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The Effect of Dexamethasone versus Methylprednisolone in the Treatment of COVID-19 Patients in Jordan

Advances in Infectious Diseases 2023年第3期13卷 508-520页

作者： Jamal Wadi Al Ramahi Nour Hasan Amal Matar Ma’en Maher Al-Ali Lara Abdulhadi dania abu kaf Waseem Saadeh Nour Hamdan Hassan abu Khalaf Mohamed Gharaibeh Hanadi Hamadallah Ala’a Bader Mohammad Atout Sae’ed Moh. Mar’I Tamer Alhamed Department of Medicine School of Medicine The University of Jordan Amman Jordan Clinical Pharmacy Al Khalidi Hospital Amman Jordan Department of General Medicine Al Khalidi Hospital Amman Jordan Department of Clinical Medical Sciences Faculty of Medicine Yarmouk University Irbid Jordan Department of Medicine The Specialty Hospital Amman Jordan Department of Anesthesia The Specialty Hospital Amman Jordan Department of Pharmacy Jordan Hospital Amman Jordan Department of Pharmacy The Specialty Hospital Amman Jordan

Background: Previous studies focused on the treatment effect of steroids versus no steroids in treating severe COVID-19 patients, a few studies evaluated outcomes for treating those patients with either dexamethasone or methylprednisolone. Currently, we evaluate the difference in mortality associated with treating COVID-19 patients with dexamethasone versus methylprednisolone. Methods: With a retrospective multicenter study, records were reviewed for the admitted patients with severe COVID-19 during the peak of the severe COVID-19 pandemic. All admitted patients on dexamethasone or methylprednisolone were included. Patients were analyzed as all populations and propensity scores matched patients. Propensity scores were calculated for several confounders by the generalized linear model, and a “greedy” near-neighbor matching algorithm was used. Continuous variables with nonnormal distribution were analyzed by Wilcoxon signed rank test. Chi-squared and Fischer exact test analyzed categorical variables. P-values were adjusted by the Bonferroni method for both data cohorts. Body mass index was in categories. Radiological findings were divided into five categories. The outcomes: mortality, the need for home oxygen therapy, recovery, and residual symptoms on discharge were analyzed by an independent two-sample test for equality of proportions (with Yates correction), and logistic regression analysis. Results: Among the 1128 reviewed records, patients on dexamethasone or methylprednisolone were 1071, and the propensity score-matched patients were 784: dexamethasone 393 and methylprednisolone 391. There was no significant difference in the characteristics of patients between the two steroids (p-value and adjusted p-value > 0.05) for most variables. PSM adjusted a few discrepant variables before analysis. The outcome of the unmatched patients demonstrated dexamethasone benefit in the need for home oxygen therapy ( 0.05). However, matched patients demonstrated significantly low

关键词： Dexamethasone Methylprednisolone COVID-19 Mortality Home Oxygen COVID-19 Recovery

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What factors explain anger and mental health during the COVID-19 pandemic? The case of Israeli society

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World Journal of Psychiatry 2021年第10期11卷 864-875页

作者： Orna Braun-Lewensohn Sarah abu-kaf Tehila Kalagy Department of Interdisciplinary Studies Conflict Management&Resolution ProgramBen-Gurion University of the NegevBeer Sheva 8410501IsraelIsrael Department of Public Policy and Management Ben-Gurion University of the NegevBeer Sheva 8410501IsraelIsrael

BACKGROUND What factors affected the levels of anger and emotional distress experienced during the coronavirus disease 2019(COVID-19)pandemic?We hypothesized that(1)sociodemographic factors and resiliency factors would partially explain psychological distress and anger,with stronger resiliency associated with lower levels of distress and anger;(2)women would report more trust in national leadership,as well as more psychological problems;(3)individuals of low socioeconomic status would report less resiliency,less trust in national leadership,and greater distress than individuals of higher socioeconomic status;and(4)hope would mediate the relationships between the other resiliency factors and both anger and *** To explore whether community resilience,hope,and trust in leaders were associated with lower levels of anger and emotional distress during the COVID-19 *** For this observational study,data were gathered in Israel during the second wave of the COVID-19 pandemic,just before the Jewish New Year(mid-September 2020),as a second lockdown was *** were gathered from 636 Israeli adults,who were recruited by the Midgam research *** participants filled out self-reported questionnaires including one on state anger,the Brief Symptom Inventory as a measure of mental-health problems(i.e.,somatization,depression,and anxiety),and questionnaires about trust in the state’s leaders,community resilience(CCRAM),and hope as measures of coping resources and resiliency.t-tests were used to explore differences between men and women and between those of lower and higher socioeconomic status.A hierarchical multiple regression analysis was then used to examine whether and how the sociodemographic and resiliency variables explained state anger and psychological distress.A Sobel test was used to evaluate the possible effects of hope on community resilience and trust in leadership in the context of both distress and *** Our results revealed di

关键词： Community resilience Hope Trust in government Anger Mental health Pandemic

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