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Acta Pharmaceutica Sinica B 2016年第4期6卷 329-335页

作者： danhong long Tao Gong Zhirong Zhang Rui Ding Yao Fu Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education West China School of PharmacySichuan University Beijing Institute for Drug Control

A phospholipid-based injectable gel was developed for the sustained delivery of leuprolide acetate(LA). The gel system was prepared using biocompatible materials(SPME), including soya phosphatidyl choline(SPC), medium chain triglyceride(MCT) and ethanol. The system displayed a sol state with low viscosity in vitro and underwent in situ gelation in vivo after subcutaneous injection. An in vitro release study was performed using a dialysis setup with different release media containing different percentages of ethanol. The stability of LA in the SPME system was investigated under different temperatures and in the presence of various antioxidants. In vivo studies in male rats were performed to elucidate the pharmacokinetic profiles and pharmacodynamic efficacy. A sustained release of LA for 28 days was observed without obvious initial burst in vivo. The pharmacodynamic study showed that once-amonth injection of LA-loaded SPME(SPME-LA) led to comparable suppression effects on the serum testosterone level as observed in LA solution except for the onset time. These findings demonstrate excellent potential for this novel SPME system as a sustained release delivery system for LA.

关键词： Phospholipids Injectable gel Leuprolide acetate Pharmacokinetics Testosterone

Hydrogen peroxide-activatable iodoBodipy-phthalhydrazid conjugate nanoparticles for cancer therapy

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Nano Research 2023年第10期16卷 12294-12303页

作者： Haijun Ning Yuxin Yang Chengyuan Lv danhong Zhou Saran long Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China

The dependence on outer light source strongly hinders clinical applications of photodynamic therapy(PDT)to the deep-seated tumor.However,the majority of documented PDT systems that function without the external light source rely on either the chemiluminescence resonance energy transfer(CRET)or fluorescence resonance energy transfer(FRET)mechanism,which decreases the energy transfer efficiency and reproducibility of PDT.Herein,we developed a novel single-molecule triplet photosensitizer(iodoBodipy(IBDP)-L)that can be chemiexcited to triplet excited state to generate reactive oxygen species instead of outer light irradiation.The direct bonding of phthalhydrazid moiety to iodoBodipy fluorophore evoked valid intramolecular energy transfer(IET),and once phthalhydrazid part is activated by hydrogen peroxide,the released reaction energy could excite the iodoBodipy-phthalhydrazid conjugate as a whole.Reaction product IBDP-L-COOH showed high triplet state quantum yield(ΦT=65%)and large spin-orbit coupling.A large amount of reactive oxygen species(ROS)was produced in MCF-7 cells,thus inhibiting the cell growth both in vitro and in vivo after IBDP-L was formulated into nanoparticles(NPs)via nanoprecipitation.We believe that the synthesized IodoBodipy-phthalhydrazid conjugate based on the IET mechanism will open a new door in the molecular design of efficient triplet photosensitizers for treating deeply seated tumors in the future.

关键词： luminol chemiexcited triplet photosensitizer cancer therapy intramolecular energy transfer(IET)mechanism

改性SiO_(2)气凝胶聚氨酯复合涂层的制备及耐蚀性能研究

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中国腐蚀与防护学报 2024年第1期44卷 167-174页

作者：李丹鸿杨腾逊孙天翔李兴霖冒马程成张玥陈守刚中国海洋大学材料科学与工程学院青岛266100

通过提高SiO_(2)气凝胶的亲水性来提高水性聚氨酯(WPU)涂料的防腐性能。采用脲醛对SiO_(2)气凝胶进行改性,并通过Fourier红外光谱(FTIR)、扫描电子显微镜(SEM)等手段表征气凝胶的结构与微观形貌;通过电化学阻抗(EIS)、附着力实验和盐雾... 详细信息

通过提高SiO_(2)气凝胶的亲水性来提高水性聚氨酯(WPU)涂料的防腐性能。采用脲醛对SiO_(2)气凝胶进行改性,并通过Fourier红外光谱(FTIR)、扫描电子显微镜(SEM)等手段表征气凝胶的结构与微观形貌;通过电化学阻抗(EIS)、附着力实验和盐雾实验等研究了涂层的防腐性能。结果表明,添加亲水改性SiO_(2)气凝胶的涂层的附着力和腐蚀防护性能有明显提高,其中,添加1%亲水改性的SiO_(2)气凝胶涂层的附着力提升36%。在3.5%NaCl溶液中浸泡70d后涂层的低频阻抗模值超过6×10^(7)Ω·cm^(2),盐雾480 h后没有明显的鼓泡现象。

