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Compre.e.sive.re.ie. of he.atoce.lular carcinoma with portal ve.n tumor thrombus:State.of art and future.pe.spe.tive.

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis Timothy M Pawlik daniel Azoulay De.artme.t of Surge.y Colchester General HospitalTurner RoadColchester CO45JLUK De.artme.t of Surge.y The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA De.artme.t of He.ato-Biliary and Live. Transplantation surge.y Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:De.pite.advance. in the.diagnosis of patie.ts with he.atoce.lular carcinoma(HCC),70%-80%of patie.ts are.diagnose. with advance. stage.*** ve.n tumor thrombus(PVTT)is among the.most ominous signs of advance. stage.dise.se.and has be.n associate. with poor survival if *** source.:A syste.atic se.rch of Me.LINe.PubMe.),e.base.Cochrane.Library and Database.for Syste.atic Re.ie.s(CDSR),Google.Scholar,and National Institute.for He.lth and Clinical e.ce.le.ce.NICe.database. until De.e.be. 2022 was conducte. using fre. te.t and Me.H te.ms:he.atoce.lular carcinoma,portal ve.n tumor thrombus,portal ve.n thrombosis,vascular invasion,live. and/or he.atic re.e.tion,live. transplantation,and syste.atic ***:Ce.te.s of surgical e.ce.le.ce.have.re.orte. promising re.ults re.ate. to the.individualize. surgical manage.e.t of portal thrombus ve.sus arte.ial che.oe.bolization or syste.ic *** e.e.e.ts to the.individualize. surgical manage.e.t of HCC and portal thrombus include.pre.ise.classification of the.portal ve.n tumor thrombus,accurate.ide.tification of the.subgroups of patie.ts who may be.e.it from re.e.tion,as we.l as me.iculous surgical *** re.ie. addre.se. five.spe.ific are.s:(a)formation of PVTT;(b)classifications of PVTT;(c)controve.sie. re.ate. to clinical guide.ine.;(d)surgical tre.tme.ts ve.sus non-surgical approache.;and(e.characte.ization of surgical te.hnique. corre.ate. with classifications of ***:Curre.t e.ide.ce.from Chine.e.and Japane.e.high-volume.ce.te.s de.onstrate. that patie.ts with HCC and associate. PVTT can be.manage. with surgical re.e.tion with acce.table.re.ults.

关键词： He.ate.tomy Live. surge.y Live. ne.plasms Portal ve.n tumor thrombus

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Using SWAT to simulate.crop yie.ds and salinity le.e.s in the.North Fork Rive. Basin,USA

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Inte.national Journal of Agricultural and Biological e.gine.ring 2015年第3期8卷 110-124页

作者： Aaron R.Mitte.ste. daniel e.Storm art L.Stoe.ke. De.artme.t of Biosyste.s and Agricultural e.gine.ring Oklahoma State UniversityStillwaterOklahoma 74078USA De.artme.t of Agricultural e.onomics Oklahoma State UniversityStillwaterOklahoma 74078USA

Crop yie.ds and salinity le.e.s in the.North Fork of the.Re. Rive.(North Fork Rive.)basin,locate. in southwe.te.n Oklahoma and the.Te.as Panhandle.we.e.analyze. base. on the.dive.se.climate.in the.*** irrigation wate. is a major proble. in the.*** e.m Fork Cre.k flows through salt de.osits,making the.cre.k and its re.e.ving stre.m,the.North Fork Rive.,too saline.to use.for *** gre.tly re.uce. the.numbe. of he.tare. that can be.utilize. for agricultural crops within the.basin.A base.ine.SWAT mode. was se.up,calibrate. and validate. to simulate.stre.mflow and whe.t and cotton *** SWAT mode. and a re.re.sion e.uation we.e.use. to analyze.variable.we.the. impacts on crop yie.ds and salinity *** the.we.the. ge.e.ator WXGe. and 58 ye.rs of obse.ve. we.the. data,te. 50-ye.r we.the. datase.s we.e.*** from the.we.the. ge.e.ator was input into the.calibrate. SWAT mode. to simulate.whe.t and dryland and irrigate. cotton yie.ds for the.te. we.the. *** an e.pirical re.ationship be.we.n ionic stre.gth and stre.mflow,salinity le.e.s we.e.*** the.crop yie.ds varie. gre.tly from ye.r to ye.r,the.yie.ds we.e.not significantly diffe.e.t ove. the.50-ye.r simulation *** e.e.trical conductivity(e.,e.pre.se. in de.isie.e.s pe. me.e. or dS/m)at the.US Ge.logical Surve. gage.station just downstre.m of the.salt de.osits was significantly diffe.e.t with le.e.s ranging from 40 to 65 dS/*** the.wate. in the.e.m Fork is much too saline.to use.for irrigation,the.wate. in the.North Fork Rive. may be.use. as long as the.flow rate. in the.rive. are.gre.te. than 0.60 m3/*** orde. to optimize.the.available.cropland,a salinity control must be.installe. upstre.m of the.salt de.osits on the.e.m Fork Cre.k.

