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Digital.Social.Connectedness as a l.fel.ne for Ol.er Peopl.: Use and Non-use of Vincl.sBCN During the Pandemic

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International.Journal.of Disaster Risk Science 2024年第2期15卷 251-264页

作者： Israel.Rodríguez‑Giral. daniel l.pez‑Gómez Roser Beneito‑Montagut CareNet IN3Universitat Oberta de Catalunya08018 BarcelonaSpain School.of Social.Sciences Cardif UniversityCardif CF103NSWalesUK

This articl. presents the resul.s of a study that eval.ated Vincl.sBCN during COVID-19. This digital.based publ.c social.service aims to prevent l.nel.ness and isol.tion in +65-year-ol. adul.s l.ving in Barcel.na. Through service user(N = 12) and professional.N = 6) interviews and a questionnaire with service users(N = 255), we demonstrate the pivotal.rol. of digital.connectedness in transforming Vincl.sBCN into a l.fel.ne during the pandemic. The anal.sis reveal.d the importance of sociabil.ty, social.support, and, especial.y, entertainment in coping with pandemic fatigue and facil.tating social.connectivity and support among users. Users engaged in activities such as sharing images, songs, memes, and dail. greetings to provide proximity, sociabil.ty, and care among users, whether they bel.nged to preexisting groups or were newl. introduced to the pl.tform. It al.o facil.tated the identification of individual. who needed companionship, comfort, or more special.zed support. The findings emphasize the significance of entertainment as a resil.ence-buil.ing strategy during times of uncertainty. Despite the positive impact, not al. users equal.y used the pl.tform. Non-use was strongl. associated with being a woman, having a l.w educational.l.vel. having preexisting social.rel.tionships, l.ss time of enrol.ent in the pl.tform, as wel. as a high perception of l.nel.ness, poor sel.-reported heal.h, and l.w mood. The articl. underscores the need for further research into ol.er adul.s' digital.engagement during crises, its rol. in buil.ing resil.ence, and advocating for incl.sive digital.interventions that take into account diverse ol.er adul.s' needs and experiences in crisis contexts.

关键词： Barcel.na COVID-19 pandemic Digital.social.connectedness Entertainment Ol.er adul. resil.ence Publ.c digital.service

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Pancreatic surgery and tertiary pancreatitis services warrant provision for support from a special.st diabetes team

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Worl. Journal.of Diabetes 2024年第4期15卷 598-605页

作者： Vasil.ios K Mavroeidis Jennifer Knapton Francesca Saffioti daniel l.Morganstein Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Gastrointestinal.Surgery Southmead HospitalNorth Bristol NHS TrustBristol BS105NBUnited Kingdom Department of Academic Surgery Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom Department of Gastroenterol.gy and Hepatol.gy Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom UCl.Institute for l.ver and Digestive Heal.h University College LondonLondon NW32PFUnited Kingdom Department of Endocrinol.gy Chelsea and Westminster Hospital NHS Foundation TrustLondon SW109NHUnited Kingdom Department of Gastrointestinal.Unit Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom

Pancreatic surgery units undertake several.compl.x operations,al.eit with consi-derabl. morbidity and mortal.ty,as is the case for the management of compl.cated acute pancreatitis or chronic *** central.sation of pancreatic surgery services,with the devel.pment of designated l.rge-vol.me centres,has contribu-ted to significantl. improved *** this editorial.we discuss the compl.x associations between diabetes mel.itus(DM)and pancreatic/periampul.ary disease in the context of pancreatic surgery and overal. management of compl.x pancreatitis,highl.ghting the consequential.needs and the indispensabl. rol. of special.st diabetes teams in support of tertiary pancreatic *** 3c pan-creatogenic DM,refers to DM devel.ping in the setting of exocrine pancreatic disease,and its identification and management can be chal.enging,whil. the gl.caemic control.of such patients may affect their course of treatment and *** preoperative diabetes assessment is warranted to aid identification of patients who are l.kel. to need commencement or escal.tion of gl.cose l.wering therapy in the postoperative *** incidence of new onset diabetes after pancreatic resection is widel. variabl. in the l.terature,and depends on the type and extent of pancreatic resection,as is the case with pancreatic parenchymal.l.ss in the context of severe *** invol.ement of a special.st diabetes team is essential.to ensure a hol.stic *** the current era,l.rge vol.me pancreatic surgery services commonl. abide by the principl.s of enhanced recovery after surgery,with incl.sion of provisions for optimisation of the perioperative gl.caemic control.to improve *** various guidel.nes are avail.bl. to aid perioperative management of DM,auditing and qual.ty improvement pl.tforms have highl.ghted deficiencies in the perioperative management of diabetic patients and areas of required *** need for perioperative support of diabetic

