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Asian journal of Andrology 2021年第2期23卷 135-139页

作者： daniel j wu Odgerel Badamjav Vikrant V Reddy Michael Eisenberg Barry Behr Department of Computer Science Stanford UniversityStanfordCA 94305USA Department of Urology University of Utah HealthSalt Lake CityUT 84108USA Department of Obstetrics and Gynecology Stanford Children’s HealthStanfordCA 94305USA Department of Urology Stanford University School of MedicineStanfordCA 94305USA

Sperm identification and selection is an essential task when processing human testicular samples for in vitro *** and identifying sperm cell(s)in human testicular biopsy samples is labor intensive and time *** developed a new computer-aided sperm analysis(CASA)system,which utilizes deep learning for near human-level performance on testicular sperm extraction(TESE),trained on a custom *** system automates the identification of sperm in testicular biopsy samples.A dataset of 702 de-identified images from testicular biopsy samples of 30 patients was *** image was normalized and passed through glare filters and diffraction *** data were split 80%,10%,and 10%into training,validation,and test sets,***,a deep object detection network,composed of a feature extraction network and object detection network,was trained on this *** model was benchmarked against embryologists’performance on the detection *** deep learning CASA system achieved a mean average precision(mAP)of 0.741,with an average recall(AR)of 0.376 on our *** proposed method can work in real time;its speed is effectively limited only by the imaging speed of the *** results indicate that deep learning-based technologies can improve the efficiency of finding sperm in testicular biopsy samples.

关键词： artificial intelligence computer vision male infertility microdissection testicular sperm extraction sperm

Recent advances in the targeted fluorescent probes for the detection of metastatic bone cancer

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Science China Chemistry 2021年第8期64卷 1283-1296页

作者： Peng wu daniel j.Siegwart Hu Xiong Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin300071China Department of Biochemistry Simmons Comprehensive Cancer CenterThe University of Texas Southwestern Medical CenterDallasTexas75390USA

Tumors of the breast,prostate,and lung are most likely to metastasize to the bone and typically indicates a poor cure and survival rate in cancer *** of metastatic bone cancer in early stage would save many lives and greatly improve patients’quality of ***,bone scintigraphy is often utilized to visualize bone metastases due to its relatively low cost and high ***,a growth number of analytical researches aimed at developing targeted fluorescent probes to noninvasively image bone metastases with improved spatial resolution and specificity has been *** this review,we will summarize and discuss the recent published fluorescent probes on the accurate detection of metastatic bone ***,the design principles of various targeted probes for imaging bone metastases will be presented,highlighting the signal moieties,targeting ligands,and physicochemical properties of the bone-specific ***,the up-to-date bone-targeting fluorescent probes will be summarized and ***,future perspectives and challenges confronting the researchers in this field will be *** believe this review will encourage novel ideas to develop smart targeted molecular probes for bone metastasis imaging,image-guided surgery,and therapeutic imaging materials.

关键词： bone metastasis targeted probes fluorescence imaging smart design bone-targeting moieties

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Achieving work hardening by forming boundaries on the nanoscale in a Ti-based metallic glass matrix composite

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journal of Materials Science & Technology 2020年第15期47卷 192-203页

作者： jing Fan Wei Rao junwei Qiao PKLiaw daniel Sopu daniel Kiener jürgen Eckert Guozheng Kang Yucheng wu College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan030024China Key Laboratory of Advanced Technologies of Materials School of Mechanics and EngineeringSouthwest Jiaotong UniversityMinistry of Education of ChinaChengdu610031China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN37996-2200USA Technische Universitat Darmstadt Institut fiir MaterialwissenschaftFachgebiet MaterialmodellierungOtto-Bemdt-Strasse 3D-64287DarmstadtGermany Erich Schmid Institute of Materials Science Austrian Academy of SciencesJahnstra'e 12A-8700LeobenAustria Department of Materials Science Montanuniversitat LeobenJahnstra'e 12A-8700LeobenAustria

Achieving work hardening in metallic glass matrix composites(MGMCs) is the key to the extensive use of these attractive materials in structural and functional *** this study,we investigated the formation of nanoscale boundaries resulted from the interaction between matrix and dendrites,which favors the work-hardening deformation in an in-situ Ti41Zr32Ni6 Ta7 Be14 MGMC with β-Ti dendrites in a glassy matrix at room *** microstructures of samples after tension were observed by highresolution transmission electron microscopy(HRTEM) and X-ray diffraction(XRD).The work-hardening mechanism of the present composites involves:(1) appearance of dense dislocation walls(DDWs),(2)proliferation of shear bands,(3) fo rmation of boundaries on the nanoscale,and(4) interactions between hard and soft phases.A theoretical model combined with experimental data reveals the deformation mechanisms in the present work,proving that the in-situ dendrites with outstanding hardening ability in the glass matrix can provide the homogeneous deformation under tensile loading at room temperature.