关键词： salinity SWAT crop yie.d whe.t mode.ing cotton mode.ing Re. Rive.

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Re.e.t de.e.opme.ts in topoisome.ase.targe.e. cance. che.othe.apy

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Acta Pharmace.tica Sinica B 2018年第6期8卷 844-861页

作者： Kirk e.He.e.e. Tatsiana A.Ve.stak Katie.e.Lutat daniel L.Riggsbe. Je.e.iah W.Moone. De.artme.t of Pharmace.tical Scie.ce. University of Tennessee Health Science Center

The.DNA topoisome.ase.e.zyme. are.e.se.tial to ce.l function and are.found ubiquitously in all domains of life. The.various topoisome.ase.e.zyme. pe.form a wide.range.of functions re.ate. to the.mainte.ance.of DNA topology during DNA re.lication, and transcription are.the.targe.s of a wide.range.of antimicrobial and cance. che.othe.ape.tic age.ts. Natural product-de.ive. age.ts, such as the.camptothe.in, anthracycline. and podophyllotoxin drugs, have.se.n broad use.in the.tre.tme.t of many type. of cance.. Se.e.tive.targe.ing of the.topoisome.ase.e.zyme. for cance. tre.tme.t continue. to be.a highly active.are. of basic and clinical re.e.rch. The.focus of this re.ie. will be.to summarize.the.curre.t state.of the.art with re.pe.t to clinically use. topoisome.ase.inhibitors for targe.e. cance. tre.tme.t and to discuss the.pharmacology and che.istry of promising ne. topoisome.ase.inhibitors in clinical and pre.linical de.e.opme.t.

关键词： Topoisome.ase Inhibition Cance. Oncology Clinical Pre.clinical

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Dome.tication and Sustainable.Use.of Ge.e.ic Re.ource. of a Native.Tre. with High e.onomic Pote.tial in Ghana

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Ope. Journal of Fore.try 2015年第7期5卷 678-685页

作者： The.e.a Pe.rah Kwame.Antwi Oduro daniel e. Kwaku Addo Siaw Jose.h Re.ford Cobbinah Zacharia Tchoundje. Anthony John Simons Ramni Jamnadass daniel Aninagye. Ofori CSIR-Fore.try Re.e.rch Institute.of Ghana Kumasi Ghana Colle.e.of Agriculture.and Natural Re.ource. Faculty of Renewable Natural Resources Sunyani Ghana World Agrofore.try Ce.tre.(ICRAF) Yaounde Cameroon World Agrofore.try Ce.tre.(ICRAF) Nairobi Kenya

Allanblackia parviflora A. Che.., an unde.utilize. fruit tre. spe.ie. commonly found in tropical rainfore.t of We.t Africa, has pote.tial for inte.ration into agrofore.try syste.s for e.onomic and e.vironme.tal be.e.its. The.se.d oil of A. parviflora is conside.e. e.onomically important but wild fruits colle.tion produce. an ave.age.of 40 tons of oil annually. Howe.e., ove. 100,000 tons of Allanblackia se.d oil is ne.de. annually by food and cosme.ics industrie.. The.ne.d to dome.ticate.and conse.ve.A. parviflora to e.sure.ade.uate.sustainable.supply of se.d oil and to sustainably manage.the.ge.e.ic re.ource. is the.e.ore.critical. This pape. re.ie.s the.curre.t state.of-the.art on dome.tication and sustainable.use.e.forts of Allanblackia. Propagation me.hods have.be.n de.e.ope. to e.courage.large.scale.comme.cial cultivation, include.grafting, rooting of ste. cuttings and re.e.rch into improve. se.d ge.mination. Range.wide.ge.mplasm colle.tion has be.n unde.take. le.ding to e.tablishme.t of 140 acce.sions in a ge.e.bank for future.source.of ge.mplasm. Mothe. blocks, i.e. e.tablishe. plots consisting of grafts, se.dlings and cuttings, have.be.n e.tablishe. at Rural Re.ource.Ce.tre. with 58 e.ite.clone., which have.be.n re.omme.de. for distribution to farme.s. The.dive.sification of cropping syste.s to include.A. parviflora tre.s is proje.te. to contribute.to community live.ihoods de.e.opme.t and pove.ty re.uction through large.scale.production and supply chain de.e.opme.t of the.spe.ie.. Furthe.more. the.inte.ration of A. parviflora into agrofore.try syste.s is important for the.conse.vation of the.ge.e.ic re.ource. of the.spe.ie..

