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Elevation transition of aquatic insects closely matches a thermal feature in the Yungas of Northwestern Argentina

Journal of Mountain science 2024年第2期21卷 433-448页

作者： Alexandra BUITRAGO-GUACANAME Carlos MOlINERI andrés lIRA-NORIEGA dani.l andrés dos santos Neotropical Biodiversity Institute(CONICET-UNT) UNT-DomesHorco Molle S/N4107 TucumánArgentina CONACYT Research Fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Biostatistics Chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Temperature is a key factor that shapes the distribution of *** knowledge about how species respond to temperature is relevant to devise strategies for addressing the impacts of climate *** insects are particularly vulnerable to climate change,yet there is still much to learn about their ecology and *** the Yungas ecoregion of Northwestern Argentina,cold-and warm-adapted species of the orders Ephemeroptera,Plecoptera,and Trichoptera(EPT)are segregated by *** modeled the ecological niche of south American EPT species in this region using available data and projected their potential distribution in geographic *** were grouped based on their ecogeographic similarity,and we analyzed their replacement pattern along elevation gradients,focusing on the ecotone where opposing thermal preferences *** this interface,we identified critical points where the combined incidence of cold and warm assemblages maximizes,indicating a significant transition *** found that the Montane Cloud Forest holds the interface,with a particularly greater suitability at its lower *** main axis of the interface runs in a N-s direction and falls between 14°C-16°C mean annual *** probability of a particular location within a basin being classified as part of the interface increases as Kira’s warmth index approaches a score around *** the interface is critical for defining the thermal limits of species distribution and designing biomonitoring *** in the location of thermal constants related to mountainous ecotones may cause vertical displacement of aquatic insects and vegetation *** have recognized significant temperature thresholds that serve as indicators of suitability for the *** global warming is anticipated to shift these indicators,we suggest using them to monitor the imprints of climate change on mountain ecosystems.

关键词： Austral Yungas Ecological Niche Model Ephemeroptera Kira’s warmth index Plecoptera Trichoptera

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Unveiling the silent crisis:global burden of suicide‑related deaths among children aged 10–14 years

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World Journal of Pediatrics 2024年第4期20卷 371-391页

作者： Irmina Maria Michalek Pawel Koczkodaj Marzena Michalek Florentino luciano Caetano dos santos Department of Cancer Epidemiology and Primary Prevention Maria Sklodowska-Curie National Research Institute of Oncologyul.Wawelska 15 BWarsawPoland Private Psychiatric Practice-Marzena Michalek MDSiedlcePoland Harvard Business school Harvard UniversityBostonMAUSA

Background The rise in suicides among children aged 10–14 years demands urgent attention *** study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering factors such as sex,geography,and sociodemographics,to inform prevention strategies and *** The data from Global Burden of Disease 2019,encompassing 204 countries and territories,were analyzed to investigate deaths and years of life lost(Ylls)due to suicide among children aged 10–14 *** analyses,including mortality rates,Ylls,and the sociodemographic index(sDI),were conducted using standardized *** In 2019,a total of 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died globally due to suicide,with a mortality rate of 1.30(95%UI=1.10–1.51)per 100,*** rates varied across countries/territories ranging between 0.05(95%UI=0.02–0.10)in south Africa and 7.49(95%UI=5.13–10.57)in *** contribution of suicide-related deaths to all-cause mortality ranged from 0.07%(95%UI=0.04%–0.15%)in south Africa to 33.02%(95%UI=24.36%–41.53%)in ***,there were approximately 636,196(95%UI=540,383–740,009)Ylls due to suicide,with a rate of 99.07(95%UI=84.15–115.23)per 100,*** association between sDI and suicide-related deaths was evident,with higher contributions observed in countries with higher *** This study reveals a concerning global burden of suicide-related deaths among children aged 10–14 *** progress in reducing mortality rates,suicide remains a significant *** overall rates have declined,the percentage of deaths caused by suicide in this age group is increasing.

关键词： Early adolescent Global Burden of Disease Incidence suicide Years of life lost

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Is magnesium deficiency the major cause of needle chlorosis of Pinus taeda in Brazil?

