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Effect of Nicotine on Dopamine and Glutathione levels in Presence of Oligoelements in Brain Regions of Young Rats——Effect of Nicotine on Brain Regions of Rat

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Neuroscience & Medicine 2012年第3期3卷 281-286页

作者： David Calderón Guzmán Ernestina Hernández García Francisca Trujillo Jiménez Gerardo Barragán Mejía Hugo Juárez Olguín José A. Saldivar González daniel Santamaria del Angel Norma Osnaya Brizuela Departamento de Farmacología Facultad de Medicina Universidad Nacional Autónoma de México laboratorio de Farmacología INP México City México laboratorio de Neuroquímica Instituto Nacional de Pediatría (INP) México City México laboratorio de Patología Experimental México City México

Aim: The purpose of this study was to understand the mechanism of nicotine mediated addiction and the role of oligoelements in reducing its effect. Methods: Male Wistar rats (weight 80 g) were treated with single and repeated doses of nicotine and/or oligoelements as follows: group 1 (control) NaCl 0.9%;group 2, nicotine (1 mg/kg);group 3, oligoelements (50 μl/rat);and group 4, nicotine (1 mg/kg) + oligoelements (50 μl/rat). All drugs were intraperitoneally administered for 4 days. Blood for the measurement of glucose was obtained from all the animals. Samples of the brain regions (cortex, hemispheres and cerebellum + medulla oblongata) of each rat were obtained and used to measure the concentrations of dopamine, GSH levels, and lipid peroxidation (TBARS) using fluorescence and spectrophotometric methods. Results: Glucose level increased in rats treated with nicotine and oligoelements (p le GSH level decreased in cerebellum/medulla oblongata and hemispheres (p ls. TBARS levels increased in cerebellum/medulla oblongata and hemispheres of animals treated with nicotine and oligoelements, but decreased in the same regions (p ly with oligoelements. The levels of dopamine decreased in cortex and hemispheres, but increased in cerebellum/medulla and oblongata regions of rats treated with both compounds (p lusions: Nicotine and oligoelements are associated with increase in the level of glucose, an effect that was more pronounced in the group treated with both drugs. Reduction of oxidative stress and dopamine metabolism may be involved in this effect.

关键词： Glutathione lipid Peroxidation Oxidative Stress

利用SAS中非线性混和效应模型分析城市中阿拉伯按蚊水体滋生环境的时空变异系数

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寄生虫与医学昆虫学报 2010年第2期17卷 85-97页

作者： Benjamin G. JACOB daniel A. GRIFFITH Joseph M. MWANGANGI Charles MBOGO Robert J. NOVAK School of Medicine Division of Infectious Diseases University of Alabama at Birmingham 845 19'h Street South Birmingham AL 35294-2170 Political and Policy Sciences The University of Texas at Dallas 800 West Campbell Road Richardson TX 75080-3021 Kenya Medical Research Institute ( KEMRI) Centre for Geographic Medicine Research-Coast PO Box 230 Kilifi Kenya

目前对于时间序列分析中出现的空间自相关现象，已经有很多的的文献详述了如何对这种现象进行识别与建模分析。但是，对于撒哈拉以南非洲地区疟疾的主要媒介-阿拉伯按蚊幼虫滋生地的地理空间相关性方面的研究还没研究报道。在空间回归... 详细信息

目前对于时间序列分析中出现的空间自相关现象，已经有很多的的文献详述了如何对这种现象进行识别与建模分析。但是，对于撒哈拉以南非洲地区疟疾的主要媒介-阿拉伯按蚊幼虫滋生地的地理空间相关性方面的研究还没研究报道。在空间回归分析中，空间相关性主要通过空间滤波方法完成，该滤波方法通过分析时间序列中随机误差的分布特征。运用基于地理连接矩阵的非参数特征向量分解空间滤波方法，以寻求能鉴别阿拉伯按蚊幼虫滋生水生环境的预测因子。首先，选择肯尼亚的两个城市，Kisumu和Malindi，进行了蚊虫滋生水体的现场采样工作。然后获取快鸟（QuickBird）卫星数据；并利用该数据对冈比亚按蚊的滋生水体进行遥感影像分析。把这些水体的地理空间信息数据输入SAS／GIS模型中，进行单因素分析、相关分析、数据分布分析、以及全局空间自相关统计。然后，利用空间协方差参数生成局部空间自相关指数（如：Moran’s指数）。并由该模型生成了选择性特征向量的粗子集，此粗子集可以被用来研究这些样方变量间的空间互作效应。最后，利用贝叶斯系数估计法定义矩阵中各参数的期望先验参数值，得知水体环境的深度是决定该水体能否滋生阿拉伯按蚊的关键预测性因素，并且深度与其滋生可能性呈明显的正相关关系；由转移空间连接矩阵生成的特征向量的特殊子集可以获知由阿拉伯按蚊水生环境预测因子以及所建立的空间回归模型中空间误差的相关性。

