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Frontiers of Environmental Science & Engineering 2020年第5期14卷 55-63页

作者： chao Pan daniel Giammar Department of Energy Environmentaland Chemical EngineeringWashington University in St.LouisSt.LouisMO 63130USA Present affiliation:Glenn *** Institute Physical&Life SciencesLawrence Livermore National LaboratoryLivermoreCA 94550USA

Hexavalent chromium(cr(Ⅵ))is a water-soluble pollutant in soil and groundwater,the mobility,bioavailability,and toxicity of which can be controlled by transforming to less mobile and more environmentally benign cr(Ⅲ)by ways of *** review focused on recent advances in identifying the reaction pathways,kinetics,and products of iron-based techniques for cr(Ⅵ)*** also examines new information regarding remobilization of cr(Ⅲ)in the existence of complexing ligands and manganese(Mn)of different oxidation states.A range of iron-based techniques can remove cr(Ⅵ)from water by adsorption or reduction-coprecipitation ***,the success of a chromium treatment or remediation strategy requires the stability of the cr(Ⅲ)-containing solids with respect to solubilization or reoxidation in the settings they are *** is ubiquitous in aquatic and terrestrial environments,and the redox cycling of manganese may greatly influence the fate,transport,and distribution of *** of redox reactions of chromium,iron,and manganese involves reaction pathways not only in the aqueous phase but also at solid-aqueous *** provide a quantitative understanding of these processes,it is essential to develop mechanistically based kinetic and transport *** research should be made on iron-based treatment of cr(Ⅵ)-contaminated water and soils and the stability of the subsequently produced cr(Ⅲ)-containing solids at environmentally relevant conditions,which will support improved predictions of chromium's environmental fate and transport and aid in decision-making for remediation and treatment of cr contamination.

关键词： chromium(Ⅵ)contamination Redox reaction Iron oxide Manganese oxide Modeling

A Training and Pruning Algorithm for wavelet Neural Networks

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A Training and Pruning Algorithm for Wavelet Neural Networks

Stabilization of complex Dynamical Networks by H∞ control

第十九届中国控制会议

作者： daniel w．c．Ho Department of Mathematics City University of Hong Kong.

＜正＞In the first part of this paper, a wavelet-based neural network （wNN） is described for approximating arbitrary nonlinear functions. In the second part of this paper, a training and pruning algorithm is proposed for training and determining the size of the wNN. The wNN is applied to system identification in simulation and the effectiveness of the proposed wNN and the training and pruning algorithm is demonstrated.

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Stabilization of Complex Dynamical Networks by H∞ Control

Neuronal circuitry reconstruction after stem cell therapy in damaged brain

第二十七届中国控制会议

作者： Ho daniel w.c. Department of Mathematics City University of Hong Kong

The problem of H control is considered in this paper for the stabilization of complex dynamical network subject to noise *** proposed dynamical network model includes both intrinsic disturbance of single node and communication noise over the network *** controller is constructed for the exponential stabilization of dynamical network,and certain prescribed H performance constraint is *** reason why only one controller is valid for H stabilization of dynamical network is the full utilization of network’s local *** important feature of this paper is the introduction of the H performance concept into the complex dynamical *** derived criteria are expressed in terms of linear matrix inequalities(LMIs),which can be easily verified by resorting to recently developed *** example is given to illustrate the effectiveness of the derived results.

关键词： H∞ control complex dynamical network Intrinsic disturbance communication noise

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Neural Regeneration Research 2022年第9期17卷 1959-1960页

作者： daniel Tornero Department of Biomedical Sciences Institute of Neuroscience and Production and Validation Center of Advanced Therapies(Creatio)University of Barcelona August Pi I Sunyer Biomedical Research Institute(IDIBAPS) Network center for Biomedical Research in Neurodegenerative Diseases(cIBERNED) BarcelonaSpain

Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brain trauma and *** functional integration of grafted neurons differentiated from stem cells into the host injured neuronal circuitry has been a major challenge in cell therapy strategies for brain repair(Palma-Tortosa et al.,2021).Even though other cell types or mechanisms may provide modest clinical improvements,neuronal replacement and reconstruction of the damaged area are crucial for an optimal and long-term recovery.

