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Occurrence of Delirium and Length of Stay of Patients in the Intensive Care Unit

Journal of Biosciences and Medicines 2021年第8期9卷 1-9页

作者： Aparecida Sátira da Silva Machado Mayara Rabello Teixeira Alves daniella Nogueira Vieira Sara Ellias de Sousa Felipe Rodrigues Maia daniel almeida da costa Leandro Raider The Medical School at the Center of Higher Education of Valenç a Unifaa Brazil

Introduction: The delirium has received little attention from professionals working in the intensive care unit, mainly due to the fact that this is, rarely, the primary reason for patient admission. Given the high prevalence of delirium in an intensive care environment, the current guidelines recommend the daily assessment of delirium and a multidisciplinary approach. Delirium is a frequent and severe form of acute brain dysfunction, as well as an important source of concern in critical care. Objective: To assess the occurrence of delirium and time of stay in the intensive care unit. Method: This is a quantitative, descriptive study, with a cross-sectional design, which was carried out in a university hospital located in the interior of the State of Rio de Janeiro. The sample consisted of 89 patients, of both sexes, aged between 24 and 92 years. The RASS and CAM-ICU scales were used to assess delirium. The data were collected every 12 hours, for 3 months, 7 days a week and in an uninterrupted manner. Results: Were evaluated 89 patients, of which 16 were excluded according to the scale criteria, leaving 73 patients. After evaluation, 22 patients were diagnosed with delirium and 51 patients without delirium. Of the patients who presented delirium, 13 deaths and 9 had high to the nursery. Of the patients who did not have delirium, 40 had high to the nursery and 11 deaths. Patients with delirium had an average hospital stay of 23.25 days and patients who did not have delirium had an average of 4.5 days hospitalization. Conclusion: We can infer that the longer the patient spends in the intensive care unit, the greater the chance of delirium occurring. Therefore, preventive and interventional measures are necessary to decrease the mortality rate in patients with delirium and early detection is an excellent tool to improve this outcome.

关键词： Delirium Intensive Care Unit Time of Hospitalization

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Ulcerated Lesion in Buccal Mucosa in a Patient with Paracoccidioidomycosis——Case Report

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Journal of Biosciences and Medicines 2017年第10期5卷 44-50页

作者： Giovanna Lima Vaz Livia Cristina de Melo Pino Aline Gabriela Santos costa Ibrahim Yahia El Somailli Joao Roberto Resende Fernandes Elayne Christina Meireles Martins daniel Cohen Goldemberg Aline Hellen da Silva Camacho Rhanna Neves Cirqueira daniel almeida da costa College of Medicine of Valenca—FAA/Cesva ValencaBrazil National Cancer Institute—INCA Rio de JaneiroBrazil Centro Universitario de Belo Horizonte-UNIBH Belo HorizonteBrazil

Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It is a fungal infection caused by the dimorphic fungus Paracoccidioides brasiliensis. This microorganism can penetrate the human body through direct contact and can cause intense lymphadenopathy, ulcerated lesions in the oral cavity and in the skin among other alterations. In this study, we report a case of paracoccidioidomycosis with unusual clinical presentation, as it manifested in the female sex and although it did not present any relevant complaints of respiratory focus, it presented a single ulcerated lesion in the buccal mucosa. A biopsy of the lesion and a mycological examination revealed Paracoccidioidesbrasiliensis infection.

关键词： Paracoccidioidomycosis Paracoccidioides brasiliensis Endemic Mycosis

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Evaluation of the Therapeutic Response and Improvement in the Quality of Life of the Patient with darier Disease to Acitretin through an Analogy between Close Relatives

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Journal of Biosciences and Medicines 2017年第8期5卷 48-54页

作者： Thiago Sande Miguel Mateus de Oliveira Reis Bruno Fonseca dos Santos Aline da Silva Rocha Nayrton Kalys Cruz dos Anjos Lívia Cristina de Melo Pino daniel almeida da costa The Medical School at the Center of Higher Education of Valenca Valenca Brazil