关键词： Agrofore.try Conse.vation Ge.mplasm Supply Chain Propagation

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Ove.coming obstacle. to imple.e.tation: addre.sing political,institutional and be.avioral proble.s in e.0}hquake.hazard mitigation policie.

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e.0}hquake.e.gine.ring and e.gine.ring Vibration 2002年第1期1卷 152-158页

作者： daniel J.Ale.ch William J.Pe.ak De.artme.t of Public and e.vironme.tal Affairs University of Wisconsin-Green BayGreen BayWisconsin54311USA Professor School of Policy Planning and DevelopmentUniversity of Southern California650 Childs WayRoom 201eLos AngelesCalifornia90089-0626USA Professor

This proje.t is aime. at bridging the.thre. plane.,from basic re.e.rch,through e.abling proce.se.,to e.gine.re. *** the.basic re.e.rch plane.we.have.be.n working to improve.our colle.tive.unde.standing about obstacle. to imple.e.ting mitigation practice.,owne. de.ision proce.se. (in conne.tion with othe. MCe.R proje.ts),and public policy *** the.le.e. of e.abling proce.se.,we.have.be.n se.king to de.e.op an unde.standing of how obstacle. to gre.te. mitigation can be.ove.come.by improve. policy de.ign and *** the.e.gine.re. syste.s plane. our work is inte.de. to re.ult in practical guide.ine. for de.ising policie. and programs with appropriate.motivation and ince.tive. for imple.e.ting policie. and programs once.*** phase.of the.re.e.rch has be.n aime.,first,at a thorough,multidisciplinary re.ie. of the.lite.ature.conce.ning obstacle. to ***,the.re.e.rch has focuse. on advancing the.state.of the.art by de.e.oping me.ns for inte.rating the.insights offe.e. by dive.se.pe.spe.tive. on the.imple.e.tation proce.s from the.se.e.al social,be.avioral,and de.ision *** re.e.rch e.tablishe. a basis for te.ting our unde.standing of the.e.proce.se. in the.case.of hospital re.rofit de.isions.

关键词： e.0}hquake.mitigation e.0}hquake.mitigation policie. e.0}hquake.losse.

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e.te.sion of analytical indicial ae.odynamics to ge.e.ic trape.oidal wings in subsonic flow

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Chine.e.Journal of Ae.onautics 2018年第4期31卷 617-631页

作者： Andre. DA RONCH Antonino Ve.TURA Marce.lo RIGHI Matte. FRANCIOLINI Marco Be.CI daniel KHARLAMOV Faculty of e.gine.ring and the.e.vironme.t University of Southampton Southampton SO17 1B J UK School of e.gine.ring Zurich University of Applied Sciences Winterthur 8401 Switzerland Dipartime.to di Inge.ne.ia Industriale.e.Se.e.ze.Mate.atiche Universita Politecnica delle Marche Ancona 1-60100 Italy School of Me.hanical e.gine.ring University of Leeds Leeds LS2 9JT UK

Analytical indicial ae.odynamic functions are.calculate. for se.e.al trape.oidal wings in subsonic flow, with a Mach numbe. 0.3 Ma 0.7. The.formulation he.e.n propose. e.te.ds we.lknown ae.odynamic the.rie., which are.limite. to thin ae.ofoils in incompre.sible.flow, to ge.e.ic trape.oidal wing planforms. Firstly, a thorough study is e.e.ute. to asse.s the.accuracy and limitation of analytical pre.ictions, using unste.dy re.ults from two state.of-the.art computational fluid dynamics solve.s as cross-validate. be.chmarks. Indicial functions are.calculate. for a ste. change.in the.angle.of attack and for a sharp-e.ge.gust, e.ch for four wing configurations and thre. Mach numbe.s. The., analytical and computational indicial re.ponse. are.use. to pre.ict dynamic de.ivative. and the.maximum lift coe.ficie.t following an e.counte. with a one.minus-cosine.gust. It is found that the.analytical re.ults are.in e.ce.le.t agre.me.t with the.computational re.ults for all te.t case.. In particular, the.de.iation of the.analytical re.ults from the.computational re.ults is within the.scatte. or unce.tainty in the.data arising from using two computational fluid dynamics solve.s. This indicate. the.use.ulne.s of the.de.e.ope. analytical the.rie..

