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Shunting,optic nerve sheath fenestration and dural venous stenting for medically refractory idiopathic intracranial hypertension:systematic review and meta-analysis

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Annals of Eye Science 2018年第1期3卷 169-183页

作者： daniel b.scherman Adam A.Dmytriw Gia Thanh Nguyen Nhan Thi Nguyen Nana Tchantchaleishvili Julian Maingard Hamed Asadi Mark brooks Christoph Griessenauer Christopher Ogilvy Ajith J.Thomas Justin M.Moore Kevin Phan NeuroSpine Surgery Research Group(NSURG) Prince of Wales Private HospitalSydneyAustralia Department of Neurosurgery Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA Hue University of Medicine and Pharmacy Hue CityVietnam University of Medicine and Pharmacy Ho Chi Minh CityVietnam Interventional Neuroradiology Service Department of RadiologyAustin HospitalMelbourneAustralia Interventional Neuroradiology Unit Monash ImagingMonash HealthMelbourneAustralia Faculty of Health School of MedicineDeakin UniversityWaurn PondsAustralia Department of Neurosurgery Geisinger Health SystemDanvilleUSA Department of Neurosurgery Stanford UniversityStanfordUSA

background:Cerebrospinal fluid(CSF)-diversion procedures have traditionally been the standard of treatment for patients with medically refractive idiopathic intracranial hypertension(IIH).However,dural venous sinus stent(VSS)placement has been described as a safe and effective procedure for the management of medically refractive *** performed a meta-analysis comparing outcomes and complications of CSF-diversion procedures,VSS and optic nerve sheath fenestration(ONSF)for the treatment of medically refractive ***:Electronic searches were performed using six databases from 1988 to January *** was extracted and meta-analysed from the identified ***:From 55 pooled studies,there were 538 CSF-diversion cases,224 dural venous stent placements,and 872 ONSF *** improvements were found in terms of postoperative headaches(CSF *** ***:84%vs.78%vs.62%,P=0.223),papilledema(CSF *** ***:71%vs.86%vs.77%,P=0.192),whilst visual acuity changes favored venous stenting(CSF *** ***:55%vs.69%vs.44%,P=0.037).There was a significantly lower rate of subsequent procedures with venous stent placement(CSF *** ***:37%vs.13%vs.18%,Pbut other complication rates were similar(CSF *** ***:13%vs.8%vs.14%,P=0.28).Subgroup analysis of lumbar-peritoneal *** shunts found no differences in symptom improvements,complications and subsequent procedure ***:Our findings suggest that dural venous sinus stenting may be a viable alternative to traditional surgical interventions in patients who are refractory to medical treatment.

关键词： Cerebrospinal fluid diversion procedures(CSF-diversion procedures) idiopathic intracranial hypertension(IIH) optic nerve sheath fenestration(ONSF) venous sinus stent placement(VSS)

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Functionalization of Single- and Multi-Walled Carbon Nanotubes with Cationic Amphiphiles for Plasmid DNA Complexation and Transfection

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Nano Research 2009年第8期2卷 638-647页

作者： Cyrille Richard Nathalie Mignet Céline Largeau Virginie Escriou Michel bessodes daniel scherman Unitéde Pharmacologie Chimique et Génétique CNRSUMR 8151ParisF-75270 cedex France INSERM U 640ParisF-75270 cedex France UniversitéParis Descartes Facultédes Sciences Pharmaceutiques et BiologiquesParisF-75270 cedex France ENSCP ParisF-75231 cedex France

The possibility of delivering DNA effi ciently to cells represents a crucial issue for the treatment of both genetic and acquired ***,even although the effi ciency of non-viral transfection systems has improved in the last decade,none have yet proven to be suffi ciently effective in *** report herein our results on the functionalization of single-walled carbon nanotubes(SWNT)and multi-walled carbon nanotubes(MWNT)by two cationic amphiphiles(lipid RPR120535 and pyrenyl polyamine),their use for the complexation of plasmid DNA,and their efficiency in transfecting cells in *** experiments have shown that the efficiency of transfection is higher when using SWNT instead of MWNT,and that transfection effi ciency is similar or slightly higher when using nanoplexes(SWNT/lipid RPR120535/DNA)instead of lipoplexes(lipid RPR120535/DNA)and several orders of magnitude higher than that of naked *** study therefore shows both that the transfection is better when using SWNTs and that it is dependent on the nature of the amphiphilic molecules adsorbed on the nanotubes.

