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Apical Ballooning Syndrome: Recent Insights from a Consecutive Series of 104 Patients

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Health 2015年第1期7卷 9-13页

作者： Sandhya Shresthra daniel Juneau daniel hermann Gretchen L. Wells Section on Pulmonary/Critical Care Medicine Department of Internal Medicine Wake Forest School of Medicine Winston-Salem USA Section on Cardiovascular Medicine Department of Internal Medicine Wake Forest School of Medicine Winston-Salem USA

Apical ballooning syndrome (Takotsubo cardiomyopathy) is an increasingly recognized form of acute systolic dysfunction which is usually reversible. It typically occurs in post-menopausal women following a major psychological stressor. We conducted a single center, retrospective analysis of all hospitalized patients from 2001-2012 and found 104 patients who met the diagnostic criteria for apical ballooning. In this current largest series of its kind, 83% of the patients were women. Among both men and women, an antecedent stressor was not always identified. The exact pathophysiologic mechanism resulting in apical ballooning remains poorly understood. These findings challenge the paradigm that catecholamine cardiotoxicity in the setting of relative estrogen deficiency results in the cardiomyopathy.

关键词： Apical Ballooning Takotsubo Catecholamines Estrogen

Multiplex Rapid Test with Acceptable Diagnosis Performance as a Solution to Increase Diagnosis of Hepatitis B and C Viruses in Pregnant Women in an Area of High Prevalence of Both Hepatitis Viruses Associated with HIV

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Open Journal of Medical Microbiology 2024年第1期14卷 50-65页

作者： Catherine Boni-Cisse Nina Esther Onstira Ngoyi Hermione Dahlia Mossoro-Kpinde Noella Packo Rabi Senekian hermann Ndoidet Koutou Coretha Bokia-Baguida Christelle Luce Bobossi-Gadia Arthur Simplice Sombot-Ndicky daniel Yvon Gonessa Freddy Samuel Ngbonga Konzapa Voulou Christian Diamant Mossoro-Kpinde Alassane OUATTARA National Center of Medical Oncology and Radiotherapy Abidjan Ivory Cost Department of Microbiology UFR of Medical Sciences University of Cocody Abidjan Ivory Cost Laboratory of Bacteriology-Virology of Teaching Hospital Center of Brazzaville Brazzaville Republic of Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Republic of Congo Department of Labor Medicine Service of HIV and STDs Control in the Workplace Bangui Central African Republic (CAR) Faculty of Health Sciences University of Bangui Bangui Central African Republic National Reference Center of Sexually Transmitted Diseases and Antiretroviral Therapy Bangui Central African Republic National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Medicine Department District Hospital of Alindao Alindao Ouaka Prefecture Central African Republic Doctoral School of Sciences and Technology University of Bangui Bangui Central African Republic Coordination of Specialized Study of Clinical Biology University of Bangui Bangui Central African Republic Doctors without Borders Hospital Sica BanguiCRA Laboratory of Medical Analysis of Teaching Hospital Center Mother Elisabeth DOMITIEN of Bimbo Bimbo Central African Republic

Background and Objective: HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of HIV, HCV and HBV co-infections in pregnant women at Bangui Community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. HIV, HCV antibodies and HBV antigens were detected using Exacto Triplex? HIV/HCV/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of HIV and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of HIV, HBV, and HCV viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for HIV-HBV, 10.2% for HIV-HCV, 14.7% for HBV-HCV and 6.5% for HIV-HBV-HCV. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 FCFA (60 Euros) by ELISA compared to 10,000 FCFA (15.00 Euros) with Exacto Triplex? HIV/HCV/AgHBs (BioSynex, Strasbourg, France). Conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.

