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3D-printed Mg-1Ca/polycaprolactone composite scaffolds with promoted bone regeneration

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Journal of Magnesium and Alloys 2024年第3期12卷 966-979页

作者： Xiao Zhao Siyi Wang Feilong Wang Yuan Zhu Ranli Gu Fan Yang Yongxiang Xu dandan Xia Yunsong Liu Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing 100081China National Center of Stomatology National Engineering Laboratory for Digital and Material Technology of StomatologyNational Clinical Research Center for Oral DiseasesBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing 100081China Department of Dental Materials Peking University School and Hospital of StomatologyBeijing 100081China

In bone tissue engineering,polycaprolactone(PCL)is a promising material with good biocompatibility,but its poor degradation rate,mechanical strength,and osteogenic properties limit its *** this study,we developed an Mg-1Ca/polycaprolactone(Mg-1Ca/PCL)composite scaffolds to overcome these *** used a melt blending method to prepare Mg-1Ca/PCL composites with Mg-1Ca alloy powder mass ratios of 5,10,and 20 wt%.Porous scaffolds with controlled macro-and microstructure were printed using the fused deposition modeling *** explored the mechanical strength,biocompatibility,osteogenesis performance,and molecular mechanism of the Mg-1Ca/PCL *** 5 and 10 wt%Mg-1Ca/PCL composites were found to have good ***,they promoted the mechanical strength,proliferation,adhesion,and osteogenic differentiation of human bone marrow stem cells(hBMSCs)of pure *** vitro degradation experiments revealed that the composite material stably released Mg_(2)+ions for a long period;it formed an apatite layer on the surface of the scaffold that facilitated cell adhesion and *** tomography and histological analysis showed that both 5 and 10 wt%Mg-1Ca/PCL composite scaffolds promoted bone regeneration bone *** results indicated that the Wnt/β-catenin pathway was involved in the osteogenic ***,Mg-1Ca/PCL composite scaffolds are expected to be a promising bone regeneration material for clinical *** of significance:Bone tissue engineering scaffolds have promising applications in the regeneration of critical-sized bone ***,there remain many limitations in the materials and manufacturing methods used to fabricate *** study shows that the developed Ma-1Ca/PCL composites provides scaffolds with suitable degradation rates and enhanced boneformation ***,the fused deposition modeling method allows precise control of the macroscopic morphology and microsc

关键词： 3D printing Bone tissue engineering Magnesium Osteogenic Polycaprolactone Scaffold.

Mg(NO_(3))_(2)·6H_(2O)-Assisted insitu-Fabrication of Tea Residual Biochar for Ultra-Fast and High Adsorption of Rhodamine B

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Wuhan University Journal of Natural Sciences 2024年第2期29卷 165-176页

作者： HU dandan XUE Yangfan LIU Bo WU Yongjuan LI Zichen School of Chemistry&Chemical Engineering Shaanxi Xueqian Normal UniversityXi'an 710100ShaanxiChina Safe College Xi􀆳an University of Science and TechnologyXi'an 710054ShaanxiChina

In this work,porous biochar(MN-TRB_(750))was fabricated via direct pyrolysis of tea residue(TR)and Mg(NO_(3))_(2)·6H_(2)O(MN).The as-synthesized MN-TRB_(750) reached a specific surface area of 839.54 m^(2)·g^(-1)and an average pore size of 3.75 nm with multi-level pore *** decreased TR's carbonization temperature and promoted the aromatics extent,pore structure for the frizzly flake-like *** B(RhB)was chosen as the adsorbate to explore the removal performance of organic dyes in this *** results indicated that the maximum adsorption capacity of RhB on MN-TRB_(750) at 20℃ is up to 809.0 mg·g^(-1)with isotherms fitted well to Freundlich and Dubinin-Radushkevic *** adsorption kinetics followed pseudo-second-order and Elovich models with an equilibrium adsorption capacity of 757.6 mg·g^(-1)as the initial concentration of RhB is 260 mg·L^(-1).High pore filling,hydrogen bond,π-πinteraction determined the adsorption of RhB onto MN-TRB850 through a multi-active center and exothermic chemical sorption process.