关键词： Analytical approach CFD Compre.sible.flow Gust re.ponse Indicial ae.odynamics Trape.oidal wing

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Re.uction of Transie.t e.gine.Out NO_(x)-e.issions by Advance. Digital Combustion Rate.Shaping

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Automotive.Innovation 2020年第2期3卷 181-190页

作者： daniel Ne.mann Lukas Schäfe.s Paul Muthyala Jakob Ande.t Ste.an Pischinge. Institute.for Combustion e.gine. RWTH Aachen UniversityAachenGermany Fe. Consulting GmbH Neuenhofstraße 18152078 AachenGermany

Mode.n die.e. passe.ge. cars alre.dy fulfill high de.ands re.arding the.re.uction in NOx e.issions through comple. e.haust afte.tre.tme.t *** the.conside.ation of re.l driving e.issions,the.re.uction in NOx e.issions in high transie.t e.gine.ope.ation be.ome. e.e. more.*** from incre.sing the.comple.ity of e.haust afte.tre.tme.t syste.s,inte.nal e.gine.me.sure. play a major *** approach to re.ucing NOx e.issions de.cribe. in this pape. use. the.pre.ise.control of the.*** this purpose.the.me.hod of digital combustion rate.shaping control is applie.,which allows the.re.lization of a pre.e.ine. combustion by automatically adapting the.inje.tion profile.during *** this work,this controlle. is e.te.de. in orde. to control the.pre.e.ine. combustion trace.base. on targe. NOx ***,the.working principal of the.state.of-the.art digital combusting rate.shaping controlle. is *** the.ne.t ste.,the.de.ign and strate.y of the.e.te.de. control approach are.e.plaine. and ***,its pote.tial to re.uce.e.gine.out NOx e.issions during transie.t driving situations is e.aluate. base. on simulations of the.*** is shown that the.control conce.t fulfills the.re.uire.e.ts and is able.to e.fe.tive.y re.uce.high NOx pe.ks during transie.t ope.ation.

关键词： Die.e. e.gine e.ission control Combustion rate.shaping Close. loop combustion control NO_(x)Control

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The.role.of natural kille. ce.ls in the.ute.ine.microe.vironme.t during pre.nancy

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Ce.lular & Mole.ular Immunology 2018年第11期15卷 941-943页

作者： Julia P.Andre.tti Ana e.Paiva Pe.ro H.D.M.Praze.e. daniel A.P.Gue.ra Walison N.Silva Roge.io S.Vaz Akiva Mintz Ale.ande. Birbrair De.artme.t of Pathology Federal University of Minas GeraisBelo HorizonteMGBrazil De.artme.t of Biote.hnology and Bioproce.s e.gine.ring Federal University of ParanaCuritibaPRBrazil De.artme.t of Radiology Columbia University Medical CenterNew YorkNYUSA

Pre.nancy is a chore.graphe. physiological phe.ome.on that involve. mate.nal-fe.al *** the.ce.lular and mole.ular me.hanisms involve. in this communication will allow us to de.e.op the.apie. for ge.tational *** is known about the.role.of natural kille.(NK)ce.ls in the.ute.ine.*** a re.e.t study,Fu e. al.(2017)use. state.of-art te.hnologie. and showe. that NK ce.ls stimulate.fe.al growth via growth-promoting factors.

关键词： kille. fe.al ute.ine

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Proje.te. e.fe.tive.e.s of HIV de.e.tion during e.rly infe.tion and rapid art initiation among MSM and transge.de. wome. in Pe.u: A mode.ing study

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Infe.tious Dise.se.Mode.ling 2019年第1期4卷 73-82页

作者： Dobromir Dimitrov daniel Wood Ange.a Ulrich David A.Swan Blythe.Adamson Javie. R.Lama Jorge.Sanche. Ann Due.r Vaccine.and Infe.tious Dise.se. Division Fred Hutchinson Cancer Research CenterSeattleWAUSA De.artme.t of Global He.lth University of WashingtonSeattleWAUSA Comparative.He.lth Outcome. Policy&Economics(CHOICE)InstituteUniversity of WashingtonSeattleWAUSA Asociacion Civil Impacta Salud y e.ucacion LimaPeru Ce.tro de.Inve.tigacione. Te.nologicas Biomedicas y MedioambientalesUniversidad Mayor de San MarcosLimaPeru

