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Recent advances in the development of in vitro liver models for hepatotoxicity testing

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Bio-Design and Manufacturing 2021年第4期4卷 717-734页

作者： Siming Lu Jingwei Zhang Sha lin danfeng Zheng Yan Shen Jiale Qin Yangyang Li Shuqi Wang Department of Laboratory Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalNational Clinical Research Center for Infectious DiseasesZhejiang University School of MedicineHangzhou 310003China Institute of Translational Medicine Zhejiang UniversityHangzhou 310029China Key Laboratory of Women’s Reproductive Health of Zhejiang Province Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Zhejiang University School of MedicineHangzhou 310027China

Liver injury is a common cause of drug approval withdrawal during drug development,pre-clinical research,and clinical *** not properly treated,patients with severe liver injury can suffer from acute liver failure or even ***,utilization of the convenient in vitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is vital for drug development and safe personalized ***(e.g.,hydrogels,nanofibers,decellularized liver matrix)and bioengineering technologies(e.g.,microarrays,micropatterns,3D printing,and microfluidics)have been applied for in vitro hepatotoxicity assessment *** review summarizes the structure and functions of the liver as well as the components of in vitro hepatotoxicity assessment *** addition,it highlights the latest advances in developing hepatotoxicity models with the ultimate goal of further clinical translation.

关键词： Liver injury Drug toxicity In vitro model 3D culture

Synthesis, crystal structure and photocatalytic performance of polyoxometalate K_(13)[Gd(GeW_(11)O_(39))_2]·34H_2O

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Journal of Rare Earths 2019年第6期37卷 617-621页

作者： Haibin Liu lin Bai Limei Ai Wenshuang Dai danfeng Zhang Qingyin Wu Renchun Zhang School of Biomedical & Chemical Engineering Liaoning Institute of Science and Technology Department of Chemistry Zhejiang University College of Chemistry and Chemical Engineering Anyang Normal University

A polyoxometalate K_(13)[Gd(GeW_(11)O_(39))_2]·34 H_2 O was synthesized and characterized by elemental analysis,IR spectroscopy, UV spectra, XRD and thermal gravimetric analysis. X-ray single-crystal structural analysis indicates that the title compound crystallizes in the triclinic crystal system. The heteropolyanion of [Gd(GeW_(11)O_(39))_2]^(13) consists of two [GeW_(11)O_(39)]^(8-) vacant Keggin moieties linked via Gd^(3+). Photocatalytic performance of K_(13)[Gd(GeW_(11)O_(39))_2]·34 H_2 O in photodegradation of X-3 B was also *** the reaction time is 180 min, the decoloring rate reaches 71.19%. With the decrease of pH, the decolorization rate increases gradually.

关键词： Polyoxometalate Keggin structure Crystal structure Photocatalytic performance Rare earths

Filamentation initiated by Cas2 and its association with the acquisition process in cells

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International Journal of Oral Science 2019年第4期11卷 300-306页

作者： Lei Wang Xin Yu Mengjie Li Guiqin Sun lin Zou Tiansheng Li linlin Hou Yameng Guo danfeng Shen Di Qu Xunjia Cheng Li Chen Department of Medical Microbiology Key Laboratory of Medical Molecular Virology of Ministries of Education and Health School of Basic Medical Sciences Fudan University 131 Dongan Road Shanghai China and College of Medical Technology Zhejiang Chinese Medical University

Cas1-and-Cas2-mediated new spacer acquisition is an essential process for bacterial adaptive *** process is critical for the ecology of the oral microflora and oral *** molecular mechanisms for spacer acquisition are known,it has never been established if this process is associated with the morphological changes of *** this study,we demonstrated a novel Cas2-induced filamentation phenotype in *** that was regulated by co-expression of the Cas1 protein.A 30 amino acid motif at the carboxyl terminus of Cas2 is necessary for this *** imaging analysis,we provided evidence to argue that Cas-induced filamentation is a step coupled with new spacer acquisition during which filaments are characterised by polyploidy with asymmetric cell *** work may open new opportunities to investigate the adaptive immune response and microbial balance for oral health.

关键词： function. process initiated

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基于双摄像头的心率测量系统的设计与改进

半导体光电 2023年第1期44卷 115-121页

作者：徐杰胡丹峰张林王加俊苏州大学电子信息学院江苏苏州215006

针对在外部干扰或昏暗环境下利用图像光电容积描记(image Photoplethysmography,iPPG)技术进行心率测量时准确度较差,提出了一种自适应心率提取算法,并在嵌入式硬件平台上进行了验证。算法根据图像中人脸与背景区域的色度关系来识别不... 详细信息

针对在外部干扰或昏暗环境下利用图像光电容积描记(image Photoplethysmography,iPPG)技术进行心率测量时准确度较差,提出了一种自适应心率提取算法,并在嵌入式硬件平台上进行了验证。算法根据图像中人脸与背景区域的色度关系来识别不同的场景并启动合适的摄像头进行图像采集及自适应映射,接着对提取出的信号进行滤波,在信号质量评估后输出结果。上述方法在Zynq平台上进行了验证,使用双摄像头实现实时心率测量,并对结果进行可视化输出。实验结果表明:优化后的算法在光照及运动的双重干扰下的测量误差从3.36 BPM降至2.78 BPM,准确率提升了17.3%。另外,所设计的系统能够实现在极端黑暗条件下的心率采集,平均误差约为2.39 BPM。

关键词：图像光电容积描记法心率测量 Zynq 抗干扰信号处理

A high-order model for spike-type instability in axial compression systems

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A high-order model for spike-type instability in axial compr...

