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Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 173-183,I0001-I0003页

作者： Muqi Wang Huiling Deng Yuan Chen Yikai Wang Yufeng Zhang Chenrui Liu Meng Zhang Ting Li Shuangsuo dang Yaping Li Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatrics Xi'an Central HospitalXi'an 710004China Department of Infectious Diseases Xi'an Children's HospitalXi'an 710003China

Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated ***:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(ev-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different ev-A71 ***,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and ***:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the *** expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative *** levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of *** aminotransferase was correlated with BST2,MX1 and DDX58 expression ***:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.

关键词： Pattern recognition receptors(PRRs) Hand,foot,and mouth disease(HFMD) Immune Enterovirus 71(ev-A71)

Research on Iron Loss of Switched Reluctance Starter/Generator for Energy Storage

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Protection and Control of Modern Power Systems 2024年第4期9卷 147-159页

作者： Hao Chen Xing Wang Yongqiang Liu Vuong dang Quoc Wenju Yan Muhammad Saqib Antonino Musolino Guanjun Wang Yong Qi Ali Asghar Memon Alexandros G.Paspatis the Shenzhen Research Institute China University of Mining and TechnologyShenzhen 515100China the School of Electrical Engineering China University of Mining and TechnologyXuzhou 221116China Xinjiang Institute of Engineering Urumqi 830000China the International Joint Research Center of Central and Eastern European Countries on New Energy ev Technology and Equipment Xuzhou 221008China the International Cooperation Joint Laboratory of New Energy Power Generation and evs of Jiangsu Province Colleges and Universities Xuzhou 221008China the Xuzhou Key Laboratory of New Energy ev Technology and Equipment Xuzhou 221008China the the School of Electrical Engineering China University of Mining and Tech-nologyXuzhou 221116China the Laboratory of High Performance Electric Machines(HiPems) Hanoi VN 10000Viet Nam the University of Engineering and Technology Lahore 54890Pakistan the Department of Energy Pisa Uni-versity of PisaPisa IT 56126Italy the Wuxi Inspection and Testing Certification Research Institute Wuxi 214000China the Nanjing University of Science&Tech-nology Nanjing 210094China the Mehran University of Engi-neering&Technology Jamshoro PK 76062Sindh the National Technical University of Athens Zografou GR 15780Attica

In order to better realize the energy recovery and storage of hybrid evs(Hevs),a switched reluctance starter/generator(SRS/G)with both starting and power generation functions is investigated in this ***,the iron loss of SRS/G is mainly studied to reduce the motor loss and improve the power generation ***,the energy storage of hybrid evs can be effectively ***,a magnetic flux density(MFD)waveforms solution method is proposed to solve the difficulty in calculating the iron loss of the SRS/*** with the commonly used finite element method,the proposed solution method has the advantages of simple,fast and small computational ***,considering the different operating conditions of SRS/G,the iron loss models for both the time-domain and frequency-domain are *** addition,the calculation formula of the variable coefficient Bertotti three-term loss separation is *** the hysteresis loss coefficient,the Steinmetz coefficient and the stray loss coefficient are respectively fitted by the Fourier fitting *** method is also applied to solve the iron loss of SRS/***,through an experimental verification,it is indicated that the development of proposed method has high accuracy.

关键词： Switched reluctance starter/generator energy storage iron loss finite element method magnetic flux density(MFD)

Cobalt diselenide (001) surface with short-range Co-Co interaction triggering high-performance electrocatalytic oxygen evolution

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Nano Research 2021年第12期14卷 4848-4856页

作者： Kun dang Shihao Zhang Xuewei Wang Wenming Sun Ligang Wang Yang Tian Sihui Zhan Department of Chemistry Analytical Instrumentation CenterBeijing Key Laboratory for Optical Materials and Photonic DevicesCapital Normal UniversityBeijing100048China MOE Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlCollege of Environmental Science and EngineeringNankai UniversityTianjin300350China College of Science China Agricultural UniversityBeijing100193China Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

