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Open Journal of Pediatrics 2022年第1期12卷 162-169页

作者： Balla Keita Mamadou Alpha Toure Mohamed Lamie Sacko Mamadou Madiou Barry Mamadou Karamba Kaba Daniel Agbo-Panzo Pediatric Surgery Department CHU Donka Conakry Guinea Gamal Abdel Nasser University of Conakry Conakry Guinea Plastic Surgery Department CHU Donka Conakry Guinea

Introduction: Popliteal pterygium syndrome is a rare birth defect, combining craniofacial, genitourinary and musculoskeletal abnormalities. It is an autosomal dominant disease caused by a mutation in the IRF6 gene. We report in this observation the 1st Guinean case corrected by the surgical method as well as a review of the literature for a diagnostic and therapeutic approach. Patient and observation: We present the case of a 7-day old male newborn weighing 2700 g who was received for bilateral cleft lip and palate, lower lip fossa or sinuses, bilateral popliteal pterygium, and triangular skin fold above the hallux. The patient underwent several surgical procedures aimed at correcting these abnormalities. The correction of the pterygium of the lower limbs was ensured by excision of the fibrous band, the tenoplasty in z of the calcaneal tendon on the right side and the skin plasty in z in series then immobilized by plaster splints. The immediate postoperative follow-up was straightforward. Conclusion: Popliteal pterygium syndrome is a rare congenital malformation, the diagnosis is primarily clinical. Early soft tissue lengthening surgery and serial z-skin plasty provide better correction of the knee pterygium. Correct correction of facial abnormalities gives the child a better appearance. The management of this syndrome is multidisciplinary.

关键词： Popliteal Pterygium Congenital Malformation Genetic Disease Pediatric Surgery Multidisciplinary Team

Pubo-Penile Testicular Ectopia (ETPP) of the Infant of 4 Months about a Case

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Open Journal of Urology 2023年第4期13卷 108-113页

作者： Mohamed Lamine Sadou Sacko Balla Keita Thierno Saidou Barry Mory Sangare Mamadou Madiou Barry Moussa Conde Daniel Agbo-Panzo Pediatric Surgery Department of The University Hospital of Donka Donka Guinea University Gamal Abdel Nasser of Conakry Conakry Guinea

Pubo-penile testicular ectopia is a rare congenital malformation whose etiopathogenesis remains poorly understood. It represents other testicular ectopias less than 1% of all testicular migration disorders. We report a clinical observation of a 4-month-old infant who consulted for swelling at the root of the penis associated with vacuity of the right hemi scrotum. An inguinal ultrasound was performed which confirmed the presence of the right testicle. An orchidopexy was performed at 4 months of life by an inguinal approach, the postoperative course was simple with a follow-up of 6 months.

关键词： Pubo-Penile Testicular Ectopia Infant Early Orchidopexy

Abdominal Mass Revealing a Right Ovarian Cyst in a 2-Year-Old Infant: A Case Report

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Open Journal of Pediatrics 2023年第2期13卷 276-283页

作者： Mohamed Lamine Sadou Sacko Balla Keita Thierno Saidou Barry Mory Sangare Mamadou Madiou Barry Moussa Conde Daniel Agbo-Panzo Department of Pediatric Surgery Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: Ovarian cysts are rare pathologies in infants. They represent 1% to 2% of all abdominal tumors in children. Abdominal pain is the most frequent initial sign. Sometimes the discovery is fortuitous, revealed by an abdominal ultrasound. We report here the case of an ovarian cyst in an infant in order to clarify the diagnostic and therapeutic particularities. Patient and observation: 2-year-old infant, female, weighing 12 kg and with no particular pathological history, was admitted to our department for pain plus abdominal mass evolving for 2 months. The clinical examination had noted: a mass ranging from FID to hypogastrium, painless, of firm consistency, with regular contour, with a smooth and mobile surface in relation to the deep plane. The abdominal ultrasound performed had concluded to a mesenteric cyst. The treatment consisted of a monobloc total cystectomy with preservation of the healthy ovarian tissue by a transverse laparotomy under the umbilical. The postoperative course was simple;the histological study of the surgical specimen had concluded to a serous cystadenoma. Conclusion: Ovarian cysts are benign tumors in most cases. Abdominal pain is the most common initial symptom at any age. Sometimes they can be incidentally discovered by ultrasound. The preservation of healthy ovarian tissue in the rules of oncological surgery allows the preservation of subsequent fertility.