关键词： HIV-HCV-HBV Co-Infection Multiplex Immunochromatographic Rapid Test Central Africa Serology Test Cost Diagnostic Accessibility

Evaluating the morphology of the degradation layer of pure magnesium via 3D imaging at resolutions below 40 nm

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Bioactive Materials 2021年第12期6卷 4368-4376页

作者： Berit Zeller-Plumhoff daniel Laipple Hanna Slominska Kamila Iskhakova Elena Longo Alexander hermann Silja Flenner Imke Greving Malte Storm Regine Willumeit-Romer Helmholtz-Zentrum hereon GmbH Institute of Metallic BiomaterialsMax-Planck-Straße 121502GeesthachtGermany Helmholtz-Zentrum hereon GmbH Research ReactorMax-Planck-Straße 121502GeesthachtGermany Helmholtz-Zentrum hereon GmbH Institute of Materials PhysicsMax-Planck-Straße 121502GeesthachtGermany Helmholtz-Zentrum hereon GmbH Institute of Materials Systems ModellingMax-Planck-Straße 121502GeesthachtGermany Diamond Light Source Ltd. Diamond HouseHarwell Science and Innovation CampusDidcotOX110DEUnited Kingdom

Magnesium is attractive for the application as a temporary bone implant due to its inherent biodegradability,non-toxicity and suitable mechanical *** degradation process of magnesium in physiological environments is complex and is thought to be a diffusion-limited transport *** use a multi-scale imaging approach using micro computed tomography and transmission X-ray microscopy(TXM)at resolutions below 40 ***,we are able to evaluate the nanoporosity of the degradation layer and infer its impact on the degradation process of pure magnesium in two physiological *** samples were degraded in simulated body fluid(SBF)or Dulbecco’s modified Eagle’s medium(DMEM)with 10%fetal bovine serum(FBS)for one to four *** reveals the three-dimensional interconnected pore network within the degradation layer for both *** pore network morphology and degradation layer composition are similar for all *** contrast,the degradation layer thickness in samples degraded in SBF was significantly higher and more inhomogeneous than in DMEM+10%*** features could be observed within the degradation layer of samples degraded in SBF,suggesting the formation of microgalvanic cells,which are not present in samples degraded in DMEM+10%*** results suggest that the nanoporosity of the degradation layer and the resulting ion diffusion processes therein have a limited influence on the overall degradation *** indicates that the influence of organic components on the dampening of the degradation rate by the suppression of microgalvanic degradation is much greater in the present study.

关键词： Magnesium degradation Porosity Transmission X-ray microscopy 3D imaging

Energy and Material Flow Evaluation with CO2 Emissions in the Glass Production Process

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Advances in Materials Physics and Chemistry 2022年第5期12卷 82-105页

作者： Gregor Berger Zlatko Raonic daniel Forthuber Harald Raupenstrauch Robert hermann Chair of Thermal Processing Technology Montanuniversitaet Leoben Leoben Austria TüV SüD Landesgesellschaft Ö sterreich GmbH Bruck/Mur Austria

Glass manufacturing is an energy-intensive process with high demands on product quality. The wide usage of glass products results in a high end-product diversity. In the past, many models have been developed to optimize specific process steps, such as glass melting or glass forming. This approach presents a tool for the modeling of the entire glass manufacturing process for container glass, flat glass, and glass fibers. The tool considers detailed bottom-up energy and material balance in each step of the processing route with the corresponding costs and CO2 emissions. Subsequently, it provides the possibility to quantify optimization scenarios in the entire glass manufacturing process in terms of energy, material and cost flow efficiency.