Oxygen evolution reaction (OER) still suffers from the bottleneck in electrocatalytic water splitting. Herein, in virtue of volcano plots drawn by theoretical calculation, the (001) facet was screened as the superb facet of orthorhombic CoSe_(2) for OER. Afterwards, CoSe_(2)(001) nanosheets were synthesized and the exposure ratio of (001) facet is controllable with thermodynamics methods effectively. The single-facet CoSe2(001) delivered an overpotential as low as 240 mV at 10 mA·cm^(−2) in 1 M KOH, which outperformed the bulk (380 mV) as well as other CoSe_(2)-base OER catalysts reported before. Especially, a shorter Co-Co path was observed in CoSe_(2)(001) by X-ray absorption spectroscopy. Further density functional theory (DFT) studies revealed that the reversible compression on the shorter Co-Co path could regulate the electronic structure of active sites during the OER process, and thus the energy barrier of the rate-determining step was reduced by 0.15 ev. This work could inspire more insights on the modification of electronic structure for OER electrocatalysts.

关键词： CoSe2 oxygen evolution reaction(OER) water-splitting electrocatalysis crystal facet engineering electronic structure manipulation

Femtosecond Studies on Third-Order Optical Nonlinearities of Polyanilines

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Chinese Physics Letters 1994年第8期11卷 491-493页

作者： WANG Hui LAI Tianshu LIN Weizhu MO dang OUYANG Meng GONG Kecheng Department of Physics Zhongshan UniversityGuangzhou 510275 Department of Polymer South China University of TechnologyGuangzhou 510641

The ultrafast dynamics of third order nonlinearities of polyaniline(PAn)and polyaniline doped in polymethyl mathacrylate(PAn-PMMA)films are investigated using femtosecond absorption *** ultrafast initial exciton deformation time of about 100fs is observed in PAn *** PAn-PMMA film,the third-order nonlinearity results in an efficient two-photon absorption at about 2ev.

关键词： spectroscopy film absorption

A simulation study of 630 nm and 557.7 nm airglow variations due to dissociative recombination and thermal electrons by high-power HF heating

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Earth and Planetary Physics 2017年第1期1卷 44-52页

作者： Tong dang JiuHou Lei XianKang Dou WeiXing Wan CAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

One of the important effects of the ionospheric modification by high-power waves is the airglow enhancement. Both the thermal electrons and the dissociation recombination contribute to generate the airglow emissions during HF heating. However, the relative importance of the airglow emission induced by dissociative recombination and thermal electrons has been rarely investigated. In this study, we carry out a simulation study on the airglow produced by high-power HF heating at nighttime associated with dissociative recombination and thermal electrons. SAMI2(Sami2 is Another Model of the Ionosphere) is employed to simulate the ionospheric variations during the HF heating. The main conclusions from this study are as follows:(1) For the airglow induced by dissociative recombination, both 630.0 nm and 557.7 nm emissions show a decrease at the heating wave reflection height during the heating period,while when the heating is turned off, an increase is shown at lower altitudes. The reduction of airglow during the heating is caused by the rapid increase of electron temperature and the diffusion of plasmas dominates the after-heating airglow enhancement.(2) 630.0 nm emission due to thermal electrons is greatly enhanced at the wave reflection height, indicating that thermal electrons play a major role in exciting 630.0 nm emission. For the 557.7 nm emission, the excitation threshold(4.17 e V) is too high for thermal electrons.(3) The combined effect of dissociative recombination and thermal electrons could be the possible reason for the observed X-mode(extraordinary mode) suppression of 630.0 nm airglow during O-mode(ordinary mode) enhancement.

关键词： airglow thermal electron dissociative recombination HF heating

Fabrication of niobium doped titanate nanoflakes with enhanced visible-light-driven photocatalytic activity for efficient ibuprofen degradation

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Chinese Chemical Letters 2019年第12期30卷 2177-2180页

作者： Wen Liu Wei Zhang Mushi Liu Penghui Du Chenyuan dang Jialiang Liang Yunyi Li The Key Laboratory of Water and Sediment Sciences Ministry of EducationCollege of Environmental Sciences and EngineeringPeking UniversityChongqing 400044China Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment of Ministry of Education Chongqing UniversityBeijing 100871China The Beijing Innovation Center for Engineering Science and Advanced Technology(BIC-ESAT) Peking UniversityBeijing 100871China