关键词：快鸟阿拉伯按蚊特征向量空间自相关贝叶斯分析

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大面积反应磁控溅射的均匀性控制(英文)

大面积反应磁控溅射的均匀性控制(英文)

Multisystem inflammatory syndrome in adults associated with COVID-19:A rare life-threatening complication

薄膜技术高峰论坛暨广东省真空学会学术年会

作者： V.Bellido-Gonzalez B.daniel D.Monaghan J.Counsell GuangZhou HongChuang Machinery Equipment Technology Co. Ltd.Rm3508-09East TowerYang Cheng International Commercial CenterNo.122 TiYu Dong Rd.GuangZhou Gencoa ltd Physics RoadLiverpoolL24 9HPUK J.Counsell ltd. Lynwood(54)Grange Cross LaneWest KirbyCH48 8BQUK

Magnetron sputtering is an industrial coating deposition technique which is commonly used in glass coating industry in order to add functionality and properties to the base glass,properties such as antireflection,electrical conductivity, low emissivity are currently achieved thanks to magnetron *** magnetron sputtering occurs when the deposited chemical composition of the coating substantially differs from the composition of the magnetron sputtering targets, (*** coatings deposited from Ti targets) or coating physicochemical properties differ much of the sputtered or cosputtered target(*** power ZnS).Up to a certain point magnetron sputtering has been a tolerated *** Coating Industry has‘opted-out’on certain reactive sputtering processes in order to gain process stability and reproducibility. The use of compound targets has already been adopted,***,ZnO:Al;and more recently TiO which has the potential of replacing Ti reactive *** of these compound targets still would require a certain degree of reactive sputtering, especially for large area deposition requiring high coating ***,the general idea in those instances has been to limit the required control level to a minimum,almost entirely based on control of inputs rather than the monitoring of *** of the key elements in maintaining a uniform reactive sputtering process over a large area under control,is the sensor or sensors which are used as reference in the closed loop *** lack of stable sensors,and/or misuse or misplacement of sensors,has led the industry in many instances to take safer *** present paper would try to highlight the current sensor availability with its pros and cons in large area uniform reactive magnetron sputtering deposition.

关键词： magnetron sputtering uniformity reactive sputtering control

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Rheumatology & Autoimmunity 2023年第4期3卷 247-249页

作者： Sameen Zafar daniel Gonzalez leonard Kuan-Pei Wang Alexandria Soybel Emilio B.Gonzalez Vijaya Murthy Department of Internal Medicine University of Texas Medical BranchGalvestonTexasUSA

To the Editor,Herein,we report a case of a 49-year-old Caucasian man with a medical history of gastroesophageal reflux disease,occasional premature ventricular contractions,and unvaccinated against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)who presented with myalgias,fevers,and right-sided neck swelling approximately 26 days after he had tested positive for SARS-CoV-2 and 21 days after receiving the casirivimab–imdevimab(REGEN-COV)*** initial workup showed leukocytosis and thrombocytopenia(platelets:108×109/l,reference range[RR]:150−328×109/l).The SARS-CoV-2 rapid antigen-detection test was *** patient was started on intravenous antibiotics for presumed lymphadenitis;however,his fevers persisted,with subsequent development of worsening thrombocytopenia at 91×109/l and increasing C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR),with peak values at 13.4mg/dl(RR:l)and 35 mm/1 h(RR:0−10 mm/1 h),respectively.

关键词： infusion sided swelling

Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants:The case of Artemisia vulgaris *** for Artemisia annua *** Western Uganda

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TMR Integrative Medicine 2023年第4期7卷 1-13页

作者： Ivan Kahwa Clement Olusoji Ajayi Reenu Yadav Nagendra Singh Chauhan Kamal Shah Abdelgadir Alamin Abdelgadir Efrata Ashuro Shegena Salome daniel Timothy Omara John Baptist Asiimwe Hilda Ikiriza Shabnoor Iqbal Casim Umba Tolo Anke Weisheit Patrick Engeu Ogwang Pharm-BioTechnology and Traditional Medicine Centre Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy Faculty of MedicineMbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy IES UniversityBhopal-462044Madhya PradeshIndia Drugs Testing laboratory Avam Anusandhan Kendra Raipur(CG)492010India Institute of Pharmaceutical Research GLA UniversityMathuraUttar Pradesh 281406India Department of Pharmacognosy Faculty of PharmacyUniversity of GeziraP.O Box 20Wad MadaniSudan Department of Pharmaceutics and Pharmacy Practice Kampala International UniversityP.O.Box 9790Dares SalaamTanzania Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna(BOKU)Konrad-Lorenz-Straße 243430Tulln an der DonauAustria Aga Khan University P.O.Box 8842KampalaUganda Department of Biology Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Zoology Government College UniversityFaisalabadPunjab 38000Pakistan