关键词： diseases damaged

The covalent Binding of Genistein to the Non-prosthetic-heme-moiety of Bovine Lactoperoxidase Leads to Enzymatic Inactivation

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Biomedical and Environmental Sciences 2011年第3期24卷 284-290页

作者： Hebron c. cHANG daniel R. DOERGE chengHong HSIEH LIN YingJu FuuJen TSAI Department of Biotechnology Asia University Taichung 41354 Taiwan China Division of Biochemical Toxieology National center for Toxicological Research FDA Jeffkrson AR 72079 USA Department of Health and Nutritional Biotechnology Asia University Taichung 41354 Taiwan China Genetic center china Medical University Taichung 40402 Taiwan China

Objective Genistein, a major soy isoflavone metabolite （SIF）, inactivates oxidation activity of bovine lactoperoxidase （LPO）. Modification of the heme moiety of LPO by nitrogen-containing compounds has been shown to inactivate LPO. In contrast, SIF mediated inactivation of LPO does not involve a heme modification and the mechanism of SIF inhibition is poorly understood. Methods After inactivation of LPO by genistein in the presence of H202, trypsin-digested LPO peptide fragments were collected and analyzed by MALDI-TOF-MS to characterize the chemical binding of genistein（s） to LPO. Results The heme moiety of LPO was not modified by genistein. A covalent binding study showed that 3H-genistein bound to LPO with a ratio of ~12 to 1. After HPLc analysis and peak collection, trypsin-digested peptide fragments were analyzed by MALDI-TOF-MS. The 3H-genistein co-eluted peptide fragments （RT=24 min） were putatively identified as 1991VGYLDEEGVLDQNR214 with two bound genistein molecules or a genistein dimer （2 259 Da）, 486TPDNIDIwlGGNAEPMVER504 with two bound genistein molecules or a genistein dimer （2 663 Da）, and 161ARwLPAEYEDGLALPFGwTQR182 with three bound genistein molecules or a genistein trimer （3 060 Da）. The fragment with a mass of 2 792 Da （RT=36 min） was identified as 132cDENSPYR139 with three genistein molecules or a genistein trimer. conclusions The results suggest that LPO was inactivated by irreversible covalent binding of genistein or genistein polymers to particular peptide fragments constituting regions of the outward domain. No genistein interaction with the prosthetic heme moiety of LPO was observed.

关键词： Lactoperoxidase Genistein Modification of heme covalent binding Peptide fragments

Expansion of Small Terrestrial Mammals and Their Parasites into the Barun Valley (Makalu Mt. Region, Nepal Himalaya) Linked with changes in Glaciation and Human Activities

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Journal of Mountain Science 2015年第1期12卷 14-29页

作者： Milan daniel National Institute of Public Health ?robárova 48 100 42 Prague 10 Czech Republic

The article is based on collection of small terrestrial mammals(Soriculus nigrescens,Episoriculus caudatus, Neodon sikimensis,Alticola stoliczkanus, Niviventer eha and Ochotona roylei) collected in the Barun Valley, east Nepal in the pre-monsoon period of *** and ecological characteristics and altitudinal stratification of these species are analysed, depending both on abiotic(geomorphological and climatic) and biotic(vegetation, and human presence and activities)factors. All the captured mammals were examined for ecto- and endoparasities. Infestations of Trombiculid mites and Ixodid ticks were tightly linked to the local habitat where these ectoparasites must survive during their nonparasitic phase. Analysis of their occurrence completes the reconstruction of migration routes during the expansion of small mammals into the Barun Valley and the exacerbating influence of human activities(summer pasturing,mountaineering expeditions and trekking parties).An indicator of anthropogenic influence was the occurrence of synantropic flies. The potential medical importance of these findings is *** is assumed a possible occurrence of arboviruses transmitted by ticks and also rickettsioses(transmitted by ticks and chigger mites). As far bacteriological infections, plague cannot be excluded.

关键词： Himalaya Barun Makalu region Small mammal Parasite Ecology Medicalimportance

Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser

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Light(Science & Applications) 2017年第1期6卷 400-407页

作者： Evan P Perillo Jeremy w Jarrett Yen-Liang Liu Ahmed Hassan daniel c Fernée John R Goldak Andrei Bonteanu David J Spence Hsin-chih Yeh Andrew K Dunn Department of Biomedical Engineering The University of Texas at AustinTX 78712USA Department of Physics The University of Texas at AustinTX 78712USA MQ Photonics Department of Physics and AstronomyMacquarie UniversitySydneyNSW 2109Australia

