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Chinese Journal of Mechanical Engineering 2022年第3期35卷 200-206页

作者： Dong Wang daniel de becker Anish Roy Wolfson School of Mechanical and Manufacturing Engineering Loughborough UniversityLoughborough LE113TUUK department of Engineering College of EngineeringMathematics and Physical SciencesUniversity of ExeterExeter EX44QFUK

Modern-day microtomy requires high precision equipment to thinly section biological *** sectioned tissue must be of good quality not showing cutting tracks or so-called *** quality of these sections is dependent on the blade wear,which is related to the hardness of the tissue sample,cutting angle and cutting speed.A test rig has been designed and manufactured to allow these parameters to be *** has allowed for the blade wear to be analysed and quantified,and this has been completed for both ultrasonically assisted and conventional *** obtained results showed a 25.2%decrease in average blade roughness after 38 cuts when using the ultrasonically assisted cutting *** data also showed no adverse effect on the quality of the slides produced when using this cutting ***,the cutting force measured for both cutting regimes showed that ultrasonically assisted cutting required less force compared to conventional *** the reduction of surface roughness and force,it is possible to state that ultrasonically assisted cutting reduces the wear of the blade,thereby increasing the life of the *** increase of just 10%in blade life would yield a cost saving of approximately 25%thereby reducing the environmental and financial impact of microtomy.

关键词： Microtome Ultrasonically assisted cutting Blade wear

Spatially simplified scatterplots for large raster datasets

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Geo-Spatial Information Science 2016年第2期19卷前插1-前插1,81-93页

作者： Bin Li daniel A.Griffith Brian becker department of Geography College of Science and EngineeringCentral Michigan UniversityMount PleasantMIUSA School of Economic Political and Policy SciencesUniversity of Texas at DallasRichardsonTXUSA

Scatterplots are essential tools for data exploration. However, this tool poorly scales with data-size, with overplotting and excessive delay being the main problems. Generalization methods in the attribute domain focus on visual manipulations, but do not take into account the inherent nature of information redundancy in most geographic data. These methods may also result in alterations of statistical properties of data. Recent developments in spatial statistics, particularly the formulation of effective sample size and the fast approximation of the eigenvalues of a spatial weights matrix, make it possible to assess the information content of a georeferenced data-set, which can serve as the basis for resampling such data. Experiments with both simulated data and actual remotely sensed data show that an equivalent scatterplot consisting of point clouds and fitted lines can be produced from a small subset extracted from a parent georeferenced data-set through spatial resampling. The spatially simplified data subset also maintains key statistical properties as well as the geographic coverage of the original data.

关键词： Scatterplot spatial autocorrelation effective sample size

Condensation of pyrylium salts with mixed anhydrides:aryl ethers,aryl amines and sterically congested aromatics

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Organic Chemistry Frontiers 2022年第2期9卷 294-298页

作者： daniel Grabowski Susanne Alef Steven becker Ute Muller Gregor Schnakenburg Sigurd Hoger aKekulé-Institut für Organische Chemie und Biochemie Rheinische Friedrich-Wilhelms-Universität BonnGerhard-Domagk-Str.153121 BonnGermany bInstitut für Anorganische Chemie Universität BonnGerhard-Domagk-Str.153121 BonnGermany

The condensation of easily accessible and widely functionalizable 2,4,6-triaryl pyrylium salts with mixed anhydrides,formed in situ fromα-functionalized sodium acetates and an anhydride solvent,leads in good yields to the corresponding 2,4,6-triaryl benzenes functionalized at their 1-position.4-(Trifluoromethyl)benzoic anhydride has been proven as being the solvent of choice and ortho-disubstituted diphenyl ethers,triphenyl amines and phenyl carbazoles with different functionalizations are *** addition,sterically hindered anthracene diacetate is condensed with two bis-bromophenyl pyrylium salts which leads after intramolecular Yamamoto coupling to *** these,the anthracene core is surrounded by phenylenes and protected from photooxidation,leading to a highly stable blue emitting material.

关键词： material. anhydride salts

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

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World Journal of Gastroenterology 2018年第7期24卷 810-818页

作者： daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M becker Illawarra Health and Medical Research Institute University of WollongongWollongong 2500Australia School of Biological Sciences University of WollongongWollongong 2500Australia Illawarra Cancer Centre Wollongong HospitalWollongong 2500Australia CONCERT-Translational Cancer Research Centre New South Wales 2000Australia Centre for Circulating Tumor Cell Diagnostics and Research Ingham Institute for Applied Medical ResearchLiverpool HospitalSydney 2170Australia School of Medicine University of Western SydneySydney 2170Australia South Western Medical School University of New South WalesSydney 2170Australia

AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal *** Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival *** While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing.

关键词： Cryopreservation Circulating tumor cells Liquid biopsy Gastroesophageal cancer Gastric cancer

Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes

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Microsystems & Nanoengineering 2021年第2期7卷 59-69页

作者： Zeyu Wang Haichen Wang Ryan becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou daniel T.Laskowitz Tony Jun Huang department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC27708USA department of Neurology Duke UniversityDurhamNC27708USA department of Biomedical Engineering Duke UniversityDurhamNC27708USA department of Geriatrics Duke UniversityDurhamNC27708USA department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTX77840USA

Traumatic brain injury(TBI)is a global cause of morbidity and *** management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic *** particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue *** applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after *** isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow *** cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of *** levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma *** finding demonstrated the necessity of sample purification prior to exosomal biomarker *** acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI.

