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Nanomedicine approaches for treatment of hematologic and oncologic malignancies

World Journal of Clinical Oncology 2022年第7期13卷 553-566页

作者： Polyxeni Nteli danae efremia bajwa Dimitrios Politakis Charalampos Michalopoulos Anastasia Kefala-Narin Efstathios P Efstathopoulos Maria Gazouli Department of Basic Medical Sciences Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece 2^(nd) Department of Radiology Medical SchoolNational and Kapodistrian University of AthensGeneral University Hospital AttikonAthens12462Greece

Cancer is a leading cause of death ***,the therapies are inadequate and spur demand for improved *** growth in nanotechnology and novel nanomedicine products represents an opportunity to achieve sophisticated targeting strategies and *** is increasingly used to develop new cancer diagnosis and treatment methods since this technology can modulate the biodistribution and the target site accumulation of chemotherapeutic drugs,thereby reducing their *** nanotechnology and cancer immunotherapy are two parallel themes that have emerged over the last few decades while searching for a cure for *** is revolutionizing cancer treatment,as it can achieve unprecedented responses in advanced-stage patients,including complete cures and long-term survival.A deeper understanding of the human immune system allows the establishment of combination regimens in which immunotherapy is combined with other treatment modalities(as in the case of the nanodrug Ferumoxytol).Furthermore,the combination of gene therapy approaches with nanotechnology that aims to silence or express cancer-relevant genes via one-time treatment is gradually progressing from bench to *** most common example includes lipidbased nanoparticles that target VEGF-Αand KRAS *** review focuses on nanoparticle-based platforms utilized in recent advances aiming to increase the efficacy of currently available cancer *** insights provided and the evidence obtained in this paper indicate a bright future ahead for immunooncology applications of engineering nanomedicines.

关键词： Nanomedicine Cancer Immunotherapy Gene Cell therapy

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