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Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis

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World Journal of gastroenterology 2006年第15期12卷 2406-2411页

作者： Manuel Romero-gómez María Jover Daniel Díaz-Gómez Laura Collantes de Terán Regina Rodrigo Inés Camacho Miriam Echevarría Vicente Felipo Juan d Bautista Unit for the Clinical Management of digestive diseases Hospital Universitario de Valme SevillaSpain department of Biochemistry Bromatology and Toxicology Faculty of PharmacyUniversity of SevilleSpain Laboratory of Neurobiology Fundación Valenciana de Investigaciones Biomédicas ValenciaSpain Biochemistry Unit Hospital Universitario de Valme SevillaSpain Instituto de Investigaciones Biomédicas departament of Physiology University of SevilleSpain Laboratory of Neurobiology Fundación Valenciana de Investigaciones Biomédicas ValenciaSpain

瞄准：估计在老鼠的门腔静脉吻合(PCA ) 是否在肾影响蛋白质表示或谷酰胺酶的活动，肠并且在外皮的三个大脑区域，基础轧了神经胶质和小脑并且解释在肝的脑病发现的神经病学的改变(他) 。方法：称 250-350 g 的十六只男 Wistar 老鼠被... 详细信息

瞄准：估计在老鼠的门腔静脉吻合(PCA ) 是否在肾影响蛋白质表示或谷酰胺酶的活动，肠并且在外皮的三个大脑区域，基础轧了神经胶质和小脑并且解释在肝的脑病发现的神经病学的改变(他) 。方法：称 250-350 g 的十六只男 Wistar 老鼠被组织进假冒操作的控制(n=8 ) 或 portacaval (n=8 ) 。在过程以后的 28 天，动物被牺牲。十二指肠，肾和大脑被移开， homogenised 和线粒体被孤立。氨在大脑和血被测量。激活磷酸盐的谷酰胺酶(PAg ) 活动被与 O-phthalaldehyde (OPA ) 和每蛋白质(蛋白质的 mukat/g ) 的克以单位表示的特殊活动在 37 摄氏度测量氨生产追随者孵化一个小时决定。蛋白质表示被弄污的免疫测量。结果：十二指肠并且和蛋白质内容的肾 PAg 活动比在 PCA 组是显著地更高的在控制或假冒操作老鼠(十二指肠 PAg 活动是在 PCA 老鼠对在假冒操作老鼠的蛋白质的 429.19+/-126.92mukat/g 的蛋白质的 976.95+/-268.87 mukat/g；肾 PAg 活动是在 PCA 老鼠对在控制的蛋白质的 669.67+/-400.8 mukat/g 的 1259.18+/-228.79 mukat/g 蛋白质， Pg 活动和蛋白质表示在外皮是更高的并且基础在假冒操作老鼠比那些轧了神经胶质(外皮：蛋白质的 6646.6+/-1870.4 mukat/g 对在控制老鼠的蛋白质的 3573.8+/-2037.4 mukat/g， Pg 活动是在 PCA 老鼠对在假冒的操作老鼠的蛋白质的 2271.2+/-384 mukat/g 的蛋白质的 3657.3+/-1469.6 mukat/g， Pg 活动是蛋白质的 2471.6+/-701.4 mukat/g 对在 PCA 和假冒的老鼠的蛋白质的 1452.9+/-567.8 mukat/g Pg 活动能在 PCA 老鼠显著地作出贡献到 hyperammonaemia，脑病的动物模型。PAg 从外皮在 non-synaptic 线粒体被增加并且基础轧了神经胶质并且能在肝的脑病的致病被含有。因此， PAg 能是为处理的一个可能的目标他或肝机能障碍。

关键词：磷酸谷氨酰胺酶酶活性脑疾病门腔静脉吻合术

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Functional responses of cougars(Puma concolor)in a multiple prey-species system

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Integrative Zoology 2018年第1期13卷 84-93页

作者： Leroy SORIA-dÍaz Mike SFOWLER Octavio MONROY-VILCHIS daniel ORO Institute of Applied Ecology Autonomous University of TamaulipasVictoria city TamaulipasMexico department of Biosciences Swansea UniversitySwanseaUK Center for Research in Applied Biological Sciences Autonomous University of the State of MexicoCentro TolucaMexico Population Ecology group Mediterranean Institute for Advanced Studies IMEDEA(CSIC-UIB)EsporlesMallorcaSpain