关键词： Energy Efficiency Glass Industry Energy Balance Container Glass Flat Glass Glass Fiber

Fully printed origami thermoelectric generators for energy-harvesting

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npj Flexible Electronics 2021年第1期5卷 1-8页

作者： Andres Georg Rösch AndréGall Silas Aslan Matthias Hecht Leonard Franke MdMofasser Mallick Lara Penth daniel Bahro daniel Friderich Uli Lemmer Light Technology Institute Karlsruhe Institute of TechnologyEngesserstrasse 1376131 KarlsruheGermany InnovationLab Speyerer Strasse 469115 HeidelbergGermany otego GmbH Haid-und-Neu-Strase 776131 KarlsruheGermany Institute of Microstructure Technology Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Energy-harvesting from low-temperature environmental heat via thermoelectric generators(TEG)is a versatile and maintenancefree solution for large-scale waste heat recovery and supplying renewable energy to a growing number of devices in the Internet of Things(IoT)that require an independent wireless power supply.A prerequisite for market competitiveness,however,is the costeffective and scalable manufacturing of these *** approach is to print the devices using printable thermoelectric polymers and composite *** present a mass-producible potentially low-cost fully screen printed flexible origami *** a unique two-step folding technique,we produce a mechanically stable 3D cuboidal device from a 2D layout printed on a thin flexible substrate using thermoelectric inks based on PEDOT nanowires and a TiS2:Hexylamine-complex *** realize a device architecture with a high thermocouple density of 190 per cm2 by using the thin substrate as electrical insulation between the thermoelectric elements resulting in a high-power output of 47.8μWcm^(−2)from a 30 K temperature *** device properties are adjustable via the print layout,specifically,the thermal impedance of the TEGs can be tuned over several orders of magnitudes allowing thermal impedance matching to any given heat *** demonstrate a wireless energy-harvesting application by powering an autonomous weather sensor comprising a Bluetooth module and a power management system.

关键词： energy harvesting impedance

Origin of non-uniform plasticity in a high-strength Al-Mn-Sc based alloy produced by laser powder bed fusion

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Journal of Materials Science & Technology 2022年第8期103卷 121-133页

作者： Dina Bayoumy Kwangsik Kwak Torben Boll Stefan Dietrich daniel Schliephake Jie Huang Junlan Yi Kazuki Takashima Xinhua Wu Yuman Zhu Aijun Huang Monash Centre for Additive Manufacturing 15-17 Normanby RdNotting HillVIC 3168Australia Department of Materials Science and Engineering Monash UniversityClaytonVIC 3800Australia Department of Materials Science and Engineering Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Karlsruhe Nano Micro Facility(KNMF) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344Eggenstein-LeopoldshafenGermany Institute for Applied Materials(IAM-WK) Karlsruhe Institute of Technology(KIT)Engelbert-Arnold-Straße 476131 KarlsruheGermany Aeronautical Manufacturing Technology Institute Shanghai Aircraft Manufacturing Co.Ltd.Shanghai 201324China

The Al-Mn-Sc-based alloys specific for additive manufacturing(AM)have been recently developed and can reach ultrahigh strength and adequate ***,these alloys commonly exhibit nonuniform plasticity during tensile deformation,which is a critical issue hindering their wider *** this work,the origin of this non-uniform plasticity of the alloys produced by laser powder bed fusion(LPBF)has been systematically investigated for the first *** results show that the loss of uniform plasticity in the alloy originates from microstructural regions containing equiaxed fine-grains(FGs)(~650nm in size)at the bottom of the melt *** micro-tensile tests,the strength of these FG regions can reach a peak of~630 *** this,an apparent yield drop occurs,followed by rapid strain *** FG behavior is associated with intermetallic particles along grain boundaries and a lack of uniform mobile dislocations during *** columnar coarse-grain(CG)regions in the remaining melt pools show uniform plasticity and moderate work ***,the quantitative calculations indicate that the solid solution strengthening in these two regions is ***,secondary Al_(3)Sc precipitates contribute to~260 MPa strength in the FG,compared to 310 MPa in the CG due to their different number *** addition,grain boundary strengthening can reach 230 MPa in the FG region;nearly double the CG region value.

