8+CD45RO+) and effector lymphocytes (CD4+CD62l? and CD8+CD28?) in infected children compared with the control group. In contrast, naive T cells were decreased in the bacterial infected children relative to the control group. Additionally, we used ElISA assays to identify the pathogen agent in gastrointestinal and respiratory infection. Comparing different types of infection, we found that the children with respiratory bacterial infections had higher percentages of B lymphocytes, and cytotoxic lymphocytes (CD8+CD28-);and the children with gastrointestinal infections had higher percentages of CD3+ lymphocytes and effector cells (CD4+CD62l-). Conclusions The increase in B lymphocytes and CD8+CD28- cells in the children with respiratory infections and the increase of T lymphocytes and CD4+CD62l- cells in the children with gastrointestinal bacterial infections indicate that both cellular and humoral responses coincide, and both responses are necessary for eliminating the pathogen.

关键词： Memory Cells Effector Cells Bacterial Infection Immune Response

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亚马孙村民的血液汞含量和肾的生物标记物

人类环境杂志 1995年第2期24卷 103-105页

作者： Steven E.Aks Timothy B.Erickson Fernando J.O.Branches daniel O.Hryhorczuk 杨军 Toxikon Consortium Santa Rem 芝加哥市伊利诺斯大学公共卫生学院环境和职业健康科学部

本文介绍巴西巴拉州11个亚马孙村民的血液汞含量和肾的生物标记物的小规模调查结果。Ponta de Pedra村位于Tapajos河(亚马孙河支流)的河岸上,在金矿开采场下游800km处,此开采场在炼金过程中使用汞。此村的居民大量食用鱼,从而有可能由... 详细信息

本文介绍巴西巴拉州11个亚马孙村民的血液汞含量和肾的生物标记物的小规模调查结果。Ponta de Pedra村位于Tapajos河(亚马孙河支流)的河岸上,在金矿开采场下游800km处,此开采场在炼金过程中使用汞。此村的居民大量食用鱼,从而有可能由于水产食物链的污染而受到环境汞毒害的威胁。虽然这些村民的血液中的平均汞浓度(29.1mg/l)比许多工业化国家所报道的对居民取样的平均值高,但比有记录的其他大量食鱼的居民的血液中汞浓度平均值要低。对于这些村民的尿进行了生物标记物的分析,未发现有肾损坏的临床症状。

关键词：巴西血液汞含量生物标记物肾

A potential clinical based score in hepatitis C viruscirrhotic patients to exclude small hepatocellular carcinoma

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Hepatoma Research 2018年第4期4卷 14-24页

作者： Denise Cerqueira Paranaguá-Vezozzo Celso Eduardo lourenco Matielo daniel Ferraz de Campos Mazo lucas Souto Nacif Mario Guimaraes Pessoa Gleicy luz Reinoso Pereira Roque Gabriel Rezende de lima Patricia Momoyo Yoshimura Zitelli Suzane Kioko Ono Flair JoséCarrilho Division of Gastroenterology and Hepatology Department of GastroenterologyUniversity of Sao Paulo School of MedicineSao Paulo 05403-900Brazil Sao Paulo Clínicas liver Cancer Group Sao PauloCancer Institute of Sao PauloUniversity of Sao Paulo School of MedicineSao Paulo 01246-000Brazil Division of Gastroenterology(Gastrocentro) School of Medical SciencesUniversity of CampinasCampinas 13083-878Brazil

Aim: Hepatitis C virus (HCV) cirrhosis is an important cause of hepatocellular carcinoma (HCC). This study aimed to identify factors of HCC presence among HCV cirrhotic patients with and without small diameter HCC (≤ 3 cm). Methods: A case control transversal study between 1998 and 2003 including 93 patients: 31 with small diameter HCC and 62 without HCC. Groups were matched by age and gender. Multiple logistic regression analysis using Akaike Information Criteria to estimate the probability of HCC was performed. A model score was generated and bootstrap analysis was performed for internal validation. Results: Three significant laboratorial variables for HCC presence were found: alanine aminotransferase > 37 U/l [odds ratio (OR): 7.43 (1.61-34.19),P = 0.01], alpha-fetoprotein > 20 ng/ml [OR: 16.2 (4.17-63.01),P latelet count l score with an area under curve of 0.79 (95% CI: 0.7-0.89) was built based on these variables. The negative predictive value of those classified as at low risk of HCC was 99.1%. Conclusion: An easy and practical model score was generated. It may be an auxiliary tool for identification of HCV patients with low probability of small diameter HCC at initial evaluation composed of three serum examinations used in routine outpatient clinical practice.

