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中国病理生理学会危重病医学专业委员会第八届全国大会暨中...

作者： daniel a.sweeney Robert L.Danner Peter Q.Eichacker Charles Natanson Critical Care Medicine Department Clinical CenterNational Institutes of HealthBuilding 10Room 2C145BethesdaMD 20892-1662USA

＜正＞Introduction In this issue of Intensive Care Medicine,the steering committee members of the PROWESS-Shock trial pres- ent a balanced discussion of the controversies surrounding recombinant human activated protein C（rhAPC）and the challenges intrinsic to designing an industry-sponsored *** investigators have taken important steps to be transparent about financial conflicts of interest,to

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Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

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Congenital Heart Disease 2023年第3期18卷 315-323页

作者： daniel sweeney Scott Cohen Salil Ginde Jennifer Gerardin Peter Bartz Matthew Buelow Medical College of Wisconsin MilwaukeeWIUSA Department of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Department of Internal Medicine Medical College of WisconsinMilwaukeeWIUSA

Background:Women with congenital heart disease(CHD)have increased risk for adverse events during pregnancy and *** studies have assessed pregnancy and delivery outcomes at tertiary referral centers(TRC).The aim of our study was to assess pregnancy outcomes in women with CHD who deliver in a non-tertiary referral center(non-TRC).Methods:Clinical demographics were collected,including anatomic complexity,physiologic state and pre-pregnancy risk *** were stratified by delivery location,either TRC or *** and neonatal complications of pregnancy were ***:Women with CHD who delivered in a TRC had a higher pre-pregnancy risk when assessed by the Zahar and CARPREG-II scores,and had more patients fall into a higher WHO *** was no difference in rates of maternal cardiac complications between delivery locations(11%)and neonatal complications(20%)between deliveries at TRC and ***:There were not increased maternal cardiac or neonatal complications when delivery occurred at a *** complications remained high regardless of delivery *** study suggests that proper risk assessment may help identify women who are candidates for safe delivery at non-TRC in women with CHD,and that neonatal resources should be considered when planning delivery location.

关键词： Congenital heart disease pregnancy delivery outcome

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儿童游戏治疗

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作者： (美)daniel S. sweeney

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Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization

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World Journal of Gastroenterology 2016年第47期22卷 10406-10414页

作者： Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer sweeney daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad Department of Radiation Oncology H Lee Moffitt Cancer Center and Research Institute Department of Interventional Radiology H Lee Moffitt Cancer Center and Research Institute Department of Gastrointestinal Oncology H Lee Moffitt Cancer Center and Research Institute

AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver *** We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization.

关键词： F-18 fluorodeoxyglucose 宠物 Hepatocellular 癌 Radioembolization 预后 Biomarker

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Gastric intestinal metaplasia development in African American predominant United States population

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World Journal of Gastrointestinal Endoscopy 2022年第10期14卷 597-607页

作者： Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew sweeney Christopher B Swisher daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho Department of Internal Medicine MedStar Washington Hospital CenterWashingtonDC 20010United States Department of Internal Medicine Georgetown University School of MedicineWashingtonDC 20007United States Department of Gastroenterology and Hepatology INOVA Medical SystemLeesburgVA 20176United States

BACKGROUND Gastric cancer significantly contributes to cancer mortality *** intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric *** natural history of GIM formation and progression over time is not fully ***,there are no clear guidelines on GIM surveillance or management in the United *** To investigate factors associated with GIM development over time in African American-predominant study *** This is a retrospective longitudinal study in a single tertiary hospital in Washington *** retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December *** included in the study had undergone two or more EGDswith gastric *** with no GIM at baseline were followed up until they developed GIM or until the last available *** criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy *** study population was divided into two groups based on GIM *** and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(***)status on the GIM *** Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)*** gender difference was obse

关键词： Gastric intestinal metaplasia Gastric cancer Helicobacter pylori Retrospective longitudinal study Esophagogastroduodenoscopy African American population

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如何迎接市场永恒变化的挑战

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文明与宣传 2000年第11期 60-60页

作者： daniel J. sweeney 左峰

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