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Perspective: Limiting Antimicrobial Resistance with Artificial Intelligence/Machine Learning

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Biomedical Engineering Frontiers 2023年第1期4卷 1-2页

作者： daniel Amsterdam Jacobs School of Medicine&Biomedical Sciences State University of New YorkBuffaloNYUSA.Departments of Microbiology and ImmunologyMedicineand Pathology at the Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA.Department of Laboratory MedicineECMCBuffaloNYUSA

The author traces his experience with the application of computers in clinical microbiology over the past 60 years,specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the antibacterial agent(s)that could be used to treat those *** use of antibiotics will result in reduced antimicrobial resistance,which is increasing *** early form of AI,Mycin(1976),a system based on rules provided by experts designed to propose antibiotic regimens for central nervous system infections,was never applied due to the limitations in the number of rules that could be incorporated into the clinical *** learning(ML)was developed to overcome the limitations of expert *** variables that influence the outcome bacteria/drug interaction,such as the source of the infection,absence of antimicrobial resistance markers,patients’health profile,and the historical susceptibility within the hospital and the local area are incorporated in the proposed comprehensive AI/ML *** role of AI in the discovery of new antimicrobial agents is also addressed.

关键词： computer agent limitations

The Arabidopsis AP2/ERF Transcription Factor RAP2.11 Modulates Plant Response to Low-Potassium Conditions

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Molecular Plant 2012年第5期5卷 1042-1057页

作者： Min Jung Kim daniel Ruzicka Ryoung Shin daniel P. Schachtman Donald Danforth Plant Science Center St Louis MO 63132 USA RIKEN Plant Science Center Yokohama Kanagawa 230-0045 Japan Present address:Monsanto Company 700 Chesterfield Parkway Chesterfield MO 63017 USA

Plants respond to low-nutrient conditions through metabolic and morphology changes that increase their ability to survive and grow. The transcription factor RAP2.11 was identified as a component in the response to low potassium through regulation of the high-affinity K＋ uptake transporter AtHAK5 and other components of the low- potassium signal transduction pathway. RAP2.11 was identified through the activation tagging of Arabidopsis lines that contained a luciferase marker driven by the AtHAK5 promoter that is normally only induced by low potassium. This factor bound to a GCC-box of the AtHAK5 promoter in vitro and in vivo. Transcript profiling revealed that a large number of genes were up-regulated in roots by RAP2.11 overexpression. Many regulated genes were identified to be in functional cate- gories that are important in Iow-K＋ signaling. These categories included ethylene signaling, reactive oxygen species pro- duction, and calcium signaling. Promoter regions of the up-regulated genes were enriched in the GCCGGC motif also contained in the AtHAK5 promoter. These results suggest that RAP2.11 regulates AtHAK5 expression under Iow-K＋ con- ditions and also contributes to a coordinated response to low-potassium conditions through the regulation of other genes in the Iow-K＋ signaling cascade.

关键词： potassium deprivation transport transcription factor nutrient sensing signal transduction.

Renewable Diesel Fuel from Processing of Vegetable Oil in Hydrotreatment Units: Theoretical Compliance with European Directive 2009/28/EC and Ongoing Projects in Spain

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Smart Grid and Renewable Energy 2010年第2期1卷 70-73页

作者： daniel Garraín Israel herrera Carmen Lago Yolanda Lechón Rosa Sáez 不详

Oil hydrotreating units in refineries are aimed at reducing the sulfur content of fuels to accomplish standard par-ticular specifications. However, this process is currently one of the best available technologies to produce biofuels from vegetable oil in a refinery. Vegetable oils can be processed or co-processed in these units if several adaptations are performed, so some properties could be improved in comparison with conventional fuel such as density and cetane number. This study highlights the theoretical greenhouse gases (GHG) emissions (using a life cycle assessment–LCA-approach) of a hydrotreated vegetable oil (HVO) from bibliographical data. Results were compared with other biofuel production processes, such as those obtained by transesterification of vegetable oil (FAME, fatty acid methyl ester). It has also been included the comparison with conventional fossil diesel as a benchmark in order to assess the theoretical compliance with GHG savings proposed in European Directive 2009/28/EC. Finally, ongoing projects and future perspectives in Spain are mentioned.