关键词： SiO_(2)气凝胶水性聚氨酯亲水改性腐蚀防护长效防腐

上海市闵行区某镇公办小学学生肥胖因素的分析

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上海预防医学 2024年第1期36卷 84-89页

作者：莫旦红赵伟忠许多军李冰温晓飒赵琦薛文浩上海市闵行区七宝社区卫生服务中心上海202201 上海市闵行区疾病预防控制中心上海202201 复旦大学公共卫生学院上海200032

【目的】了解上海市闵行区某镇公办学校小学生的肥胖情况,分析可能导致小学生肥胖的影响因素。【方法】通过问卷星进行基础数据采集,合并体检数据后导入Excel形成数据库,并使用SPSS 22.00软件进行数据分析。采用logistic回归分析进行单... 详细信息

【目的】了解上海市闵行区某镇公办学校小学生的肥胖情况,分析可能导致小学生肥胖的影响因素。【方法】通过问卷星进行基础数据采集,合并体检数据后导入Excel形成数据库,并使用SPSS 22.00软件进行数据分析。采用logistic回归分析进行单因素和多因素分析。【结果】根据《国家学生体质健康标准(2014年修订)》得出的上海市闵行区某镇公办小学学籍在册小学生肥胖检出率为29.63%。男生超重及肥胖比例为32.1%,女生为26.9%,男生高于女生,不同年级的超重及肥胖趋势在不同性别中的趋势类似。独生子女(χ^(2)=9.300,P0.05)。动态分析得出不积极参加校内体育锻炼与肥胖相关(P<0.05)。【结论】公办小学生肥胖问题受家庭、饮食、心理、静态、动态等多因素影响。小学生肥胖干预需要学校、社会、家庭、自我认知等多方面共同努力。

关键词：小学生肥胖超重电子产品

Edge-driven convection and thinning of craton lithosphere:Two-dimensional thermal-mechanical modeling

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Science China Earth Sciences 2019年第12期62卷 2106-2120页

作者： danhong LIU Lin CHEN State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

There are usually abrupt changes in lithospheric thickness at the boundaries between ancient cratons and adjacent young mobile belts.Lateral variations in temperature and density between the two can trigger small-scale mantle convection(edge-driven convection,EDC).Here,we use two-dimensional thermal-mechanical simulations to explore the EDC caused by the lithospheric step between a craton and a mobile belt,and its role in the thinning of the craton lithosphere.The results show that the impact of EDC on a craton depends on the properties of the craton lithosphere and on their contrasts with the adjacent mobile belt,given the same initial condition.When the craton lithospheric density is relatively large,a high-strength craton has strong ability to resist EDC,and craton lithospheric thinning is limited to the edge.In contrast,the ability of a low-strength craton to resist EDC is weak,and the craton lithosphere is gradually eroded by the downward flow,eventually leading to large-scale thinning of the cratonic lithosphere.When the craton lithospheric density is relatively small,regardless of the strength of the cratonic lithosphere,the craton can well withstand the impacts of EDC.In this case,upwelling flow drives cratonic lithosphere materials to the base of the mobile belt,and lithospheric thinning only occurs at the edge of the craton lithosphere.The Archean North China Craton(NCC)was surrounded by Phanerozoic mobile belts,and its lithospheric thinning first occurred on the northern and eastern margins,a process that lasted for a long time.We suggest that EDC has played an important role in lithospheric thinning of the NCC,in particular the initiation of lithospheric thinning,but we cannot rule out the additional contributions from other mechanisms.