关键词： Aluminium alloy Laser powder bed fusion Crystal plasticity Microstructures Strengthening

Antioxidant and Antimicrobial Capacities of Two Medicinal Plants Used against Urinary Infections in Burkina Faso

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Advances in Microbiology 2022年第12期12卷 671-683页

作者： Sami Eric Kam Roland Nâg-Tiéro Meda Soufiane Domalick Sanou Windmi Kagambega Clarisse Ouedraogo Franck Téounviel Somda Isaac Saamou Boni Eliasse Zongo daniel Kobo Gnada Azouman Da Benjamin Kouliga Koama hermann Yempabou Ouoba Georges Anicet Ouedraogo Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales Université Nazi Boni Bobo-Dioulasso Burkina Faso Laboratoire de Recherche en Bactériologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso Laboratoire de Médicine et Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé Direction Régionale de l’Ouest Bobo-Dioulasso Burkina Faso

Objective: This study aimed to evaluate the antioxidant and antimicrobial capacities of extracts from Euphorbia hirta L. and Terminalia avicennioides GUILL & PERR. Methodology: The crude hydro-acetonic and aqueous extracts as well their fractionations were prepared. The total phenolic, flavonoids and tannins contents were assessed using the Folin-Ciocalteu, aluminum chloride and vanillin acid methods, respectively. The antioxidant and antibacterial activities were investigated using standard methods. Results: Euphorbia hirta showed significant contents of total phenolic and flavonoids in n-Butanol (145.14 ± 1.37 GAE/100mg extracts) and ethyl acetate (23.56 ± 0.68 mg QE/ 100mg extracts) fractions. Total tannins were high in hydro-acétonique extract (11.18 ± 0.31 mg TAE/100mg extracts) and aqueous fraction (11.12 ± 0.28 mg TAE/100mg extracts) of Terminalia avicennioides stem barks. Extracts and fractions of both plants demonstrated a strongly antioxidant capacity through the free radicals scavenging and the ferric ions reducing. Concerning antimicrobial screening the extracts of Terminalia avicennioides were effective against 16 causative pathogens of urinary tract infections. Bactericidal effect against Staphylococcus aureus ATCC 29213, Staphylococcus aureus and 2 methicillin-resistant Staphylococcus haemolyticus strains was found with aqueous fraction of Terminalia avicennioides leaves. This fraction also highlighted a synergetic effect with some antibiotics used against these bacterial strains. Conclusion: Terminalia avicennioides leaves could be recommended as an herbal drug formulation for the urinary infections management.

关键词： Antimicrobial Antioxidant Euphorbia hirta L. Terminalia avicennioides GUILL & PERR Urinary Infections

Thorium/uranium mixed oxide nanocrystals： Synthesis, structural characterization and magnetic properties

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Nano Research 2014年第1期7卷 119-131页

作者： Damien Hudry Jean-Christophe Griveau Christos Apostolidis Olaf Walter Eric Colineau Gert Rasmussen Di wang Venkata Sai Kiran Chakravadhaluna Eglantine Courtois Christian Kubel daniel Meyer European Commission: Joint Research Centre Institute for Transuranium Elements P. O. Box 2340 76125 Karlsruhe Germany Karlsruhe Institute of Technology Institute ofNanotechnology Hermann-von-Helmholtz-Platz1 76344 Eggenstein-Leopoldshafen Germany Karlsruhe Institute of Technology Karlsruhe Nano Micro Facility Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen Germany Helmholtz Institute UIm for Electrochemical Energy Storage Albert-Einstein-Allee 11 89069 UIm Germany Institut de Chimie Separative de Marcoule UMR 5257 BP 1717 1 30207 Bagnols sur Ceze Cedex France Karlsruhe Institute of Technology Institute for Catalysis Research and Technology Hermann-von-Helmholtz-Platz 1 76344 Eggenstein Leopoldshafen Germany