关键词： diagnosis separation injury

A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments

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Psychoradiology 2021年第1期1卷 3-12页

作者： Keith M.Kendrick Joerg Daumann daniel Wagner Philip Koester Marc Tittgemeyer Qiang Luo Euphrosyne Gouzoulis-Mayfrank Benjamin becker The Clinical Hospital of Chengdu Brain Science Institute Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduChina department of Psychiatry and Psychotherapy University of CologneGermany Max-Planck Institute for Neurological Research CologneGermany Institute of Science and Technology for Brain-Inspired Intelligence Ministry of Education Key Laboratory of Computational Neuroscience and Brain-Inspired IntelligenceFudan UniversityShanghaiPR China LVR Clinics of Cologne CologneGermany

Background:Amphetamine-type stimulants(ATS)have become a critical public health *** models have indicated a clear neurotoxic potential of *** humans,chronic use has been associated with cogni-tive deficits and structural brain ***,cross-sectional retrospective designs in chronic users cannot truly determine the causal direction of the ***:To prospectively determine effects of occasional ATS use on cognitive functioning and brain ***:In a prospective longitudinal study design,cognitive functioning and brain structure were assessed at baseline and at 12-month follow-up in occasional ATS users(cumulative lifetime usedeclined verbal memory performance and putamen volume in users with high relative to low interim ATS *** the entire sample,interim ATS use,memory decline,and putamen volume reductions were strongly ***:The present findings support the hypothesis that ATS use is associated with deficient dorsal stri-atal morphology that might reflect alterations in dopaminergic *** importantly,these findings strongly suggest that even occasional,low-dose ATS use disrupts striatal integrity and cognitive functioning.

关键词： amphetamines brain volume dorsal striatum MDMA prospective stimulants

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门多萨中央公园

新建筑 2015年第6期 83-84页

作者： daniel becker Claudio Ferrari Oscar Fuentes 宋玮 EMBT中国地区

城市的文化体验给予门多萨市一种独特的观感,这样的体验是由遍布于历史事件的网络所构成。这就是经由时间积累形成下来的场所意义不应被低估的原因。也许在许多方面这一观点已经过时,但是该公司仍然坚持用非量产的方式,关注除城市铁路... 详细信息

城市的文化体验给予门多萨市一种独特的观感,这样的体验是由遍布于历史事件的网络所构成。这就是经由时间积累形成下来的场所意义不应被低估的原因。也许在许多方面这一观点已经过时,但是该公司仍然坚持用非量产的方式,关注除城市铁路交通发展之外的其他不确定性因素。

关键词：中央公园不确定性因素城市铁路历史事件交通发展场所

脑脊液漏的治疗进展新技术将改进单侧清亮鼻溢的治疗

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英国医学杂志中文版 2002年第1期5卷 5-6页

作者：高晶 N S Jones daniel G becker department of Otorhinolaryngology University Hospital department

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泰勒海关

新建筑 2015年第6期 78-79页

作者： Enrique Bares Federico Bares Nicolas Bares daniel becker Claudio Ferrari Florence Schnack Facundo de Zuviria 胡辞华中科技大学建筑与城市规划学院

这个项目是对古代海关大厦的保护和更新,包括基址的复原,以及将其改造成一个现代博物馆。200周年纪念博物馆位于阿根廷一处最密集的历史街区中。这项工作的主要目标是对建筑整体的材料和象征意义进行复原。在庭院上覆以玻璃顶以保护庭院... 详细信息

这个项目是对古代海关大厦的保护和更新,包括基址的复原,以及将其改造成一个现代博物馆。200周年纪念博物馆位于阿根廷一处最密集的历史街区中。这项工作的主要目标是对建筑整体的材料和象征意义进行复原。在庭院上覆以玻璃顶以保护庭院,并起到覆盖和保护古迹遗址的作用。

关键词：海关泰勒历史街区象征意义博物馆保护阿根廷复原

200周年纪念文化中心——原邮政电报大厦及其周边地区的修复与改造

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新建筑 2015年第6期 80-82页

作者： Enrique Bares Federico Bares Nicolas Bares daniel becker Claudio Ferrari Florence Schnack 胡辞华中科技大学建筑与城市规划学院

对位于阿根延布宜诺斯艾利斯政治和文化中心的原邮政电报大厦及其周边历史区域的修复与再利用,包括将原邮政电报大厦这座具有很高历史价值的建筑遗产改建为200周年纪念文化中心1。作为国际竞赛一等奖的获奖作品,该项目融合了前卫的建筑... 详细信息

对位于阿根延布宜诺斯艾利斯政治和文化中心的原邮政电报大厦及其周边历史区域的修复与再利用,包括将原邮政电报大厦这座具有很高历史价值的建筑遗产改建为200周年纪念文化中心1。作为国际竞赛一等奖的获奖作品,该项目融合了前卫的建筑方案和细致的修复工作。200周年纪念文化中心包含若干音乐厅、展厅和礼堂,其表面积超过10万m^2,将成为世界上最大的文化中心。

关键词：文化中心修复工作周边地区大厦电报邮政布宜诺斯艾利斯改造