关键词： Mg(NO_(3))_(2)·6H_(2)O porous biochar mechanism rhodamine B adsorption

Promotion effect of epoxy group neighboring single-atom Cu site on acetylene hydrochlorination

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Chinese Chemical Letters 2024年第6期35卷 258-262页

作者： Junchen Peng Xue Yin dandan Dong Zhongyuan Guo Qinqin Wang Minmin Liu Fei He Bin Dai Chaofeng Huang School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi UniversityShihezi 832000China College of Chemistry&Chemical Engineering Yantai UniversityYantai 264010China School of Material Science and Engineering University of JinanJi’nan 250022China

Carbon materials have been used as the support for catalysts in the field of acetylene hydrochlorination,the influence of inevitable oxygen-containing moieties on the reaction is often ignored and the mechanism of the oxygen-doping structure remains ***,we explored the effect of the oxygen-containing group(C-O-C)in the support on the activity of single-atom dispersed Cu *** immersing the Cu single-atom catalyst in an alkaline solution,the epoxy species on the carbon support was cleaved to obtain a pure ether species while the Cu site was modified to a more electron-deficient *** turnover frequency value of Cu/O-FLP catalyst with epoxy groups was 1.6-fold higher than that of alkaline treated *** result indicated that the epoxy groups could assist adjacent single-atom Cu sites to synergistically promote the adsorption and cleavage of the reactant hydrogen chloride toward form C-OH and Cu-Cl bonds,and reduce the reaction energy *** presence of electron deficient Cu sites and ether species could induce competitive adsorption of the acetylene and hydrogen chloride,thereby reducing the activity of the *** study highlights the influence of surface oxygen species and the tunability of the support,providing the foundation for the fabrication of higher-activity Cu catalysts for acetylene hydrochlorination.

关键词： Epoxy group Acetylene hydrochlorination Single-atom Cu catalyst Synergistic dissociation

Clinical analysis of patients with deep sternal wound infection-induced sepsis:a retrospective cohort study

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Emergency and Critical Care Medicine 2024年第2期4卷 67-73页

作者： Bin Song Zhentian Cui Hongyan Ju Yue Sun dandan Liu Guanggang Li Department of Critical Care 7th Medical Center of Chinese PLA General HospitalBeijingChina Department of Cardiac and Macrovascular Surgery 7th Medical Center of Chinese PLA General HospitalBeijingChina

Background:This study aimed to summarize the clinical characteristics of patients with deep sternal wound infection-induced sepsis after median sternotomy and improve the treatment outcomes of infection-related ***:A retrospective cohort study was conducted on 21 patients with deep sternal wound infection-induced sepsis after median sternotomy who were admitted to the Department of Critical *** clinical manifestations,laboratory test results,infection control,and organ and nutritional support of the patients were summarized,and the follow-up data were ***:The primary symptoms of deep sternal wound infection-induced sepsis included dyspnea,high fever,chills,and altered state of *** test results revealed increased inflammatory markers and decreased oxygenation *** and liver function injury were observed in 8 and 4 patients,respectively;18 and 12 patients demonstrated elevated D-dimer and N-terminal Pro B type natriuretic peptide levels,*** the 8 patients whose wound secretions tested positive for bacteria,Acinetobacter baumannii and Staphylococcus aureus infections were present in 6 and 2 patients,*** of the 6 patients whose blood cultures tested positive for bacteria demonstrated Candida albicans *** patients received ventilator-assisted ventilation and 2 patients received renal replacement *** all the 21 patients,17 were cured,2 died,and 2 were ***:Postmedian sternotomy sepsis attributed to a deep sternal wound infection usually results from a preexisting *** most prominent clinical manifestation is dyspnea,which is sometimes accompanied by the impairment of organ *** prevention,proper nutrition support,and maintenance of healthy organ function are the cornerstones for successful treatment outcomes.