关键词： Carbon nanotubes amphiphile gene delivery plasmid DNA in vitro

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Mechanical circulatory support in cardiogenic shock and post-myocardial infarction mechanical complications

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Journal of Geriatric Cardiology 2022年第2期19卷 130-136页

作者： daniel Rob Jan bělohlávek nd Department of Medicine-Department of Cardiovascular Medicine First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic

Despite advanced therapies,the mortality of patients with myocardial infarction(MI)complicated by cardiogenic shock(CS)remains around 50%.Mechanical complications of MI are rare nowadays but associated with high mortality in patients who present with *** treatment strategies and mechanical circulatory support(MCS)devices have been increasingly used to improve the grim prognosis of refractory *** article discusses current evidence regarding the use of MCS in MI complicated by CS,ventricular septal rupture,free wall rupture and acute mitral *** selection should be tailored according to the cause and severity of *** MCS initiation and multidisciplinary team cooperation is mandatory for good *** associated bleeding remains a major complication and an obstacle to better *** prospective randomized trials will improve current knowledge regarding MCS indications,timing,and patient selection in the coming years.

关键词： mortality infarction rupture

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Design of synthetic materials for intracellular delivery of RNAs： From siRNA-mediated gene silencing to CRISPR/Cas gene editing

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Nano Research 2018年第10期11卷 5310-5337页

作者： Jason b. Miller daniel J. Siegwart Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX 75390 USA Department of biochemistry University of Texas Southwestern Medical Center Dallas TX 75390 USA

Ribonucleic acids （RNAs） possess great therapeutic potential and can be used to treat a variety of diseases. The unique biophysical properties of RNAs, such as high molecular weight, negative charge, hydrophilicity, low stability, and potential immunogenicity, require chemical modification and development of carriers to enable intracellular delivery of RNAs for clinical use. A variety of nanornaterials have been developed for the effective in vivo delivery of short/ small RNAs, messenger RNAs, and RNAs required for gene editing technologies including clustered regularly interspaced palindromic repeat （CRISPR）/Cas. This review outlines the challenges of delivering RNA therapeutics, explores the chemical synthesis of RNA modifications and carriers, and describes the efforts to design nanomaterials that can be used for a variety of clinical indications.

关键词： nucleic acid therapeutics nanoparticles synthetic nanomaterials RNA interference (RNAi) messenger RNA (mRNA) clustered regularly inter-spaced palindromic repeat(CRISPR)/Cas

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Energy Dissipation Within the Wave Run-Up at Stepped Revetments

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Journal of Ocean University of China 2017年第4期16卷 649-654页

作者： KERPEN Nils b bUNG daniel b VALERO Darnel SCHLURMANN Torsten Ludwig-Franzius-lnstitute Leibniz Universitat Hannover30167 HannoverGermany Hydraulic Engineering Section Fachhochschule Aachen52066 AachenGermany

To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment,hydraulic model tests with steady flow conditions are conducted and correlated with unsteady flow conditions of the wave run-up within a short time *** irregular waves,the run-up reduction over a stepped revetment is dependent on the Iribarren number and decreases for decreasing Iribarren *** gradients are found to be similar in a steady and unsteady flow regime near the pseudo-bottom.

关键词： run-up stepped revetment roughness: energy dissipation

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Stability and scour development of bed material on crossbar block ramps

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International Journal of Sediment Research 2015年第4期30卷 344-350页

作者： Mario Oertel daniel b.bung Hydraulic Engineering Section Lbeck University of Applied Sciences Hydraulic Engineering Section Aachen University of Applied Sciences

block ramps are ecologically oriented drop structures with adequate energy dissipation and partially moderate flow velocities.A special case is given with crossbar block ramps,where the upstream and downstream level difference is reduced by a series of *** prevent the total structure from failing,the stability of single boulders within the crossbars and the bed material in between must be *** present paper addresses the stability of bed material and scour development for various flow *** bed material erosion may affect the stability of the crossbar boulders,which in turn can result in major damages of the *** new design approaches are developed to choose an appropriate bed material size and to avoid failures of crossbar block ramp structures.

关键词： Crossbar block ramp Scouring bed material erosion Particle densimetric Froude number

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A critical evaluation of subjective ratings： Unacquainted observers can reliably assess certain personality traits

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Current Zoology 2014年第2期60卷 162-169页

作者： Matthew b.PETELLE daniel T.bLUMSTEIN Department of Ecology and Evolutionary biology University of California Los Angeles CA 90095-1606 USA Rocky Mountain biological Laboratory Crested Butte CO 81224 USA