The study of predator-prey interactions is commonly analyzed using functional responses to gain an understanding of predation patterns and the impact they have on prey populations.despite this,little is known about predator-prey systems with multiple prey species in sites near the equator.Here we studied the functional response of cougars(Puma concolor)in relation to their main prey,armadillo(dasypus novemcinctus),coati(Nasua narica)and white-tailed deer(Odocoileus virginianus).Between 2004 and 2010,cougar scats were collected along 5 transects to estimate the consumption of different prey species.A relative abundance index(RAI)was calculated for each prey species and cougar using 18 camera traps.We compared Holling type I,II and III functional response models to determine patterns in prey consumption based on the relative abundance and biomass of each prey species consumed.The 3 main prey species comprised 55%(armadillo),17%(coati)and 8%(white-tailed deer)of the diet.Type I and II functional responses described consumption of the 2 most common prey species armadillos and coati similarly well,while a type I response best characterized consumption of white-tailed deer.A negative correlation between the proportions of armadillo versus coati and white-tailed deer biomass in cougar scats suggests switching to consume alternative prey,confirming high foraging plasticity of this carnivore.This work represents one of the few studies to compare functional responses across multiple prey species,combined with evidence for prey-switching at low densities of preferred prey.

关键词： cougar functional responses Holling model comparison multiple prey

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Sampling lattices in semi-grand canonical ensemble with autoregressive machine learning

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npj Computational Materials 2022年第1期8卷 588-597页

作者： James damewood daniel Schwalbe-Koda Rafael gómez-Bombarelli department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02319USA

Calculating thermodynamic potentials and observables efficiently and accurately is key for the application of statistical mechanics simulations to materials science.However,naive Monte Carlo approaches,on which such calculations are often dependent,struggle to scale to complex materials in many state-of-the-art disciplines such as the design of high entropy alloys or multi-component catalysts.To address this issue,we adapt sampling tools built upon machine learning-based generative modeling to the materials space by transforming them into the semi-grand canonical ensemble.Furthermore,we show that the resulting models are transferable across wide ranges of thermodynamic conditions and can be implemented with any internal energy model U,allowing integration into many existing materials workflows.We demonstrate the applicability of this approach to the simulation of benchmark systems (AgPd,CuAu) that exhibit diverse thermodynamic behavior in their phase diagrams.Finally,we discuss remaining challenges in model development and promising research directions for future improvements.

关键词： canonical thermodynamic directions

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Predicting intensive care unit-acquired weakness:A multilayer perceptron neural network approach

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World Journal of Clinical Cases 2024年第12期12卷 2023-2030页

作者： Carlos Martin Ardila daniel gonzález-Arroyave Mateo Zuluaga-gómez department of Basic Sciences University of AntioquiaMedellín 52-59Colombia department of Surgery Pontificia Universidad BolivarianaMedellín 0057Colombia department of Emergency Universidad Pontificia BolivarianaMedellín 0057Colombia

In this editorial,we comment on the article by Wang and Long,published in a recent issue of the World Journal of Clinical Cases.The article addresses the challenge of predicting intensive care unit-acquired weakness(ICUAW),a neuromuscular disorder affecting critically ill patients,by employing a novel processing strategy based on repeated machine learning.The editorial presents a dataset comprising clinical,demographic,and laboratory variables from intensive care unit(ICU)patients and employs a multilayer perceptron neural network model to predict ICUAW.The authors also performed a feature importance analysis to identify the most relevant risk factors for ICUAW.This editorial contributes to the growing body of literature on predictive modeling in critical care,offering insights into the potential of machine learning approaches to improve patient outcomes and guide clinical decision-making in the ICU setting.

关键词： Intensive care units Intensive care unit-acquired weakness Risk factors Machine learning Computer neural network

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以金属氧化物为原料改进燃烧法合成γ-LiAlO_2（英文）

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Transactions of Nonferrous Metals Society of China 2018年第9期28卷 1793-1800页

作者： daniel CRUZ H.B.ORTIZ-OLIVEROS L.M.PéREZ-díaz R.M.FLORES-ESPINOSA g.ROSANO-ORTEgA Facultad de Ingeniería Química Benemérita Universidad Autónoma de Puebla14 Sur y San ClaudioCiudad UniversitariaC.P.72570Cd.PueblaMéxico Instituto Nacional de Investigaciones Nucleares Dirección de Investigación TecnológicaApartado Postal 18-102711801 MéxicoDFMéxico Universidad Popular Autónoma del Estado de Puebla 21 Sur no.1103Colonia SantiagoC.P.72410PueblaMéxico

提出一种合成γ-LiAlO_2的替代解决方案—改进燃烧法直接合成γ-LiAlO_2,并将其用于相对简单的反应体系中,原料为非氧化性化合物如Al_2O_3和LiOH,燃料为尿素。采用1:1、1.5:1和2:1的非化学计量Li/Al摩尔比,在900和1000°C下反应5 min,制... 详细信息

