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Effects of Naotan Pill on repair of neural cells and cognitive disorders in juvenile rats following hypoxia and ischemia

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Neural Regeneration Research 2009年第6期4卷 455-461页

作者： Yuxiang Wei Huiqing Zhang Shenglu Lu bingrong dang Jianping Hong Qingxiang Gao Gansu Provincial Rehabilitation Center Hospital Lanzhou 730000 Gansu Province China Department of Traditional Chinese Medicine Second Military Medical University of Chinese PLA Shanghai 200433 China Lanzhou Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 Gansu Province China Institute of Human Anatomy Histology Embryology and Neuroscience School of Basic Medical Sciences Lanzhou University Lanzhou 730000. Gansu Province. China

BACKGROUND： Hypoxia and ischemia induce neuronal damage, decreased neuronal numbers and synaptophysin levels, and deficits in learning and memory functions. Previous studies have shown that lycium barbarum polysaccharide, the most effective component of barbary wolfberry fruit, has protective effects on neural cells in hypoxia-ischemia. OBJECTIVE： To investigate the effects of Naotan Pill on glutamate-treated neural cells and on cognitive function in juvenile rats following hypoxia-ischemia. DESIGN, TIME AND SETTING： The randomized, controlled, in vivo study was performed at the Cell Laboratory of Lanzhou University, Lanzhou Institute of Modern Physics of Chinese Academy of Sciences, and Department of Traditional Chinese Medicine of Gansu Provincial Rehabilitation Center Hospital, China from December 2005 to August 2006. The cellular neurobiology, in vitro experiment was conducted at the Institute of Human Anatomy, Histology, Embryology and Neuroscience, School of Basic Medical Sciences, Lanzhou University, and Department of Traditional Chinese Medicine of Gansu Provincial Rehabilitation Center Hospital, China from March 2007 to January 2008. MATERIALS： Naotan Pill, composed of barbary wolfberry fruit, danshen root, grassleaf sweetflag rhizome, and glossy privet fruit, was prepared by Gansu Provincial Rehabilitation Center, China. Rabbit anti-synaptophysin, choline acetyl transferase polyclonal antibody, streptavidin-biotin complex kit and diaminobenzidine kit （Boster, Wuhan, China）, as well as glutamate （Hualian, Shanghai, China） were used in this study. METHODS： Cortical neural cells were isolated from neonatal Wistar rats. Neural cell damage models were induced using glutamate, and administered Naotan Pill prior to and following damage. A total of 54 juvenile Wistar rats were equally and randomly assigned into model, Naotan Pill, and sham operation groups. The left common carotid artery was ligated, and then rat models of hypoxic-ischemic injury were assigned to

关键词： Naotan Pill cognition synaptophysin choline acetyl transferase ceil damage glutamate juvenile hypoxia-ischemia rats

A Wall-less Proportional Counter for Microdosimetry

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IMP & HIRFL Annual Report 1995年 178-179页

作者： dang bingrong Wei Zengquan Zhang Shumin and Li Qiang

Ａ　Ｗａｌｌ－ｌｅｓｓ　Ｐｒｏｐｏｒｔｉｏｎａｌ　Ｃｏｕｎｔｅｒ　ｆｏｒ　ＭｉｃｒｏｄｏｓｉｍｅｔｒｙＡＷａｌｌ－ｌｅｓｓＰｒｏｐｏｒｔｉｏｎａｌＣｏｕｎｔｅｒｆｏｒＭｉｃｒｏｄｏｓｉｍｅｔｒｙ￥ＤａｎｇＢｉｎｇｒｏ...

Ａ　Ｗａｌｌ－ｌｅｓｓ　Ｐｒｏｐｏｒｔｉｏｎａｌ　Ｃｏｕｎｔｅｒ　ｆｏｒ　ＭｉｃｒｏｄｏｓｉｍｅｔｒｙＡＷａｌｌ－ｌｅｓｓＰｒｏｐｏｒｔｉｏｎａｌＣｏｕｎｔｅｒｆｏｒＭｉｃｒｏｄｏｓｉｍｅｔｒｙ￥ＤａｎｇＢｉｎｇｒｏｎｇ；ＷｅｉＺｅｎｇｑｕａｎ；Ｚｈ...

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用于剂量计算的核反应总截面经验公式

核技术 2005年第6期28卷 486-488页

作者：党秉荣李文建中国科学院近代物理研究所兰州730000

在核物理及核物理应用研究中,利用核反应总截面经验公式进行理论计算具有现实意义。这方面的计算公式很多,本文以中能区应用的Kox经验公式为基础,结合重离子治疗肿瘤计算剂量深度模型的需要,对Kox经验公式的参数进行了修正,使其具有更... 详细信息

在核物理及核物理应用研究中,利用核反应总截面经验公式进行理论计算具有现实意义。这方面的计算公式很多,本文以中能区应用的Kox经验公式为基础,结合重离子治疗肿瘤计算剂量深度模型的需要,对Kox经验公式的参数进行了修正,使其具有更广泛的应用价值,同时对修正参数的物理意义进行了探讨。