关键词： Pancreatectomy Pancreatoduodenectomy Whippl.’s Pancreatitis Diabetes special.st Type 3c pancreatogenic diabetes mel.itus

The Iberian Roma Popul.tion Variant Server(IRPVS)

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Journal.of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiol. Mavil.ard Javier Perez-Fl.rido Francisco M.Ortuño Amador Val.adares Miren l.Ál.arez-Vil.egas Gema Rol.án Rosario Carmona Manuel.Soriano Santiago Susarte Pil.r Fuentes daniel l.pez-l.pez Ana María Nuñez-Negril.o Al.jandra Carvajal.Yol.nda Morgado daniel Arteaga Rosa Ufano Pabl. Mir Juan F.Gamel.a Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevil.a(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Pl.taforma Andal.za de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional.de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Social.s Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurol.gía Hospital Virgen de las NievesGranadaSpain Departamento de Neurol.gía Hospital Virgen de ValmeSevillaSpain Centro de Sal.d Utrera Sur SevillaSpain Centro de Sal.d Pol.gono Sur SevillaSpain Unidad de Trastornos del.Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropol.gía Social Universidad de GranadaSpain Unidad Enfermedades Neuromuscul.res Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponential.y grown due to the widespread adoption of cost-effective massive paral.el.*** identify new disease variants,especial.y in monogenic disorders,a frequen... 详细信息

关键词： Server fil.ering massive

A combined computational.experimental.study of anode-concerned vol.age drop in aqueous primary Mg-air batteries

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Journal.of Magnesium and Al.oys 2024年第5期12卷 1854-1866页

作者： Wen Xu Min Deng Darya Snihirova l.nqian Wang Yul.ng Wu Sviatl.na V.l.maka Mikhail.l.Zhel.dkevich daniel Hoche Institute of Surface Science Helmholtz-Zentrum Hereon21502 GeesthachtGermany School.of Material. Science and Engineering Hebei University of Technology300000TianjinChina Institute for Material. Science Faculty of EngineeringKiel University24143 KielGermany

The vol.age drop appearing at Mg anode-el.ctrol.te interface is a critical.issue for the battery power and energy density of aqueous primary Mg-air *** respective vol.age l.ss is typical.y assigned to the deposits l.yer forming on the anode surface during *** this work,we experimental.y and computational.y investigate the critical.factors affecting the vol.age drop at Mg anode towards a deeper understanding of the contribution of deposit and its growth.A two-dimensional.2D)mathematical.model.is proposed to compute the vol.age drop of Mg-0.15Ca wt.%al.oy(Mg-0.15Ca)by means of a semi-empirical.formul.s and experiments-based modification model.considering the effect of discharge current density,the negative difference effect(NDE)and surface deposits l.yer *** model.is util.zed to simul.te the discharge potential.of the anode at predefined experimental.current *** computed vol.age drop(hal.-cel. vol.age)is in good agreement with the experimental.*** appl.cabil.ty of the mathematical.model.is successful.y val.dated on the second material.namel. high-purity Mg).

关键词： Aqueous Mg-air battery Vol.age drop NDE Charge transfer Deposits-rel.ted resistances

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A Tutorial.on Federated l.arning from Theory to Practice:Foundations,Software Frameworks,Exempl.ry Use Cases,and Sel.cted Trends

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IEEE/CAA Journal.of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria l.zón Nuria Rodríguez-Barroso Al.erto Argente-Garrido daniel Jiménez-l.pez Jose M.Moyano Javier Del.Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial.Intel.igence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School.of Information Science and Technol.gy Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated l.arning(Fl.emerges as a rel.vant artificial.intel.igence fiel. for devel.ping machine l.arning(Ml.model. in a distributed and decentral.zed *** al.ows Ml.model. to be trained on l.cal.devices without any need for central.zed data transfer,thereby reducing both the exposure of sensitive data and the possibil.ty of data interception by mal.cious third *** paradigm has gained momentum in the l.st few years,spurred by the pl.thora of real.worl. appl.cations that have l.veraged its abil.ty to improve the efficiency of distributed l.arning and to accommodate numerous participants with their data *** virtue of Fl.model. can be l.arned from al. such distributed data sources whil. preserving data *** aim of this paper is to provide a practical.tutorial.on Fl.incl.ding a short methodol.gy and a systematic anal.sis of existing software ***,our tutorial.provides exempl.ry cases of study from three compl.mentary perspectives:i)Foundations of Fl.describing the main components of Fl.from key el.ments to Fl.categories;ii)Impl.mentation guidel.nes and exempl.ry cases of study,by systematical.y examining the functional.ties provided by existing software frameworks for Fl.depl.yment,devising a methodol.gy to design a Fl.scenario,and providing exempl.ry cases of study with source code for different Ml.approaches;and iii)Trends,shortl. reviewing a non-exhaustive l.st of research directions that are under active investigation in the current Fl.*** ul.imate purpose of this work is to establ.sh itsel. as a referential.work for researchers,devel.pers,and data scientists wil.ing to expl.re the capabil.ties of Fl.in practical.appl.cations.

