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Gibberellic acid induced parthenocarpic‘Honeycrisp’apples(Malus domestica)exhibit reduced ovary width and lower acidity

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Horticulture Research 2019年第1期6卷 1129-1141页

作者： Kelsey d.Galimba daniel G.Bullock Chris dardick Zhongchi Liu Ann M.Callahan Appalachian Fruit Research Station Agricultural Research ServiceUnited States Department of Agriculture2217 Wiltshire RoadKearneysvilleWV 25430USA department of Cell Biology and Molecular Genetics College of Mathematics and Natural SciencesUniversity of MarylandCollege ParkMD 20742USA

Fruit set and development are dependent on auxin,gibberellin,and cytokinin,which cause parthenocarpic development in many species when applied *** sprays containing these hormones are used to improve apple fruit set,size,and shape,but have been implicated negatively in other aspects of fruit *** applied gibberellic acid(GA_(3)),synthetic auxin(NAA),and the auxin-transport inhibitor NPA to‘Honeycrisp’apple *** retention and size were quantified throughout development,and seed number and fruit quality parameters were measured at ***_(3)alone caused the development of seedless parthenocarpic *** maturity,GA_(3)-treated apples were narrower due to reduced ovary width,indicating that GA_(3)induced normal growth of the hypanthium,but not the ***_(3)-treated fruits were also less acidic than hand-pollinated controls,but had similar firmness,starch,and sugar *** further understand the regulation of parthenocarpy,we performed tissue-specific transcriptome analysis on GA_(3)-treated,NAA-treated,and control fruits,at 18 days after treatment and again at ***,transcriptome analysis showed GA_(3)-treated and hand-pollinated fruits were highly similar in RNA expression *** expression differences in putative cell division,cytokinin degradation,and cell wall modification genes in GA_(3)-treated ovaries correlated with the observed shape differences,while early expression differences in the acidity gene Ma1 may be responsible for the changes in *** together,our results indicate that GA_(3)triggers the development of parthenocarpic apple fruit with morphological deviations that correlate with a number of candidate gene expression differences.

关键词： maturity width acidity

Surgery in the age of biologics

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Gastroenterology Report 2019年第2期7卷 77-90,I0001页

作者： daniel J.Wong Eve M.Roth Joseph d.Feuerstein Vitaliy Y.Poylin department of Surgery Division of Colon&Rectum SurgeryBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA department of Medicine Division of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA

Since the introduction of the first anti-tumor necrosis factor antibodies in the late 1990s,biologic therapy has revolutionized the medical treatment of patients with inflammatory bowel disease(IBd).Nevertheless,surgery continues to play a significant role in treating IBd *** of intestinal resection in patients with Crohn’s disease or colectomy in ulcerative colitis are reducing but not substantially over the long *** increasing variety of biologic medications are now available to treat IBd patients in various clinical ***,a number of questions persist about how biologic medications affect the need for surgery and overall course in IBd *** the trend for earlier and more frequent use of biologic medications in IBd patients,a working knowledge of the effects of these medications on surgical decision-making and outcomes is essential for the practicing colorectal surgeon and *** review seeks to summarize the relevant literature surrounding biologic use and IBd surgery with a focus on the effect of biologics on the frequency,type and complications of surgery in this‘age of biologics’.

关键词： Biologics inflammatory bowel disease surgery review

simplifyEnrichment:A Bioconductor Package for Clustering and Visualizing Functional Enrichment Results

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 190-202页

作者： Zuguang Gu daniel Hübschmann Molecular Precision Oncology Program National Center for Tumor Diseases(NCT)HeidelbergD-69120 HeidelbergGermany Heidelberg Institute of Stem Cell Technology and Experimental Medicine(HI-STEM) D-69120 HeidelbergGermany German Cancer Consortium(dKTK) D-69120 HeidelbergGermany department of Pediatric Immunology Hematology and OncologyUniversity Hospital HeidelbergD-69120 HeidelbergGermany

Functional enrichment analysis or gene set enrichment analysis is a basic bioinformatics method that evaluates the biological importance of a list of genes of ***,it may produce a long list of significant terms with highly redundant information that is difficult to *** tools to simplify enrichment results by clustering them into groups either still produce redundancy between clusters or do not retain consistent term similarities within *** propose a new method named binary cut for clustering similarity matrices of functional *** comprehensive benchmarks on both simulated and real-world datasets,we demonstrated that binary cut could efficiently cluster functional terms into groups where terms showed consistent similarities within groups and were mutually exclusive between *** compared binary cut clustering on the similarity matrices obtained from different similarity measures and found that semantic similarity worked well with binary cut,while similarity matrices based on gene overlap showed less consistent *** implemented the binary cut algorithm in the R package simplifyEnrichment,which additionally provides functionalities for visualizing,summarizing,and comparing the *** simplifyEnrichment package and the documentation are available at https://***/packages/simplifyEnrichment/.