关键词： Hydrotreated Vegetable Oil Fatty Acid Methyl Ester GHG Emissions Savings Directive 2009/28/EC Renewable Diesel Fuel

Round Top Mountain rhyolite(Texas, USA), a massive, unique Y-bearing-fluorite-hosted heavy rare earth element(HREE) deposit

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Journal of Rare Earths 2014年第1期32卷 90-96页

作者： PINGITORE Nicholas CLAGUE Juan GORSKI daniel Department of Geological Sciences The University of Texas at El Paso Texas Rare Earth Resources

Round Top Mountain in Hudspeth County, west Texas, USA is a surface-exposed rhyolite intrusion enriched in Y and heavy rare earth elements （HREEs）, as well as Nb, Ta, Be, Li, F, Sn, Rb, Th, and U. The massive tonnage, estimated at well over 1 billion tons, of the deposit makes it a target for recovery of valuable yttrium and HREEs （YHREEs）, and possibly other scarce ele-ments. Because of the extremely fine grain size of the mineralized rhyolite matrix, it has not been clear which minerals host the YHREEs and in what proportions. REE-bearing minerals reported in the deposit included bastn？site-Ce, Y-bearing fluorite, xeno-time-Y, zircon, aeschynite-Ce, a Ca-Th-Pb fluoride, and possibly ancylite-La and cerianite-Ce. Extended X-ray absorption fine struc-ture （EXAFS） indicated that virtually all of the yttrium, a proxy for the HREEs, resided in a coordination in the fluorite-type crystal structure, rather than those in the structures of bastn？site-Ce and xenotime-Y. The YREE grade of the Round Top deposit was just over 0.05%, with 72%of this consisting of YHREEs. This grade was in the range of the South China ionic clay deposits that supply essentially all of the world’s YHREEs. Because the host Y-bearing fluorite is soluble in dilute sulfuric acid at room temperature, a heap leaching of the deposit appeared feasible, aided by the fact that 90%-95%of the rock consists of unreactive and insoluble feld-spars and quartz. The absence of overburden, remarkable consistency of mineralization grade throughout the massive rhyolite, prox-imity （a few km） to a US interstate highway, major rail systems and gas and electricity, temperate climate, and stable political location in the world’s largest economy all enhanced the potential economic appeal of Round Top.

关键词： heavy rare earth elements yttrium-beating fluorite yttrofluorite heap leaching rhyolite Round Top deposit

Analysis of drop deformation dynamics in turbulent flow

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Chinese Journal of Chemical Engineering 2016年第2期24卷 264-277页

作者： Stephanie Nachtigall daniel Zedel Matthias Kraume Chair of Chemical and Process Engineering Technische Universitat Berlin

Drop breakage and coalescence influence the particle formation in liquid-liquid dispersions. In order to reduce the influencing factors of the whole dispersion process, single drops where coalescence processes can be neglected were analyzed in this work. Drops passing the turbulent vicinity of a single stirrer blade were investi- gated by high-speed imaging. In order to gain a statistically relevant amount of drops passing the area of interest and corresponding breakage events, at least 1600 droplets were considered for each parameter set of this work. A specially developed fully automatic image analysis based on Matlab was used for the evaluation of the resulting high amount of image data. This allowed the elimination of the time-consuming manual analysis and further- more, allowed the objective evaluation of the drops＇ behavior. Different deformation parameters were consid- ered in order to describe the drop deformation dynamics properly. Regarding the ratio of both main particle axes （0axes）, which was therefore approximated through an ellipse, allowed the determination of very small de- viations from the spherical shape. The perimeter of the particle （0peri） was used for the description of highly de- formed shapes. In this work the results of a higher viscosity paraffin oil （ηd =127 mPa. s） and a low viscosity solvent （petroleum, ηd = 1.7 mPa-s） are presented with and without the addition of SDS to the continuous water phase. All results show that the experimentally determined oscillation but also deformation times underlie a wide spreading. Drop deformations significantly increased not only with increasing droplet viscosity, but also with decreasing interfacial tension. Highly deformed particles of one droplet species were more likely to break than more or less spherical particles. As droplet fragmentation results from a variety of different macro-scale de- formed particles, it is not assumed that a critical deformation value must be reached for the fragmentati