关键词： Edge-driven convection Lithospheric steps Lithospheric thinning Numerical modeling Craton

环形行波超声波电机动态接触摩擦特性建模与分析

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电工技术学报 2023年第8期38卷 2036-2047页

作者：蒋春容赵子龙陆旦宏金龙南京工程学院电力工程学院南京211167 东南大学电气工程学院南京210096

超声波电机的接触摩擦模型对电机结构设计和性能优化具有重要作用。该文考虑定子齿结构,基于Dahl摩擦这一动态摩擦定律,分析了定子振动的瞬态响应过程、定子齿质点与转子的法向接触和切向摩擦及转子运动方程,建立了环形行波超声波电机... 详细信息

超声波电机的接触摩擦模型对电机结构设计和性能优化具有重要作用。该文考虑定子齿结构,基于Dahl摩擦这一动态摩擦定律,分析了定子振动的瞬态响应过程、定子齿质点与转子的法向接触和切向摩擦及转子运动方程,建立了环形行波超声波电机定转子动态接触摩擦解析模型。基于所建立的模型,研究了定转子间的接触状态和法向接触应力,以及相对速度和切向摩擦应力,并分析了电机的输出性能。最后,测量了样机的输出特性,将测量值与所建立模型的计算值进行比较,二者基本吻合。此外,也对比了忽略定子齿结构并采用库仑摩擦定律的接触摩擦模型的计算值,结果表明,所建立模型的计算值能更好地与实验值相吻合,说明所建立的模型能够更准确地描述定转子接触摩擦传动特性。

关键词：超声波电机行波接触摩擦定子齿输出特性

Velocity forecasts using a combined deep learning model in hybrid electric vehicles with V2V and V2I communication

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Science China(Technological Sciences) 2020年第1期63卷 55-64页

作者： PEI JiaZheng SU YiXin ZHANG danhong QI Yue LENG ZhiWen School of Automation Wuhan University of TechnologyWuhan 430070China China Ship Development and Design Center Wuhan 430064China

Vehicle velocity forecast is an important clue in improving the performance of energy management in hybrid electric vehicles(HEV). This paper presents a new combined model for predicting vehicle’s velocity time series. The main features of the model are to combine the feature extraction capability of deep restricted Boltzmann machines(DBM) and sequence pattern predicting capability of bidirectional long short-term memory(BLSTM). Hence, the model is named as DBMBLSTM. In addition, the DRMBLSTM model utilizes the vehicle driving information and roadside infrastructure information provided respectively through vehicle-to-vehicle(V2V) and vehicle-to-infrastructure(V2I) communication channels to predict vehicle velocity at various length of prediction horizon. Furthermore, the predictions results of this study are compared with the state of the art of vehicle velocity forecasts. The root mean square error(RMSE) is used as an evaluation criteria of predictions accuracy. Finally,these compared prediction model are applied in model predictive control(MPC) energy management strategy for the verifications of fuel economy improvement of a HEV. Simulation results confirm that the proposed combined deep learning model performs better than other five prediction methods. Therefore, it is a means of arriving at a reliable forecast model for HEV.

关键词： vehicle velocity prediction restricted Boltzmann machines deep belief network long short-term memory,model predictive control

基于层次分析法的城镇建设适宜性评价——以京津冀为例

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华北地质 2024年第1期47卷 94-103页

作者：白耀楠王国明刘宏伟李状韩博苗晋杰徐丹虹中国地质调查局天津地质调查中心(华北地质科技创新中心) 天津300170 中国地质调查局雄安城市地质研究中心天津300170

【研究目的】京津冀是工业化、城镇化高度聚集的世界级城市群。长期以来,京津冀地区人地关系矛盾突出,国土空间开发格局与资源环境空间布局匹配程度相对较低,需要科学全面的评价城镇建设适宜性和识别未来适宜城镇建设的潜力空间,以期为... 详细信息