darier disease (DD), also known as follicular keratosis, is a rare autosomal dominant hereditary acantholytic dermatosis caused by a mutation in the ATP2A2 gene. Skin lesions are characterized by persistent confluent papules, preferentially located on the seborrheic areas of the face, chest and back. The hands, feet and nails are also commonly affected. DD has a chronic course with frequent relapses. Their treatment is often difficult and unsatisfactory. We present the case of a 54-year-old male with a history of keratotic papules with a brownish-black color, with a foul-smelling, pruritic and ardent appearance on the back and trunk, since the age of 19, which worsen in the summer. His 27-year-old daughter has a similar picture with her skin lesions started at age of 17 in the region below the breast, back, trunk, feet and hands. After the skin biopsy, the diagnosis was confirmed and acitretin 30 mg/day was instituted. The importance of this case report is to alert health professionals that the diagnosis of DD should be considered in family members of patients, especially those in the first degree, and also in patients with follicular keratolytic dermatoses, being an important differential diagnosis of this group of patients diseases.

关键词： darier’s Disease Follicular Keratosis Hereditary Dermatosis

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Epidemiological Profile of Breast Neoplasia in the Municipality of Valença (RJ Brazil): Study from 2009 to 2017

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Journal of Biosciences and Medicines 2020年第6期8卷 179-187页

作者： Catharina Ferrari Salgado Fernandes Helena Torres Passos Izabela Cristina Ferreira Marina Coelho de Paulo Raquel Alencar Sampaio Ferraz Filomena Aste Silveira João Alfredo Seixas daniel almeida da costa Faculty of Medicine of Valenç a UNIFAA Valen&ccedil a Brazil

Breast neoplasms are the main oncological pathology in Gynecology and Obstetrics, with increasing rates of incidence and mortality in the female population. According to the World Health Organization (WHO), more than 1 million new cases of breast cancer are diagnosed worldwide every year. This study aims to understand and analyze the epidemiological profile of patients diagnosed with breast cancer in the last nine years in the city of Valença—RJ, Brazil. A descriptive, documentary-retrospective analysis was carried out from January 2009 to December 2017, on 96 records of women who underwent breast biopsy at the Escola Escola de Valença (HEV), referred by the HEV Gynecology outpatient clinic. The results compared the variables age, race, parity, alcoholism, smoking, comorbidities, histological type, family history and screening performed with the scenario of breast cancer in the world, concluding that it is essential to identify patients at risk development of breast cancer to guide prevention, screening and early detection of pathology. The cases in the municipality are similar to other studies in relation to smoking, alcohol consumption, associated comorbidities, histological type and family history. However, the prevalence in younger people stands out, as well as the high percentage of women who have not had previous screening, which highlights the importance of the development and spread of women’s health in this city in the south of the state.

关键词： Breast Neoplasia Epidemiological Profile Comorbidity

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Importance of Primary Health Care in Medicine: Simultaneous Analysis of Two Colleges, under the Vision of Teachers and Students

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Journal of Biosciences and Medicines 2017年第11期5卷 6-12页

作者： Sebastiao Celio Horta Coelho Filho Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Mateus de Oliveira Reis Bruna Sande Miguel Vinicius Sande Miguel Aline Gabriela Santos costa Lilian costa Brito Bruno Fonseca dos Santos Veronica Clemente Villar Martini daniel almeida da costa The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil

Introduction: The involvement of undergraduate student at the beginning of their training in activities based on Primary Health Care (PHC), provides preventive and health promoting actions, and ensures the evaluation of the vulnerability of communities and people. Objectives: To analyze the opinion of students and teachers of two medicine higher education institutions on the relevance of Primary Health Care in this course. METHODS: Students and teachers should be effectively enrolled in order for the study to be conducted, being chosen in a random manner and without interferences on the part of the researchers so that the work was as reliable as possible. A cross-sectional study was conducted with interviews structured in questionnaires about what they thought about PHC. To some students and teachers of the medical course of Valen?a and Grande Rio University (UNIGRANRIO). Before receiving the questionnaire, all interviewed signed a Free and Informed Consent Term, which included the objectives and methodology of the work. Results: 310 students and 51 teachers participated in the study, where 91.43% of the students and 100% of the teachers affirmed that primary care plays a fundamental role in medical education. 94.86% of students and 97.91% of teachers, claimed that the discipline allows a greater contact between undergraduates and community. When questioned about the encouragement that teachers give to students to pursue a career in PHC, 57.87% of the students and 70.83% of the professors said they lacked in such a stimulus. Conclusion: PHC is still very neglected by governmental policies, educational institutions and by the own teachers, that often, turn they attention only to tertiary medicine and, as a consequence, a discouragement of this area occur. Therefore, a higher PHC value is necessary, allowing a more humane look at the patient, valuing their feelings, anguishes and their pathological framework.