关键词： Functional enrichment Simplify enrichment Clustering R/Bioconductor Software Visualization

Risk factors for long COVId in children and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第2期20卷 133-142页

作者： daniel G.Rayner Elaine Wang Cloris Su Om d.Patel Stephanie Aleluya Alessandra Giglia Evelyn Zhu Maha Siddique department of Health Research Methods Evidenceand ImpactFaculty of Health SciencesMcMaster University1280 Main St WHamiltonONL8S 4K1Canada Faculty of Health Sciences McMaster University1280 Main St WHamiltonON L8S 4K1Canada Faculty of Science McMaster University1280 Main St WHamiltonONL8S 4K1Canada

Background The long-term sequelae of COVId-19 in children and adolescents remain poorly understood and *** systematic review and meta-analysis sought to summarize the risk factors for long COVId in the pediatric *** We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVId or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression *** registries,reference lists of included studies,and preprint servers were hand-searched for relevant ***-effects meta-analyses were conducted to pool odds ratios for each risk *** study risk of bias was rated using QUIPS,and the GRAdE framework was used to assess the certainty of evidence for each unique *** Sixteen observational studies(N=46,262)were included,and 19 risk factors were amenable to *** moderate certainty in the evidence,age(per 2-year increase),allergic rhinitis,obesity,previous respiratory diseases,hospitalization,severe acute COVId-19,and symptomatic acute COVId-19 are probably associated with an increased risk of long *** sex,asthma,comorbidity,and heart diseases may be associated with an increased risk of long COVId,and Asian and Black races may be associated with a decreased risk of long *** did not observe any credible subgroup effects for any risk *** The current body of literature presents several compelling risk factors for the development of long COVId in the pediatric *** research is necessary to elucidate the pathophysiology of long COVId.

关键词： COVId-19 Long COVId Post-acute COVId-19 syndrome Pediatrics Risk factors

Relating environmental variables with aquatic community structure in an agricultural/urban coldwater stream

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Ecological Processes 2021年第1期10卷 481-499页

作者： daniel T.L.Myers Richard R.Rediske James N.McNair Aaron d.Parker E.Wendy Ogilvie Annis Water Resources Institute Grand Valley State University740 W Shoreline DriveMuskegonMI 49401USA. Michigan department of Environment Great Lakesand Energy525 W Allegan StreetLansingMI 48909USA. Grand Valley Metropolitan Council 678 Front Avenue NWSuite 200Grand RapidsMI 49504USA.

Background:Urban areas are often built along large rivers and surrounded by agricultural *** may lead to small tributary streams that have agricultural headwaters and urbanized lower *** study objectives assessed are as follows:(1)landscape,geomorphic,and water quality variables that best explained variation in aquatic communities and their integrity in a stream system following this agricultural-to-urban land use gradient;(2)ways this land use gradient caused aquatic communities to differ from what would be expected for an idealized natural stream or other longitudinal gradients;and(3)whether the impacts of this land use gradient on aquatic communities would grow larger in a downstream direction through the agricultural and urban *** study area was an impaired coldwater stream in Michigan,***:Many factors structured the biological communities along the agricultural-to-urban land use *** woody debris had the strongest relationship with EPT(Ephemeroptera,Plecoptera,and Trichoptera)abundance and richness and were most common in the lower,urbanized *** streambed substrate had the strongest relationship with diptera taxa and surface air breather macroinvertebrates and was dominant in agricultural *** community assemblage was influenced largely by stream flow and temperature regimes,while poor fish community integrity in lower urban reaches could be impacted by geomorphology and episodic urban pollution *** macroinvertebrates were most abundant in deforested,first-order agricultural headwaters,while EPT macroinvertebrate richness was the highest downstream of agricultural areas within the urban zone that had extensive forest ***:Environmental variables and aquatic communities would often not conform with what we would expect from an idealized natural *** richness improved downstream of agricultural *** shows promise for the recovery of aquatic systems using we

关键词： Land use Habitat Stream Fish Macroinvertebrate Gradient

diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 28-40页

作者： daniel T.Payne Mandeep KChahal Vaclav Brezina Whitney A.Webre Katsuhiko Ariga Francis d’Souza Jan Labuta Jonathan P.Hill WPI Center for Materials Nanoarchitectonics National Institute for Materials ScienceIbaraki 305-0044Japan department of Macromolecular Physics Faculty of Mathematics and PhysicsCharles University18000 PragueCzech Republic department of Chemistry University of North TexasDentonTX 76203USA department of Advanced Materials Science Graduate School of Frontier SciencesThe University of TokyoChiba 277-8561Japan