关键词： Metallic glass matrix composites Plastic deformation Work hardening Dense dislocation walls Nanoscale boundaries

Psychological, social, and sexual challenges affecting men receiving male infertility treatment: a systematic review and implications for clinical care

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Asian journal of Andrology 2023年第4期25卷 448-453页

作者： Winston wu justin La Kathryn M Schubach daniel Lantsberg Darren j Katz Department of Urology Western HealthSt AlbansVIC 3021Australia Department of Urology Kaiser Permanente San Rafael Medical CenterSan RafaelCA 94903USA Men’s Health Melbourne MelbourneVIC 3000Australia Reproductive Services Unit The Royal Women’s HospitalParkvilleVIC 3052Australia Melbourne IVF East MelbourneVIC 3002Australia Department of Surgery Western PrecinctUniversity of MelbourneParkvilleVIC 3010Australia

In recent years, social research surrounding the consequences of infertility has increasingly focused on the male perspective;however, a gap exists in the understanding of men’s experiences of male infertility treatment. This review aims to synthesize theexisting evidence concerning the psychological, social, and sexual burden of male infertility treatment on men, as well as patientneeds during clinical care. A systematic search identified 12 studies that are diverse in design, setting, and methods. Psychologicalevaluations have found that urological surgery may have a lasting impact on infertility-specific stress, and treatment failure canlead to feelings of depression, grief, and inadequacy. Men tended to have an avoidant coping mechanism throughout fertilitytreatment, and their self-esteem, relationship quality, and sexual functions can be tied to outcomes of treatment. Partner bonds canbe strengthened by mutual support and enhanced communication;couple separation, however, has been noted as a predominantreason for discontinuing male infertility treatment and may be associated with difficult circumstances surrounding severe maleinfertility. Surgical treatments can affect the sexual functioning of infertile men;however, the impact of testicular sperm extractionoutcomes appears to be psychologically driven whereas the improvements after microsurgical varicocelectomy are only evident inhypogonadal men. Clinically, there is a need for better inclusion, communication, education, and resource provision, to addressreported issues of marginalization and uncertainty in men. Routine psychosocial screening in cases of severe male infertility andfollow-up in cases of surgical treatment failure are likely beneficial.

关键词： male infertility male infertility treatment patient experience patient-centered care psychosocial sexual

Hypoxia inducible factor in hepatocellular carcinoma:A therapeutic target

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World journal of Gastroenterology 2015年第42期21卷 12171-12178页

作者： daniel Lin jennifer wu Fellow Hematology and Medical Oncology Program NYU School of Medicine Perlmutter Cancer Center NYU Langone Medical Center Division of Hematology and Oncology NYU School of Medicine Subdivision of GI Oncology Perlmutter Cancer Center NYU Langone Medical Center Division of Hematology and Oncology

Hepatocellular carcinoma(HCC) is one of the most commonly diagnosed and deadly cancers worldwide; its incidence has been rising in the United States due to the increase in hepatitis C associated cirrhosis and the growing epidemic of obesity. There have been no effective therapeutic options in the advanced disease setting beyond sorafenib, a multi-targeted tyrosine kinase inhibitor that showed significant survival benefit. Because of this, there is an urgent need to search for novel pathways in sorafenib experienced patients. This review will focus on the role of hypoxia and hypoxiainducible factor alpha(HIF-1α) in cancer development, specifically in HCC. We will discuss the biology of HIF-1α, the pathways with which it interacts, and the function of HIF-1α in HCC. Furthermore, we will review studies highlighting the relevance of HIF-1α in the clinical setting, as well as the pre-clinical data supporting its further investigation. Finally, we will conclude with a discussion of the potential role of a HIF-1α m RNA antagonist for the treatment of HCC, and hypothesize the ways in which such an inhibitor may be best utilized in the management of advanced HCC. Hypoxia plays a significant role in the development of HCC. HIF-1α is a key transcription factor involved in the hypoxic response of cancer cells. It activates transcription of genes responsible for angiogenesis, glucose metabolism, proliferation, invasion and metastasis in HCC. Its involvement in multiple, essential tumor pathways makes it an attractive potential therapeutic target in HCC.