关键词： Primary Health Care Graduation Medicine

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Nodular Amyloidosis Overlapping and Polymyositis in a Patient with Skin Manifestations Lupus Fax: Case Report

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Journal of Biosciences and Medicines 2017年第11期5卷 33-40页

作者： Eneas Van Der Maas do Bem Filho Laiza Maria dos Santos Couto Antonio Luiz da costa Soares Jr Pedro Paulo Andrade Thiago Sande Miguel Sebastiao Celio Horta Coelho Filho daniel almeida da costa Livia Cristina de Melo Pino Thayro Van Der Maas do Bem The Medical School at the Center of Higher Education of Valenca ValencaBrazil

Amyloidosis is the result of fibrous and insoluble amyloid protein deposition in extracellular spaces of tissues and organs, including the skin. Through the analysis of medical records, clinical condition and laboratory tests, this article proposes a rare case report of an adult patient with symptoms and diagnosis of polymyositis, histopathology of nodular amyloidosis with skin lesions suggestive of lupus. The patient is still being followed at the dermatology clinic of Valença Medical School, in order to improve the prognosis and prevent the progression of existing symptoms.

关键词： Nodular Amyloidosis Polymyositis

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Evaluation of Cytotoxicity of <i>Gossypium barbadense</i>L. Extract in Bone Cord Cells through the Micronucleus Test

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Journal of Biosciences and Medicines 2017年第7期5卷 84-91页

作者： Thiago Dornelas de Oliveira Joice Meire Rodrigues Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Juscélio Clemente de Abreu Lamara Laguardia Valente Rocha Raquel Xavier Ligeiro Dias daniel almeida da costa Academic of the Graduate Course in Medicine of the University Center of Caratinga Caratinga Brazil Religious Sciences from the Pontifical Catholic University of Sao Paulo Sao Paulo Brazil The Medical School at the Center of Higher Education of Valenca Valenca Brazil The Institute of Health Sciences of the University Center of Caratinga Caratinga Brazil Federal University of Lavras Lavras Brazil Federal University of Vicosa Vicosa Brazil Department of Biochemistry and Molecular Biology at the Federal University of Vicosa Vicosa Brazil Faculty of Medicine of Valenca Valenca Brazil

The cotton plant is a plant belonging to the family Malvaceae and its leaves are often used in folk medicine. The present study aimed to evaluate the mutagenic or antimutagenic activity of the ethanolic extract of Gossypium barbadense L. (EEG) and to analyze its capacity to prevent or repair mutagenic lesions caused by cyclophosphamide (CP). For the Micronucleus test, Swiss mice were divided into 5 groups: negative control;Positive control: treated with 50 mg/kg cyclophosphamide (CP), group receiving EEG 500 mg/kg for 7 days;Group receiving EEG 500 mg/kg for 7 days associated with CP24h before euthanasia;Group who received CP and EEG 500 mg/kg for 7 days. After the treatment period, the animals were euthanized, the bone marrow removed and the blood smear prepared. From this analysis, it was observed that the EEG caused a significant increase in the number of micronucleated erythrocytes, indicating mutagenic activity of the extract. In addition, it was verified that the extract did not present the capacity to prevent, but it presented the capacity of repair of the chromosomal damages caused by CP.

关键词： Gossypium Mutagenesis Phytotherapy

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Subacute Cutaneous Lupus Erythematosus in Older Man: Case Report

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Journal of Biosciences and Medicines 2017年第10期5卷 25-33页

作者： Debora Trindade Martins Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Sebastiao Celio Horta Coelho Filho Vinicius Moreira Paladino Bruna Sande Miguel Vinicius Sande Miguel daniel almeida da costa Livia Cristina de Melo Pino The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects mainly women, presents several clinical manifestations and has no known exact cause. The skin is one of the organs that can be affected, with subacute cutaneous lupus erythematosus (SCLE) being one of the classifications according to cutaneous lupus erythematosus lesions. SCLE is commonly found in young to middle age women and carries characteristics related to sun exposure. In this report, there is a rare case of a male and elderly patient that presents SCLE subgroup initially asymptomatic, with subsequent appearance of macular skin lesions and vitiligo appearance. This is an important case to alert health professionals that the disease can manifest itself and open its clinical profile even in patients of sex and unusual ages.

