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What do the recent American Heart Association/American College of Cardiology Foundation Clinical Practice Guidelines tell us about the evolving management of coronary heart disease in older adults?

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Journal of Geriatric Cardiology 2013年第2期10卷 123-128页

作者： daniel Forman Nanette K Wenger Harvard Medical School Brigham and Women's Hospital Boston MA 02115USA Emory University School of Medicine Emory Heart and Vascular Center Atlanta GA 30303 USA

Biological aging predisposes older adults to increased cardiovascular disease (CHD) and greater disease complexity. Given the high age-related prevalence of CHDand age-related compounding factors, the recently updatedAmerican HeartAssociation/American College of Cardiology Foundation CHD-related guidelines increased their focus on older patients. These guidelines are predominately evidence-based (using data from quality randomized clinical trials) and are organized to delineate medications and procedures that best treat particular cardiovascular *** such rationale and thought work well in young and middle aged adults, they become problematic in patientswho are very old. Data pertaining to adults aged ≥80 are virtually absent from most randomized clinical trials, and even in the instances when very old patients were included, eligibility criteria typically excluded candidates with co-morbidities and complexities of customary CHD patients. While medications and interventions yielding benefit in clinical trials should theoretically produce the greatest benefits for patients with high intrinsic risk, age-related cardiovascular complexities also increase iatrogenic risks. Navigating between the potential for high benefit and high risk in “evidence-based”cardiovascular management remains a key Geriatric Cardiology challenge. In this review we consider the expanded Geriatric Cardiology content of current guidelines, acknowledging both the progress that has been made, as well as the work that still needs to be accomplished to truly address the patient-centered priorities of older CHDpatients.

关键词： Cardiovascular disease Elderly patient Guidelines

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Semen analysis and sperm function testing

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Asian Journal of Andrology 2012年第1期14卷 6-13,174页

作者： daniel R Franken Sergio Oehninger Department of Obstetrics and Gynaecology Tygerberg Hospita Tygerberg Cape Town 7505 South Africa Department of Obstetrics and Gynaecology Eastern Virginia Medical School Jones Institute for Reproductive Medicine Norfolk VA 23507 USA

Despite controversy regarding the clinical value of semen analysis, male fertility investigation still relies on a standardized analysis of the semen parameters. This is especially true for infertility clinics in both developing and developed countries. Other optional tests or sophisticated technologies have not been widely applied. The current review addresses important changes in the analysis of semen as described in the new World Health Organization （WHO） manual for semen analysis. The most important change in the manual is the use of evidence-based publications as references to determine cutoff values for normality. Apart from the above mentioned changes, the initial evaluation and handling methods remain, in most instances, the same as in previous editions. Furthermore, the review evaluates the importance of quality control in andrology with emphasis on the evaluation of sperm morphology. WHO sperm morphology training programmes for Sub-Saharan countries were initiated at Tygerberg Hospital in 1995. The external qualitY control programme has ensured that the majority of participants have maintained their morphological reading skills acquired during initial training. This review reports on current sperm functional tests, such as the induced acrosome reaction, and sperm-zona pellucida binding assays, as well as the impact of sperm quality in terms of DNA integrity, and the relationship of sperm function tests to sperm morphology.

关键词： male infertility quality assurance semen analysis spermatozoa sperm concentration sperm function sperm morphology sperm motility

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DNMT1-dependent regulation of cortical interneuron function and survival

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Neural Regeneration Research 2021年第12期16卷 2405-2406页

作者： daniel Pensold Geraldine Zimmer-Bensch RWTH Aachen University Institute for Biology IIDepartment of Functional Epigenetics in the Animal ModelAachenGermany

Increased occurrence of age-associated disabilities and neurodegenerative diseases is the price we pay for the tremendous elevation in life expectancy in our modern *** comes along with structural,neurochemical and physiological alterations in the brain that cause memory decline and cognitive impairments(Rozycka and Liguz-Lecznar,2017).Numerous factors contribute to cognitive aging including hormonal,metabolic,and immune dysregulation,elevated oxidative stress and inflammation,changes in neurotransmission,and diminished neurotrophic support of neurons(Rozycka and Liguz-Lecznar,2017).