关键词： Hypoxia Hypoxia-inducible factor alpha Hepatocellu

Flame Synthesis of Zr/ZSM-5 Catalysts with Tunable Acidity for the Oxidative Dehydrogenation of Propane to Propene

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journal of Thermal Science 2024年第1期33卷 268-283页

作者： daniel Samuel FONZEU MONGUEN Cedric Karel wu Lingnan TIAN Zhenyu Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Tuning the surface acidity of ZSM-5 catalyst is essential to achieve desired propene selectivity and *** several ratios of Zr were utilized to modify ZSM-5 via flame spray pyrolysis technique coupled with a pulse spray evaporation *** interaction between Zr and ZSM-5 in the flame influenced the physicochemical and acidity properties of the Zr/*** increasing Zr ratio in ZSM-5 shows coated layers of irregular nano-sized Zr with an increase in crystallite sizes due to the synergetic effect between Zr and *** surface chemical analysis revealed increased lattice oxygen on the Zr modified ZSM-5(1:4) sample compared to other *** acidity analysis revealed the Lewis and Br?nsted acid distribution in the weak and medium acid sites on the catalyst ***,the increase in Zr loading decreased the concentration of Br?nsted acid sites and tuned the catalyst surface to more Lewis acidity,promoting propene selectivity and hindering the over-oxidation of *** modified ZSM-5 catalysts were examined in a fixed bed reactor within 300℃-700℃ at a gas hourly space velocity(GHSV) of 6000 mL·g(catalysts)^(-1)·h^(-1) for the oxidative dehydrogenation of propane(ODHP) to *** the catalysts,Zr/ZSM-5(1:4) exhibited the best propene yield, with 57.19% propane conversion and 75.54% selectivity to propene and the highest *** work provides a promising strategy for tuning the surface acidity of ZSM-5 with Zr for ODHP applications.

关键词： flame synthesis Zr modified ZSM-5 catalyst ODHP surface acidity lattice oxygen

Personalized gesture interactions for cyber-physical smart-home environments

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Science China(Information Sciences) 2017年第7期60卷 144-158页

作者： Yihua LOU Wenjun wu Radu-daniel VATAVU Wei-Tek TSAI State Key Laboratory of Software Development Environment Beihang University Mint Viz Research Lab Integrated Center for Research Developmentand Innovation in Advanced MaterialsNanotechnologies and Distributed Systems for Fabrication and Control (MANSiD) & Department of Computer Science University Stefan cel Mare of Suceava

A gesture-based interaction system for smart homes is a part of a complex cyber-physical environment, for which researchers and developers need to address major challenges in providing personalized gesture interactions. However, current research efforts have not tackled the problem of personalized gesture recognition that often involves user identification. To address this problem, we propose in this work a new event-driven service-oriented framework called gesture services for cyber-physical environments(GS-CPE) that extends the architecture of our previous work gesture profile for web services(GPWS). To provide user identification functionality, GS-CPE introduces a two-phase cascading gesture password recognition algorithm for gesture-based user identification using a two-phase cascading classifier with the hidden Markov model and the Golden Section Search, which achieves an accuracy rate of 96.2% with a small training dataset. To support personalized gesture interaction, an enhanced version of the Dynamic Time Warping algorithm with multiple gestural input sources and dynamic template adaptation support is implemented. Our experimental results demonstrate the performance of the algorithm can achieve an average accuracy rate of 98.5% in practical scenarios. Comparison results reveal that GS-CPE has faster response time and higher accuracy rate than other gesture interaction systems designed for smart-home environments.