关键词： Right Ovarian Cyst in Infants Conservative Treatment

Acute Alithiasis Cholecystitis in Children: Diagnostic and Therapeutic Approach in the Pediatric Surgery Department of the CHU of Conakry

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Open Journal of Pediatrics 2023年第1期13卷 86-91页

作者： Balla Keita Mamadou Alpha Toure Mohamed Lamine Sadou Sacko Thierno Saidou Barry Mohamed Lamine Diallo Mamadou Madiou Barry Daniel Agbo-Panzo Department of Pediatric Surgery National Hospital of Donka/CHU Conakry Guinea Faculty of Science and Technology University Gamal Abdel Nasser of Conakry Conakry Guinea

Acute alithiasic cholecystitis (AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. It is a rare pathology in children. The aim was to describe the clinical, diagnostic and therapeutic characteristics of this disease. Materials and Method: This was a 3-year retrospective study (January 2008 to December 2010) including 66 patient records collected for CAA. Results: The frequency of AAC was 3.57%, the mean age of the patients was 8 ± 3.52 years, and there were 36 boys and 30 girls. The main clinical features were right hypochondrial pain (66 cases), positive Murphy’s (66 cases), fever (53 cases) and jaundice or sub-jaundice (51 cases). The main ultrasound signs were thickened vesicular wall 50 cas (75.76%), vesicular distension 50cas (75.76%) and positive ultrasound Murphy 47 cas (71.21%). Medical treatment was exclusive in 64 patients (96.97%) and surgical treatment in 2 patients (3.03%). Conclusion: Acute alithiasic cholecystitis is a rare pathology in children, the clinical picture is not very specific and abdominal ultrasound is the key to early diagnosis. Conservative treatment is the first choice in the absence of any complications.

关键词： Acute Alithiasic Cholecystitis Children Medical Treatment

Urinary Lithiasis Secondary to Urethral Duplication: A Case Report

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泌尿学期刊(英文) 2023年第10期13卷 453-458页

作者： Mohamed Lamine Sadou Sacko Balla Keita Thierno Saidou Barry Mory Sangare Mamadou Madiou Barry Moussa Conde Seydou Keita Daniel Agbo-Panzo Department of Pediatric Surgery CHU de Donka Conakry Guinea Gamal Abdel Nasser University Conakry Guinea General Surgery Department Ignace Deen University Hospital Conakry Guinea

Urethral duplication is a rare congenital anomaly, mainly involving boys, although cases in girls have been reported. The majority of duplications of the urethra are asymptomatic and the discovery of this malformation can be done at any age. Diagnosis and determination of its type are based on urethrocystography with mid-void images, which helps to guide the surgical approach. The treatment is not yet well codified and the therapeutic attitude varies from one author to another. We report a clinical observation of a urethral duplication with a calculus in a six-year-old boy who underwent a partial urethrectomy of the supernumerary urethra in whom a lithotomy and a urethrectomy were performed via a suspension approach. This observation illustrates the possibility of urinary stone formation after partial urethrectomy of the supernumerary urethra.

关键词： Urethra Duplication Calculus Child

Prolapsed Juvenile Polyp of the Anus in 2 Cases

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Open Journal of Pediatrics 2023年第6期13卷 785-790页

作者： Mohamed Lamine Sadou Sacko Balla Keita Thierno Saidou Barry Mory Sangare Mamadou Madiou Barry Moussa Conde Seydou Keita Salif Mariértou Sylla Daniel Agbo-Panzo Department of Pediatric Surgery CHU de Donka Conakry Guinea Gamal Abdel Nasser University Conakry Guinea General Surgery Department Ignace Deen University Hospital Conakry Guinea Gastroenterology Department Conakry Military Hospital Conakry Guinea

Introduction :Rectal polyps are well-circumscribed, sessile or pedunculated formations that develop on the digestive mucosa. Juvenile polyps are seen in 4% - 12% of cases during pediatric colonoscopies. In children, rectal bleeding is a frequent warning sign, often a recurrent bleed with no impact on general condition. Diagnosis is based on clinical, imaging and digestive investigations, but anatomopathological examination remains the only means of confirmation. There are a number of treatment options, ranging from abstention to surgical excision. We report two (2) cases of isolated hemorrhagic juvenile polyp prolapsed to the anus in order to analyze the diagnostic and therapeutic features of this pathology. Patients and observations: A 7-year-old female patient presented to the pediatric emergency department of the Donka National Hospital with a hemorrhagic anal mass. On clinical examination, the patient was found to be in satisfactory general condition, with a hemorrhagic pedicle mass prolapsed to the anus. The mass was removed under general anesthesia. Postoperative management was straightforward. Conclusion: Juvenile polyps are the most common proctological condition in this age group. Clinical examination must be meticulous, as certain signs may point to a particular pathology. Colonoscopy is the diagnostic test of choice, and can also be used as a therapeutic tool.