In this study,a novel class of niobium(Nb) doped titanate nanoflakes(TNFs) are fabricated through a onestep hydrothermal *** doping affects the curving of titanate nanosheet,leading to the formation of nanoflake *** addition,Nb5+ filled in the interlayers of [TiO6] alters the light adsorption property of pristine *** band gap of Nb-TNFs is narrowed to 2.85 ev,while neat titanate nano tubes(TNTs) is 3.4 *** enhanced visible light adsorption significantly enhances the visible-lightdriven activity of Nb-TNFs for ibuprofen(IBP) *** pseudo-first order kinetics constant for Nb-TNFs is calculated to be 1.04 h^-1,while no obvious removal is observed for ***-generated holes(h^+) and hydroxyl radicals(·OH) are responsible for IBP *** photocatalytic activity of Nb-TNFs depends on pH condition,and the optimal pH value is found to be *** addition,Nb-TNFs exhibited superior photo-stability during the reuse *** results demonstrated Nb-TNFs are very promising in photocatalytic water purification.

关键词： Titanate Niobium Photocatalysis Element doping Ibuprofen

Spectroellipsometric Study of Lead Lanthanum Zirconate Titanate Amorphous Ferroelectric-Like Thin Films

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Chinese Physics Letters 1998年第8期15卷 600-602页

作者： LI Qiu-jun ZHU De-rui MO dang XU Yu-huan JDMackenzie Department of Physics Zhongshan UniversityGuangzhou 510275 Department of Material Science and Engineering University of CaliforniaLos AngelesCA90024U.S.A.

Lead lanthanum zirconate titanate(PLZT)amorphous thin films whose composition is stoichiometric 9/65/35 have been grown and they show some wonderful ferroelectric-like *** ellipsometric spectra of the PLZT ferroelectric-like amorphous films have been obtained by a homemade automatic ellipsometer in the wave-length range of 200-700nm,and their optical constant(refractive index n and extinction coefficient k)spectra have been *** the photon energy changes from 1.9 to 5.8ev,the refractive index n of the PLZT amorphous films increases from 2.13 to 2.46,then decreases to *** absorption edge of the PLZT amorphous films is about 300nm,while that of the transparent ceramics with the same composition is about 377nm.

关键词： properties. amorphous ferroelectric

Histopathological Features and Viral Antigen Distribution in the Lung of Fatal Patients with Enterovirus 71 Infection

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Virologica Sinica 2018年第3期33卷 278-281页

作者： Zhenli Liang Hongbo Pan Xijing Wang Yinchuan Zhu Yiwu dang Xiaohui Fan Lingxi Gao Zengfeng Zhang Department of Microbiology Guangxi Medical University Department of Pathology Guangxi Medical University

Dear Editor,Enterovirus 71(ev71)infection causes hand-foot-andmouth disease(HFMD)in infants and *** with HFMD usually have good prognosis;however,in some extreme cases the infection can be accompanied by central nervo... 详细信息

关键词：组织病理感染特征和神经系统疾病分发抗原病毒学说

Molecular mechanism of SCARB2-mediatec attachment and uncoating of ev71

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Protein & Cell 2014年第9期5卷 692-703页

作者： Minghao dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao National Laboratory of Macromolecules Institute of Biophysics Chinese Academy of Science Beijing 100101 China Laboratory of Structural Biology School of Medicine Tsinghua University Beijing 100084 China School of Life Sciences School of Pharmacy Nankai University Tianjin 300071 China National Institutes for Food and Drug Control Beijing 100050 China

Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models for such viruses, and initiate this entry process by their functional receptors. Here we present the structural and functional studies of SCARB2, a functional receptor of the important human enterovirus 71 （ev71）. SCARB2 is responsible for attachment as well as uncoating of ev71. Differences in the structures of SCARB2 under neutral and acidic conditions reveal that SCARB2 undergoes a pivotal pH-dependent conformational change which opens a lipid-transfer tunnel to mediate the expulsion of a hydrophobic pocket factor from the virion, a pre-requisite for uncoating. We have also identified the key residues essential for attachment to SCARB2, identifying the canyon region of ev71 as mediating the receptor interaction. Together these results provide a clear understanding of cellular attachment and initiation of uncoating for enteroviruses.

关键词： viral entry uncoating picornavirusesreceptor binding SCARB2 ev71 lipid transfer tunnel