关键词： alterations elevated function

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Avalonia,get bent!–Paleomagnetism from SW Iberia confirms the Greater Cantabrian Orocline

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Geoscience Frontiers 2021年第2期12卷 805-825页

作者： Bruno daniel Leite Mendes daniel Pastor-Galan Mark J.Dekkers Wout Krijgsman Paleomagnetic Laboratory Fort Hoofddijk Department of Earth SciencesUtrecht UniversityBudapestlaan 173584CDthe Netherlands Frontier Research Institute for Interdisciplinary Sciences Tohoku UniversityJapan Department Earth Science Tohoku UniversityJapan Center for North East Asia Studies Tohoku University980-857641 KawauchiAoba-kuSendaiMiyagiJapan

The amalgamation of Pangea formed the contorted Variscan-Alleghanian orogen,suturing Gondwana and Laurussia during the *** all swirls of this orogen,a double curve in Iberia stands out,the coupled Cantabrian Orocline and Central Iberian *** Cantabrian Orocline formed at ca.315–290 Ma subsequent to the Variscan *** formation mechanism of the Cantabrian Orocline is disputed,the most commonly proposed mechanisms include either(1)that south-westernmost Iberia would be an Avalonian(Laurussian)indenter or(2)that the stress field changed,buckling the *** contrast,the geometry and kinematics of the Central Iberian curve are largely *** some authors defend both curvatures are genetically linked,others support they are distinct and formed at different *** uncertainty adds an extra layer of complexity to our understanding of the final stages of Pangea’s *** solve these issues,we study the late Carboniferous–early Permian vertical-axis rotations of SW Iberia with *** results show up to 70counterclockwise vertical-axis rotations during late Carboniferous times,concurring with the anticipated kinematics if SW Iberia was part of the southern limb of the Cantabrian *** results do not allow the necessary penecontemporaneous clockwise rotations in Central Iberia to support a concomitant formation of both Cantabrian and Central Iberian *** coherent rotation of both Gondwanan and Avalonian pieces of SW Iberia discards the Laurussian indenter hypothesis as a formation mechanism of the Cantabrian Orocline and confirms the Greater Cantabrian Orocline *** Greater Cantabrian Orocline likely formed as a consequence of a change in the stress field during the late Carboniferous and extended beyond the Rheic Ocean suture affecting the margins of both Laurussia and Gondwana.

关键词： Pangea Variscan orogeny Greater Cantabrian Orocline Paleomagnetism Central Iberian curve

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Utilizing semantic-level computer vision for fracture trace characterization of hard rock pillars in underground space

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Geoscience Frontiers 2024年第2期15卷 366-391页

作者： Chuanqi Li Jian Zhou daniel Dias Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble 38000France School of Resources and Safety Engineering Central South UniversityChangsha 410083China

This study utilizes a semantic-level computer vision-based detection to characterize fracture traces of hard rock pillars in underground *** trace images captured by photogrammetry are used to establish the database for training two convolutional neural network(CNN)-based models,i.e.,U-Net(University of Freiburg,Germany)and DeepLabV3+(Google,USA)*** code technology,polyline approximation algorithm,and the circular window scanning approach are combined to quantify the main characteristics of fracture traces on flat and uneven surfaces,including trace length,dip angle,density,and *** extraction results indicate that the CNN-based models have better performances than the edge detection methods-based Canny and Sobel operators for extracting the trace and reducing noise,especially the DeepLabV3+***,the quantization results further prove the reliability of extracting the fracture *** a result,a case study with two types of traces(i.e.,on flat and uneven surfaces)demonstrates that the applied semantic-level computer vision detection is an accurate and efficient approach for characterizing the fracture trace of hard rock pillars.

关键词： Fracture trace Hard rock pillar Semantic-level computer vision Convolutional neural network(CNN) Underground space

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The Roper resonance in a finite volume

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Communications in Theoretical Physics 2020年第7期72卷 49-59页

作者： daniel Severt Ulf-G Meiβner Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron PhysicsForschungszentrum JülichD-52425 JiilichGermany Tbilisi State University 0186 TbilisiGeorgia

We calculate the energy levels corresponding to the Roper resonance based on a two-flavor chiral effective Lagrangian for pions,nucleons,deltas,and the Roper resonance at the leading one-loop *** show that the Roper m... 详细信息

关键词： Lattice QCD Roper resonance finite volume methods

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Effect of surcharge loading on horseshoe-shaped tunnels excavated in saturated soft rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1339-1346页

作者： Dianchun Du daniel Dias Ngocanh Do School of Civil Engineering Southeast UniversityNanjingChina School of Automotive and Transportation Engineering Hefei University of TechnologyHefeiChina Antea Group AntonyFrance Department of Underground and Mining Construction Faculty of Civil EngineeringHanoi University of Mining and GeologyHanoiViet Nam

