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Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components

Bioactive Materials 2023年第1期19卷 642-652页

作者： Michaela B.Cooley Eric C.Abenojar dana wegierak Anirban Sen Gupta Michael C.Kolios Agata A.Exner Department of Biomedical Engineering Case Western Reserve UniversityClevelandOH44106United States Department of Radiology Case Western Reserve UniversityClevelandOH44106United States Department of Physics Ryerson UniversityTorontoOntarioM5B 2K3Canada Institute for Biomedical Engineering and Science Technology A Partnership Between Ryerson University and St.Michael’s HospitalTorontoOntarioM5B 1T8Canada

Nanoscale ultrasound contrast agents,or nanobubbles,are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in *** sub-micron particles are approximately 10x smaller than clinically available *** allows them to effectively traverse compromised physiological barriers and circulate for extended periods of *** various aspects of nanobubble behavior have been previously examined,their behavior in human whole blood has not yet been ***,herein we examined,for the first time,the short and long-term effects of blood components on nanobubble acoustic *** observed differences in the kinetics of backscatter from nanobubble suspensions in whole blood compared to bubbles in phosphate buffered saline(PBS),plasma,or red blood cell solutions(RBCs).Specifically,after introducing nanobubbles to fresh human whole blood,signal enhancement,or the magnitude of nonlinear ultrasound signal,gradually increased by 22.8±13.1%throughout our experiment,with peak intensity reached within 145 *** contrast,nanobubbles in PBS had a stable signal with negligible change in intensity(􀀀1.7±3.2%)over 8 *** the same conditions,microbubbles made with the same lipid formulation showed a􀀀56.8±6.1%decrease in enhancement in whole *** confocal,fluorescent,and scanning electron microscopy analysis revealed attachment of the nanobubbles to the surface of RBCs,suggesting that direct interactions,or hitchhiking,of nanobubbles on RBCs in the presence of plasma may be a possible mechanism for the observed *** phenomenon could be key to extending nanobubble circulation time and has broad implications in drug delivery,where RBC interaction with nanoparticles could be exploited to improve delivery efficiency.

关键词： Nanobubbles Ultrasound contrast agents Red blood cells Hitchhiking Ultrasound Drug delivery

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Current role of extracorporeal membrane oxygenation for the management of trauma patients:Indications and results

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World Journal of Critical Care Medicine 2025年第1期14卷 42-48页

作者： Mohammed Abdulrahman Maryam Makki Malak Bentaleb dana Khamis Altamimi Marcelo AF Ribeiro Junior Department of Surgery College of Medicine and Health SciencesKhalifa UniversityAbu Dhabi 11001United Arab Emirates Department of Surgery Division of TraumaCritical Care and Acute Care SurgerySheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Surgery Sheikh Shakhbout Medical CityAbu Dhabi 91888ADUnited Arab Emirates Department of Surgery R Adams Cowley Shock Trauma CenterUniversity of MarylandBaltimoreMD 21201United States

Extracorporeal membrane oxygenation(ECMO)has emerged as a vital circulatory life support measure for patients with critical cardiac or pulmonary conditions unresponsive to conventional *** allows blood to be extracted from a patient and introduced to a machine that oxygenates blood and removes carbon *** blood is then reintroduced into the patient’s circulatory *** process makes ECMO essential for treating various medical conditions,both as a standalone therapy and as adjuvant ***-venous(VV)ECMO primarily supports respiratory function and indicates respiratory ***,veno-arterial(VA)ECMO provides hemodynamic and respiratory support and is suitable for cardiac-related *** study reviews recent literature to elucidate the evolving role of ECMO in trauma care,considering its procedural intricacies,indications,contraindications,and associated ***,the use of ECMO in trauma patients,particularly for acute respiratory distress syndrome and cardiogenic shock,has demonstrated promising outcomes despite challenges such as anticoagulation management and complications such as acute kidney injury,bleeding,thrombosis,and *** studies have shown that VV ECMO was associated with significantly higher survival rates than conventional mechanical ventilation,whereas other studies have reported that VA ECMO was associated with lower survival rates than VV *** plays a critical role in managing trauma patients,particularly those with acute respiratory *** research is necessary to explore the full potential of ECMO in trauma *** should have a clear understanding of the indications and contraindications for the use of ECMO to maximize its benefits in treating trauma patients.

