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Reduced macular thickness and vascular density in abnormal glucose metabolism patients:A meta-analysis of optical coherence tomography(OCT)and OCT angiography studies

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Chinese Medical Journal 2024年第9期137卷 1054-1068页

作者： Xiangyu Fu Xiang Ren Wenyue Chen danian Chen Department of Ophthalmology West China HospitalSichuan UniversityChengduSichuan 610041China Research Laboratory of Ophthalmology and Vision s.iences State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Ophthalmology The People’s Hospital of Guizhou ProvinceGuiyangGuizhou 550002China

Background:Alterations.in macular thickness and vascular density before clinically visible diabetic retinopathy(DR)remain *** study aimed to determine whether retinal manifestations.in abnormal glucose metabolism(AGM)patients differ from those in the healthy ***:PubMed,Embase,and Web of s.ience were searched between 2000 and *** eligibility criteria were AGM patients without *** and secondary outcomes measured by optical coherence tomography(OCT)and OCT angiography(OCTA)were analyzed and expressed as standardized mean differences(sMDs)with 95%confidence intervals(Cis).A random-effects model was used in the data *** potential publication bias for the variables was evaluated using Egger’s ***:A total of 86 observational studies.involving 13,773 participants and 15,416 eyes were *** revealed that compared to healthy controls,the total macular thickness of AGM patients was thinner,including the thickness of fovea(-0.24,95%Ci[-0.39,-0.08];P=0.002,i^(2)=87.7%),all regions of parafovea(-0.32,95%Ci[-0.54,-0.11];P=0.003;i^(2)=71.7%)and the four quadrants of perifovea;the thickness of peripapillary retinal nerve fiber layer(pRNFL),macular retinal nerve fiber layer(mRNFL),and ganglion cell layer(GCL)also *** indicated that the superficial and deep vascular density decreased,the foveal avascular zone(FAZ)area enlarged,and the acircularity index(Ai)reduced in AGM ***:Retinal thinning and microvascular lesions have occurred before the advent of clinically detectable DR;OCT and OCTA may have the potential to detect these preclinical ***:PROsPERO;http://***/prospero/;***42021269885.

关键词： Abnormal glucose metabolism Optical coherence tomography Optical coherence tomography angiography Diabetic retinopathy Prediabetes Meta-analysis

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Crustal thickness and composition in the south China Block:Constraints from earthquake receiver function

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s.ience China Earth s.iences 2022年第4期65卷 698-713页

作者： Changxin CHEN Qingtian LÜ Ling CHEN danian s.i Jiayong YAN Yinshuang Ai Chinese Academy of Geological s.iences Beijing 100037China Chinese MNR Laboratory of Deep Earth s.iences and Technology Beijing 100094China Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China state Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China CAs Center for Excellence in Deep Earth s.ience Guangzhou 510640China University of Chinese Academy of s.iences Beijing 100049China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

Crustal thickness and composition are closely related to geology and tectonic evolution of the *** the differences.in the crustal thickness and composition of the south China Block(sCB)is.important to gain a comprehensive understanding of multi-phase amalgamation,breakup,reworking,and regional geodynamic *** this study,teles.is.ic data from 135 high-density portable broadband stations from sino Probe were processed using Common Conversion Point(CCP)stacking and H-κstacking *** Moho depth and P-wave and s-wave velocity ratio(V_(p)/V_(s))were *** results revealed several insights about the tectonic processes.in the ***,the crustal structure and V_(p)/V_(s)ratios of the Cathaysia Block,Jiangnan Orogenic Belt,and Yangtze Block were significantly *** average depth of the Moho in the Cathaysia Block was approximately 31 km,and the V_(p)/V_(s)ratios.increased from the inland area(1.66)to the coastal area(1.78),indicating the oceanward increase of mafic proportion in the lower crust,which is related to the influence of the Paleo-Pacific Plate westward ***,the crustal thickness of Jiangnan Orogenic Belt deepens from east ca.31 to the west ca.42 km and the V_(p)/V_(s)ratios varied from 1.75 to 1.64,illustrating a relatively felsic crust,which could have been related to the Mesozoic upper crustal thickening under compres.ion followed by the lower crust removal under the extensional ***,the average crustal thickness of the Yangtze Block was 42 km,and the V_(p)/V_(s)ratios ranged from 1.64 to 1.84,presenting a positive correlation between the Moho depth and the V_(p)/V_(s)ratio,which is explained by the relatively thick mafic lower *** on the variations.in the crustal structure and V_(p)/V_(s)ratios of the profile,we inferred that the central part of the Jiangnan Orogenic Belt was bounded by the Jiangshan-shaoxing-Hengyang in the east and the Jiujiang-s.itai-Jishou in the *** small-scale

