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Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review

Neural Regeneration Research 2024年第6期19卷 1221-1232页

作者： dandan chu Xingyue Yang Jing Wang Yan Zhou Jin-Hua Gu Jin Miao Feng Wu Fei Liu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products Coinnovation Center of Neuroregeneration Nantong University 2. Department of Pharmacology School of Pharmacy Nantong University 3. Department of Biochemistry and Molecular Biology School of Medicine Nantong University 4. Department of Clinical Pharmacy Affiliated Maternity and Child Health Care Hospital of Nantong University Nantong University 5. Laboratory of Animal Center Nantong University Department of Neurochemistry Inge Grundke-Iqbal Research Floor New York State Institute for Basic Research in Developmental Disabilities

Alzheimer’s disease is characterized by two major neuropathological hallmarks—the extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein. Recent studies suggest that dysregulation of the microtubuleassociated protein Tau, especially specific proteolysis, could be a driving force for Alzheimer’s disease neurodegeneration. Tau physiologically promotes the assembly and stabilization of microtubules, whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers, resulting in them gaining prion-like characteristics. In addition, Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent manner. This review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments, investigates the role of specific truncations in physiological and pathological states of Alzheimer’s disease, and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer’s disease.

关键词： Alzheimer's disease cleavage site diagnosis marker neurofibrillary tangles phosphorylation Tau Tau aggregation therapy truncation

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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： dandan chu Mengyang Zhao Shisong Rong Wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual *** incidence of DED is gradually increasing with the highfrequency use of electronic *** inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from ***,current therapies merely targeting inflammation show the failure of DED ***,a novel dual-atom nanozymes(DAN)-based eye drops are *** antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic *** in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell ***,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious *** findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

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数据挖掘算法在低压漏电定位中的应用

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集成电路应用 2024年第2期41卷 168-169页

作者：吴金利贾欢徐幸褚丹丹国网菏泽供电公司山东274000

阐述现有桥接方法中的问题及原因,提出一种综合考虑电力系统特点和桥接需求的优化模型。实验结果显示,优化模型能够显著改善桥接效率、稳定性和功率损耗的性能指标。

关键词：数据挖掘人工智能算法低压漏电定位

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Boosting Enantioselectivity of Chiral Molecular Catalysts with Supramolecular Metal-Organic Cages

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CCS Chemistry 2022年第4期4卷 1180-1189页

作者： dandan chu Wei Gong Hong Jiang Xianhui Tang Yong Cui Yan Liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240

The search for new methodologies to tune and control the enantioselectivities of molecular catalysts is of great importance in the field of asymmetric ***,we have illustrated that chiral molecular catalysts can be boosted from very low enantioselectivity to high enantioselectivity when installed in supramolecular metal-organic *** deliberately designing two optically active 1,1′-spirobiindane-7,7′-diol(SPINOL)-based dipyridine linkers,we synthesized two chiral Pd_(3)L_(6) cages featuring chiral dihydroxyl or dimethoxymethyl auxiliaries in the nanosized *** treatment with metal ions,the cage featuring dihydroxyl groups could serve as efficient catalysts for asymmetric conjugate addition of styrylboronic acids toα,β-enones to produce γ,δ-unsaturated ketone and the asymmetric addition of diethylzinc to aldehydes to afford secondary *** the molecular SPINOL display very low enantioselectivity,restriction of its freedom in the cages led to 91−99.6% and 80−99.9% enantiomeric excess(ee)of products,respectively,which were increased by up to 35% and 78% ee,compared with the molecular ***,our present work paves a way of utilizing supramolecular porous assemblies to manipulate the enantioselectivities of molecular catalysts.