One of the primary aims of the actinide community within nanoscience is to develop a good understanding similar to what is currently the case for stable elements. As a consequence, efficient, reliable and versatile synthesis techniques dedicated to the formation of new actinide-based nano-objects （e.g., nanocrystals） are necessary. Hence, a ＂library＂ dedicated to the preparation of various actinidebased nanoscale building blocks is currently being developed. Nanoscale building blocks with tunable sizes, shapes and compositions are of prime importance. So far, the non-aqueous synthesis method in highly coordinating organic media is the only approach which has demonstrated the capability to provide size and shape control of actinide-based nanocrystals （both for thorium and uranium, and recently extended to neptunium and plutonium）. In this paper, we demonstrate that the non-aqueous approach is also well adapted to control the chemical composition of the nanocrystals obtained when mixing two different actinides. Indeed, the controlled hot co-injection of thorium acetylacetonate and uranyl acetate （together with additional capping agents） into benzyl ether can be used to synthesize thorium/uranium mixed oxide nanocrystals covering the full compositional spectrum. Additionally, we found that both size and shape are modified as a function of the thorium：uranium ratio. Finally, the magnetic properties of the different thorium/uranium mixed oxide nanocrystals were investigated. Contrary to several reports, we did not observe any ferromagnetic behavior. As a consequence, ferromagnetism cannot be described as a universal feature of nanocrystals of non-magnetic oxides as recently claimed in the literature.

关键词： thorium uranium mixed oxide non-aqueous synthesis nanoparticle nanocrystal magnetism

Pharmacological Tie2 activation in kidney transplantation

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World Journal of Transplantation 2016年第3期6卷 573-582页

作者： Kristina Thamm Florence Njau Paul Van Slyke daniel J Dumont Joon-Keun Park hermann Haller Sascha David Department of Nephrology and Hypertension Medical School Hannover Vasomune Therapeutics Inc Biological Sciences Sunnybrook Research Institute

AIM To investigate the therapeutic potential of vasculotide(VT)- a Tie2 activating therapeutic- in kidney *** We performed a murine MHC-mismatched renal transplant model(C57Bl/6 male into Balb/c female) with 60 min cold and 30 min warm ischemia time. 500 ng VT was administered i.p. to donor mice 1 h before organ removal. In addition, recipients received 500 ng VT i.p. directly and 3 d after surgery. Survival was monitored and remaining animals were sacrificed 28 d after transplantation. In this model, we analyzed:(1) organ function;(2) Kaplan-Meier survival;(3) organ damage(periodic acid Schiff staining) via semi-quantitative scoring [0-4(0 = no injury/inflammation to 4 = very severe injury/inflammation)];(4) expression of renal endothelial adhesion molecules(ICAM-1) viaimmunofluorescence(IF) staining, immunoblotting and q PCR;(5) infiltration of inflammatory cells(IF Gr-1, F4/80); and(6) fibrosis via staining of α-smooth muscle actin(αSMA), Sirius red staining and immunoblotting of SMAD3 *** Exogenous activation of Tie2 with VT resulted in diminished expression of peritubular and glomerular endothelial adhesion molecules. Consequently, infiltration of inflammatory cells(analyzed as ICAM-1, Gr-1 and F4/80 positive cells) was reduced in VT-treated mice compared to controls. Additionally, VT was protective against fibrogenesis after kidney transplantation. Trends towards lower serum creatinine(vehicle: 142 ± 17 μmol/L vs VT: 94 ± 23 μmol/L), urea(vehicle: 76 ± 5 mmol/L vs VT: 60 ± 8 mmol/L) and lactate dehydrogenase(vehicle: 1288 ± 383 iU vs VT: 870 ± 275 iU) were observed on day 6 after transplantation. Kaplan-Meier survival analysis showed improved survival rates in the VT-treated mice that did not reach statistical significance(27% vs 54%, P = 0.24, n = 11 per group). Exogenous activation of Tie2 via VT might reduce infiltration of inflammatory cells into renal tissue thereby protecting the transplant from early graft dysfunction

关键词： Vasculotide Tie2 Kidney transplantation Endothelium Angiopoietin