Chiral 1,1’-binaphthyl-linked diporphyrin‘tweezers’(R)-1/(S)-1 and the corresponding zinc(II)complexes(R)-2/(S)-2 were prepared as chiral host molecules,and their utility for chiral analyses(especially enantiomeric excess(ee)determinations)were ***(1-n-dodecyl)porphyrins were used for the first time as the interacting *** capabilities of the diporphyrin tweezers were investigated by titrations with(R,R)-and(S,S)-cyclohexane-1,2-diamine(CHdA).The host molecules could be used as multichannel probes of ee by using UVvis,circular dichroism(Cd),fluorescence emission and 1H nuclear magnetic resonance(1 H-NMR)*** configurations could also be differentiated using Cd or 1HNMR *** three optical techniques give good resolution of ee with reasonable sensitivity considering the low concentrations used(ca.10^-6 mol·L^-1).The ee determination of CHdA enantiomers using NMR spectroscopy is also possible because of the reasonably well separated resonances in the case of(R,R)-and(S,S)-***-metallated(R)-1/(S)-1 hosts could not be used to detect chiral information in a strongly acidic chiral *** work demonstrates the utility of 1,1’-binapthyllinked chiral hosts for chiral analysis of ditopically interacting enantiomers.

关键词： porphyrin dimer chirality enantiomeric excess Cd fluorescence

The effect of wilderness and medical training on injury and altitude preparedness among backcountry hikers in Rocky Mountain National Park

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World Journal of Emergency Medicine 2018年第3期9卷 172-177页

作者： Michael d.T.Yue david W.Spivey daniel B.Gingold douglas G.Sward University of Maryland School of Medicine BaltimoreMarylandUSA department of Emergency Medicine University of Maryland School of MedicineBaltimoreMarylandUSA division of Hyperbaric Medicine Program in TraumaUniversity of Maryland Medical CenterBaltimoreMarylandUSA

BACKGROUNd:The purpose of this study was to document the correlation between medical and wilderness training with levels of preparedness for acute mountain sickness(AMS),illness,and injury among backcountry ***:We conducted a cross-sectional,convenience survey in Rocky Mountain National Park in July and August *** study group consisted of 380 hikers who completed a written survey that collected information about demographics,wilderness experience,altitude experience,hiking equipment,communications devices,and trip ***:Factors such as wilderness training(wilderness first aid[WFA],wilderness first responder[WFR],or wilderness emergency medical technician[WEMT]),wilderness experience,and altitude experience all affected hikers’emergency *** with medical training were more prepared to avoid or respond to AMS(62.3%vs.34.3%[Pd to avoid or manage injury/illness than hikers without medical training(37.7%vs.20.7%[P=0.003]).Participants with wilderness training were more likely to be prepared to avoid or respond to AMS(52.3%vs.36.8%[P=0.025])but not significantly more likely to be prepared to manage illness/injury(31.8%vs.22.0%[Pdjusting for experience,wilderness training,age,and gender,we found that medical training was associated with increased preparedness for AMS(OR2.72;95%CI 1.51–4.91)and injury/illness(OR 2.71;95%CI 1.5–4.89).CONCLUSION:Medically trained hikers were more likely to be prepared to avoid or manage AMS,medical emergencies,and injuries than their non-medically trained *** training increased hikers’preparedness for AMS but did not significantly alter preparedness for illness/injury.

关键词： Hiking wilderness Acute mountain illness Injury Training

The Roper resonance in a finite volume

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Communications in Theoretical Physics 2020年第7期72卷 49-59页

作者： daniel Severt Ulf-G Meiβner Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron PhysicsForschungszentrum JülichD-52425 JiilichGermany Tbilisi State University 0186 TbilisiGeorgia

We calculate the energy levels corresponding to the Roper resonance based on a two-flavor chiral effective Lagrangian for pions,nucleons,deltas,and the Roper resonance at the leading one-loop *** show that the Roper m... 详细信息

关键词： Lattice QCd Roper resonance finite volume methods

Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure

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Hepatobiliary & Pancreatic diseases International 2012年第4期11卷 383-392页

作者： Rishikesh M Kulkarni Louis W Kutcher William d Stuart daniel J Carson Mike A Leonis Susan E Waltz departments of Cancer and Cell Biology University of CincinnatiCincinnatiOH 45267-0521USA Biology University of CincinnatiCincinnatiOH 45267-0521USA division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229USA department of Research Shriner's Hospital for Children and Cincinnati Veterans Affairs Medical CenterCincinnatiOH 45267-0521USA

BACKGROUNd:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in d-galactosamine(GalN)sensitized *** aim of this study was to identify the role of Ron in the regulation of hepatic gene ***:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of *** array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture ***:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and *** hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to ***:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.

关键词： Mst1R suppressors of cytokine signaling Met receptor hepatocyte growth factor-like protein