关键词： P wave receiver function The south China Block Crustal thickness Crustal composition Block boundary

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Dynamic response of a Q&P steel to high-strain-rate tension

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Acta Mechanica solida sinica 2017年第5期30卷 484-492页

作者： Huanran Wang Wenchao Zhang Dongfang Ma Bohan Ma danian Chen Xin Yang Chunlei Fan Mechanics and Materials s.ience Research Center Ningbo UniversityNingboZhejiang 315211China China s.ience Lab Research&Development CenterGeneral Motors CompanyShanghai 202106China

The experimental study on the volume fraction of retained austenite for QP980CR steel under high-strain-rate tension is briefly described. An interrupted tensile split Hopkinson bar （TsHB） is developed to control the elongation of specimens. The QP980CR steel sam- ples recovered from the interrupted Tst-iB tests are inves.igated using synchrotron X-ray diffraction （XRD） to analyze the effects of strain and strain rate on the martensitic trans- formation of retained austenite. A cons.itutive model of QP980CR steel coupling with the transformation-induced plas.icity （TRiP） effect is presented based on Delannay＇s mean-field modeling. The stress-strain curves of quasi-static and dynamic tensile tests for QP980CR steel are compared with the results predicted by the presented cons.itutive model. The dif- fuse necking of QP980CR steel sheet specimens.in TsHB tests.is analyzed using Batra and Vv＇ei＇s.instability criterion and the presented cons.itutive model. The effects of strain rate and temperature on the dynamic tensile fracture strain of QP980CR steel are also given.

关键词： interrupted Hopkinson testPhase transformationMultiphase cons.itutive modelDynamic fractureQP980CR steel

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As.imilating temperature and salinity profiles using Ensemble Kalman Filter with an adaptive observation error and T-s constraint

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Acta Oceanologica sinica 2016年第1期35卷 30-37页

作者： LiU danian s.i Ping sHU Yeqiang YAO Jinglong WANG Dongxiao sUN Lu state Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China south China sea Monitoring Center South China Sea Branch State Oceanic Administration Guangzhou 510301 China

Temperature （T） and salinity （s） profiles from conductivity-temperature-depth data collected during the Northern south China sea Open Cruise from August 16 to september 13, 2008 are as.imilated using Ensemble Kalman Filter （EnKF）. An adaptive observational error strategy is used to prevent filter from diverging. in the meantime, aiming at the limited improvement in some sites caused by the T and s biases.in the model, a T-s constraint scheme is adopted to improve the as.imilation performance, where T and s are separately updated at these locations. Validation is performed by comparing as.imilated outputs with independent in situ data （satellite remote sensing sea level anomaly （sLA）, the OsCAR velocity product and s.ipboard ADCP）. The results show that the new EnKF as.imilation scheme can significantly reduce the root mean square error （RMsE） of oceanic T and s compared with the control run and traditional EnKF. The system can also improve the simulation of circulations and sLA.

关键词： Ensemble Kalman Filter adaptive observation error T-s constraint

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salt tolerance of transgenic rice (Oryza sativa L.) with mtlD gene and gutD gene

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Chinese s.ience Bulletin 2000年第18期45卷 1685-1690页

作者： WANG Huizhong HUANG danian LU Ruifang LiU Junjun QiAN Qian PENG Xuexian Department of Biology Hangzhou Teacher’s CollegeHangzhou 310012China China National Rice Research ins.itute Hangzhou 310006China ins.itute of Microbiology Chinese Academy of SciencesBeijing 100080China

southern blot analysis.indicated that mtiD gene (encoding mannitol-1 -phosphate dehydrogenase) and gutD gene (encoding glucitol-6-phosphate dehydrogenase) had been integrated into the rice genome mediated by Agrobacterium tumefaciens LBA4404(pBiGM). The expres.ion of the above two genes.in transgenic rice plants was demonstrated by Northern blot analysis and enzymatic activity assay. Analysis of sugar alcohol showed that transgenic rice plants could produce and accumulate mannitol and sorbitol. The salt tolerance of transgenic plants was much higher than that of their controls.