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Journal of Forestry Research 2024年第2期35卷 209-221页

作者： Antônio Carlos Vargas Motta shizuo Maeda Valdécio dos santos dos santos Rodrigues Tamires Maiara Ercole stephen Arthur Prior Ana Elisa lyra Brumat Amanda Pacheco Cardoso Moura Julierme Zimmer Barbosa João Bosco Vasconcellos Gomes Department of soil sciences and Agriculture Engineering Federal University of ParanáR.dos Funcionários1540.CuritibaParanáCEP 80035‑050Brazil Brazilian Agricultural Research Company Embrapa FlorestasEstr.da Ribeira–Br‑476Km 111–Parque Monte Castelo.ColomboParanáCEP 83411‑000Brazil United states Department of Agriculture‑Agricultural Research service USDA-ARS National Soil Dynamics Laboratory411 South Donahue DriveAuburnAL 36832USA Reforestation Remasa Rodovia PR 170–Km 522.BiturunaParanáCEP 84640‑000Brazil Federal Institute of southeast of Minas Gerais R.Luz Interior360.Juiz de ForaMinas Gerais CEP 36030‑713Brazil

Needle chlorosis(NC)in Pinus taeda *** in Brazil becomes more frequent after second and third harvest rotation *** a study to identify factors contributing to yellowing needle chorosis(YNC),trees were grown in soils originating from contrasting parent materials,and soils and needles(whole,green and chlorotic portions)from 1-and 2-year-old branches and the first and second needle flush release at four sites with YNC on *** were analyzed for various elements and *** soils had very low base levels(Ca^(2+),Mg^(2+)and K^(+))and P,suggesting a possible lack of multiple *** symptoms started at needle tips,then extended toward the needle base with *** flush needles had longer portions with YNC than second flush needles *** from the lower crown also had more symptoms along their length than those higher in the *** were similar to those reported for *** chlorotic portions,Mg and Ca concentrations were well below critical values;in particular,Mg levels were only one third of the critical value of 0.3 g kg^(-1).Collectively,results suggest that Mg deficiency is the primary reason for NC of *** in various parent soils in Brazil.

关键词： Nutritional deficiency Forest management soil depletion Pine foliar analysis Needle chlorosis

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Artemisia vulgaris Induces Tumor-selective Ferroptosis and Necroptosis via lysosomal Ca^(2+) signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： lucas dos santos Zamarioli Michele Rosana Maia santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira soraya s smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo Js Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and sKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPlC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,sKBR-3 and K562 cells(Plity of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(Plls with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(Pse of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(Please mainly from lysosomes in K562 cells(Pllular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(Plusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.dos santos P.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui l.Reis N.Neves s.Camarero-Espinosa M.B.Baker l.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVs/3B’s-PT Government Associate laboratory 4806-909 Braga/GuimarãesPortugal POlYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBAsQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCl5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCl75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCl *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMsCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending surface functionalization surface density Click chemistry Human

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Maternal supplementation with n-3 fatty acids affects placental lipid metabolism, inflammation, oxidative stress, the endocannabinoid system, and the neonate cytokine concentrations in dairy cows

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Journal of Animal science and Biotechnology 2024年第5期15卷 2012-2030页

作者： Priscila dos santos silva Gitit Kra Yana Butenko Jayasimha Rayalu Daddam Yishai levin Maya Zachut Department of Ruminant science Institute of Animal SciencesARO Volcani InstituteRishon LeZionIsrael Department of Animal science The Robert H.Smith Faculty of AgricultureFood and EnvironmentThe Hebrew University of JerusalemRehovotIsrael Department of Animal sciences Michigan State UniversityEast LansingMIUSA The Nancy and stephen Grand Israel National Center for Personalized Medicine Weizmann Institute of ScienceRehovotIsrael

