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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

A Ring-Reinforced Right Ventricle to Pulmonary Artery Conduit Is Associated with Better Regional Mechanics after Stage I Norwood Operation

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Congenital Heart Disease 2022年第5期17卷 591-603页

作者： Benjamin Zielonka David M.Harrild Sunil j.Ghelani Eleni G.Elia Christopher W.Baird Andrew j.powell Rahul H.Rathod Department of Cardiology Boston Children’s HospitalBostonUSA Department of Pediatrics Harvard Medical SchoolBostonUSA Department of Cardiothoracic Surgery Boston Children’s HospitalBostonUSA Department of Surgery Harvard Medical SchoolBostonUSA

Background:The right ventricle to pulmonary artery conduit(RVPAC)may impair right ventricular(RV)function in patients with functional single right *** of the RVPAC using a ring-reinforced end with dunked insertion into the RV through a limited ventriculotomy may reduce the impact on RV *** compared RV segmental strain between patients with a traditional RVPAC and ring-reinforced RVPAC using feature tracking cardiovascular magnetic resonance(CMR)***:Patients with CMR examinations after Stage I operation with RVPAC between 2000 and 2018 were *** mass,volumes,late gadolinium enhancement(LGE),and peak radial and circumferential strain of the 4 segments near the RVPAC insertion site were ***:The study included 71 CMR examinations in 61 patients(30 traditional RVPAC,31 ring-reinforced RVPAC).Prior to Stage II,the ring-reinforced RVPAC group had better peak radial strain and circumferential strain in 1 of 4 segments proximal to the RVPAC insertion site compared to the traditional RVPAC *** to Stage III operation,the ring-reinforced group had better peak radial and circumferential strain in 2 of 4 *** at the RVPAC insertion site was observed in 97%of patients before Stage II and 95%of patients before Stage *** type and regional strain were not associated with transplant-free survival during a median follow-up of 6.3 ***:Compared to a traditional RVPAC,the ring-reinforced RVPAC is associated with improved regional mechanics at the conduit insertion *** investigation of long-term outcomes after ring-reinforced RVPAC is warranted.

关键词： Single ventricle hypoplastic left heart syndrome cardiovascular magnetic resonance feature tracking

Detection of Arterial Occlusions Using Viscoelastic Wave Propagation

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Advances in Applied Mathematics and Mechanics 2009年第1期1卷 1-28页

作者： H.T.Banks j.R.Samuels,jr. Center for Research in Scientific Computation North Carolina State UniversityCampus Box 8212RaleighNC 27695-8212USA

We consider the problem of detecting cardiac artery occlusions using stenosis driven viscoelastic(VE)waves propagated through biotissue to body surface *** investigate possible statistical model formulations(ordinary least squares(OLS),generalized least squares(GLS))and post analysis techniques(residual plots)to ascertain uncertainty in estimates as well as validity of the statistical models as part of a methodology for stenosis detection using viscoelastic waves.

关键词： Inverse problems viscoelastic models wave propagation in biotissue statistical models

Up-regulation of Long Non-coding RNA TUG1 in Hibernating Thirteen-lined Ground Squirrels

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Genomics, Proteomics & Bioinformatics 2016年第2期14卷 113-118页

作者： jacques j.Frigault Daneck Lang-Ouellette Pier Morin jr. Department of Chemistry and Biochemistry Faculty of Sciences Universite'de Moncton

Mammalian hibernation is associated with multiple physiological, biochemical, and molecular changes that allow animals to endure colder temperatures. We hypothesize that long non-coding RNAs（lnc RNAs）, a group of non-coding transcripts with diverse functions, are differentially expressed during hibernation. In this study, expression levels of lncRNAs H19 and TUG1 were assessed via qRT-PCR in liver, heart, and skeletal muscle tissues of the hibernating thirteen-lined ground squirrels（Ictidomys tridecemlineatus）. TUG1 transcript levels were significantly elevated 1.94-fold in skeletal muscle of hibernating animals when compared with euthermic animals. Furthermore, transcript levels of HSF2 also increased 2.44-fold in the skeletal muscle in hibernating animals. HSF2 encodes a transcription factor that can be negatively regulated by TUG1 levels and that influences heat shock protein expression. Thus, these observations support the differential expression of the TUG1-HSF2 axis during hibernation. To our knowledge, this study provides the first evidence for differential expression of lnc RNAs in torpid ground squirrels, adding lnc RNAs as another group of transcripts modulated in this mammalian species during hibernation.

关键词： Hibernation Hypometabolism Cold adaptation Non-codiag RNAs lncRNAs

Elevated temperature intensity,timing,and duration of exposure affect soybean internode elongation,mainstem node number,and pod number per plant

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The Crop journal 2018年第2期6卷 148-161页

作者： Leon Hartwell Allen jr. Lingxiao Zhang Kenneth j.Boote Bernard A.Hauser U.S.Department of Agriculture-Agricultural Research Service GainesvilleFL 32608USA Department of Agronomy University of FloridaGainesvilleFL 32611USA Department of Biology University of FloridaGainesvilleFL 32611USA