关键词： Oryza sativa L. Agrobacterium tumefaciens D-mannitol-1-phosphate dehydrogenase D-glucitol-6-phosphate dehydrogenase salt tolerance.

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MicroRNA-505调控PLK1对前列腺癌细胞恶性生物学行为的影响及机制研究

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国际泌尿系统杂志 2024年第5期44卷 819-824页

作者：年智穆元忠申大年李国权青海省第五人民医院泌尿外科西宁810000 青海省第五人民医院肿瘤科西宁810000

目的探讨miR-505通过调控Polo样激酶1(PLK1)表达对前列腺癌PC-3细胞增殖、迁移和侵袭的影响。方法取第4代对数生长期PC-3细胞,随机分为对照组、NC组、miR-505 inhibitor组、mimic NC组和miR-505 mimic组,除对照组外,其余各组细胞分别转... 详细信息

目的探讨miR-505通过调控Polo样激酶1(PLK1)表达对前列腺癌PC-3细胞增殖、迁移和侵袭的影响。方法取第4代对数生长期PC-3细胞,随机分为对照组、NC组、miR-505 inhibitor组、mimic NC组和miR-505 mimic组,除对照组外,其余各组细胞分别转染inhibitor NC、miR-505 inhibitor、mimic NC和miR-505 mimic,48 h后,分别采用qRT-PCR检测细胞中miR-505的表达量、MTT法检测细胞存活率、划痕实验检测细胞的迁移能力、Transwell实验检测细胞的侵袭能力、双荧光素酶报告基因检测miR-505与PLK1的靶向关系、蛋白印迹法检测PLK1、波形蛋白、神经钙黏蛋白(N-cad)和上皮钙黏蛋白(E-cad)的相对表达量。结果与对照组比较,miR-505 inhibitor组的miR-505表达量和E-cad蛋白相对表达量降低,细胞存活率、细胞迁移率以及PLK1、波形蛋白和N-cad蛋白相对表达量升高,细胞侵袭能力增强(均PiR-505 mimic组的miR-505表达量和E-cad蛋白相对表达量升高,细胞存活率、细胞迁移率以及PLK1、波形蛋白和N-cad蛋白相对表达量降低,细胞侵袭能力减弱(均PiR-505 inhibitor组的miR-505表达量和E-cad蛋白相对表达量降低,细胞存活率、细胞迁移率以及PLK1、波形蛋白和N-cad蛋白相对表达量升高,细胞侵袭能力增强(均PiR-505 inhibitor组比较,miR-505 mimic组的miR-505表达量和E-cad蛋白相对表达量升高,细胞存活率、细胞迁移率以及PLK1、波形蛋白和N-cad蛋白相对表达量降低,细胞侵袭能力减弱(均Pimic NC组比较,miR-505 mimic组的miR-505表达量和E-cad蛋白相对表达量升高,细胞存活率、细胞迁移率以及PLK1、波形蛋白和N-cad蛋白相对表达量降低,细胞侵袭能力减弱(均PiR-505可减弱前列腺癌细胞的增殖、迁移和侵袭能力,其机制可能是通过抑制PLK1的表达发挥作用。

关键词：前列腺肿瘤 Polo样激酶1 miR-505 细胞增殖细胞运动

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Two Chinese Pioneers of Relativity

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自然科学史研究 2005年第B07期24卷 90-110页

作者： danian Hu City College of New York USA

1introductionOn December 17, 1922, Albert Einstein wrote from Kyoto, Japan to Xia Yuanli, a physics professor at Peking *** by Xia’s letter, Einstein nonetheless.informed Xia that he might not be able to come to Beijing, for which he could not help lamenting,“Beijing is so close and yet i cannot fulfill my long-cherished wish [to visit it], you can imagine how frustrated i am.”①Einstein had planned to visit Peking University and lecture for a few weeks at the beginning of ***, the planned trip was cancelled due to a series of *** the cancellation, however, the expected visit by Einstein triggered a wave of “relativity craze” among the educated Chinese public.