Background:Different parts of Artemisia vulgaris l.(***)are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever,ulcers,and ***,anecdotal evidence shows that the plant is often substituted for Artemisia annua l.(***)by herbalists in Western Uganda due to similarities in their *** of medicinal plants and mislabelling of herbal products have been incriminated in toxicity and adverse health outcomes in traditional medicine *** safety continues to be a major issue with the use of herbal remedies,it becomes imperative therefore that medicinal plants should be correctly ***:This study focused on investigating the macroscopic,microscopic,physicochemical characteristics and phytochemical composition of *** leaves compared to *** to ease its correct ***:The results showed that there are some colour differences between the leaves of the two species,with a close arrangement of microscopic features but different leaf *** leaves of the two Artemisia species had similar tastes,but their shapes and colours(greenish-yellow for *** and dark green for ***)can be used by the local community to distinguish between *** artemisinin content was higher in *** leaves(1.72%)than in ***(1.43%),but the reverse was observed for the total flavonoid ***:This observation could justify the change in the use of *** by the indigenous community in western *** studies should consider the pharmacognostic comparison of *** with other species in the genus Artemisia and the use of molecular techniques such as DNA barcoding.

关键词： Artemisinin traditional medicine misidentification microscopic studies

Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods

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Plant Phenomics 2021年第1期3卷 277-285页

作者： Etienne David Mario Serouart daniel Smith Simon Madec Kaaviya Velumani Shouyang liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner leBauer Morten lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo Arvalis Institut du Végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance School of Food and Agricultural Sciences The University of QueenslandGatton4343 QLDAustralia Hiphen SAS 120 Rue Jean DaussetAgroparcBâtiment Technicité84140 AvignonFrance Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Wheat Genetics Resource Center Dep.of Plant PathologyKansas State Univ.4024 Throckmorton Plant Sciences CenterManhattanKansasUSA Global Wheat Program International Maize and Wheat Improvement Centre(CIMMYT)MexicoD.F.Mexico Faculty of Biosciences Norwegian University of Life SciencesP.O.Box 5003NO-1432ÅsNorway Agricultural Research Corporation Wheat Research ProgramP.O.Box 126Wad MedaniSudan Arid land Research Center Tottori UniversityTottori 680-0001Japan laboratories of Plant Genetics and Plant Breeding Graduate School of AgricultureKyoto UniversityJapan CSIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Institute of Agricultural Sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland Plant Sciences Department Rothamsted ResearchHarpendenUK Institute of Crop Science National Agriculture and Food Research OrganizationJapan Hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan Biosystems Dynamics and Exchanges TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Plant Sciences TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Graduate School of Agricultural and life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan Department of Computer Science University of SaskatchewanCanada Department of Plant Sciences University of SaskatchewanCanada College of Agriculture and life Sciences University of ArizonaTucsonArizona

The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/*** an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science *** this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label *** address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat *** now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version.

关键词： Wheat adding release

Antioxidant and Antimicrobial Capacities of Two Medicinal Plants Used against Urinary Infections in Burkina Faso

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Advances in Microbiology 2022年第12期12卷 671-683页

作者： Sami Eric Kam Roland Nâg-Tiéro Meda Soufiane Domalick Sanou Windmi Kagambega Clarisse Ouedraogo Franck Téounviel Somda Isaac Saamou Boni Eliasse Zongo daniel Kobo Gnada Azouman Da Benjamin Kouliga Koama Hermann Yempabou Ouoba Georges Anicet Ouedraogo laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales Université Nazi Boni Bobo-Dioulasso Burkina Faso laboratoire de Recherche en Bactériologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso laboratoire de Médicine et Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé Direction Régionale de l’Ouest Bobo-Dioulasso Burkina Faso