关键词： Drop deformation Drop breakage Liquid-liquid system Turbulent mixing Image analysis High-speed imaging

New opportunities for light-based tumor treatment with an“iron fist”

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Light(Science & Applications) 2022年第4期11卷 457-459页

作者： Riccardo Marin Erving Ximendes daniel Jaque Nanomaterials for Bioimaging Group(NanoBIG) Departamento de Ffsica de MaterialesFacultad de CienciasUniversidad Aut6noma de MadridMadrid 28030Spain

The efficacy of photodynamic treatments of tumors can be significantly improved by using a new generation of nanoparticles that take advantage of the unique properties of the tumor microenvironment.

关键词： protective light treatment

Engineering the Smart Factory

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1046-1051页

作者： HARRISON Robert VERA daniel AHMAD Bilal Warwick Manufacturing Group University of Warwick

The fourth industrial revolution promises to create what has been called the smart factory. The vision is that within such modular structured smart factories, cyber-physical systems monitor physical processes, create a virtual copy of the physical world and make decentralised decisions. This paper provides a view of this initiative from an automation systems perspective. In this context it considers how future automation systems might be effectively configured and supported through their lifecycles and how integration, application modelling, visualisation and reuse of such systems might be best achieved. The paper briefly describes limitations in current engineering methods, and new emerging approaches including the cyber physical systems （CPS） engineering tools being developed by the automation systems group （ASG） at Warwick Manufacturing Group, University of Warwick, UK.

关键词： index terms--smart factory Industry 4.0 automation systems cyber-physical systems engineering lifecycle

Forecasting complex group behavior via multiple plan recognition

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Frontiers of Computer Science 2012年第1期6卷 102-110页

作者： Xiaochen LI Wenji MAO daniel ZENG State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Group behavior forecasting is an emergent re- search and application field in social computing. Most of the existing group behavior forecasting methods have heavily re- lied on structured data which is usually hard to obtain. To ease the heavy reliance on structured data, in this paper, we pro- pose a computational approach based on the recognition of multiple plans/intentions underlying group behavior. We fur- ther conduct human experiment to empirically evaluate the effectiveness of our proposed approach.

关键词： group behavior forecasting multiple planrecognition graph search

A CALCULUS FOR SERVICES INNOVATION

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Journal of Systems Science and Systems Engineering 2007年第2期16卷 129-165页

作者： James M. TIEN daniel BERG Department of Decision Sciences and Engineering Systems Rensselaer Polytechnic Institute Troy New York USA

Innovation in the services area - especially in the electronic services （e-services） domain - can be systematically developed by first considering the strategic drivers and foci, then the tactical principles and enablers, and finally the operational decision attributes, all of which constitute a process or calculus of services innovation. More specifically, there are four customer drivers （i.e., collaboration, customization, integration and adaptation）, three business foci （i.e., creation-focused, solution-focused and competition-focused）, six business principles （i.e., reconstruct market boundaries, focus on the big picture not numbers, reach beyond existing demand, get strategic sequence right, overcome organizational hurdles and build execution into strategy）, eight technical enablers （i.e., software algorithms, automation, telecommunication, collaboration, standardization, customization, organization, and globalization）, and six attributes of decision informatics （i.e., decision-driven, information-based, real-time, continuously-adaptive, customer-centric and computationally-intensive）. It should be noted that the four customer drivers are all directed at empowering the individual - that is, at recognizing that the individual can, respectively, contribute in a collaborative situation, receive customized or personalized attention, access an integrated system or process, and obtain adaptive real-time or just-in-time input. The developed process or calculus serves to identify the potential white spaces or blue oceans for innovation. In addition to expanding on current innovations in services and related experiences, white spaces are identified for possible future innovations; they include those that can mitigate the unforeseen consequences or abuses of earlier innovations, safeguard our rights to privacy, protect us from the always-on, interconnected world, provide us with an authoritative search engine, and generate a GDP metric that can adequately measure the gro

关键词： Services innovation decision informatics software algorithms automation globalization collaboration customization integration adaptation standardization telecommunication organization business principles