关键词：爱因斯坦相对论物理学中国科学研究

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New insights.into the Mesozoic Large-scale intra-plate Magmatism and Mineralization in south China from s.is.ic Tomography

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Acta Geologica sinica(English Edition) 2023年第4期97卷 1243-1251页

作者： s.i danian LÜQingtian sHEN Yang XU Xiaoming ZHANG Yongqian XU Yao ZHAO Jinhua GU Yumin s.i Jianyu CHEN Changxin sinoProbe Laboratory Chinese Academy of Geological SciencesBeijing 100037China University of Rhode island KingstonRhode IslandUSA ins.itute of Geophysics China Earthquake AdministrationBeijing 100081China National Marine Environmental Forecas.ing Center Beijing 100081China

A great amount of new s-wave data has been combined to image the mantle structure down to lower mantle depth near the southeastern margin of Eurasia and understand the tectonics.in south China since the *** results reveal a large-scale structure beneath the south China sea,with a prominent,broad low-velocity feature of at least 1500-km wide in and below the mantle transition zone(MTZ)and a pronounced low-velocity feature of nearly 500-km wide in the lowermost *** these features may represent the head-and-tail of an upwelling mantle plume that has.interacted with and deformed by the subducting plates.in the *** Andaman-sumatra plate is seen subducting steeply without stagnation in the MTZ over the large-scale low-velocity structure,sugges.ing that the upwelling mantle may have exerted significant influence on the overlying plate *** results suggest a long-term extensional regime near the southeastern margin of Eurasia,which may help to understand the formation of the large-scale intra-plate magmatism and mineralization with accumulation of huge amount of rare metal elements.in south China during the Mesozoic,and the continental breakup,the southeastward extrusion of indochina,and the opening of the south China sea during the Cenozoic.

关键词： s.is.ic tomography intra-plate tectonics mantle dynamics south China

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病人参与量表的汉化及信效度检验

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护理研究 2024年第12期38卷 2116-2119页

作者：杨丽君李琪魏丹莲王相淇李晓彤史丽娜马宏文天津中医药大学研究生院天津301617 天津市人民医院

目的:翻译病人参与量表(Patient Participation scale,PPs),并检验其信效度。方法:遵循Bris.in翻译模式对PPs进行直译、回译以及文化调适、预调查,形成中文版PPs。选取2023年3月—4月在天津市某三级甲等医院门诊就诊或住院病人进行调查... 详细信息

目的:翻译病人参与量表(Patient Participation scale,PPs),并检验其信效度。方法:遵循Bris.in翻译模式对PPs进行直译、回译以及文化调适、预调查,形成中文版PPs。选取2023年3月—4月在天津市某三级甲等医院门诊就诊或住院病人进行调查,检验其信效度。结果:中文版PPs包括4个维度,共21个条目。量表总体Cronbach′sα系数为0.851,总体重测信度为0.731,总体折半信度为0.690。条目水平的内容效度指数(i⁃CVi)为0.857~1.000,量表水平的内容效度指数(s⁃CVi)为0.904。探索性因子分析共提取出4个因子,累计方差贡献率为67.788%。结论:中文版PPs信效度良好,可以用于评估病人参与程度。

关键词：病人参与量表信度效度

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symmetrical Distributions of Cities and Urbanization Trends.in China

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Journal of Geographical s.iences 2012年第2期22卷 382-383页

作者： YE danian HE Wei Li Zhe XU Wendong Anhui Education Press Hefei 2011 x ＋ 260 pp ISBN 978 7 5336 5737 6 （hardback） CHY 58.00

As products of urbanization, cities are focal points for social and economic interaction. Though China is an ancient civilization, only recently has the urban population surpassed that in rural areas. During the last three decades, unprecedented urbanization has reshaped China＇s geographical, social, economic and cultural landscapes. Among the social-economic transformations having occurred in China in recent history, urbanization is probably the most impres.ive and dynamic process; it has changed daily life of Chinese population and profoundly impacted the regional and global economy.

关键词： Chinese population urban population dynamic process global economy rural areas

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