关键词： Polyp Juvenile Prolapse Child

Uterovaginal Prolapse in the Newborn: A Case Report from the University Hospital of Conakry

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Open Journal of Pediatrics 2023年第1期13卷 69-73页

作者： Balla Keita Sacko Mohamed Lamine Sadou Toure Mamadou Alpha Barry Thierno Saidou Barry Mamadou Madiou agbo-panzo daniel Pediatric Surgery Department Donka University Hospital Conakry Guinea Gamal Abdel Nasser University of Conaky Conakry Guinea

Uterovaginal prolapse is an exceptional pathology in the newborn. It is defined by the descent and protrusion of the uterus and vaginal walls to the outside via the vaginal orifice. It particularly affects newborns with neural tube defects. The diagnosis is usually made at birth. Different types of conservative or surgical treatment have been suggested for genital prolapse in neonates. We report the case of a newborn of 6 hours of life who was received for congenital utero-vaginal without neural tube closure anomaly. He was successfully treated with digital reduction of the mass associated with a cerclage of the vaginal orifice. Conclusion: Digital reduction of the prolapse associated with a cerclage of the vaginal orifice is simple, effective and avoids any recurrence.

关键词： Newborn Utero-Vaginal Prolapsed Congenital

Congenital Cervico-Mandibular Cystic Lymphangioma in Pediatric Surgical Setting in Guinea

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Open Journal of Pediatrics 2024年第1期14卷 164-173页

作者： Thierno Saïdou Barry Mohamed Lamine Sadou Sacko Balla Keita Aissatou Bailo Balde Mamadou Alpha Diallo Moussa Conde Ibrahima Kalil Dioubate Mory Sangare Salamata Sall Mariama Dalanda Diallo Daniel Agbo-Panzo Pediatric Surgery Department Donka National Hospital (HND) of Conakry University Hospital (Gamal Abdel Nasser University of Conakry (UGANC) of Guinea) Conakry Guinea Hadja Bilguissou BARRY Medical-Surgical Clinic (HBB) Conakry Guinea Albert Royer Children’s Service Cheikh Anta DIOP University (UCAD) Dakar Senegal Surgery Department of the Regional Hospital Center of Ziguinchor (CHRZ) Ziguinchor Senegal

Introduction: Cystic lymphangiomas are rare benign malformative tumors of the lymphatic system of obscure etiopathogenesis. The cervico-facial location remains the most common (75%). Although benign, these tumors remain potentially fatal, due to possible compression of the upper aero-digestive tract. The aim of this work is to study the epidemiological, diagnostic and therapeutic characteristics of cervico-mandibular congenital cystic lymphangiomas in the pediatric surgery department of the Donka National Hospital (HND) Conakry. Patients and methods: This is a retrospective and descriptive study of 13 files lasting 7 years from January 2015 to December 31, 2021. The files of children whose age is less than or equal to 15 years operated on cervical tumor with histological evidence of cystic lymphangioma were retained. The data were analyzed using SPSS statistical software 21 and anonymously. Results: The incidence of this study was 1.86 cases per year and a sex ratio of 0.62 in favor of girls. The average age was 8 months 19 days. In the antecedents, we only find poorly monitored pregnancies. The average size of the tumors was 11.85 cm. Cervical ultrasound and standard x-ray of the cervical mass were the only examinations performed. Total surgical excision of the cervical tumor was performed in all patients. The mass was polycystic on exploration. The histological examination of the surgical specimens was in favor of a cystic lymphangioma. The surgical consequences were simple in 11 patients (84.62%) and complicated by parietal suppuration in 2 cases (15.38%). There were no cases of recurrence after one year of follow-up. Conclusion: Cervico-mandibular cystic lymphangiomas are the most frequent locations of congenital lymphangiomas in children. Their severity is linked to the risk of compression of the aero-digestive tracts. Their diagnosis must be confirmed by the histology of the surgical specimen. Despite the therapeutic arsenal, excision of the cystic mass remains the only effective alternative in our socio-ec

