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Material and regenerative properties of an osteon-mimetic cortical bone-like scaffold

Regenerative Biomaterials 2019年第2期6卷 89-98页

作者： danial barati Ozan Karaman Seyedsina Moeinzadeh Safaa Kader Esmaiel Jabbari Biomimetic Materials and Tissue Engineering Laboratory Department of Chemical EngineeringUniversity of South CarolinaColumbiaSC 29208USA Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC 29208USA Department of Biomedical Engineering Izmir Katip Celebi UniversityIzmir 35620Turkey

The objective of this work was to fabricate a rigid,resorbable and osteoconductive scaffold by mimicking the hierarchical structure of the cortical *** peptide-functionalize nanofiber microsheets were generated with calcium phosphate(CaP)content similar to that of the natural cortical ***,the CaP-rich fibrous microsheets were wrapped around a microneedle to form a laminated microtube mimicking the structure of an ***,a set of the osteon-mimetic microtubes were assembled around a solid rod and the assembly was annealed to fuse the microtubes and form a ***,an array of circular microholes were drilled on the outer surface of the shell to generate a cortical bone-like scaffold with an interconnected network of Haversian-and Volkmann-like *** CaP content,porosity and density of the bone-mimetic microsheets were 240 wt%,8%and 1.9 g/ml,respectively,which were close to that of natural cortical *** interconnected network of microcanals in the fused microtubes increased permeability of a model protein in the *** cortical scaffold induced osteogenesis and vasculogenesis in the absence of bone morphogenetic proteins upon seeding with human mesenchymal stem cells and endothelial colony-forming *** localized and timed-release of morphogenetic factors significantly increased the extent of osteogenic and vasculogenic differentiation of human mesenchymal stem cells and endothelial colony-forming cells in the cortical *** cortical bonemimetic nature of the cellular construct provided balanced rigidity,resorption rate,osteoconductivity and nutrient diffusivity to support vascularization and osteogenesis.

关键词： bone regeneration cortical bone-like osteon-mimetic calcium phosphate nucleated nanofiber microsheet vascularized osteogenesis

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