关键词： coordination cage self-assembly asymmetric catalysis supramolecular catalysis host-guest chemistry

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Activating MoO_(3) nanobelts via aqueous intercalation as a near-infrared type I photosensitizer for photodynamic periodontitis treatment

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SmartMat 2023年第6期4卷 112-124页

作者： Bohua Li dandan chu Haohao Cui Zhanrong Li Zhan Zhou Chaoliang Tan Jingguo Li Henan Provincial People's Hospital People's Hospital of Zhengzhou UniversityZhengzhouChina College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyangChina Department of Electrical and Electronic Engineering The University of Hong KongHong Kong SARChina

Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy,chemodynamic therapy,and catalytic therapy,their utilization as photosensitizers for photodynamic therapy(PDT)have been rarely reported so ***,we report the activation of MoO_(3) nanobelts via aqueous co-intercalation of Na+and H_(2)O into their van der Waals gaps as a near-infrared Type I photosensitizer for photodynamic periodontitis *** Na^(+)/H_(2)O intercalation of MoO_(3) nanobelts can shorten its length,generate rich oxygen vacancies,and enlarge its interlayer *** structural changes thus can induce the color change from white to dark blue with a strong near-infrared(NIR)*** used as a photosensitizer,the I-MoO_(3−x) nanobelts exhibit much higher activities for the generation of superoxide radical(·O_(2)^(−))under an 808 nm laser irradiation than that of the pristine MoO_(3) ***,the prepared I-MoO_(3)−x nanobelts show a spectral antibacterial activity against Escherichia coli and Saccharomyces aureus,thus yielding a good clinical therapeutic effect on *** study proves that aqueous intercalation can be a simple but powerful strategy to activate layered MoO_(3) nanomaterials for high-performance PDT.

关键词： intercalation MoO_(3) nanobelts periodontitis treatment photodynamic therapy Type I photosensitizer

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学位论文文献综述的元文性分析

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当代修辞学 2022年第1期 62-76页

作者：储丹丹复旦大学《当代修辞学》编辑部上海200433

论文从元文性的理论视角出发,以人文社科类博士学位论文文献综述为研究对象,对篇际互文关系展开研讨。论文借鉴系统功能语言学和互文语篇理论,首先考察元文性的动态层级关系,重点分析学位论文文献综述中显性、隐性元文关系及其语篇功能... 详细信息

论文从元文性的理论视角出发,以人文社科类博士学位论文文献综述为研究对象,对篇际互文关系展开研讨。论文借鉴系统功能语言学和互文语篇理论,首先考察元文性的动态层级关系,重点分析学位论文文献综述中显性、隐性元文关系及其语篇功能,在此基础上提取了文献综述文本建构过程中的评论模式,讨论了如何在动态的语篇关系中把握意义的生成与理解,在作者-读者-语境的三维空间中确定语篇的意义和功能。

关键词：元文性篇际互文关系互文层级文献综述显性隐性评论模式

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Ca^(2+)-supplying black phosphorus-based scaffolds fabricated with microfluidic technology for osteogenesis

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Bioactive Materials 2021年第11期6卷 4053-4064页

作者： Zhanrong Li Xingcai Zhang Jiang Ouyang dandan chu Fengqi Han Liuqi Shi Ruixing Liu Zhihua Guo Grace X.Gu Wei Tao Lin Jin Jingguo Li Henan Provincial People’s Hospital Zhengzhou University People’s HospitalZhengzhou450003People’s Republic of China International Joint Research Laboratory for Biomedical Nanomaterials of Henan Zhoukou Normal UniversityZhoukou466001People’s Republic of China Center for Nanomedicine Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115United States School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138United States School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139United States Department of Mechanical Engineering University of CaliforniaBerkeleyCA94720-1740United States

Effective osteogenesis remains a challenge in the treatment of bone *** emergence of artificial bone scaffolds provides an attractive *** this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect *** fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 *** 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated *** in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone ***,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical *** is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss.

