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Notch signaling pathway in cancer:from mechanistic insights to targeted therapies

Signal Transduction and Targeted Therapy 2024年第6期9卷 2527-2563页

作者： Qingmiao Shi Chen Xue Yifan Zeng Xin Yuan Qingfei Chu Shuwen Jiang Jinzhi Wang Yaqi Zhang danhua zhu Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Notch signaling,renowned for its role in regulating cell fate,organ development,and tissue homeostasis across metazoans,is highly conserved throughout *** Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences,typically necessitating receptor-ligand interaction to initiate classical Notch signaling *** evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer *** of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies,closely linked to cancer proliferation,invasion,and ***,the Notch signaling pathway contributes to maintaining stem-like properties in cancer cells,thereby enhancing cancer *** regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing oncogenic and tumor suppressive ***,the Notch signaling pathway is implicated in conferring chemoresistance to tumor ***,a comprehensive understanding of these biological processes is crucial for developing innovative therapeutic strategies targeting Notch *** review focuses on the research progress of the Notch signaling pathway in cancers,providing in-depth insights into the potential mechanisms of Notch signaling regulation in the occurrence and progression of ***,the review summarizes pharmaceutical clinical trials targeting Notch signaling for cancer therapy,aiming to offer new insights into therapeutic strategies for human malignancies.

关键词： Notch invasion involvement

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价值构筑、地方书写与路径探索:边疆少数民族地区农村公益电影放映考察

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当代电影 2024年第5期 83-89页

作者：朱丹华里晓行昆明理工大学艺术与传媒学院澳门科技大学人文艺术学院中国澳门

20世纪末,我国开始实施“2131工程”。二十多年来,农村公益电影放映极大地丰富了广大农民群众的文化娱乐生活,已成为我国电影事业的重要组成部分。本文以云南文山的农村公益电影放映活动为考察对象,分析了边疆少数民族地区农村公益电影... 详细信息

20世纪末,我国开始实施“2131工程”。二十多年来,农村公益电影放映极大地丰富了广大农民群众的文化娱乐生活,已成为我国电影事业的重要组成部分。本文以云南文山的农村公益电影放映活动为考察对象,分析了边疆少数民族地区农村公益电影放映事业在铸牢中华民族共同体意识、构筑边疆文化安全体系、形塑乡村文化景观等方面发挥的重要作用,对边疆少数民族地区农村公益电影放映的发展路径进行了探讨。

关键词：农村公益电影放映 “2131工程” 中华民族共同体意识乡村文化景观

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A FULL-NEWTON STEP INFEASIBLE INTERIOR-POINT ALGORITHM FOR P_*(κ) LINEAR COMPLEMENTARITY PROBLEM

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Journal of Systems Science & Complexity 2014年第5期27卷 1027-1044页

作者： zhu danhua ZHANG Mingwang College of Science China Three Gorges University

This paper proposes a new infeasible interior-point algorithm with full-Newton steps for P_*(κ) linear complementarity problem(LCP),which is an extension of the work by Roos(SIAM ***.,2006,16(4):1110-1136).The main iteration consists of a feasibility step and several centrality *** authors introduce a specific kernel function instead of the classic logarithmical barrier function to induce the feasibility step,so the analysis of the feasibility step is different from that of Roos' *** kernel function has a finite value on the *** result of iteration complexity coincides with the currently known best one for infeasible interior-point methods for P_*(κ) *** numerical results are reported as well.

关键词：不可行内点算法线性互补问题牛顿迭代复杂性内核函数 Optim 屏障功能内点方法

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Biomimetic hybrid hydrogel for hemostasis,adhesion prevention and promoting regeneration after partial liver resection

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Bioactive Materials 2022年第5期7卷 41-51页

作者： Zuhong Li Yalei Zhao Xiaoxi Ouyang Ya Yang Yangjun Chen Qixia Luo Yanhong Zhang danhua zhu Xiaopeng Yu Lanjuan Li State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou325027China