提出一种合成γ-LiAlO_2的替代解决方案—改进燃烧法直接合成γ-LiAlO_2,并将其用于相对简单的反应体系中,原料为非氧化性化合物如Al_2O_3和LiOH,燃料为尿素。采用1:1、1.5:1和2:1的非化学计量Li/Al摩尔比,在900和1000°C下反应5 min,制备LiAlO_2,并对其组织和结构进行表征。考察Li/Al摩尔比对材料形貌和高γ射线辐照下材料稳定性的影响。结果表明,所得粉体的晶体结构为?-LiAlO_2和?-LiAlO_2,其取决于Li/Al摩尔比。因此,用该方法可以成功合成微砖状、多面体状和层状?-LiAlO_2,而无需任何后续处理。γ辐照结果表明,所得到的?-LiAlO_2不分解,只形成少量的Li_2CO_3;由此可以确定,辐照会导致固结,不利于氚的有效提取;结果证明,用燃烧法生产高纯度?-LiAlO_2不需要硝酸盐前驱体。

关键词：尿素氧化物燃烧铝酸锂陶瓷

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Learning Matter:Materials design with Machine Learning andAtomistic Simulations

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Accounts of Materials Research 2022年第3期3卷 343-357页

作者： Simon Axelrod daniel Schwalbe-Koda Somesh Mohapatra James damewood Kevin P.greenman Rafael gómez-Bombarelli department of Chemistry and Chemical Biology Harvard UniversityCambridgeMassachusetts 02138United States department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

CONSPECTUS:designing new materials is vital for addressing pressing societal challenges in health,energy,and sustainability.The combination of physicochemical laws and empirical trial and error has long guided material design,but this approach is limited by the cost of experiments and the difficulty of deriving complex guiding principles.The space of hypothetical materials to be considered is incredibly large,and only a small fraction of possible compounds can ever be tested experimentally.The computational techniques of atomistic simulation and machine learning(ML)offer an avenue to rapidly invent new materials and navigate this enormous space.Together,they can be used to infer complex design principles and identify high-quality candidates more rapidly than trial-and-error experimentation.In this Account,we review our group’s recent contributions to simulation and ML for materials design.We begin by discussing the numerical representation of materials for use in ML.Representations can be produced through deterministic algorithms,learnable encodings,or physics-based methods and lead to vector,graph,and matrix outputs.We describe how these different approaches offer distinct material-and application-specific advantages.We provide demonstrations from our own work on small-molecule drugs,macromolecules,dyes,electrolytes,and zeolites.In several cases,we show how the appropriate representation led to guiding principles that facilitated experimental materials design.Next,we highlight the development of ML methods for enhancing atomistic simulation.These advances help to improve simulation accuracy and expand the time and length scales that can be explored.They include differentiable atomistic simulations in which ensemble-averaged quantities are differentiated with respect to system parameters,and novel autoregressive methods for enhanced sampling of challenging physical distributions.Other developments include learnable coarse-grained models,which can accelerate molecular dynamics while minimizing the loss of all-atom

关键词： zeolite differentiable latter

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Anchoring of 10-phenylphenothiazine to mesoporous silica materials:A water compatible organic photocatalyst for the degradation of pollutants

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Journal of Materials Science & Technology 2022年第8期103卷 134-143页

作者： daniel gonzález-Muñoz Almudena gómez-Avilés Carmen B.Molina Jorge Bedia Carolina Belver Jose Alemán Silvia Cabrera Organic Chemistry department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Chemical Engineering department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autónoma de Madrid28049 MadridSpain Inorganic Chemistry department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain

The application of organic photocatalysts towards the oxidation of pollutants in water is hampered by different limitations such as their insolubility in the media.Herein,we report that the grafting of a photoorganocatalyst into mesoporous silica materials is an ideal approach to obtain effective catalysts.Thereby,the photocatalyst 10-phenylphenothiazine(PTH)was easily anchored into three different mesoporous silica-based materials(MSN,MSU-2 and SBA-15)with different particle sizes and pore sizes through an amide bond formation.The materials were characterized using IR analysis,solid-state X-ray diffraction,porosity and microscopy(SEM and TEM)techniques,showing that PTH is immobilized inside the pores of the materials and its optical properties are maintained after the anchoring.Although homogeneous PTH was inactive in water media,the three photocatalytic materials were active for the degradation of pollutants.SBA-15-AP-PTH exhibited the highest catalytic performance towards the degradation of acetaminophen and diclofenac under solar irradiation,finding in this manner a new strategy for the decontamination of pollutants.

关键词： Organic semiconductors Silica support Solar photocatalysis Water treatment Pharmaceuticals

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橄榄林中的乡村酒店

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现代装饰 2021年第4期 138-145页

作者： Antonio José galisteo Espartero álvaro Fernández Navarro Francisco Jesús Camacho gómez david Melero Herrera.Arquitecto Fausto Santarosa.Arquitecto Juan Francisco Mata díaz.Ingeniero ángel gabriel Pacheco Rodado.Ingeniero daniel Montoya López.Aparejador Francisco Torreblanca Herrero 郭映琴

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特...