Underground facilities are usually constructed under existing buildings,or buildings are constructed over existing underground *** is then imperative to account for the current overburden loads and future surface loadings in the design of *** addition,tunnels are often constructed beneath the groundwater level,such as cross-river ***,it is also important to consider the water pressure impact on the tunnel lining *** excavated by a conventional tunnelling method are considered in this *** hyperstatic reaction method(HRM)is adopted in this study to investigate the effect of surcharge loading on a horseshoe-shaped tunnel behaviour excavated in saturated soft *** results obtained from the HRM and numerical modelling are in good *** studies were then performed to show the effects of the water pressure,surcharge loading value and its width,and groundwater level on the behaviour of the horseshoe-shaped tunnel lining,in terms of internal forces and *** displays that the bending moment,normal forces and radial displacements are more sensitive to the water pressure,surcharge loading and groundwater level.

关键词： Surcharge loading Horseshoe-shaped tunnel Hyperstatic reaction method(HRM) Saturated soft rocks

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The role of L-arginine metabolism in neurocritical care patients

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Neural Regeneration Research 2022年第7期17卷 1446-1453页

作者： Marius Marc-daniel Mader Patrick Czorlich Department of Neurosurgery University Medical Center Hamburg-EppendorfHamburgGermany Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanfordCAUSA

Nitric oxide is an important mediator of vascular autoregulation and is involved in pathophysiological changes after acute neurological *** oxide is generated by nitric oxide synthases from the amino acid L-arginine.L-arginine can also serve as a substrate for arginases or lead to the generation of dimethylarginines,asymmetric dimethylarginine,and symmetric dimethylarginine,by *** dimethylarginine is an endogenous inhibitor of nitric oxide synthase and can lead to endothelial *** review discusses the role of L-arginine metabolism in patients suffering from acute and critical neurological disorders often requiring neuro-intensive care *** addressed in this review include intracerebral hemorrhage,aneurysmal subarachnoid hemorrhage,and traumatic brain *** therapeutic advances in the field are described including current randomized controlled trials for traumatic brain injuries and hemorrhagic stroke.

关键词： arginine brain injuries,traumatic cerebral hemorrhage dimethylarginine nitric oxide stroke subarachnoid hemorrhage

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What’s new in inflammatory bowel disease in 2008?

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World Journal of Gastroenterology 2008年第3期14卷 329-330页

作者： daniel C Baumgart Department of Medicine Division of Gastroenterology and Hepatology Charité Medical Center-Virchow Hospital Medical School of the Humboldt-University of Berlin D-13353 Berlin Germany

Ulcerative colitis and Crohn’s disease represent the two major forms of inflammatory bowel disease. In this highlight topic series of articles we cover the latest developments in genetics and epidemiology, intestinal physiology, mucosal immunology, mechanisms of epithelial cell injury and restitution, current medical therapy, modern surgical management, important extra- intestinal complications such as primary sclerosing cholangitis, cholangiocellular carcinoma and autoimmune hepatitis as well as endoscopic and molecular screening, detection and prevention of small bowel and colorectal cancer.

关键词： Gastroenterology

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Current status and trends of carbon-based electrodes for fully solution-processed perovskite solar cells

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Journal of Energy Chemistry 2022年第5期31卷 222-246页

作者： Laura MGonzález daniel Ramirez Franklin Jaramillo Centro de Investigación Innovacióny Desarrollo de MaterialesCIDEMATFacultad de IngenieríaUniversidad de Antioquia UdeACalle 70 No.52-21Medellín 050010Colombia

Perovskite solar cells(PSCs) have revolutionized photovoltaic research. As a result, a certified power conversion efficiency(PCE) of 25.5% was recorded in late 2020. Although this efficiency is comparable with silicon solar cells;some issues remain partially unsolved, such as lead toxicity, instability of perovskite materials under continuous illumination, moisture and oxygen, and degradation of the metallic counter electrodes. As an alternative to tackle this last concern, carbon materials have been recently used, due to their good electrical and thermal conductivity, and chemical stability, which makes them one of the most promising materials to replace metallic counter electrodes in the fabrication of PSCs. This review highlights the recent advances of carbon-based PSCs, where the carbon electrode(CE) is the main *** have become very promising candidates for PSCs;they are mainly fabricated using a simple combination of graphite and carbon black powders embedded in a binder matrix, giving a paste that is then solution-processable, resulting in devices with improved quality stability, when compared to metallic electrodes. In this review, CE’s composition is emphasized, since it can give both, high and lowtemperature processed electrodes, compatible with different device configurations. Finally, the tendencies and opportunities to use CE in PSCs devices are presented.

关键词： Perovskite solar cells Carbon electrodes Scaling up Stability Solution processing

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