Two-color multiphoton microscopy through wavelength mixing of synchronized lasers has been shown to increase the spectral window of excitable fluorophores without the need for wavelength ***,most currently available dual output laser sources rely on the costly and complicated optical parametric generation *** this report,we detail a relatively simple and low cost diamond Raman laser pumped by a ytterbium fiber amplifier emitting at 1055 nm,which generates a first Stokes emission centered at 1240 nm with a pulse width of 100 *** two excitation wavelengths of 1055 and 1240 nm,along with the effective two-color excitation wavelength of 1140 nm,provide an almost complete coverage of fluorophores excitable within the range of 1000–1300 *** compared with 1055 nm excitation,two-color excitation at 1140 nm offers a 90%increase in signal for many far-red emitting fluorescent proteins(for example,tdKatushka2).we demonstrate multicolor imaging of tdKatushka2 and Hoechst 33342 via simultaneous two-color two-photon,and two-color three-photon microscopy in engineered 3D multicellular *** further discuss potential benefits and applications for two-color three-photon *** addition,we show that this laser system is capable of in vivo imaging in mouse cortex to nearly 1 mm in depth with two-color excitation.

关键词： microscopy nonlinear processes three-dimensional imaging ultrafast lasers

Determining minimum sample size for the conditioned Latin hypercube sampling algorithm

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Pedosphere 2024年第3期34卷 530-539页

作者： daniel D.SAURETTE Asim BISwAS Richard J.HEcK Adam w.GILLESPIE Aaron A.BERG School of Environmental Sciences University of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada) Ontario Ministry of Agriculture Food and Rural Affairs1 Stone Rd WestGuelph ON N1G 2Y4(Canada) Geography Environment&GeomaticsUniversity of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada)

In digital soil mapping(DSM),a fundamental assumption is that the spatial variability of the target variable can be explained by the predictors or environmental *** to adequately sample the predictors have been well documented,with the conditioned Latin hypercube sampling(cLHS)algorithm receiving the most attention in the DSM *** advances in sampling design,a critical gap remains in determining the number of samples required for DSM *** propose a simple workflow and function coded in R language to determine the minimum sample size for the cLHS algorithm based on histograms of the predictor variables using the Freedman-Diaconis rule for determining optimal bin *** preprocessing was included to correct for multimodal and non-normally distributed data,as these can affect sample size determination from the *** on a user-selected quantile range(QR)for the sample plan,the densities of the histogram bins at the upper and lower bounds of the QR were used as a scaling factor to determine minimum sample *** technique was applied to a field-scale set of environmental covariates for a well-sampled agricultural study site near Guelph,Ontario,canada,and tested across a range of *** results showed increasing minimum sample size with an increase in the QR *** sample size increased from 44 to 83 when the QR increased from 50% to 95% and then increased exponentially to 194 for the 99%*** technique provides an estimate of minimum sample size that can be used as an input to the cLHS algorithm.

关键词： bin width digital soil mapping normal distribution quantile range sampling design

nhe regulation and deregulation of wnt signaling by PARK genes in health and disease

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Journal of Molecular cell Biology 2014年第1期8卷 3-12页

作者： daniel c. Berwick Kirsten Harvey Department of Pharmacology UCL School of Pharmacy University College London 29-39 Brunswick Square London WCIN lAX UK

wingless/Int （wnt） signaling pathways are signal transduction mechanisms that have been widely studied In the field of embryogen- esis. Recent work has established a critical role for these pathways in brain development, especially of midbrain dopaminergic neu- rones, However, the fundamental importance of wnt signaling for the normal function of mature neurones in the adult central nervous system has also lately been demonstrated by an increasing number of studies. Parkinson＇s disease （PD） is the second most prevalent neurodegenerative disease worldwide and is currently incurable. This debilitating disease is characterized by the progres- sive loss of a subset of midbrain dopaminergic neurones in the substontla nigm leadingto typical extrapyramidal motor symptoms. The aetiology of PD is poorly understood but work performed over the Last two decades has identified a growing number of genetic defects that underlie this condition. Herewe review a growing body of data connecting genes implicated in PD--most notablythe PARKgenes-- with wnt signaling. These observations provide clues to the normal function of these proteins in healthy neurones and suggest that deregulated wnt signaling might be a frequent pathomechanlsm leading to PD. These observations have implications for the patho- genesis and treatment of neurodegenerative diseases in general.

关键词： wnt signaling neurodegeneration Parkinson's disease genetics of Parkinson's disease LRRK2 treatment