关键词： Black phosphorus Bone defect Osteogenesis Artificial bone scaffold Biomineralization

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基于嵌入式GSM-R的监测系统研究

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电子技术应用 2013年第7期39卷 17-20页

作者：褚丹丹赛景波北京工业大学电子信息与控制工程学院北京100124

目前绝大多数GSM-R数据监测装置是以PC机为控制器,通过移动监测车辆搭载复杂的设备对铁路沿线的GSM-R信号进行监测。针对此状提出了一种以OMAP-L138作为嵌入式微处理器的GSM-R便携式数据监测系统。本系统利用GSM-R网络,通过监测终端的... 详细信息

目前绝大多数GSM-R数据监测装置是以PC机为控制器,通过移动监测车辆搭载复杂的设备对铁路沿线的GSM-R信号进行监测。针对此状提出了一种以OMAP-L138作为嵌入式微处理器的GSM-R便携式数据监测系统。本系统利用GSM-R网络,通过监测终端的数据采集模块接收GSM-R数字中频信号,数据处理模块完成GSM-R数字中频信号的监测和干扰分析。若存在干扰,数据解析模块则解析出受干扰小区ID和干扰源小区ID,使分析干扰更具有针对性。该系统体积小,功能丰富,操作控制方便,具有广阔的前景。

关键词：嵌入式Linux GSM—R 监测系统 CDMA GSM

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新时代北大荒精神爱国主义价值取向研究

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大庆师范学院学报 2024年第1期44卷 23-32页

作者：初金哲佟丹丹黑龙江八一农垦大学经济管理学院黑龙江大庆163319 黑龙江八一农垦大学动物科技学院黑龙江大庆163319

北大荒精神形成于特定的地域、行业、群体和时代,与爱国主义精神交融互通、一脉相承,其显示出来的独特的爱国主义价值和意义,随着经济社会的高速发展而日趋丰富和完善。新时代要紧密结合中国特色社会主义伟大实践,使北大荒精神担负起爱... 详细信息

北大荒精神形成于特定的地域、行业、群体和时代,与爱国主义精神交融互通、一脉相承,其显示出来的独特的爱国主义价值和意义,随着经济社会的高速发展而日趋丰富和完善。新时代要紧密结合中国特色社会主义伟大实践,使北大荒精神担负起爱国主义教育的使命和任务,突出思想教育、励志教育和人才教育,围绕实践活动、教育文化、环境建设等几个方面拓展新时代北大荒精神爱国主义教育的传承路径,为推动龙江全面振兴全方位振兴贡献力量。

关键词：红色文化北大荒精神爱国主义教育新时代

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面向智慧城市的LoRa和物联网云平台的智能充电监控系统

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机电工程技术 2024年第4期53卷 30-35,70页

作者：褚洋李丹丹东北林业大学计算机与控制工程学院哈尔滨150040 东北林业大学机电工程学院哈尔滨150040

在智能充电监控过程中要求传感器能够正确采集数据,数据传输设备传输数据过程不受外界干扰等。基于此,提出一种面向智慧城市充电设备的LoRa智能充电监控系统。使用国产APM32中控芯片开发充电桩终端设备和网关,设备与网关的通信与数据传... 详细信息

在智能充电监控过程中要求传感器能够正确采集数据,数据传输设备传输数据过程不受外界干扰等。基于此,提出一种面向智慧城市充电设备的LoRa智能充电监控系统。使用国产APM32中控芯片开发充电桩终端设备和网关,设备与网关的通信与数据传输模块采用LoRa模块,网关通过LoRa协议以“N叉树”模型的一对多方式实现与多个LoRa设备节点通信的功能;采用BL0939电能计量模块实时采集充电过程中的工作电压、电流、功率电能等。每个设备和网关都内置AT24C02型EEP ROM数据存储模块,可以在电力线路运行中突然停电时起到数据保护作用;选择4G模块WH-GM5作为网关无线通信模块网关与服务器通信。LoRa协议可以有效地减少同频干扰,从而提高网络的可靠性和可用性。实验验证了该系统能够满足在智慧城市、资源勘探以及其他环境下的监测需求。

关键词：智能充电传感器 LoRa协议同频干扰 N叉树

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