【研究目的】京津冀是工业化、城镇化高度聚集的世界级城市群。长期以来,京津冀地区人地关系矛盾突出,国土空间开发格局与资源环境空间布局匹配程度相对较低,需要科学全面的评价城镇建设适宜性和识别未来适宜城镇建设的潜力空间,以期为城镇开发边界划定、城镇用地集约节约高效利用提供科学依据和决策支持。【研究方法】本文基于“双评价”指南建立京津冀地区城镇建设适宜性评价指标体系,利用层次分析-加权平均综合指数法对该地区的城镇建设适宜性进行了评价。在此基础上,结合土地“三调”数据,按照优先生态保护、稳定耕地数量的原则,依次从城镇建设适宜区中扣除生态保护极重要区,自然保护地,现状湿地、城镇和基础设施建设用地、特殊用地等,识别未来适宜城镇建设的潜力空间。【研究结果】京津冀城镇建设适宜区面积123027.2 km^(2),占全区陆地面积的56.98%,一般适宜区面积45773.43 km^(2),占21.20%,不适宜区面积4850.16 km^(2),占2.25%,城镇建设适宜区潜力规模为4676.30 km^(2),河北张家口市和承德市城镇建设用地建设潜力较大,其次为保定市、唐山市和秦皇岛市。【结论】北京东部、天津西部、保定东南部、沧州南部-衡水东、邯郸东部地下水严重超采且存在地面沉降问题,建议结合地下水禁(限)采,有条件时适度优化调整土地利用方式。活动断裂带通过地段可能直接影响城市、交通等重大工程规划建设及运行安全,建议加强活动断裂带调查评价,采取避让活动断层或提高相应抗震设防等级等措施。

关键词：京津冀城镇建设适宜性评价建设潜力

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混合细菌觅食算法求解无人艇路径规划问题

华中科技大学学报（自然科学版） 2022年第3期50卷 68-73页

作者：龙洋苏义鑫廉城张丹红武汉理工大学自动化学院湖北武汉430070

针对细菌觅食优化算法(BFO)解决水面无人艇路径规划存在的易于陷入局部最优的问题,提出了一种混合模拟退火机制的BFO算法.该算法保留BFO算法的三层嵌套结构,将模拟退火机制引入到BFO算法的迁移操作中,计算更新前后的迁移个体的适值度,并... 详细信息

针对细菌觅食优化算法(BFO)解决水面无人艇路径规划存在的易于陷入局部最优的问题,提出了一种混合模拟退火机制的BFO算法.该算法保留BFO算法的三层嵌套结构,将模拟退火机制引入到BFO算法的迁移操作中,计算更新前后的迁移个体的适值度,并以Metropolis准则接受新解,使BFO算法能更好地从局部极值中跳出.按驱动形式对动态障碍物进行分类,并结合COLREGS规则设计水面无人艇产生对遇、交叉和追越三种情况的避碰策略.仿真结果表明:提出的算法收敛速度快、求解质量高,不仅可以成功地避让静态障碍物,还能高效地规划局部路径.

关键词：水面无人艇路径规划模拟退火算法细菌觅食优化算法避碰策略

ZG市街头抢劫者作案地选择及其影响因素研究

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地理研究 2022年第5期41卷 1422-1436页

作者：龙冬平刘丹红陈建国广州大学地理科学与遥感学院公共安全地理信息分析中心广州510006

以往关于作案地选择的研究,缺乏考虑不同属性群体间的空间差异。以中国ZG市为例,利用离散空间选择模型,基于不同年龄属性的视角,进行街头抢劫者作案地选择及影响因素的对比分析,并据此提出犯罪防控建议。研究发现:①不同年龄的街头抢劫... 详细信息

以往关于作案地选择的研究,缺乏考虑不同属性群体间的空间差异。以中国ZG市为例,利用离散空间选择模型,基于不同年龄属性的视角,进行街头抢劫者作案地选择及影响因素的对比分析,并据此提出犯罪防控建议。研究发现:①不同年龄的街头抢劫者作案地选择存在显著的空间差异。即少年抢劫者趋向在劳动密集型产业集聚区和中小学密集区作案,而年轻的成年抢劫者仅趋向于劳动密集型产业集聚区,但成年抢劫者的作案地却偏向于客运站所在社区及其周边地区。②年龄相关的活动节点、周围人口的监护作用和青少年人口比例是形成这种空间差异的主要因素。研究结果对犯罪防控与社会治理具有重要的参考意义,如:①在青少年抢劫者频繁作案的劳动密集型产业集聚区,调控网吧、酒吧等年龄相关活动节点的数量。②在成年抢劫者作案密集的客运站及其周边社区,规划一定数量周围人口的持续存在,以发挥出更好的监护作用。③在青少年人口比例较高的社区,通过问题青少年的摸底调查,加强精准引导与帮扶。论文首次验证了不同年龄的街头抢劫者作案地选择差异及成因,并在理论上弥补了犯罪者作案地选择缺乏细分人群的不足。

关键词：作案地选择影响因素年龄属性 ZG市