关键词： Clinical analysis Deep sternal wound infection Sepsis

Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice

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Food Science and Human Wellness 2024年第3期13卷 1422-1438页

作者： Xiuxiu Wu Tianyi Guo Biao Li Shuai Han Zuomin Hu Yi Luo dandan Qin Yaping Zhou Feijun Luo Qinlu Lin National Research Center of Rice Deep Process and Byproducts Hunan Provincial Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Provincial Key Laboratory of Forestry Edible Resources Safety and ProcessingCentral South University of Forestry and TechnologyChangsha 410004China College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China Department of Clinical Medicine Medical College of XiangyaCentral South UniversityChangsha 410008China

Dietary parboiled rice(PR)has a low risk of disease,but little is known about the contribution of PR to the prevention of *** potential role and underlying mechanisms of PR in hyperlipidemia were evaluated in this *** C57BL/6J mice were fed with a normal diet,high-fat diet(HFD)containing refined rice(HFDRR)or PR(HFDPR).It was found that PR intervention improved lipid accumulation in *** data analysis revealed that 27 genes were up-regulated(mostly involved in lipid breakdown)and 86 genes were down-regulated(mostly involved in inflammatory responses)in the HFDPR group compared to the HFDRR *** 15 differentially expressed genes(DEGs)were validated by quantitative real-time PCR(RT-qPCR),while protein interaction network showed that protein tyrosine phosphatase receptor type C(PTPRC)has a central *** gut microbiota of mice was also altered after different dietary treatments,with higher ratio of Firmicutes and Bacteroidetes,increased abundances of Ruminococcaceae,Lachnospiraceae,Christensenellaceae,Porphyromonadaceae,Rikenellaceae and Prevotellaceae,and decreased abundances of Lactobacillaceae,Peptostreptococcaceae,Erysipelotrichaceae and Actinobacteria in the HFDRR *** addition,it was observed that PPAR signaling pathway may act as a bridge between DEGs and differential gut *** results suggested that PR can prevent hyperlipidemia by modulating liver genes and gut microbiota.

关键词： Parboiled rice Blood lipids Transcriptome Gut microbiota PPAR Signaling pathway

Postmastectomy radiotherapy in breast reconstruction:Current controversies and trends

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Cancer Innovation 2024年第1期3卷 113-123页

作者： Honghong Zhang dandan Song Liangxi Xie Ning Zhan Wenjia Xie Jianming Zhang Department of Radiation Oncology Xiang'an Hospital of Xiamen UniversityCancer Research CenterSchool of MedicineXiamen UniversityXiang'anXiamenFujianChina Fujian Provincial Key Laboratory of Intelligent Identification and Control of Complex Dynamic System Quanzhou Institute of Equipment ManufacturingHaixi InstitutesChinese Academy of SciencesQuanzhouFujianChina

Breast cancer is the most common cancer among women *** radiotherapy(PMRT)is an essential component of combined therapy for early-stage,high-risk breast *** reconstruction(BR)is often considered for patients with breast cancer who have undergone *** has been a considerable amount of discussion about the optimal approach to combining PMRT with BR in the treatment of breast *** may increase the risk of complications and prevent good aesthetic results after BR,while BR may increase the complexity of PMRT and the radiation dose to surrounding normal *** purpose of this review is to give a broad overview and summary of the current controversies and trends in PMRT and BR in the context of the most recent literature available.

关键词： breast reconstruction postmastectomy radiotherapy radiotherapy techniques

A novel cabazitaxel liposomes modified with ginsenoside Rk1 for cancer targeted therapy

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Acupuncture and Herbal Medicine 2024年第1期4卷 113-121页

作者： dandan Huang Zhongjie Tang Xiao Pu Tianqi Wang Feiyan Gao Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqingChina Department of Pharmacy National University of SingaporeSingapore 117545Singapore