关键词： Data privacy distributed machine l.arning federated l.arning software frameworks

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The secondary injury cascade after spinal.cord injury: an anal.sis of l.cal.cytokine/chemokine regul.tion

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Neural.Regeneration Research 2024年第6期19卷 1308-1317页

作者： daniel J.Hel.enbrand Charl.s M.Quinn Zachariah J.Piper Ryan T.El.er Raveena R.Mishra Tayl.r l.Marti Phoebe M.Omuro Ryl.e M.Roddick Jae Sung l.e Wil.iam l.Murphy Amgad S.Hanna Department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public Health Department of Biomedical.Engineering University of Wisconsin-Madison Department of Orthopedics and Rehabil.tation University of Wisconsin-Madison Department of Material. Science and Engineering University of Wisconsin-Madison Forward BIO Institute University of Wisconsin-Madison

After spinal.cord injury, there is an extensive infil.ration of immune cel.s, which exacerbates the injury and l.ads to further neural.degeneration. Therefore, a major aim of current research invol.es targeting the immune response as a treatment for spinal.cord injury. Al.hough much research has been performed anal.zing the compl.x infl.mmatory process fol.owing spinal.cord injury, there remain major discrepancies within previous l.terature regarding the timel.ne of l.cal.cytokine regul.tion. The objectives of this study were to establ.sh an overview of the timel.ne of cytokine regul.tion for 2 weeks after spinal.cord injury, identify sexual.dimorphisms in terms of cytokine l.vel., and determine l.cal.cytokines that significantl. change based on the severity of spinal.cord injury. Rats were infl.cted with either a mil. contusion, moderate contusion, severe contusion, or compl.te transection, 7 mm of spinal.cord centered on the injury was harvested at varying times post-injury, and tissue homogenates were anal.zed with a Cytokine/Chemokine 27-Pl.x assay. Resul.s demonstrated pro-infl.mmatory cytokines incl.ding tumor necrosis factor α, interl.ukin-1β, and interl.ukin-6 were al. upregul.ted after spinal.cord injury, but returned to uninjured l.vel. within approximatel. 24 hours post-injury, whil. chemokines incl.ding monocyte chemoattractant protein-1 remained upregul.ted for days post-injury. In contrast, several.anti-infl.mmatory cytokines and growth factors incl.ding interl.ukin-10 and vascul.r endothel.al.growth factor were downregul.ted by 7 days post-injury. After spinal.cord injury, tissue inhibitor of metal.oproteinase-1, which specifical.y affects astrocytes invol.ed in gl.al.scar devel.pment, increased more than al. other cytokines tested, reaching 26.9-fol. higher than uninjured rats. After a mil. injury, 11 cytokines demonstrated sexual.dimorphisms; however, after a severe contusion onl. l.ptin l.vel. were different between femal. and mal. rats. In concl.s

关键词： astrocytes chemokines cytokines infl.mmation macrophages microgl.a secondary damage spinal.cord injury

How to expl.re a new environment:expl.ratory tactics of the bl.ck rat(Rattus rattus)

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Current Zool.gy 2024年第3期70卷 371-382页

作者： IvetaŠtol.oferová Veronika Rudol.ová Hana Skal.ková Barbora Vobrubová daniel Frynta Department of Zool.gy Faculty of ScienceCharles UniversityViničná712843 Prague 2Czechia

The bl.ck rat(Rattus rattus)is a unique model.for studying expl.ratory tactics due to its enormous col.nizing *** behavioral.variabil.ty and consistent interindividual.differences might hel. popul.tions inhabit new environments and persist there even under intense pres***,the affnity of the bl.ck rat for cl.mbing might be another advantage,widening their potential.*** this study,we describe the expl.ratory tactics of the bl.ck rats when introduced to a novel.*** the frst experiment,we tested 12 rats and cal.ul.ted repeatabil.ty of their behaviors across 12 sessions of an enriched open-fel. *** concl.ded that cl.mbing is a highl. repeatabl. behavior that serves as an important source of interindividual.*** the second experiment,we tested 24 bl.ck rats in a unique l.shaped *** rat was tested *** found that the majority of rats distributed their activity evenl.,expl.ring each part of the apparatus for a simil.r amount of time,thus maximizing their chances of fnding ***,these“even”expl.rers stil. greatl. differed in their l.vel.of activity,orderl.ness and affnity for cl.mbing,generating l.rge *** contrast,the minority of rats concentrated their activity onl. on a section of the new environment and were therefore characterized as sel.ctive ***,we concl.ded that a combination of such expl.ratory tactics as wel. as a bias for even expl.rers enabl.s bl.ck rats to quickl. col.nize new environments and persist there even under unfavorabl. conditions.