关键词：核反应总截面重离子治疗肿瘤 Kox经验公式

Protective Effect of Beta-D-glucan on Cell Injury Induced by Carbon Ion Irradiation

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IMP & HIRFL Annual Report 2018年第1期 137-138页

作者： Wang Zhuanzi Liu Fang Li Wenjian Wei Wei dang bingrong 不详

Charged particle radiation is known to be more biologically effective than photon *** example of this is the damage of human blood vessels,and this effect is an important factor influencing human health and is relevant to space travel as well as to cancer ***,research on the protection endothelial cells from heavy ions radiation damage is of great *** showed that beta-D-glucan is one of the potential radioprotectors[1],but most of the studies were focused on the protection of beta-glucan on the immune and hematopoietic after X-/-rays *** the present study,we chose human umbilical endothelial cell line ***926 as a model system to investigate the protective effect of beta-D-glucan on the injury induced by high-LET carbon ions irradiation,and explore the possible mechanism of the action.

关键词： protective damage travel

In Vivo Protective Effect of beta-D-glucan on X-rays Radiation Injury

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IMP & HIRFL Annual Report 2017年第1期 130-131页

作者： Wang Zhuanzi Liu Fang Li Wenjian Wei Wei dang bingrong 不详

Ionizing radiation is a powerful treatment modality against tumor cells,but it is not tumor specific and may affect neighboring normal cell as *** to normal tissue is an obstacle to radiotherapy of ***,strategies to protect cancer patients from the harmful side effects of radiation without compromising the anti-cancer effects are of considerable interest in *** against ionizing radiation is also important during accidental and unavoidable exposures to radiation,such as nuclear industries,radiation accidents,space travels,radiation diagnosis,etc。

关键词： diagnosis cancer travel

4-38 DNA Damage in Bone Marrow Mononuclear Cells of Mice Following Total Body Irradiation with Carbon Ions

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IMP & HIRFL Annual Report 2016年第1期 156-157页

作者： Wang Zhuanzi Liu Fang Li Wenjian Wei Wei dang bingrong 不详

Among the many special factors in the space environment,space radiation especially high energy heavy ion radiation is widely regarded as one of the crucial factors that hazard the health and safety of *** is well known that biological effects of radiation are dependent on the linear-energy-transfer(LET)of the emergent *** ions have high LET and could induce complex and clustered DNA damage,which is more difficult to be repaired than individual lesions and is even irreparable.

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4-37 DNA Damage in Bone Marrow Mononuclear Cells of Mice Detected by Two Dimensional Comet Assay

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IMP & HIRFL Annual Report 2016年第1期 155-156页

作者： Wang Zhuanzi Liu Fang Li Wenjian Wei Wei dang bingrong 不详

Heavy ion irradiation attract a large interest for two applications:radiotherapy and space radiation protection in manned space *** to heavy ions radiation results in multiple effects through DNA damage ***-cell gel electrophoresis or comet assay is known for its ability to detect DNA damage at the single cell level and has been used for years to assess DNA *** can detect low levels of DNA strand breaks in a short time,just using a few sample *** double strand breaks(DSBs)are measured at the neutral comet assay condition;under the alkaline comet assay condition both DNA single strand breaks(SSBs)and part DSBs are *** two dimensional comet assay is a modification of the two original comet assay,can simultaneously detect DNA SSBs and DSBs in the same human spermatozoa.

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Damage and Transcriptional Response of Murine Bone Marrow Cells Exposed to Total-body Carbon Ion Irradiation

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IMP & HIRFL Annual Report 2018年第1期 136-137页

作者： Wang Zhuanzi Liu Fang Li Wenjian Wei Wei dang bingrong 不详

It becomes more importance to understand the toxic effects of heavy ion irradiation on normal tissue as more people spend more time in the space environment and as carbon ion radiotherapy become increasingly used in the treatment of *** tissue damage due to therapeutic or accidental radiation exposure is a pervasive *** marrow,the predominant site of hematopoiesis and the differentiation of blood cells,is extremely sensitive to ionizing *** with even as little as 0.1 Gy X-ray could cause a significant increase in micronucleated reticulocytes in *** to heavy ion irradiation can have even more detrimental effects on bone marrow *** induction of bone marrow damage cannot be predicted correctly as the biological and molecular mechanisms altered after irradiation is still largely *** and characterization of these molecular processes is not only imperative for the development of protective measures for cancer patients undergoing high LET radiotherapy,but also for astronauts in space.

关键词： protective damage predominant

G2-Chromosome fragments after irradiation with Carbon ions

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生物物理学报 2009年第S1期25卷 480-481页

作者： Wang Zhuanzi, Li Wenjian, Wei Wei, Jing Xigang, dang bingrong, Liu jinting Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Nanchang road 509

Measurements of chromosome aberrations in peripheral blood lymphocytes are currently the most sensitive and reliable indicator of radiation exposure that can be used for

关键词： Carbon ions G2-Chromosome fragments PCC technique