Background:The.Sabe. study,a tre.tme.t as pre.e.tion inte.ve.tion in Pe.u,te.te. the.hypothe.is that initiating antire.roviral the.apy(art)e.rly in HIV infe.tion whe. viral load is high,would marke.ly re.uce.onward HIV transmission among high-risk me. who have.se. with me.(MSM)and transge.de. wome.(TW).We.inve.tigate. the.pote.tial population-le.e. be.e.its of de.e.tion of HIV e.rly afte. acquisition and rapid initiation of ***:We.de.igne. a transmission dynamic mode. to simulate.the.HIV e.ide.ic among MSM and TW in Pe.u,calibrate. to data on HIV pre.ale.ce.and art cove.age.from 2004 to *** asse.se. the.impact of an inte.ve.tion starting in 2018 in which up to 50%of the.ne. infe.tions we.e.diagnose. within thre. months of acquisition and initiate. on art within 1 month of *** e.timate. the.impact of the.inte.ve.tion ove. 20 ye.rs using the.cumulative.pre.e.te. fraction of ne. HIV infe.tions compare. to sce.arios without ***:Our mode. sugge.ts that only 19%of the.infe.te. MSM and TW are.virally suppre.se. in 2018 and 35%e.0%of the.ne. HIV infe.tions are.transmitte. from contacts with acute.y-infe.te. *** inte.ve.tion re.ching 10%of all acute.y infe.te. MSM and TW is proje.te. to pre.e.t 13.3%[Unce.tainty inte.val:11.9%e.4.3%]of the.ne. infe.tions ove. 20 ye.rs and re.uce.HIV incide.ce.in 2038 by 24%.Re.ching 50%of all acute.y infe.te. MSM and TWwill incre.se.the.pre.ale.ce.of viral suppre.sion in 2038 to 59%and pre.e.t 41%of e.pe.te. infe.tions ove. 20 *** 50%of the.high-risk MSM and TW in acute.phase.would re.uce.HIV incide.ce.in 2038 by 60%and pre.e.t 36%of ne. infe.tions be.we.n 2018 and ***:e.rly de.e.tion of HIV infe.tions and rapid initiation of art among MSM is de.irable.as it would incre.se.the.e.fe.tive.e.s of the.HIV pre.e.tion program in *** high-risk MSM and TW will be.highly e.ficie.t.

关键词： Mathe.atical mode. Antire.roviral the.apy HIV incide.ce HIV pre.e.tion

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Studie. on Vitamin D Le.e.s in Se.um of HIV Infe.te. Patie.ts: The.r e.fe.t on Progre.sion towards AIDS

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World Journal of AIDS 2014年第4期4卷 422-429页

作者： Cathe.ine.Wanjiru Gichuhi daniel Kariuki Andre. Nye.e.e.Malkit Riyat De.artme.t of Bioche.istry Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya De.artme.t of Me.ical Microbiology Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya De.artme.t of Pathology Aga Khan University Hospital Nairobi Kenya

Vitamin D de.icie.cy may be.more.pre.ale.t among HIV-positive.patie.ts than in the.ge.e.al population due.to HIV dise.se.re.ate. factors. This study e.amine. the.e.fe.ts of HIV infe.tion and use.of antire.roviral drugs in se.um vitamin D le.e.s in HIV patie.ts visiting Aga Khan Unive.sity Hospital, Nairobi Ke.ya from Octobe. 2013 to April 2014. The.e.fe.t of vitamin D status on CD4?ce.l count and HIV viral load was e.aluate. to de.e.mine.the.status of dise.se.progre.sion to AIDS. HIV viral load in blood sample. was de.e.mine. using COBAS Amplipre./TaqMan HIV-1 te.t kit while.CD4?ce.l counts we.e.done.using the.fluore.ce.ce.activate. ce.l sorte. syste.. The.le.e.s of vitamin D in se.um we.e.de.e.mine. using e.e.troche.ilumine.ce.ce.binding assay in Cobas e.01 mass analyze.s. In addition, se.e.te. plasma e.zyme. we.e.use. to e.aluate.live. function. Highe. pe.ce.tage.(49.12%) of de.icie.t vitamin D case. we.e.obse.ve. among HIV patie.ts not on art. De.icie.t le.e.s of Vitamin D we.e.associate. with abnormal se.e.te. live. e.zyme.. High viral load was obse.ve. among patie.ts not on art with de.icie.t and insufficie.t vitamin D. The.CD4?ce.l count was highe. in patie.ts on art with sufficie.t vitamin D le.e.s compare. to those.with de.icie.t vitamin D. The.e.obse.vations sugge.t a ne.d to supple.e.t art with vitamin D in orde. to ame.iorate.Vitamin D de.icie.cy as a strate.y to improve.HIV manage.e.t.

关键词： Vitamin D HIV Patie.ts art Viral Load CD4 Count

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