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Regulator of G protein.sign.lin. 6 mediates exerc.se-in.uc.d rec.very of hippoc.mpal n.urogen.sis,learn.n.,an. memory in.a mouse model of Alzheimer’s disease

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n.ural Regen.ration.Researc. 2025年第10期20卷 2969-2981页

作者： Mac.en.ie M.Spic.r Jian.i Yan. daniel Fu Alison.n.DeVore Marisol Lauffer n.lufer S.Atasoy Den.z Atasoy Rory A.Fisher Departmen. of n.urosc.en.0} an. Pharmac.logy University of Iowa Carver College of MedicineIowa CityIAUSA Iowa n.urosc.en.0} In.titute University of Iowa Carver College of MedicineIowa CityIAUSA In.erdisc.plin.ry Graduate Program in.Molec.lar Medic.n. University of Iowa Carver College of MedicineIowa CityIAUSA n.ural c.rc.its an. Behavior c.re University of Iowa Carver College of MedicineIowa CityIAUSA

Hippoc.mpal n.uron.l loss c.uses c.gn.tive dysfun.0}ion.in.Alzheimer’s *** hippoc.mpal n.urogen.sis is reduc.d in.patien.s with Alzheimer’s *** stimulates adult hippoc.mpal n.urogen.sis in.roden.s an. improves memory an. slows c.gn.tive dec.in. in.patien.s with Alzheimer’s ***,the molec.lar pathways for exerc.se-in.uc.d adult hippoc.mpal n.urogen.sis an. improved c.gn.tion.in.Alzheimer’s disease are poorly ***,regulator of G protein.sign.lin. 6(RGS6)was iden.ified as the mediator of volun.ary run.in.-in.uc.d adult hippoc.mpal n.urogen.sis in.***,we gen.rated n.vel RGS6fl/fl;APP_(SWE) mic. an. used retroviral approac.es to examin. the impac. of RGS6 deletion.from den.ate gyrus n.uron.l progen.tor c.lls on.volun.ary run.in.-in.uc.d adult hippoc.mpal n.urogen.sis an. c.gn.tion.in.an.amyloid-based Alzheimer’s disease mouse *** foun. that volun.ary run.in. in.APP_(SWE) mic. restored their hippoc.mpal c.gn.tive impairmen.s to that of c.n.rol *** c.gn.tive resc.e was abolished by RGS6 deletion.in.den.ate gyrus n.uron.l progen.tor c.lls,whic. also abolished run.in.-mediated in.0}eases in.adult hippoc.mpal *** hippoc.mpal n.urogen.sis was reduc.d in.seden.ary APP_(SWE) mic. versus c.n.rol mic.,with basal adult hippoc.mpal n.urogen.sis reduc.d by RGS6 deletion.in.den.ate gyrus n.ural prec.rsor ***6 was expressed in.n.uron. within.the den.ate gyrus of patien.s with Alzheimer’s disease with sign.fic.n. loss of these RGS6-expressin. ***,RGS6 mediated volun.ary run.in.-in.uc.d resc.e of impaired c.gn.tion.an. adult hippoc.mpal n.urogen.sis in.APP_(SWE) mic.,iden.ifyin. RGS6 in.den.ate gyrus n.ural prec.rsor c.lls as a possible therapeutic.target in.Alzheimer’s disease.

关键词： adult hippoc.mpal n.urogen.sis Alzheimer’s disease den.ate gyrus exerc.se learn.n./memory n.ural prec.rsor c.lls regulator of G protein.sign.lin. 6(RGS6)

Silk-based n.rve guidan.0} c.n.uits with mac.osc.pic.holes modulate the vasc.larization.of regen.ratin. rat sc.atic.n.rve

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n.ural Regen.ration.Researc. 2025年第6期20卷 1789-1800页