关键词： Clinical score hepatocellular carcinoma hepatitis C

自发性脑出血管理指南美国心脏协会／美国卒中协会针对医疗专业人员的指南

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国际脑血管病杂志 2015年第10期23卷 721-739页

作者： J. Claude Hemphill Ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok Mary Cushman Gordon l. Fung Joshua N. Goldstein R. lochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, daniel Woo 高圆圆徐欣不详南京大学医学院附属鼓楼医院神经内科 210008

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定... 详细信息

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南，重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。

关键词：美国心脏协会科学声明血压凝血功能障碍诊断脑出血脑室出血外科手术治疗

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橄榄林中的乡村酒店

现代装饰 2021年第4期 138-145页

作者： Antonio José Galisteo Espartero álvaro Fernández Navarro Francisco Jesús Camacho Gómez David Melero Herrera.Arquitecto Fausto Santarosa.Arquitecto Juan Francisco Mata Díaz.Ingeniero ángel Gabriel Pacheco Rodado.Ingeniero daniel Montoya lópez.Aparejador Francisco Torreblanca Herrero 郭映琴

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特...

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特的自然环境致以最真诚的敬意,四周的美景令人印象深刻。设计的关键在于使室内外空间相互渗透,不破坏原有建筑的特质。城市规划发展组织将与酒店相连的另一栋用于农业开发的仓库一并纳入了该项目,复杂的行政程序使得这两栋建筑只能进行简单的改造,而该项目的翻新和扩建的设计方案有效地满足了此需求。

关键词：

HⅠVertical Structure of Nearby Edge-on Galaxies from CHANG-ES

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Research in Astronomy and Astrophysics 2022年第8期22卷 49-62页

作者： Yun Zheng Jing Wang Judith Irwin Qdaniel Wang Jiangtao li Jayanne English Qingchuan Ma Ran Wang Ke Wang Marita Krause Toky H.Randriamampandry Rainer Beck Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Physics Engineering Physics&AstronomyQueen’s UniversityKingstonONK7L 3N6Canada Astronomy Department University of MassachusettsAmherstMA 01003USA Department of Astronomy University of MichiganAnn ArborMI48109-1107USA Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Department of Physics and Astronomy University of ManitobaWinnipegManitobaR3T 2N2Canada Max-Planck-Institut für Radioastronomie Auf dem Hügel D-6953121 BonnGermany

We study the vertical distribution of the highly inclined galaxies from the Continuum Halos in Nearby Galaxies—an EVlA Survey(CHANG-ES).We explore the feasibility of photometrically deriving the HⅠdisk scale heights from the moment-0 images of the relatively edge-on galaxies with inclination>80°,by quantifying the systematic broadening effects and thus deriving correction equations for direct *** corrected HⅠdisk scale heights of the relatively edge-on galaxies from the CHANG-ES sample show trends consistent with the quasiequilibrium model of the vertical structure of gas *** procedure provides a convenient way to derive the scale heights and can easily be applied to statistical samples in the future.

关键词： galaxies:ISM galaxies:spiral galaxies:structure

Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery

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World Journal of Gastroenterology 2017年第13期23卷 2376-2384页

作者： Amilcare Parisi daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio Department of Digestive Surgery St.Mary's HospitalUniversity of Perugia Klinik und Poliklinik fuer Chirurgie Klinikum Rechts der IsarTechnical University Munich Department of Surgery General and Oncologic Surgery UnitSanta Croce e Carle Hospital Department of Surgery Division of Gastrointestinal SurgeryUniversity of CaliforniaIrvine Medical Center Gastrointestinal Surgery Tianjin Medical University General Hospital Division of Oncological and Robotic Surgery Department of OncologyCareggi University Hospital Unit of general and endocrine surgery Center of oncologic minimally invasive surgery(COMIS)Careggi University Hospital Department of General Surgery Hospital of Cittàdi CastelloUSL1 Umbria Department of General Surgery Division of GeneralGastroenterologic and Minimally Invasive SurgeryG.B.Morgagni Hospital Department of General Surgery School of MedicineIstanbul Medeniyet University Department of Digestive and Hepatobiliary Surgery Estaing University Hospital Department of Surgery Robotic General Surgery UnitSan Giovanni Addolorata Hospital Esophageal Surgery Unit Tuscany Regional Referral Center for the Diagnosis and Treatment of Esophageal DiseaseMedical University of Pisa Department of General Surgery The Affiliated Hospital of Qingdao University Unitédes Maladies de l'Appareil Digestif et Endocrine Centre Hospitalier de Luxembourg Service de Chirurgie Digestive et Cancérologique CHU Bocage Department of Surgical Oncology and HPB Surgery Englewood Hospital and Medical Center Department of General Surgery Jinling HospitalMedical SchoolNanjing University Department of Surgery Ruijin HospitalShanghai Jiaotong UniversitySchool of Medicine Department of General Surgery Erzincan UniversitySchool of Medicine Department of Surgical Science “La Sapienza”University Department of Digestive Surgery St.Mary's Hospital of Terni-University of Perugia

AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological *** This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(lG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also *** The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, lG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; lG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the lG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), lG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P lar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between *** laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recov

关键词： Gastric cancer Gastrectomy Minimally invasive surgery Robotic Robot-assisted laparoscopy