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特的自然环境致以最真诚的敬意,四周的美景令人印象深刻。设计的关键在于使室内外空间相互渗透,不破坏原有建筑的特质。城市规划发展组织将与酒店相连的另一栋用于农业开发的仓库一并纳入了该项目,复杂的行政程序使得这两栋建筑只能进行简单的改造,而该项目的翻新和扩建的设计方案有效地满足了此需求。

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Usefulness of Impella support in different clinical settings in cardiogenic shock

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Journal of geriatric Cardiology 2022年第2期19卷 115-124页

作者： María Isabel Barrionuevo-Sánchez Albert Ariza-Solé daniel Ortiz-Berbel Joségonzález-Costello Joan Antoni gómez-Hospital Victòria Lorente Oriol Alegre Isaac Llaó JoséCarlos Sánchez-Salado Josep gómez-Lara Arnau Blasco-Lucas Josep Comin-Colet Cardiology department Intensive Cardiac Care UnitBellvitge University HospitalL’Hospitalet de LlobregatBarcelonaSpain Cardiac Surgery department Heart Disease InstituteBellvitge University HospitalL’Hospitalet de LlobregatBarcelonaSpain

BACKgROUNd The Impella pump has emerged as a promising tool in patients with cardiogenic shock(CS).despite its attractive properties,there are scarce data on the specific clinical setting and the potential role of Impella devices in CS patients from routine clinical practice.METHOdS This is an observational,retrospective,single center,cohort study.All consecutive patients with diagnosis of CS and undergoing support with Impella 2.5?,Impella CP?or Impella 5.0?from April 2015 to december 2020 were included.Baseline characteristics,management and outcomes were assessed according to CS severity,age and cause of CS.Main outcome measured was in-hospital mortality.RESULTS A total of 50 patients were included(median age:59.3±10 years).The most common cause of CS was acute coronary syndrome(ACS)(68%),followed by decompensation of previous cardiomyopathy(22%).A total of 13 patients(26%)had profound CS.Most patients(54%)improved pulmonary congestion at 48 h after Impella support.A total of 19 patients(38%)presented significant bleeding.In-hospital mortality was 42%.Among patients with profound CS(n=13),five patients were previously supported with venoarterial extracorporeal membrane oxygenation.A total of eight patients(61.5%)died during the admission,and no patient achieved ventricular recovery.Older patients(≥67 years,n=10)had more comorbidities and the highest mortality(70%).Among patients with ACS(n=34),35.3%of patients had profound CS;and in most cases(52.9%),Impella support was performed as a bridge to recovery.In contrast,only one patient from the decompensated cardiomyopathy group(n=11)presented with profound CS.In 90.9%of these cases,Impella support was used as a bridge to cardiac transplantation.There were no cases of death.CONCLUSIONS In this cohort of real-life CS patients,Impella devices were used in different settings,with different clinical profiles and management.despite a significant rate of complications,mortality was acceptable and lower than those observed in other series.

关键词： Impella clinical routine

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Low-power SiPM readout BETA ASIC for space applications

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Nuclear Science and Techniques 2024年第3期35卷 153-169页

作者： Anand Sanmukh Sergio gómez Albert Comerma Joan Mauricio Rafel Manera Andreu Sanuy daniel guberman Roger Catala Albert Espinya Marina Orta Oscar de la Torre david gascon departament de Física Quàntica i Astrofísica(FQA) Institut de Ciències del Cosmos(ICCUB)Universitat de Barcelona(UB)08028 BarcelonaSpain Institut d’Estudis Espacials de Catalunya(IEEC) 08034 BarcelonaSpain Electronics department Serra Hunter fellow at Polytechnic University of Catalonia(UPC)08019 BarcelonaSpain

The BETA application-specific integrated circuit(ASIC)is a fully programmable chip designed to amplify,shape and digitize the signal of up to 64 Silicon photomultiplier(SiPM)channels,with a power consumption of approximately~1 mW/channel.Owing to its dual-path gain,the BETA chip is capable of resolving single photoelectrons(phes)with a signal-to-noise ratio(SNR)>5 while simultaneously achieving a dynamic range of~4000 phes.Thus,BETA can provide a cost-effective solution for the readout of SiPMs in space missions and other applications with a maximum rate below 10 kHz.In this study,we describe the key characteristics of the BETA ASIC and present an evaluation of the performance of its 16-channel version,which is implemented using 130 nm technology.The ASIC also contains two discriminators that can provide trigger signals with a time jitter down to 400 ps FWHM for 10 phes.The linearity error of the charge gain measurement was less than 2%for a dynamic range as large as 15 bits.

关键词： Radiation detectors Silicon photomultipliers Photon sensors Front-end electronics Mixed-mode ASICs Space technology

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