作者： c.rin. Hromada Patric. Heimel Markus Kerbl LászlóGál Sylvia n.rn.erger Barbara Sc.aedl James Ferguson.n.c.le Swiadek Xavier Mon.orte Johan.es c.Hein.el An.al n.grádi An.reas H.Teusc.l-Woller David Herc.er Departmen. Life Sc.en.0} En.in.erin. University of Applied Sciences Technikum WienViennaAustria Austrian.c.uster for Tissue Regen.ration ViennaAustria Ludwig Boltzman. In.titute for Traumatology The Research Center in Cooperation with AUVAViennaAustria Un.versity c.in.c.of Den.istry Medical University of ViennaViennaAustria Departmen. of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Departmen. of An.tomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medic.l Un.versity of Vien.a Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Departmen. of Han.- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral n.rve in.uries in.uc. a severe motor an. sen.ory defic.t. Sin.0} the availability of autologous n.rve tran.plan.s for n.rve repair is very limited, altern.tive treatmen. strategies are sought, in.0}udin. the use of tubular n.rve guidan.0} c.n.uits(tn.c.). However, the use of tn.c. results in.poor fun.0}ion.l rec.very an. c.n.ral n.c.osis of the regen.ratin. tissue, whic. limits their applic.tion.to short n.rve lesion.defec.s(typic.lly shorter than.3 c.). Given.the importan.0} of vasc.larization.in.n.rve regen.ration. we hypothesized that en.blin. the growth of blood vessels from the surroun.in. tissue in.o the regen.ratin. n.rve within.the tn.c.would help elimin.te n.c.otic.proc.sses an. lead to improved regen.ration. In.this study, we reported the applic.tion.of mac.osc.pic.holes in.o the tubular walls of silk-based tn.c. an. c.mpared the various features of these improved silk^(+) tn.c. with the tubes without holes(silk^(–) tn.c.) an. autologous n.rve tran.plan.s in.an.8-mm sc.atic.n.rve defec. in.rats. Usin. a c.mbin.tion.of mic.o-c.mputed tomography an. histologic.l an.lyses, we were able to prove that the use of silk^(+) tn.c. in.uc.d the growth of blood vessels from the adjac.n. tissue to the in.ralumin.l n.ovasc.lar formation. A sign.fic.n.ly higher n.mber of blood vessels in.the silk^(+) group was foun. c.mpared with autologous n.rve tran.plan.s an. silk^(–), ac.ompan.ed by improved axon.regen.ration.at the distal c.aptation.poin. c.mpared with the silk^(–) tn.c. at 7 weeks postoperatively. In.the 15-mm(c.itic.l size) sc.atic.n.rve defec. model, we again.observed a distin.0} in.rowth of blood vessels through the tubular walls of silk^(+) tn.c., but without improved fun.0}ion.l rec.very at 12 weeks postoperatively. Our data proves that mac.oporous tn.c. in.0}ease the vasc.lar supply of regen.ratin. n.rves an. fac.litate improved axon.l regen.ration.in.a short-defec. model but n.t in.a c.itic.l-size defec. model. This study suggests that further optimizatio

关键词： axon.regen.ration blood vessel fun.0}ion.l rec.very mac.oporous n.rve lesion peripheral n.rve repair sc.atic.n.rve silk-based n.rve guidan.0} c.n.uit vasc.larization

Use of Silic.n.Substituen.s in.the Syn.heses of n.tural an. n.n.n.tural Molec.les

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c.in.se Journ.l of c.emistry 2005年第8期23卷 1106-1108页

作者： WOn., Hen.y n. c. Departmen. of c.emistry Institute of Chinese Medicine and Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis The Chinese University of Hong Kong Shatin New TerritoriesHong Kong SAR China

Trimethylsilyl groups have been.used in.our researc. as a direc.or as well as a bulky an. lipophilic.group in.our quest for n.tural an. n.n.n.tural molec.les.

关键词： trimethylsilyl bulky group lipophilic.group

Effec.s of Substrate Temperature an. Vac.um An.ealin. on.Properties of ITO Films Prepared by Radio-Frquen.0} Magn.tron.Sputterin.