Partial liver resection is an established treatment for hepatic ***,surgical bleeding,intra-abdominal adhesion and rapid liver regeneration are still major challenges after partial liver resection,associated with morbidity and ***,a biomimetic hybrid hydrogel,composed of oxidized hyaluronic acid,glycol chitosan and MenSCs-derived conditioned medium(CM),is presented to address these *** hybrid hydrogel is formed through reversible Schiff base,and possesses injectability and self-healing ***,hybrid hydrogel exhibits the capabilities of hemostasis,anti-infection,tissue adhesion and controllable release of *** on in vivo studies of the multifunctional hybrid hydrogel,it is demonstrated that acute bleeding in partial liver resection can be ceased immediately by virtue of the hemostasis features of hybrid ***,a significant reduction of intra-abdominal adhesion is confirmed in hybrid hydrogel-treated resection ***,upon the treatment of hybrid hydrogel,hepatic cell proliferation and tissue regeneration can be significantly improved due to the controllably released cytokines from MenSCs-derived CM,exerting the effects of mitogenesis and anti-inflammation in ***,the biomimetic hybrid hydrogel can be a promising candidate with great potential for application in partial liver resection.

关键词： Hybrid hydrogel Partial liver resection Hemostasis Adhesion prevention Liver regeneration

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Lens distortion correction based on one chessboard pattern image

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Frontiers of Optoelectronics 2015年第3期8卷 319-328页

作者： Yubin WU Shixiong JIANG Zhenkun XU Song zhu danhua CAO School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 China

This paper proposes a detection method of chessboard comer to correct camera distortions -including radial distortion, decentering distortion and prism distor- tion. This proposed method could achieve high comer detection rate. Then we used iterative procedure to optimize distortion parameter to minimize distortion residual. In this method, first, non-distortion points are evaluated by four points near image center; secondly, Levenberg-Marquardt nonlinear optimization algorithm was adopted to calculate distortion parameters, and then to correct image by these parameters; thirdly, we calculated comer points on the corrected image, and repeated previous two steps until distortion parameters converge. Results showed the proposed method by iterative procedure can make the impact of slight distortion around image center negligible and the average of distortion residual of one line is almost 0.3 pixels.

关键词： computer vision camera distortion distortion correction comer detection

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Two-step preparation of carbon nanotubes/Ru02/polyindole ternary nanocomposites and their application as high-performance supercapacitors

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Frontiers of Materials Science 2020年第2期14卷 109-119页

作者： danhua zhu Qianjie ZHOU Aiqin LIANG Weiqiang ZHOU Yanan CHANG Danqin LI Jing WU Guo YE Jingkun XU Yong REN Jiangxi Key Laboratory of Organic Chemistry Jiangxi Science and Technology Normal UniversityNanchang 330013China Department of Mathematical Sciences Zibo Normal CollegeZibo 255130China

A ternary single-walled carbon nanotubes/RuO2/polyindole(SWCNT/RuO2/PIn)nanocomposite was fabricated by the oxidation polymerization of indole on the prefabricated SWCNT/RuO2 binary *** nanocomposite was measured by FTIR,XRD,SEM,TEM,EDS and XPS,together with the electrochemical *** electrochemical results demonstrated that the symmetric supercapacitor used SWCNT/RuO2/PIn as electrodes presented 95%retention rate after 10000 cycles,superior capacitive performance of1203 F·g^-1 at1 A·g^-1,and high energy density of 33 w h·kg^-1 at 5000 W·kg^-*** high capacitance performance of SWCNT/RuO2/PIn nanocomposite was mainly ascribed to the beneficial cooperation effect among *** indicated that the SWCNT/RuO2/PIn nanocomposite would be a good candidate for high-performance supercapacitors.

关键词： SWCNT/RuO2/PIn nanocomposite supercapacitor

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从水月轩到南屏大戏院:云南早期电影放映活动考察(1901-1949)

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电影评介 2023年第3期 42-46页

作者：朱丹华崔颖昆明理工大学艺术与传媒学院

在中国早期电影的发展版图中,地处西南边陲的云南并不起眼;但是由于特殊的历史原因,云南与西方其他国家的联系颇为紧密,因此云南的电影拍摄和放映活动要比很多内地省份出现得更早。云南的电影放映活动最早由法国人推动,放映范围较小;然... 详细信息