Analyzing of Hopf Bifurcation Based on Deterministic Learning

第36届中国控制会议

作者： Peng lin danfeng Chen Cong Wang School of Automation Science and Engineering South China University of Technology School of Automation Foshan University

ISBN: (纸本)9781538629185

Inlet flow non-uniformity（inlet distortion） can influence the transient behavior of stall disturbances and trigger the compression system instability. Physical modeling is a direct and effective method to study stall phenomena of axial compression systems with inlet distortion. In this paper, by using the general Galerkin projection and the spatial discretization methods, highorder ordinary differential equations（ODEs） are derived for analyzing the complex spike-type stall inception process in axial compression systems with inlet distortion. Considering the high-order stall modes, the wave propagating around the compressor annulus has a rich harmonic structure for compression systems with inlet distortion, and then the high-order model can more accurately depict the dynamics of rotating stall, especially the transient behavior of spike-type stall inception. Finally, numerical simulations are performed on an eighteenth-order model to illustrate the effectiveness of the high-order model.

关键词： Axial compression systems rotating stall spike-type stall inlet distortion

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Analyzing of Hopf Bifurcation Based on Deterministic Learnin...

TiO_2掺杂对ZnO-Bi_2O_3-TiO_2低压压敏电阻电学性能的影响

第36届中国控制会议

作者： danfeng Chen Peng lin Cong Wang School of Automation Foshan University School of Automation Science and Engineering South China University of Technology

ISBN: (纸本)9781538629185

For parameter dependent nonlinear system, once the parameter reaches a critical point, the equivalent relationship of the system trajectory will be destroyed and further lead to structural instability of the whole system. This is the dynamic bifurcation phenomenon and is also the fundamental cause of instability oscillations and dynamic failures for most practical *** this research, Hopf bifurcation, the most common and typical dynamic bifurcation, will be discussed through deterministic learning theory. Firstly, an algebraic criterion of Hopf bifurcation is proposed according to the classical Hurwitz criterion, which provides a more convenient tool for Hopf bifurcation analyzing. Then, the bifurcation process with the change of system dynamics due to abnormal parameter variation is analyzed through deterministic learning. A C-norm based measure and negative exponential dynamic index are presented according to the structural stability theory, which can be used to analyze the steady state of current system. Finally, the classical Hodgkin-Hexley model is introduced to verify the feasibility and validity of the proposed algorithm.

关键词： system identification Hopf bifurcation deterministic learning nonlinear dynamics structure stability HH model

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硅酸盐学报 2007年第1期35卷 21-25页

作者：林枞徐政孙丹峰同济大学材料科学与工程学院上海200092 苏州中普电子有限公司苏州215011

通过研究微米粉体、纳米粉体和纳米胶体TiO2掺杂的ZnO压敏电阻的电性能,发现纳米胶体TiO2掺杂的ZnO压敏电阻具有较低的电压梯度和漏电流,而非线性系数较高。对电性能结果的分析表明:在ZnO–Bi2O3–TiO2低压压敏电阻中,晶界击穿电压不是... 详细信息

通过研究微米粉体、纳米粉体和纳米胶体TiO2掺杂的ZnO压敏电阻的电性能,发现纳米胶体TiO2掺杂的ZnO压敏电阻具有较低的电压梯度和漏电流,而非线性系数较高。对电性能结果的分析表明:在ZnO–Bi2O3–TiO2低压压敏电阻中,晶界击穿电压不是一个固定值;漏电流中的线性分量对TiO2掺杂的ZnO压敏电阻电学性能影响很大。

关键词：氧化锌压敏电阻纳米胶体二氧化钛掺杂电性能

共沉淀纳米掺杂制备ZnO压敏电阻数学模拟(Ⅰ)

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同济大学学报（自然科学版） 2007年第11期35卷 1515-1519页

作者：林枞徐政孙丹峰同济大学材料科学与工程学院上海200092 苏州中普电子有限公司江苏苏州215011

从多种离子反应平衡角度,对最常见的氨法共沉淀过程进行理论分析,并在此基础上提出了氨法共沉淀的数学模型和计算方法.对ZnO压敏电阻粉体共沉淀反应中的既能与NH3也能与OH-络合的金属离子(A类二价金属离子)进行了理论分析和模拟计算,得... 详细信息

从多种离子反应平衡角度,对最常见的氨法共沉淀过程进行理论分析,并在此基础上提出了氨法共沉淀的数学模型和计算方法.对ZnO压敏电阻粉体共沉淀反应中的既能与NH3也能与OH-络合的金属离子(A类二价金属离子)进行了理论分析和模拟计算,得到了沉淀反应中沉淀系数、络合反应系数及pH值和氨水添加量之间的关系.

关键词： ZnO压敏电阻共沉淀数学模拟

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《论语》中的政德思想及其时代价值

福建开放大学学报 2022年第1期 26-30页

作者：钟丹凤林明惠福建师范大学马克思主义学院福建福州350100 福建医科大学马克思主义学院福建福州350100

在儒家思想的经典代表性著作《论语》中,孔子提出的政德思想,其中蕴含着丰富的治国理政智慧,影响中华民族时间长达两千多年。政德思想主要包括:以德治国的为政之道、以仁为本的治国理念、取信于民的治国之基、身正为范的为政表率、全面... 详细信息

在儒家思想的经典代表性著作《论语》中,孔子提出的政德思想,其中蕴含着丰富的治国理政智慧,影响中华民族时间长达两千多年。政德思想主要包括:以德治国的为政之道、以仁为本的治国理念、取信于民的治国之基、身正为范的为政表率、全面察人的长远目光。直至今天,政德思想仍有丰富的时代价值。从政者在治国理政中可以从《论语》中汲取大量智慧,将《论语》中的政德思想运用于新时代中国特色社会主义事业的伟大建设中。

关键词：政德道德治国理政