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Ultrasonically Assisted Cutting of Histological Sections for Reducing the Environmental and Financial Impact of Microtomy

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 200-206页

作者： Dong Wang daniel De Becker Anish Roy Wolfson School of Mechanical and Manufacturing Engineering Loughborough UniversityLoughborough LE113TUUK Department of Engineering College of EngineeringMathematics and Physical SciencesUniversity of ExeterExeter EX44QFUK

Modern-day microtomy requires high precision equipment to thinly section biological *** sectioned tissue must be of good quality not showing cutting tracks or so-called *** quality of these sections is dependent on the blade wear,which is related to the hardness of the tissue sample,cutting angle and cutting speed.A test rig has been designed and manufactured to allow these parameters to be *** has allowed for the blade wear to be analysed and quantified,and this has been completed for both ultrasonically assisted and conventional *** obtained results showed a 25.2%decrease in average blade roughness after 38 cuts when using the ultrasonically assisted cutting *** data also showed no adverse effect on the quality of the slides produced when using this cutting ***,the cutting force measured for both cutting regimes showed that ultrasonically assisted cutting required less force compared to conventional *** the reduction of surface roughness and force,it is possible to state that ultrasonically assisted cutting reduces the wear of the blade,thereby increasing the life of the *** increase of just 10%in blade life would yield a cost saving of approximately 25%thereby reducing the environmental and financial impact of microtomy.

关键词： Microtome Ultrasonically assisted cutting Blade wear

Meta-analysis of capsule endoscopy in patients diagnosed or suspected with esophageal varices

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World Journal of Gastroenterology 2010年第6期16卷 785-786页

作者： daniel Ahn Praveen Guturu Department of Internal Medicine University of Texas Southwestern Medical Center Department of Internal Medicine University of Texas Medical Branch

The PillCam ESO(Given Imaging,Israel) or esophageal capsule endoscopy(ECE) is a novel technique used in the diagnostic evaluation of *** studies have been performed to compare the accuracy of ECE against the current gold standard esophagogastro-duodenoscopy and a meta-analysis recently published by Lu et al suggests that ECE may have an acceptable sensitivity and specificity in detecting esophageal *** would like to discuss the importance and implication of publication bias in this meta-analysis.

关键词： Capsule endoscopy Screening varices

Organic practices and gender are effective strategies to provide healthy pork loin

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Journal of Integrative Agriculture 2016年第3期15卷 608-617页

作者： Javier Alvarez-Rodríguez daniel Villalba Dolors Cubiló daniel Babot Marc Tor Animal Science Department University of Lleida-Agrotecnio Center Lleida 25198 Spain

This study evaluated the influence of husbandry（organic feed and management but not free-ranging vs. conventional） and sex（barrows vs. gilts） on pork meat quality. A total of 60 Longissimus thoracis pork muscle samples from different 3-way crossbred genotypes were chosen from 3 conventional and 2 organic pig farms. Technological meat quality was measured at 24 h post-mortem and muscle fatty acid content and composition was analysed by gas chromatography. The loin from organic pigs at 24 h of retail display had lower pH, but it had no detrimental effects on drip loss. All the International Commission on Illumination colour attributes except meat lightness differed between husbandry systems. Moisture and crude protein content were lower whereas intramuscular fat content was greater in organic than in conventional pork. Total saturated fatty acid（SFA）, monounsaturated fatty acid（MUFA）, polyunsaturated fatty acid（PUFA） and PUFA n-6 contents did not differ between husbandry systems, but total PUFA n-3（mainly C18：3 n-3） were greater in organic than in conventional pork. Sex did not affect ultimate p H or meat colour attributes but barrows showed lower moisture and greater intramuscular fat than gilts. Total SFA and MUFA content were similar but all the PUFA（both n-6 and n-3） were lower in barrows than in gilts. These results suggest that some bioactive compounds from dietary origin, i.e., linolenic acid（C18：3 n-3） content from dietary vegetable oils（soybean or olive olein）, might be used to highlight the nutritive value of（not free-ranging） organic pork meat. In addition, gilts were leaner than barrows and showed a more favourable PUFA/SFA ratio.

关键词： Longissimus muscle chemical composition intramuscular fat fatty acids pigs

Quantitative Analysis of Crime Incidents in Chicago Using Data Analytics Techniques

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Computers, Materials & Continua 2019年第5期59卷 389-396页

作者： daniel Rivera Ruiz Alisha Sawant Courant Institute of Mathematical Sciences New York University251 Mercer StNew York 10012USA

In this paper we aim to identify certain social factors that influence,and thus can be used to predict,the occurrence of *** factors under consideration for this analytic are social demographics such as age,sex,poverty,etc.,train ridership,traffic density and the number of business licenses per community area in Chicago,IL.A factor will be considered pertinent if there is high correlation between it and the number of crimes of a particular type in that community area.