Objective: This study aimed to evaluate the antioxidant and antimicrobial capacities of extracts from Euphorbia hirta l. and Terminalia avicennioides GUIll & PERR. Methodology: The crude hydro-acetonic and aqueous extracts as well their fractionations were prepared. The total phenolic, flavonoids and tannins contents were assessed using the Folin-Ciocalteu, aluminum chloride and vanillin acid methods, respectively. The antioxidant and antibacterial activities were investigated using standard methods. Results: Euphorbia hirta showed significant contents of total phenolic and flavonoids in n-Butanol (145.14 ± 1.37 GAE/100mg extracts) and ethyl acetate (23.56 ± 0.68 mg QE/ 100mg extracts) fractions. Total tannins were high in hydro-acétonique extract (11.18 ± 0.31 mg TAE/100mg extracts) and aqueous fraction (11.12 ± 0.28 mg TAE/100mg extracts) of Terminalia avicennioides stem barks. Extracts and fractions of both plants demonstrated a strongly antioxidant capacity through the free radicals scavenging and the ferric ions reducing. Concerning antimicrobial screening the extracts of Terminalia avicennioides were effective against 16 causative pathogens of urinary tract infections. Bactericidal effect against Staphylococcus aureus ATCC 29213, Staphylococcus aureus and 2 methicillin-resistant Staphylococcus haemolyticus strains was found with aqueous fraction of Terminalia avicennioides leaves. This fraction also highlighted a synergetic effect with some antibiotics used against these bacterial strains. Conclusion: Terminalia avicennioides leaves could be recommended as an herbal drug formulation for the urinary infections management.

关键词： Antimicrobial Antioxidant Euphorbia hirta l. Terminalia avicennioides GUIll & PERR Urinary Infections

美国2007年农业法案对发展中国家的启示(上)

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WTO经济导刊 2008年第4期 12-14页

作者：迪姆·卓斯林（Tim Josling）丹尼尔A．塞莫尔（daniel A．Sumner）罗伯特l．汤普森（Robert l．Thompson）玛丽·查普里斯（Mary Chambliss）卡拉·兰尼（Kara laney）王晓宇（翻译）刘健男（校译）斯坦福大学弗里曼·斯波格里国际研究学会资深会员加利福尼亚大学农业问题中心主任伊利诺依大学香槟分校农业政策教授国际食品援助问题方面的独立咨询人国际食品与农业贸易政策委员会的政策助理商务部世贸司

近年来，经合组织（OECD）国家对农业实行大量补贴，而发展中国家的农民却面临困难，这两者之间的联系已经成为人们关注的焦点。毫无疑问，经合组织国家的农业计划对世界市场的结构产生了巨大的影响，对贸易量、贸易流向及国际农产品价... 详细信息

近年来，经合组织（OECD）国家对农业实行大量补贴，而发展中国家的农民却面临困难，这两者之间的联系已经成为人们关注的焦点。毫无疑问，经合组织国家的农业计划对世界市场的结构产生了巨大的影响，对贸易量、贸易流向及国际农产品价格都产生了影响。世界银行的一份评估认为，它对不同产品的国际价格的影响在10到50％之间不等（见表1）。与此同样重要的一个启示是：许多经合组织国家的农业政策旨在保护他们的农业部门不受外国竞争，甚至在鼓励其他国家开放农产品市场时也是如此。

关键词：发展中国家农业法案经合组织国家农产品价格美国国际价格农产品市场世界市场

食物中添加ι-卡尼汀对大鼠肝代谢ι-丙氨酸的作用(英文)

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Acta Pharmacologica Sinica 2002年第4期23卷 10-13页

作者： Vilma A F G GAZOlA, Gisele lOPES, daniel M lIMEIRA, Ricardo GAllETTO, Sebastiao GAZOlA, Rui CURI, Roberto B BAZOTTE (State University of Maringa, SUM, Department of Pharmacy and Pharmacology, Maringa, PR, 87020-900 University of Sao Paulo, Sao Paulo, SP, 05508-900, Brazil) State University of Maringo SUM Department of Pharmacy and PharmacologyMaringo PR

AIM:To investigate the effects of chronic supplementation with l-carnitine (lCT) on hepatic catabolism of l-alanine. METHODS: Two groups of male adult Wistar rats were used: 1) supplemented with lCT (1.2 mmol·kg-1·d-1) dissolved in the drinking water (lCT group) and 2) control group (COG) without lCT supplementation . After one week of lCT supplementation livers from 24 h-fasted rats were perfused in situ and the production of glucose, urea, pyruvate, and l-lactate from l-alanine (5 mmol/l) were measured. RESUlTS: lCT decreased the production of glucose and urea from l-alanine. In agreement, pyruvate and l-lactate production from l-alanine were decreased. However, the supplementation with lCT did not show any significant effect on hepatic glucose production from pyruvate (5 mmol/l) and l-lactate (2 mmol/l). CONClUSION: lCT supplementation decreased the conversion of l-alanine to pyruvate. However the ability of the liver to convert pyruvate to glucose was not affected by lCT treatment.

关键词：卡尼汀肝代谢糖原异生丙氨酸