A study was conducted in four compartments of a polycarbonate greenhouse at Gainesville,FL, USA to investigate how a soybean(Glycine max L. Merr.) cultivar, Maverick(maturity group III, indeterminate), responded to three elevated temperatures, ELT,(day/night of 34/26 °C, 38/30 °C, and 42/34 °C) in comparison to a control growth temperature(30/22 °C).Carbon dioxide(CO_2) concentration was maintained at 700 μmol mol^(-1) in each compartment by a processor controlled air-sampling and CO_2-injection system. Three sequential experiments were conducted at different times of year(summer, autumn, and early spring)to investigate the effect of intensity, timing, and duration of ELT on soybean node number,internode elongation, mainstem length, and number of pods set per plant. At the control temperature, the soybean plants grown in the polycarbonate greenhouse were taller than field-grown plants. When plants were grown under continuous ELT applied soon after sowing or at initial flowering, the number of nodes increased with increasing ELT intensity,whereas the length of individual internodes decreased. When ELT treatment was applied during the beginning of flowering stage(R1–R2) or earlier, more nodes were produced and the length of affected internodes was decreased. When the ELT was imposed later at reproductive stage R5+ just before the beginning of seed filling, effects on node numbers and internode lengths were negligible. Short-term(10-day) duration of ELT applied at four stages from V3 to R5+ did not significantly affect final mean numbers of nodes or mean mainstem lengths. Possible mechanisms of elevated temperature effects on soybean internode elongation and node number(internode number) are discussed. Total pod numbers per plant increased linearly with mainstem node numbers and mainstem ***, total pod numbers per plant were greatest at 34/26 °C rather than at the control temperature of 30/22 °C(and remained high at 38/30 °C). Mild increases in temperatu

关键词： Elevated temperature Internode elongation Node number Pod yield Soybean phenology

ADVANCES IN LIQUID CRYSTALLINE POLYESTERS

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Chinese journal of Polymer Science 1992年第3期10卷 195-202页

作者： W. j. jackson jr. Research Laboratories Eastman Chemical Company Eastman Kodak Company Kingsport Tennessee U.S.A.Research Laboratories Eastman Chemical Company Eastman Kodak Company Kingsport Tennessee U.S.A.

Advances have been made in understanding the interactions of composition, molecular weight, liquid crystallinity,orientation, and three-dimensional crystallinity on the properties of injection-molded and melt-spun liquid crystalline polyesters (LCP's). Two classes of potentially low-cost LCP's were compared:(1) semiflexible LCP's prepared from 1,6-hexanediol and the dimethyl ester of either trans-4, 4'stilbenedicarboxylic acid or 4.4 ' biphenyldicarboxylic acid and (2) all-aromatic LCP's prepared from terephthalic acid, 2, 6-naphthalenedicarboxylic acid, the diacetate of hydroquinone, and the acetate of p-hydroxybenzoic acid. The effects of composition on the plastic properties of the 4-component all-aromatic LCP's were determined with the aid of a 3 x 3 factorial statistically designed experiment, the generation of equations with a computer program, and the plotting of three-dimensional figures and contour diagrams. The effects of absolute molecular weight (M_w) on the tensile strengths of the semiflexible LCP's and one of the all-aromatic LCP's having an excellent balance of plastic properties were also compared, and it was observed that the semiflexible LCP's required M_w's about 4 times higher than the all-aromatic LCP to attain a given strength. Persistence lengths and molecular modeling were used to explain these differences.

关键词： Liquid crystal thermotropic polyester plastic properties

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可重复使用的无心感应炉筑衬钢模(英)

工业加热 1987年第6期19卷 50-51,33页

作者： j.powell 彭规锦

铸铁车间无心感应炉修筑炉衬,传统上是使用自耗钢模,以手工或振动围绕钢模捣筑耐火材料,钢模在炉衬烧结时加热熔化,成为第一炉铁水的一部分。新炉衬第一炉熔炼时,工频炉钢模中要装入起熔块。自耗钢模的主要缺点是筑一次炉衬就消耗一个... 详细信息

铸铁车间无心感应炉修筑炉衬,传统上是使用自耗钢模,以手工或振动围绕钢模捣筑耐火材料,钢模在炉衬烧结时加热熔化,成为第一炉铁水的一部分。新炉衬第一炉熔炼时,工频炉钢模中要装入起熔块。自耗钢模的主要缺点是筑一次炉衬就消耗一个钢模,增加筑衬费用,特别是大炉子(6吨炉,每个钢模值240英磅;12吨炉,每个钢模值365英磅)。除此之外,还有以下缺点: 1.炉衬尚未完全烧结。坩埚底部先形成熔池,由于铁水过热,使炉衬烧结质量不均匀;

关键词：钢模云母片炉衬烧结无心感应炉可重复使用

Deadlock-free dynamic resource assignment in multi-robot systems with multiple missions:application in wireless sensor networks

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控制理论与应用（英文版） 2010年第1期8卷 12-19页

作者： P.M.BALLAL A.C.TRIVEDI V.GIORDANO j.MIRELES jr. F.L.LEWIS Automation & Robotics Research Institute University of Texas at Arlington

In unstructured environments, dynamic resource assignment is required for effective cooperation of robot teams. In some scenarios, robots are in charge of executing multiple missions simultaneously. This creates risks of deadlock due to the presence of shared resources among various missions. The main contribution of this paper is the development of a novel approach that combines the one-step look-ahead deadlock avoidance policy with dynamic resource assignment. The dynamicresource assignment is achieved using greedy resource assignment for multi-mission robot teams in the framework of a matrix-based discrete event controller. Simulation results are presented in MATLAB to discuss in detail the proposed control strategy. The paper also discusses the toolkit developed in LabVIEW which is used to implement this control framework using a suitable example.

关键词： Discrete event systems Wireless sensor networks Deadlock avoidance Petri nets

外源性细胞因子对优化嵌合抗原受体修饰的T细胞抗肿瘤作用的研究

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外源性细胞因子对优化嵌合抗原受体修饰的T细胞抗肿瘤作用的研究