关键词： Analytics big data Chicago correlation crime

simplifyEnrichment:A Bioconductor Package for Clustering and Visualizing Functional Enrichment Results

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 190-202页

作者： Zuguang Gu daniel Hübschmann Molecular Precision Oncology Program National Center for Tumor Diseases(NCT)HeidelbergD-69120 HeidelbergGermany Heidelberg Institute of Stem Cell Technology and Experimental Medicine(HI-STEM) D-69120 HeidelbergGermany German Cancer Consortium(DKTK) D-69120 HeidelbergGermany Department of Pediatric Immunology Hematology and OncologyUniversity Hospital HeidelbergD-69120 HeidelbergGermany

Functional enrichment analysis or gene set enrichment analysis is a basic bioinformatics method that evaluates the biological importance of a list of genes of ***,it may produce a long list of significant terms with highly redundant information that is difficult to *** tools to simplify enrichment results by clustering them into groups either still produce redundancy between clusters or do not retain consistent term similarities within *** propose a new method named binary cut for clustering similarity matrices of functional *** comprehensive benchmarks on both simulated and real-world datasets,we demonstrated that binary cut could efficiently cluster functional terms into groups where terms showed consistent similarities within groups and were mutually exclusive between *** compared binary cut clustering on the similarity matrices obtained from different similarity measures and found that semantic similarity worked well with binary cut,while similarity matrices based on gene overlap showed less consistent *** implemented the binary cut algorithm in the R package simplifyEnrichment,which additionally provides functionalities for visualizing,summarizing,and comparing the *** simplifyEnrichment package and the documentation are available at https://***/packages/simplifyEnrichment/.

关键词： Functional enrichment Simplify enrichment Clustering R/Bioconductor Software Visualization

Integrated management of cardiac failure:the cardiac failure clinic

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Frontiers of Medicine 2011年第1期5卷 20-25页

作者： daniel LOISANCE La Pitie Hospital Paris 75013France

The prevalence of the risk factors and the risk of cardiac failure are both increasing in *** might be the consequence of the changes of the life conditions(emigration to the urban areas,changes in the diet and life style,lack of physical exercise,etc.).The wide range of clinical presentations of cardiac failure(acute or chronic)and of therapeutic approaches(medical or surgical)makes necessary the integration within the same structure of the various experts involved in the diagnosis and the treatment of cardiac *** and human resources required to offer all the options represent a multifaceted commitment which should be focused optimally in dedicated *** these centers,collaboration should replace competition between the medical and the surgical cardiac *** of team work should permit to optimize the cost efficacy of the *** of all,such a structure will facilitate the translation of innovative therapies between the research centers and clinical facilities.

关键词： cardiac failure cardiac transplantation mechanical circulatory support

New developments in the treatment of castration resistant prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 555-560页

作者： Roxanne Wadia daniel P Petrylak Department of Medicine Smilow Cancer Center Yale University School of Medicine Yale Comprehensive Cancer Center New Haven Connecticut USA

In the past 5 years, the treatment and understanding of metastatic castrate resistant prostate cancer （CRPC） have improved dramatically. Our understanding of the mechanisms of castration resistance has allowed for the development of new drugs to target prostate cancer, and our understanding of genetic mutations may give us new tools with which to more accurately diagnose and be able to predict the course of this heterogeneous disease. This article summarizes the recent advances in the understanding of the development of CRPC, as well as the new drugs and targets, which have evolved from this basic research.

关键词： castration resistant prostate cancer abiraterone enzalutamide chemotherapy docetaxel cabazitaxel PSMA antibody

Utility of faecal calprotectin analysis in adult inflammatory bowel disease

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World Journal of Gastroenterology 2012年第46期18卷 6782-6789页

作者： Lyn A Smith daniel R Gaya Inflammatory Bowel Diseases Service Gastroenterology Unit Glasgow Royal Infirmary

The inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are chronic relapsing, remitting disorders. Diagnosis, along with assessment of disease activity and prognosis present challenges to managing clinicians. Faecal biomarkers, such as faecal calprotectin, are a non-invasive method which can be used to aid these decisions. Calprotectin is a calcium and zinc binding protein found in the cytosol of human neutrophils and macrophages. It is released extracellularly in times of cell stress or damage and can be detected within faeces and thus can be used as a sensitive marker of intestinal inflammation. Faecal calprotectin has been shown to be useful in the diagnosis of IBD, correlates with mucosal disease activity and can help to predict response to treatment or relapse. With growing evidence supporting its use, over the last decade this faecal biomarker has significantly changed the way IBD is managed.

关键词： Faecal calprotectin Inflammatory bowel disease Crohn's disease Ulcerative colitis Faecal biomarker

It takes two to tango: Unraveling a new post-translational modification involved in SnRK2.6 activation

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Molecular Plant 2021年第11期14卷 1779-1781页

作者： Miguel daniel-Mozo Armando Albert Instituto de Quimica Ffsica Rocasolano Consejo Superior de Investigaciones Cientificas(IQFR-CSIC)Calle Serrano 11928006 MadridSpain

Protein kinases are a conserved superfamily of proteins that play an essential role in signal transduction by attaching a phosphoryl group to serine,threonine,or tyrosine residues of a protein,hence converting them to *** process,which can be reversed by protein phosphatases,regulates vital cellular processes in plants,including metabolism,proliferation,and *** is also key to trigger response mechanisms to drought,increased salinity,and other abiotic stresses(Zhu,2016).

关键词： hence reversed translational