Objective:In this study,we aim to enhance the anti-prostate cancer efficacy of cabazitaxel(CTX)and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1(Rk1/CTX-Lip).Methods:Physical and chemical properties of Rk1/CTX-Lip were *** evaluated the biological functions of Rk1/CTXLip,both in vitro and in vivo.A subcutaneous prostate cancer(RM-1)-bearing mouse model was established to study the efficacy of Rk1/CTX-Lip inhibition in ***,a Candida albicans infection model was established in tumor-bearing mice to study the infection-relieving efficacy of Rk1/***,biocompatibility and in vivo safety of Rk1/CTX-Lip were ***:We successfully prepared Rk1/CTX-Lip,achieving high CTX encapsulation efficiency(97.24±0.75)%and physical ***1/CTX-Lip demonstrated evasion of macrophage phagocytosis,effective tumor tissue targeting,and a significant reduction(>50%)in average tumor volume compared with Chol/***,it relieved the concurrent infection burden and effectively regulated immune organs and cells,demonstrating superior ***:Rk1/CTX-Lip presents a promising new therapy for prostate cancer and holds potential for relieving concurrent fungal infections in cancer patients with low immunity.

关键词： Cabazitaxel Fungal infection Ginsenoside Rk1 Liposome-drug delivery system Prostate cancer

Defect and nanostructure engineering of polymeric carbon nitride for visible-light-driven CO2 reduction

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The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells

结构化学 2024年第3期43卷 10-18页

作者： Ziruo Zhou Wenyu Guo Tingyu Yang dandan Zheng Yuanxing Fang Xiahui Lin Yidong Hou Guigang Zhang Sibo Wang State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou350116China College of Environment and Safety Engineering Fuzhou UniversityFuzhou350108China

Sunlight-induced photocatalytic carbon dioxide(CO2)reduction to energy-rich chemicals by metal-free polymeric carbon nitride(CN)semiconductor is a promising tactic for sustained solar fuel ***,the reaction efficiency of CO2 photoreduction is restrained seriously by the rapid recombination of photogenerated carriers on CN ***,we incorporate 2-aminopyridine molecule with strong electron-withdrawing group into the skeleton edge of CN layers through a facile one-pot thermal polymerization strategy using urea as the precursor,which renders a modified carbon nitride(ACN)with extended optical harvesting,abundant nitrogen defects and ultrathin nanosheet ***,the ACN photocatalyst with desirable structural features attains enhanced separation and migration of photoexcited charge *** visible light irradiation with Co(bpy)32+as a cocatalyst,the optimized ACN sample manifests a high CO2 deoxygnative reduction activity and high sta-bility,providing a CO yielding rate of 17 μmol h-1,which is significantly higher than that of pristine *** key intermediates engaged in CO2 photoreduction reaction are determined by the in situ diffuse reflectance infrared Fourier transform spectroscopy,which sponsors the construction of the possible photocatalytic CO2 reduction mechanism on ACN nanosheets.

关键词： Carbon nitride Photocatalysis CO_2 reduction Nitrogen defects Nanosheets

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Science China Life Sciences 2024年第9期67卷 1867-1880页

作者： Weixiao Yan Xiaotong Wang Wenjing Wang Qi Guo Na Huang Hao Chen Xing-Jie Liang Yu Han dandan Liu Jinchao Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education College of Chemistry and Materials Science Chemical Biology Key Laboratory of Hebei Province Hebei University CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology

Cancer stem cells(CSCs) play an important role in metastasis development, tumor recurrence, and treatment resistance, and are essential for the eradication of cancer. Currently, therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape, which leads to enhanced aggressive behaviors compared with CSCs that have never been treated. However, the underlying mechanisms regulating the therapeutic escape remain unknown. To this end, we established a model to isolate the therapeutic escaped CSCs(TSCSCs) from breast CSCs and performed the transcription profile to reveal the mechanism. Mechanistically, we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway, resulting in TSCSCs exhibiting enhanced motility and metastasis. Notably,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo, which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and *** obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy.

关键词： therapeutic escape breast cancer stem cells motility p38/MAPK signaling pathway molecular mechanism

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