关键词： gesture interaction personalization gesture recognition user identification event-driven architec ture

Effect of Temperature on the Release of Transparent Exopolymer Particles(TEP)and Aggregation by Marine Diatoms(Thalassiosira weissflogii and Skeletonema marinoi)

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journal of Ocean University of China 2021年第1期20卷 56-66页

作者： CHEN jie GUO Kangli daniel COThornton wu Yi Fourth Institute of Oceanography Ministry of Natural ResourcesBeihai 536007China Department of Oceanography Texas A&M UniversityCollege StationTexas 77843USA

The presence of diatoms is accompanied by the production of a large amount of extracellular polymeric substances,which are mainly composed of *** exopolymer particles(TEP)are a large class of extracellular polymeric substances with high stickiness that promotes the formation of aggregates and marine snow,which affects marine bio-carbon pump *** purpose of this research was to determine how temperature increases affect the allocation of cellular carbohydrates and the formation and aggregation of *** results showed that the responses of two different diatom species(Thalassiosira weissflogii and Skeletonema marinoi)differed according to *** cell density and chlorophyll a concentration of the former were not significantly correlated with temperature,while those of the latter were significantly decreased with increasing *** indicates that the two species of diatom may have different heat tolerance ranges.A temperature increase will promote significant formation of TEP by both types of diatoms,including aggregation of *** as the temperature rises,meaning that the high temperature will produce an aggregate with a larger particle size and thus may increase the sedimentation rate of organic ***,the TEP aggregation of *** did not increase;therefore,its particle size was smaller,and so it may remain on the sea surface at high temperatures for longer *** influences have a profound impact on the biogeochemical cycling of carbon.

关键词： transparent exopolymer particles diatom Thalassiosira weissflogii Skeletonema marinoi aggregation

Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?

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World journal of Gastroenterology 2012年第35期18卷 4944-4958页

作者： Chen Sun daniel Ansari Roland Andersson De-Quan wu Department of Surgery Second Af-filiated Hospital of Harbin Medical University Harbin 150086Heilongjiang Province China Department ofSurgery Clinical Sciences Lund Lund University Sk~ne Univer-sity Hospital SE-22185 Lurid Sweden

AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment ***:A quantitative up-to-date meta-analysis was undertaken to investigate the efficacy of gemcitabine-based combination treatment compared with gemcitabine monotherapy in locally advanced or metastatic pancreatic *** was limited to highquality randomized clinical ***:Twenty-six studies were included in the present analysis,with a total of 8808 patients *** studies were divided into four subgroups based on the different kinds of cytotoxic agents,including platinum,fluoropyrimidine,camptothecin and targeted *** treated with gemcitabine monotherapy had significantly lower objective response rate [risk ratio(RR),0.72;95% confidence interval(CI):0.63-0.83;P < 0.001],and lower 1-year overall survival(RR,0.90;95%CI:0.82-0.99;P = 0.04).Gemcitabine monotherapy caused fewer complications,including fewer grade 3-4 toxicities:including vomiting(RR,0.75;95%CI:0.62-0.89;P = 0.001),diarrhea(RR,0.66;95%CI:0.49-0.89;P = 0.006),neutropenia(RR,0.88;95%CI:0.72-1.06;P = 0.18),anemia(RR,0.96;95%CI:0.82-1.12;P = 0.60),and thrombocytopenia(RR,0.76;95%CI:0.60-0.97;P = 0.03) compared with gemcitabine combination ***:Gemcitabine combination therapy provides a modest improvement of survival,but is associated with more toxicity compared with gemcitabine monotherapy.

关键词： Pancreatic cancer Gemcitabine Combina-tion therapy Outcome Meta-analysis

Inferring object properties from human interaction and transferring them to new motions

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Computational Visual Media 2021年第3期7卷 375-392页

作者： Qian Zheng Weikai wu Hanting Pan Niloy Mitra daniel Cohen-Or Hui Huang Shenzhen University ShenzhenChina University College London UK. Tel Aviv University Tel-AvivIsrael

Humans regularly interact with their surrounding *** interactions often result in strongly correlated motions between humans and the interacting *** thus ask:"Is it possible to infer object properties from skeletal motion alone,even without seeing the interacting object itself?"In this paper,we present a fine-grained action recognition method that learns to infer such latent object properties from human interaction motion *** inference allows us to disentangle the motion from the object property and transfer object properties to a given *** collected a large number of videos and 3 D skeletal motions of performing actors using an inertial motion capture *** analyzed similar actions and learned subtle differences between them to reveal latent properties of the interacting *** particular,we learned to identify the interacting object,by estimating its weight,or its *** results clearly demonstrate that motions and interacting objects are highly correlated and that related object latent properties can be inferred from 3 D skeleton sequences alone,leading to new synthesis possibilities for motions involving human *** dataset is available at http://***/research/2020/***.

关键词： human interaction motion object property inference motion analysis motion synthesis