Methods to measure consistent individual differences in behavior （i.e. animal personality） fall into two categories, subjective ratings and behavioral codings. Ratings are seldom used despite being potentially more efficient than codings. One potential limitation for the use of ratings is that it is assumed that long-term observers or experts in the field are required to score individuals. This can be problematic in many cases, especially for long-term ecological studies where there is high turnover in personnel. We tested whether raters who were unacquainted with subjects could produce reliable and valid personality assessments of yellow-bellied marmots Marmota flaviventris. Two raters, previously unacquainted with individuals and marmot be- havior, scored 130 subjects on fifteen different adjectives in both open-field （OF） and mirror image stimulation （MIS） trials. Eight OF and nine MIS adjectives were reliable as indicated by both a high degree of intra-observer and inter-observer reliability. Additionally, some ratings were externally valid, correlating with behavioral codings. Our data suggest that activity/exploration and sociability can be a reliable and valid measurement of personality traits in studies where raters were unacquainted with subjects. These traits are observable with the personality tests we used; otherwise researchers using unacquainted raters should be cautious in the tests they employ [Current Zoology 60 （2）： 162-169, 2014].

关键词： Animal personality behavior codings Marmots Subjective ratings

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Contributors’enrollment in collaborative online communities:the case of OpenStreetMap

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Geo-Spatial Information Science 2017年第3期20卷 282-295页

作者： daniel bégin Rodolphe Devillers Stéphane Roche Department of Geography Memorial University of NewfoundlandSt.John’sCanada Centre de Recherche en Géomatique UniversitéLavalQuébecCanada

The number of people registering in an online community depends on two main factors:interest in,and awareness of,the *** to a project does not,however,imply contributing to it,as lacking the knowledge and skills can be a barrier to *** order to identify the nature of events that might have facilitated or hindered enrollments in the OpenStreetMap(OSM)project over time,we analyzed the correlations between the number of new participants and the events that dotted its *** different metrics were defined to characterize participants’behaviors:the daily number of registrations,the daily number of participants that made a first contribution,the delays between contributors’registration and their first edits,and a daily contribution ratio built from the number of new contributors and the number of new registered *** series analyses were used to identify trends,and outstanding variations of the number of *** inventory of events that took place along the OSM project’s history was created and appreciable variations of the metrics have been linked to events that seemed to be *** a correlation does not imply causality,many of the explanations these correlations suggest are supported by the results of other studies,either directly or *** instance,when considering the time participants spend as“lurker”,as well as on the nature of the contribution of early *** other cases,they suggest new explanations for the origin of the spam accounts that affect registration statistics,or the decline in the proportion of registered members who actually become contributors.

关键词： OpenStreetMap(OSM) contributors lurkers participation knowledge motivation

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Iron regulatory protein 1: the deadly switch of ferroptosis

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Neural Regeneration Research 2024年第3期19卷 477-478页

作者： daniel A.bórquez Pamela J.Urrutia Center for biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Institute of Nutrition&Food Technology(INTA) Universidad de ChileSantiagoChile Geroscience Center for brain Health and Metabolism SantiagoChile

Ferroptosis,an iron-dependent cell death:Ferroptosis is a type of regulated necrosis,characterized by redox-active iron accumulation and increased free radical production derived by Fenton chemistry,that triggers oxidation of polyunsaturated fatty acids in phospholipids,loss of cellular membranes integrity,and leakage of intracellular contents.

关键词： integrity switch Iron

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A Light-Weight Deep Learning-based Architecture for Sign Language Classification

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Intelligent Automation & Soft Computing 2023年第3期35卷 3501-3515页

作者： M.daniel Nareshkumar b.Jaison Department of Electronics and Communication Engineering R.M.K.Engineering CollegeKavaraipettai601206India Department of Computer Science and Engineering R.M.K.Engineering CollegeKavaraipettai601206India

With advancements in computing powers and the overall quality of images captured on everyday cameras,a much wider range of possibilities has opened in various *** fact has several implications for deaf and dumb people as they have a chance to communicate with a greater number of people much *** than ever before,there is a plethora of info about sign language usage in the real *** languages,and by extension the datasets available,are of two forms,isolated sign language and continuous sign *** main difference between the two types is that in isolated sign language,the hand signs cover individual letters of the *** continuous sign language,entire words’hand signs are *** paper will explore a novel deep learning architecture that will use recently published large pre-trained image models to quickly and accurately recognize the alphabets in the American Sign Language(ASL).The study will focus on isolated sign language to demonstrate that it is possible to achieve a high level of classiﬁcation accuracy on the data,thereby showing that interpreters can be implemented in the real *** newly proposed Mobile-NetV2 architecture serves as the backbone of this *** is designed to run on end devices like mobile phones and infer signals(what does it infer)from images in a relatively short amount of *** the proposed architecture in this paper,the classiﬁcation accuracy of 98.77%in the Indian Sign Language(ISL)and American Sign Language(ASL)is achieved,outperforming the existing state-of-the-art systems.

关键词： Deep learning machine learning classiﬁcation ﬁlters american sign language

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