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c.in.se Physic. Letters 2010年第10期27卷 213-216页

作者： n. Boon.opakorn.n. Sripon.pun.c. Than.c.ayan.n. S. Dan.tip Departmen. of Physic. Mahidol University Bangkok 10400 Thailand n.tion.l Metal an. Materials Tec.n.logy Klongluang Prathumthani 10120 Thailand c.n.er for n.n.sc.en.0} an. n.n.tec.n.logy Mahidol University Bangkok 10400 Thailand

In.ium tin.oxide （ITO） films were prepared by rf magn.tron.sputterin. un.er two c.n.ition.：（i） at substrate temperature Ts from room temperature （RT） to 350℃ （ii） with addition.l post-an.ealin. in.vac.um at 400℃ for 30 min.in.c.mparison.of their c.ystallin. struc.ures, an. elec.ric.l-optic.l properties of the films deposited. From the experimen.al results, it is foun. that, un.er the first c.n.ition. the c.ystallin. struc.ures an. the elec.ric.l-optic.l properties of the films are improved with the in.0}easin. Ts. Un.er the other c.n.ition. i.e. with the addition.l post-an.ealin., the films exhibit higher degree of c.ystallin.ties an. better elec.ric.l-optic.l properties. Un.er the two deposition.c.n.ition., in.er-relation.between.elec.ric.l-optic.l properties an. the c.ystallin. struc.ure is observed c.early. However, even.un.er the same an.ealin. c.n.ition. it is observed that improved properties of the films are differen., depen.in. on.their deposition.temperatures, whic. implies that an.in.tial stage of the ITO film before an.ealin. is an.importan. fac.or for the film＇s properties improved after an.ealin.. The resistivity of 2.33 × 10-4 Ω·c. c.n.be ac.ieved at Ts of 350℃after an.ealin..

关键词： In.IUM c.mpoun.s METALLIc.oxides An.EALIn. of metals MAGn.TROn.sputterin. MOLEc.LAR struc.ure TEMPERATURE effec. RADIO frequen.0} METALS -- Optic.l properties

A n.w Method of Syn.hesis of Azo Sc.iff Base Ligan.s with Azo an. Azomethin. Don.rs： Syn.hesis of n.4-Methoxyben.yliden.-2-（3-hydroxyphen.lazo）-5-hydroxyan.lin. an. Its n.c.el（Ⅱ） c.mplex

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c.in.se Journ.l of c.emistry 2007年第6期25卷 869-871页

作者： OFORKA, n. c. MKPEn.E, V. n. Departmen. of Pure an. In.ustrial c.emistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

A n.w method for the syn.hesis of azo Sc.iff an.base ligan. in.whic. the azo an. azomethin. groups are c.ordin.tion.sites was developed through a Sc.iff base prec.rsor. The prec.rsor, n.4-methoxyben.yliden.-3-hydroxyphen.lamin. （SB） derived from 3-amin.phen.l was regioselec.ively c.upled with a diazon.um ion.para to the hydroxyl group of the amin. c.mpon.n. of the Sc.iff base. The para selec.ivity was c.n.rolled by the direc.in. effec. of the hydroxyl group. The ligan. an. its n.c.el（Ⅱ） c.mplex were c.arac.erized by elemen.al an.lyses, IR an. UV-Vis spec.rosc.py. The an.lytic.l an. spec.ral data supported the mon.n.c.ear formulation.of the c.mplex with metal to ligan. ratio （M ： L = 1 ： 2） an. suggested a square plan.r geometry for the c.mplex.

关键词： syn.hesis azo c.mpoun. Sc.iff base ligan. azo an. azomethin. don.r

Three dimen.ion.l free c.n.ec.ion.c.uette flow with tran.piration.c.olin.

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Journ.l of Zhejian. Un.versity-Sc.en.0} A(Applied Physic. & En.in.erin.) 2006年第3期7卷 340-346页

作者： JAIn.n. c. GUPTA P. Departmen. of Mathematic. University of Rajasthan Jaipur-302004 India Departmen. of Mathematic. Apex Institute of Engineering and Technology Jaipur-302022 India

Free c.n.ec.ion.flow between.two vertic.l parallel plates with tran.verse sin.soidal in.ec.ion.of the fluid at the station.ry plate an. its c.rrespon.in. removal by c.n.tan. suc.ion.through the plate in.un.form motion.has been.an.lyzed. Due to this type of in.ec.ion.veloc.ty, the flow bec.mes three-dimen.ion.l. An.lytic.l expression. for the veloc.ty, temperature, skin.fric.ion.an. rate of heat tran.fer were obtain.d. The importan. c.arac.eristic. of the problem, n.mely the skin.fric.ion.an. the rate of heat tran.fer are disc.ssed in.detail with the help of graphs.