在中国早期电影的发展版图中,地处西南边陲的云南并不起眼;但是由于特殊的历史原因,云南与西方其他国家的联系颇为紧密,因此云南的电影拍摄和放映活动要比很多内地省份出现得更早。云南的电影放映活动最早由法国人推动,放映范围较小;然后在本地商业力量的介入下。

关键词：电影拍摄内地省份电影放映中国早期电影商业力量法国人

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Transcriptomics Curation of SARS-CoV-2 Related Host Genes in Mice With COVID-19 Comorbidity:A Pilot Study

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Infectious Microbes & Diseases 2020年第2期2卷 42-47页

作者： Kunkai Su Xin Huang Kaijin Xu Weibo Du danhua zhu Meifang Yang Wenji Yuan Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina Biotherapeutics Research Center the Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina.

The pandemic of coronavirus disease 2019(COVID-19),a respiratory disease caused by a novel severe acute respiratory syndrome coronavirus-2,is causing substantial morbidity and *** with the respiratory symptoms,underlying diseases in senior patients,such as diabetes,hypertension,and coronary heart disease,are the most common comorbidities,which cause more severe outcomes and even *** cellular attachment and entry of severe acute respiratory syndrome coronavirus-2,the key protein involved is the angiotensin I converting enzyme 2(ACE2),which is located on the membrane of host ***,we aim to curate an expression profile of Ace2 and other COVID-19 related genes across the available diabetes murine *** on strictly manual curation and bioinformatics analysis of the publicly deposited expression datasets,Ace2 and other potentially involved genes such as Furin,Tmprss2,Ang,and Ang2 were *** found that Ace2 expression is rather ubiquitous in three selected diabetes prone strains(db/db,ob/ob and diet-induced obese).With the most abundant datasets present,the liver shows a medium Ace2 expression level compared with the lungs,pancreatic islets,brain and even T *** is a more critical factor for Ace2 expression in db/db compared with the other two *** Ace2,the other four host genes showed varied levels of correlation to each *** accelerate research on the interaction between COVID-19 and underlying diseases,the Murine4Covid transcriptomics database(***/Murine4Covid)will facilitate the design of research on COVID-19 and comorbidities.

关键词： ACE2 COVID-19 diabetes murine model SARS-CoV-2

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司美格鲁肽治疗2型糖尿病合并冠状动脉粥样硬化性心脏病1例

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中华糖尿病杂志 2022年第S1期14卷 224-227页

作者：何俊莹朱丹华谭晓霞吴伟华深圳大学第三附属医院内分泌科深圳518001

报道1例2型糖尿病合并冠状动脉粥样硬化性心脏病患者应用司美格鲁肽的诊疗经过。患者为63岁男性,因“发现血糖升高22年余,活动后胸闷1年”入院,患者糖尿病病程长,平素血糖控制不达标,有活动后胸闷症状及超重,冠状动脉CT血管成像提示多... 详细信息

报道1例2型糖尿病合并冠状动脉粥样硬化性心脏病患者应用司美格鲁肽的诊疗经过。患者为63岁男性,因“发现血糖升高22年余,活动后胸闷1年”入院,患者糖尿病病程长,平素血糖控制不达标,有活动后胸闷症状及超重,冠状动脉CT血管成像提示多支病变,狭窄程度30%~90%;根据指南推荐的“对糖尿病合并冠状动脉粥样硬化性心脏病予胰高糖素样肽-1受体激动剂治疗”,予该患者基础胰岛素联合司美格鲁肽治疗,血糖控制良好,期望能降低患者主要心血管不良事件(心血管死亡、非致死性心肌梗死或非致死性卒中)风险。

关键词：糖尿病,2型冠状动脉粥样硬化性心脏病司美格鲁肽

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21世纪泰国电影产业发展概况

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当代电影 2018年第5期 68-72页

作者：崔颖朱丹华昆明理工大学艺术与传媒学院讲师650504

21世纪以来,在泰国电影"新浪潮运动"的引领之下,电影创作艺术水平和技术水准均实现了质的飞跃,泰国电影工业生态日渐成熟,产业格局日渐清晰,已成为东南亚电影产业的领头羊。本文对21世纪以来泰国电影产业的发展概况进行了梳理和分析。

关键词：东南亚电影泰国电影产业政策

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