Background The placenta plays a crucial role in supporting and influencing fetal *** compared the effects of prepartum supplementation with omega-3(n-3)fatty acid(FA)sources,flaxseed oil(FlX)and fish oil(FO),on the expression of genes and proteins related to lipid metabolism,inflammation,oxidative stress,and the endocannabinoid system(ECs)in the expelled placenta,as well as on FA profile and inflammatory response of ***-pregnant Holstein dairy cows were supplemented with saturated fat(CTl),FlX,or *** cotyledons(n=5)were collected immediately after expulsion,and extracted RNA and proteins were analyzed by RTPCR and proteomic *** blood was assessed for FA composition and concentrations of inflammatory *** FO increased the gene expression of fatty acid binding protein 4(FABP4),interleukin 10(Il-10),catalase(CAT),cannabinoid receptor 1(CNR1),and cannabinoid receptor 2(CNR2)compared with CTl *** expression of ECs-enzyme FA-amide hydrolase(FAAH)was lower in FlX and FO than in *** analysis identified 3,974 proteins;of these,51–59 were differentially abundant between treatments(P≤0.05,|fold change|≥1.5).Top canonical pathways enriched in FlX *** and in FO *** were triglyceride metabolism and inflammatory *** n-3 FA increased the placental abundance of FA binding proteins(FABPs)3 and *** abundance of CNR1 cannabinoid-receptor-interacting-protein-1(CNRIP1)was reduced in FO *** silico modeling affirmed that bovine FABPs bind to *** FlX increased the abundance of inflammatory CD44-antigen and secreted-phosphoprotein-1,whereas prostaglandin-endoperoxide synthase 2 was decreased in FO *** *** FO enriched neonatal plasma with n-3 FAs,and both FlX and FO reduced interleukin-6 concentrations compared with *** Maternal n-3 FA from FlX and FO differentially affected the bovine placenta;both enhanced lipid metabolism and modulated oxidative s

关键词： Antioxidants Dairy cows Endocannabinoid system Inflammation Omega-3 fatty acids Placenta

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The Colíder Paleoproterozoic felsic volcanism:New insights into stratigraphy and petrogenesis in the southern Amazonian Craton

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Geoscience Frontiers 2024年第2期15卷 274-303页

作者： andré Massanobu Ueno Kunifoshita Felipe Holanda dos santos Maria JoséMesquita Instituto de Geociências Universidade Estadual de Campinas(UNICAMP)Rua Carlos Gomes250CEP:13083-855 CampinasSão PauloBrazil Departamento de Geologia Universidade Federal do CearáCampus do PiciBloco 912CEP:60440-554 FortalezaCearáBrazi

The eastern side of Alta Floresta Mineral Province(AFMP)(União do Norte region)comprises an effusive/-subvolcanic phase,explosive phase,and epiclastic *** effusive/subvolcanic phase comprises massive porphyritic rhyolite with different degrees of crystallinity,porphyritic rhyolite with flow structure,and microcrystalline *** explosive phase is characterized by welded lapilli tuff,lapilli tuff with flow structure,stratified lapilli tuff,and tuff with accretionary *** and siltstones characterize epiclastic *** are porphyritic rhyolite dikes that cut the volcanic *** rocks of the Colíder Group are rhyolites(>70%siO2)with calcic-alkaline to alkaline-calcic affinity.A rhyolitic rock is predominantly ferroan and metaluminous,while a pyroclastic rock is predominantly magnesian to ferroan and meta-to peraluminous in *** rocks have a high lREE content,and slight fractionation of HREE suggests they have hybrid geochemical characteristics of high potassium calc-alkaline,shoshonitic,and suggestive affinities of A-type magmas,probably produced in a post-collisional orogenic *** rocks have a relatively high level of Ba and Rb and a negative anomaly for sr,P,Nb,Ta,and Ti,suggesting an intra-plate mantle source with contributions from a metasomatized mantle *** rocks do not have adakitic characteristics nor fertility for Cu-Au(sr/YlaN/YbNs in other regions of the *** welded lapilli tuff rocks show U-Pb age of 1838±17 Ma and 1817±2 Ma and are the older explosive *** effusive/subvolcanic phase has U-Pb ages of 1800±3 Ma and 1792±3 Ma obtained in the massive porphyritic *** age interval of approximately 46 Ma(1838–1792 Ma)suggests the presence of two or more volcanic cycles or distinct volcanic *** on the interpretation of volcanic and epiclastic deposits and remote sensing products,the paleoenvironmental reconstruction includes subaerial with effusive/subvolcani

关键词： Paleoproterozoic volcanism Eroded volcanic caldera lithofacies analysis Colíder Group Amazonian Craton