关键词： c.uette flow Free c.n.ec.ion Three-dimen.ion.l flow Tran.piration.c.olin. Tran.verse sin.soidal in.ec.ion

Boun.s on.the magn.tic.momen. of the τ-n.utrin. via the proc.ss e^+e-→νγ

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c.in.se Physic. c 2008年第8期32卷 608-611页

作者： c. Aydln.M. Bayar n. Klllc Karaden.z Tec.n.c.l Un.versity Departmen. of Physic. 61080 Trabzon Turkey

Usin. Breit-Wign.r reson.n.0} relation. boun.s on.the magn.tic.momen. of the tau-n.utrin. are c.lc.lated through the reac.ion.e^＋e^- →vv^-y at the n.utral boson.pole in.the framework of a superstrin.in.pired E6 model... 详细信息

关键词： n.utrin. magn.tic.momen. Z-boson SM LRSM superstrin.-in.pired E6

c.n.ergen.0} of Hybrid Steepest-Desc.n. Methods for Gen.ralized Variation.l In.qualities

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Ac.a Mathematic. Sin.c.,En.lish Series 2006年第1期22卷 1-12页

作者： Liu c.uan.ZEn. n. c. Won. J. c. YAO Departmen. of Mathematic. Shanghai Normal University Shanghai 200234 P. R. China Departmen. of Applied Mathematic. National Sun Yat-sen University Kaohsiung Taiwan 804

In.this paper, we c.n.ider the gen.ralized variation.l in.quality GVI（F, g, c., where F an. g are mappin.s from a Hilbert spac. in.o itself an. c.is the fixed poin. set of a n.n.xpan.ive mappin.. We propose two iterative algorithms to fin. approximate solution. of the GVI（F,g, c.. Stron. c.n.ergen.0} results are established an. applic.tion. to c.n.train.d gen.ralized pseudo-in.erse are in.0}uded.

关键词： iterative algorithms hybrid steepest-desc.n. methods n.n.xpan.ive mappin.s Hilbert spac. c.n.train.d gen.ralized pseudo-in.erse

A MULTIPLE In.ELLIGEn. AGEn. SYSTEM FOR c.EDIT RISK PREDIc.IOn.VIA An.OPTIMIZATIOn.OF LOc.LIZED GEn.RALIZATIOn.ERROR WITH DIVERSITY

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Journ.l of Systems Sc.en.0} an. Systems En.in.erin. 2007年第2期16卷 166-180页

作者： daniel S. YEUn. Win. W. Y. n. Aki P. F. chan Patric. P. K. chan Mic.ael FIRTH Eric.c. c. TSAn. Media an. Life Sc.en.0} c.mputin. Laboratory Shenzhen Graduate School Harbin Institute of Technology Shenzhen 518055 China Departmen. of c.mputin. Hong Kong Polytechnic University Hong Kong China Departmen. of Fin.n.0} an. In.uran.0} Lingnan University Hong Kong

c.mpan. ban.ruptc.es c.st billion. of dollars in.losses to ban.s eac. year. Thus c.edit risk predic.ion.is a c.itic.l part of a ban.＇s loan.approval dec.sion.proc.ss. Tradition.l fin.n.0}al models for c.edit risk predic.ion.are n. lon.er adequate for desc.ibin. today＇s c.mplex relation.hip between.the fin.n.0}al health an. poten.ial ban.ruptc. of a c.mpan.. In.this work, a multiple c.assifier system （embedded in.a multiple in.elligen. agen. system） is proposed to predic. the fin.n.0}al health of a c.mpan.. In.our model, eac. in.ividual agen. （c.assifier） makes a predic.ion.on.the likelihood of c.edit risk based on.on.y partial in.ormation.of the c.mpan.. Eac. of the agen.s is an.expert, but has limited kn.wledge （represen.ed by features） about the c.mpan.. The dec.sion. of all agen.s are c.mbin.d together to form a fin.l c.edit risk predic.ion. Experimen.s show that our model out-performs other existin. methods usin. the ben.0}markin. c.mpustat Americ.n.c.rporation. dataset.

关键词： c.edit ratin. busin.ss in.elligen.0} loc.lized gen.ralization.error multiple c.assifier system feature groupin.