关键词： Autoimmune-Disease Skin Man Lupus

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Auditory Health and Risk Factors in Rural Workers Exposed to Pesticides in Piedade de Caratinga County-Minas Gerais

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Journal of Biosciences and Medicines 2017年第7期5卷 37-55页

作者： Paula Critina da Silva Botelho Valdênia Gomes Rocha Tamires Ribeiro Dutra Júlio César Alves Feitosa Ricardo Campos de Assis Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos daniel almeida da costa Lina Claudia Pereira Lopes Lamara Laguardia Valente Rocha Department of Nursing University Center of Caratinga Caratinga Brazil Graduating in medicine University Center of Caratinga Caratinga Brazil Graduating in Psychology University Center of Caratinga Caratinga Brazil The Medical School at the Center of Higher Education of Valenca Valenca Brazil Department of Medicine Graduate Program in Medicine Faculty of Medicine of Valencia Brazil Speech Therapist The Medical School at the Center of Higher Education of Valenca Valenca Brazil Department of Morphology University Center of Caratinga Caratinga Brazil

In Brazil, the amount of pesticides consumed doubled in the last 10 years. Thus, in 2008 it assumed the lead position in the world. However, its indiscriminate application in agriculture without the use of the necessary care has contributed to environmental degradation and increased occupational exposures, making it a serious health problem in the country. The recent study looked to evaluate the auditory health and risk factors in rural workers exposed to pesticides in Piedade de Caratinga County—MG, and chart their socioeconomic profile and lifestyle while identifying the types of crops and the use and management of pesticides. Developed, then, a descriptive and exploratory study involving 23 men, rural workers, exposed to pesticides, with no history of exposure to noise, with changes in meatoscopy and aged ≤50 years of age. The results show the sample consisted of 23 men with a mean age of 36.7 ± 9.3, whom have low education, with a monthly income of 1 minimum wage, working in the fields for over 15 years. There was a predominance of horticulture using organophosphate pesticides and pyrethroids. Part of the sample shows auditory loss, the most common sensorineural conductive loss. It is essential that the population exposed to this type of risk is informed and receives guidance from educational campaigns developed by the multidisciplinary team of basic health units.

关键词： Auditory Health Pesticides Audiometry and Rural Workers

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Effects of Gaseous Drinks in Wistar Rats Esophagus

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Journal of Biosciences and Medicines 2017年第5期5卷 32-43页

作者： Thiago Dornelas de Oliveira Marcelli Elioterio Gaspar Larissa Menezes Viana Braga Joice Meire Rodrigues Rebeca Nogueira Falcao Santos Suelen Gaudino Moura Nayara Barbosa Bicalho Lamara Laguardia Valente Rocha daniel almeida da costa Marcus Vinicius de Mello Pinto Academic of the Graduate Course in Medicine of the University Center of Caratinga CaratingaBrazil Religious Sciences from the Pontifical Catholic University of Sao Paulo-PUC/SP Sao PauloBrazil University Center of Caratinga CaratingaBrazil The Institute of Health Sciences at UNEC CaratingaBrazil The Medical School at the Center of Higher Education of Valenca ValencaBrazil The Cellurare Institute Center of Laser Treatment and Cell Therapy PetropolisBrazil

The consumption of beverages and processed foods, mainly soft drinks, has been incorporated into the usual diet of children, adolescents and adults frequently in recent years. The present study aimed to study the effects of carbonated drinks on Wistar rats, based on the macroscopic and histological morphology of the esophagus. Fifteen Wistar rats were divided into three groups: control group;group fed with ration and cola-type refrigerant ad libitum and group fed with ration and gas industrialized water ad libitum, for a trial period of 90 days. For histopathology and morphology, the esophagus was removed, prepared in slides and stained with hematoxylineosin. Images of the sections were captured for analysis and classification of the inflammatory infiltrate. For morphometry, ten grid fields of 100 points were evaluated in the 40x eyepiece, totaling 3000 points per animal. The results demonstrate that the refrigerant treatment induced the following structural changes in the rats: significant reduction of weight in relation to the control group;inflammatory infiltrate predominantly diffuse mild to moderate and tissue edema. The rats treated with carbonated water had similar results to the control, besides signs of healing and tissue repair.

关键词： Soft Drinks Consumption Inflammation Carbonate Beverages

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