关键词： Congenital Cystic Lymphangioma (LKC) Child Pediatric Surgery Guinea

Therapeutic efficacy of voltage‑gated sodium channel inhibitors in epilepsy

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Acta Epileptologica 2023年第2期6卷 65-85页

作者： John agbo Zainab G.Ibrahim Shehu Y.Magaji Yahkub Babatunde Mutalub Philemon Paul Mshelia daniel H.Mhyha Department of Clinical Pharmacology and Therapeutics Faculty of Basic Clinical SciencesCollege of Medical SciencesAbubakar Tafawa Balewa UniversityBauchi 740272Nigeria Department of Physiology Faculty of Basic Medical ScienceCollege of Medical SciencesAbubakar Tafawa Balewa UniversityBauchi 740272Nigeria Department of Medical Biochemistry Faculty of Basic Medical ScienceCollege of Medical SciencesAbubakar Tafawa Balewa UniversityBauchi 740272Nigeria

Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges of the brain and a predisposition to generate epileptic seizures resulting in a broad spectrum of neurobiological insults,imposing psychological,cognitive,social and also economic burdens to the sufferer.Voltage-gated sodium channels(VGSCs)are essential for the generation and propagation of action potentials throughout the central nervous system.Dysfunction of these channels has been implicated in the pathogenesis of epilepsy.VGSC inhibitors have been demonstrated to act as anticonvulsants to suppress the abnormal neuronal firing underlying epileptic seizures,and are used for the management and treatment of both genetic-idiopathic and acquired epilepsies.We discuss the forms of idiopathic and acquired epilepsies caused by VGSC mutations and the therapeutic efficacy of VGSC blockers in idiopathic,acquired and pharmacoresistant forms of epilepsy in this review.We conclude that there is a need for better alternative therapies that can be used alone or in combination with VGSC inhibitors in the management of epilepsies.The current anti-seizure medications(ASMs)especially for pharmacoresistant epilepsies and some other types of epilepsy have not yielded expected therapeutic efficacy partly because they do not show subtype-selectivity in blocking sodium channels while also bringing side effects.Therefore,there is a need to develop novel drug cocktails with enhanced selectivity for specific VGSC isoforms,to achieve better treatment of pharmacoresistant epilepsies and other types of epileptic seizures.

关键词： Epilepsy Voltage-gated sodium channels Idiopathic epilepsy Acquired epilepsy Anti-seizure medications Pharmacoresistant epilepsy

A regional GNSS-VTEC model over Nigeria using neural networks： A novel approach

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Geodesy and Geodynamics 2016年第1期7卷 19-31页

作者： daniel Okoh Oluwafisavo Owolabi Christovher Ekechukwu Olanike Folarin Gila Arhiwo Joseph agbo Segun Bolaji Babatunde Rabiu NASRDA Center for Atmospheric Research Kogi State University Anyigba Campus Nigeria Ionospheric & Space Physics Laboratory Department of Physics University of Lagos Nigeria Department of Physics University of Calabar Nigeria Department of Physics Federal University of Agriculture Makurdi Nigeria Department of Surveying & Geo-informatics Nnamdi Azikiwe University Awka Nigeria

A neural network model of the Global Navigation Satellite System - vertical total electron content （GNSS-VTEC） over Nigeria is developed. A new approach that has been utilized in this work is the consideration of the International Reference Ionosphere＇s （IRI＇s） critical plasma frequency （foF2） parameter as an additional neuron for the network＇s input layer. The work also explores the effects of using various other input layer neurons like distur- bance storm time （DST） and sunspot number. All available GNSS data from the Nigerian Permanent GNSS Network （NIGNET） were used, and these cover the period from 2011 to 2015, for 14 stations. Asides increasing the learning accuracy of the networks, the inclusion of the IRI＇s foF2 parameter as an input neuron is ideal for making the networks to learn long-term solar cycle variations. This is important especially for regions, like in this work, where the GNSS data is available for less than the period of a solar cycle. The neural network model developed in this work has been tested for time-varying and spatial per- formances. The latest 10% of the GNSS observations from each of the stations were used to test the forecasting ability of the networks, while data from 2 of the stations were entirely used for spatial performance testing. The results show that root-mean-squared-errors were generally less than 8.5 TEC units for all modes of testing performed using the optimal network. When compared to other models, the model developed in this work was observed to reduce the prediction errors to about half those of the NeQuick and the IRI model.

关键词： Global Navigation Satellite System（GNSS） ionosphereTotal electron content （TEC）Nigerian permanent GNSS network（NIGNET）Neural networkInternational reference ionosphere（IRI）