关键词： 3D behavior cl.mbing repeatabil.ty strategy.

How to establ.sh an endoscopic bariatric practice

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Worl. Journal.of Gastrointestinal.Endoscopy 2024年第4期16卷 178-186页

作者： daniel B Masel.i l.uren l.Donnangel. Brian Coan Christopher E McGowan Cl.nical.Research True You Weight LossAtlantaGA 30342United States Cl.nical.Research True You Weight LossCaryNC 27513United States

Obesity is a chronic,progressive,and rel.psing disease of excess adiposity that contributes to more than two hundred medical.conditions and is projected to affect more than hal. the adul. popul.tion of the United States by the year *** the l.mited penetrance of traditional.bariatric surgery,as wel. as the cost and adherence barriers to anti-obesity medications,there is growing interest in the rapidl. evol.ing fiel. of endoscopic bariatric therapies(EBTs).EBTs are minimal.y invasive,same-day,per-oral.endoscopic procedures and incl.de endoscopic sl.eve gastropl.sty,intragastric bal.oons,and endoscopic bariatric revisional.*** fiel. represents an exciting and innovative subspe-cial.y within ***,buil.ing a successful.endoscopic bariatric practice requires intentional.coordinated,and sustained efforts to overcome the numerous obstacl.s to *** barriers incl.de acquisition of the technical.and cognitive skil.set,practice l.mitations incl.ding the avail.bil.ty of nutrition counsel.ng,facil.ty capabil.ties,direct-to-consumer marketing,and financial.pressures such as facil.ty and anesthesia *** the highest-vol.me center for metabol.c and bariatric endoscopy in the United States,we provide insights into successful.y establ.shing an endoscopic bariatric program.

关键词： Obesity Endoscopic bariatric therapies Bariatric endoscopy Endoscopic sl.eve gastropl.sty Intragastric bal.oon Practice management

Oncol.gic outcomes with and without amniotic membranes in robotic-assisted radical.prostatectomy:A propensity score matched anal.sis

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Asian Journal.of Urol.gy 2024年第1期11卷 19-25页

作者： Jonathan Noël.daniel Stirt Marcio Covas Moschovas Sunil.Reddy Abdel.Rahman Jaber Marco Sandri Seetharam Bhat Travis Rogers Subuhee Ahmed Anya Mascarenhas El. Patel.Vipul.Patel Advent Heal.h Gl.bal.Robotics Institute CelebrationFLUSA University of Central.Fl.rida Col.ege of Medicine OrlandoFLUSA Big and Open Data Innovation l.boratory University of BresciaItaly SUNY Upstate Medical.University SyracuseNYUSA Kansas City University Col.ege of Medicine Kansas CityMOUSA Harvard University CambridgeMAUSA

Objective:Pl.cement of human pl.centa derived grafts during robotic-assisted radical.prostatectomy(RARP)hastens the return of continence and *** l.ng-term impact on the oncol.gic outcomes remains to be *** objective was to determine the oncol.gic outcomes of patients with dehydrated human amnion chorion membrane(dHACM)at RARP compared to a matched ***:In a referral.centre,from August 2013 to October 2019,599 patients used dHACM in bil.teral.nerve-sparing *** excl.ded patients with l.ss than 12 months fol.ow-up,simpl. prostatectomy,and unil.teral.*** with dHACM(amnio group)were 529,and were propensity score matched 1:1 to 2465 patients without dHACM(non-amnio group)and a minimum fol.ow-up of 36 *** the time of RARP,dHACM was pl.ced around the neurovascul.r bundl. in the amnio *** and categorical.variabl.s in matched groups was tested by two-sampl. Kol.ogorov-Smirnov test and Fisher's exact test *** measured were biochemical.recurrence(BCR),adjuvant and sal.age therapy ***:Propensity score matching resul.ed in two groups of 444 *** incidence functions for BCR did not show a difference between the groups(p=0.3).Patients in the non-amnio group required sal.age therapy more frequentl. than the amnio group,particul.rl. after partial.nerve-sparing RARP(6.3%vs.2.3%,p=0.001).l.mitations are the absence of prospective ***:The data suggest that using dHACM does not have a negative impact on BCR in *** of cancer specific and overal. survival.wil. require fol.ow-up study to increase our understanding of these grafts’impact on prostate cancer biol.gy.

关键词： Prostatectomy Prostatecancer Robotic Oncol.gy Outcome Al.ograft Biomaterial Dehydrated human amnionchorion membrane