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Cardiovascular risk burden and disability:findings from the International Mobility in Aging study(IMIAs)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal Carmen-lucia Curcio Juliana Fernandes Afshin Vafael Cristiano dos santos Gomes Fernando Gomez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Group in Geriatrics and Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department of Public Health sciences Queen’s UniversityKingstonONCanada Department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGROUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRs)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International Mobility in Aging study(IMIAs)study who had up to three repeated measures of FGCRs between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the short Physical Performance Battery(sPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRs ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCRs had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRs,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(Plternatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(PlUsIONs Higher cardiovascular risk burden is associated with decreased physical performance,especially in *** suggest sPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

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A dynamic database of solid-state electrolyte(DDsE)picturing all-solid-state batteries

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Nano Materials science 2024年第2期6卷 256-262页

作者： Fangling Yang Egon Campos dos santos Xue Jia Ryuhei sato Kazuaki Kisu Yusuke Hashimoto shin-ichi Orimo Hao li Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai980-8577Japan Key laboratory of Radiation Physics and Technology Ministry of EducationCollege of PhysicsSichuan UniversityChengdu610065People's Republic of China Institute for Materials Research(IMR) Tohoku UniversitySendai980-8577Japan Tohoku Forum for Creativity Tohoku UniversitySendai980-8577Japan

All-solid-state batteries(AssBs)are a class of safer and higher-energy-density materials compared to conventional devices,from which solid-state electrolytes(ssEs)are their essential *** date,investigations to search for high ion-conducting solid-state electrolytes have attracted broad ***,obtaining ssEs with high ionic conductivity is challenging due to the complex structural information and the less-explored structure-performance *** provide a solution to these challenges,developing a database containing typical ssEs from available experimental reports would be a new avenue to understand the structureperformance relationships and find out new design guidelines for reasonable ***,a dynamic experimental database containing>600 materials was developed in a wide range of temperatures(132.40–1261.60 K),including mono-and divalent cations(e.g.,li^(+),Na^(+),K^(+),Ag^(+),Ca^(2+),Mg^(2+),and Zn^(2+))and various types of anions(e.g.,halide,hydride,sulfide,and oxide).Data-mining was conducted to explore the relationships among different variates(e.g.,transport ion,composition,activation energy,and conductivity).Overall,we expect that this database can provide essential guidelines for the design and development of high-performance ssEs in AssB *** database is dynamically updated,which can be accessed via our open-source online system.

关键词： solid-state electrolyte(ssE) All-solid-state battery(AssB) Ionic conductivity Dynamic database Machine learning

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Capacitorless solid-state Power Filter for single-phase DC-AC Converters

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CEs Transactions on Electrical Machines and systems 2024年第3期 367-377页

作者： Haitham Kanakri Euzeli C. dos santos, Jr. IEEE Purdue University Electrical and Computer Engineering Department

Converters rely on passive filtering as a crucial element due to the high-frequency operational characteristics of power electronics. Traditional filtering methods involve a dual inductor-capacitor(lC) cell or an inductor-capacitor-inductor(lCl) T-circuit. However, capacitors are susceptible to wear-out mechanisms and failure modes. Nevertheless, the necessity for monitoring and regular replacement adds to an elevated cost of ownership for such systems. The utilization of an active output power filter can be used to diminish the dimensions of the lC filter and the electrolytic dc-link capacitor, even though the inclusion of capacitors remains an indispensable part of the system. This paper introduces capacitorless solid-state power filter(ssPF) for single-phase dc-ac converters. The proposed configuration is capable of generating a sinusoidal ac voltage without relying on capacitors. The proposed filter, composed of a planar transformer and an H-bridge converter operating at high frequency, injects voltage harmonics to attain a sinusoidal output voltage. The design parameters of the planar transformer are incorporated, and the impact of magnetizing and leakage inductances on the operation of the ssPF is illustrated. Theoretical analysis, supported by simulation and experimental results, are provided for a design example for a single-phase system. The total harmonic distortion observed in the output voltage is well below the IEEE 519 standard. The system operation is experimentally tested under both steady-state and dynamic conditions. A comparison with existing technology is presented, demonstrating that the proposed topology reduces the passive components used for filtering.

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