关键词： Extracorporeal membrane oxygenation treatments Multiple trauma Respiratory distress syndrome Cardiogenic shock Contraindications Anticoagulants

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新鲜微播报

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少年科普世界 2025年第3期 2-3页

作者： dana·Q(文/图) 不详

会端茶倒水的机器人这款人形机器人名叫擎天柱Optimus,是2024年10月11日特斯拉公司举办的We Robot发布会上推出的。在发布会现场,Optimus机器人在人群中穿梭,打招呼,在舞台上跳舞,它还可以完成倒水、比心、拿礼物、猜拳等多种动作,并能... 详细信息

会端茶倒水的机器人这款人形机器人名叫擎天柱Optimus,是2024年10月11日特斯拉公司举办的We Robot发布会上推出的。在发布会现场,Optimus机器人在人群中穿梭,打招呼,在舞台上跳舞,它还可以完成倒水、比心、拿礼物、猜拳等多种动作,并能顺利识别物体,躲避障碍物。而且,它会乖乖自主充电,然后继续工作。

关键词：人形机器人自主充电 Robot 躲避障碍物发布会打招呼

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少年科普世界 2025年第1期 20-21页

作者： dana·Q(文/图) 不详

神奇墨水能打印多种色彩来自美国伊利诺伊大学厄巴纳-香槟分校的科研团队近日研制出一种新型的3D打印技术,只需要一种打印墨水就能实现多彩效果,而且能实现主流3D打印不具备的渐变效果。

关键词：打印墨水科研团队渐变效果

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Alkaline Treatment of Straw for Composite Material Production and Its Impact on Water Vapor Adsorption Characteristics

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Journal of Renewable Materials 2025年第2期13卷 363-383页

作者： Martin Böhm MilošJerman Martin Keppert Klára Kobetičová dana Koňáková Milena Pavlíková RobertČerný Department of Materials Engineering and Chemistry Faculty of Civil EngineeringCzech Technical University in PragueThákurova 7Prague16629Czech Republic

The effect of using 2%and 10%sodium hydroxide solution as surface treatment of rape straw on its water vapor adsorption properties is analyzed in the relative humidity(RH)range of 0%to 98%.Scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),and Fourier-transform infrared spectroscopy(FTIR)are used to investigate the morphological,chemical and structural changes of the treated straw *** mineral particles formed on the surface after the treatment are analyzed using X-ray diffraction(XRD).The application of sodium hydroxide solution results in the disruption of the straw *** the concentration of sodium hydroxide increases,the disruption of the straw surface increases,and the ability of the straw to adsorb water vapor also increases over the entire RH *** addition to the surface disruption and chemical changes caused by the alkaline treatment,the differences in the equilibrium moisture content of treated and untreated rape straw can also be attributed to the formation of minerals on the straw surface,namely calcite for the 2%sodium hydroxide solution,and gaylussite and thermonatrite for the 10%solution.

关键词： Modification of straw surface alkaline treatment sorption mechanism Guggenheim-Anderson-de Boer model(GAB)

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After Artificial Intelligence Breaks Longstanding Matrix Multiplication Records,Humans Quickly Do Better

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Engineering 2023年第9期28卷 1-3页

作者： dana Mackenzie Senior Technology Writer

In October 2022,machine learning experts at Deep Mind(London,UK),a subsidiary of Google(Mountain View,CA,USA),reported a“breakthrough”on an extremely common mathematical algorithm called matrix multiplication[1].In previous years,DeepMind has made headlines with its successes in using deep learning to master various games,such as Go[2],chess,and even the strategic board game Diplomacy,and,in a more recent and clearly practical application with its Alpha Fold program[3].

关键词： breakthrough Quick Deep

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The diffuse ionized gas in the Milky Way galaxy

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Science China(Physics,Mechanics & Astronomy) 2022年第12期65卷 70-71页

作者： dana S.Balser National Radio Astronomy Observatory Charlottesville VA 22903USA

Existence of a warm(104K),diffuse(0.1 cm^(-3)),ionized gas component in the Galactic disk in our Milky Way was first suggested by Hoyle and Ellis[1]based on low frequency radio continuum *** studies,primarily using H... 详细信息

关键词： primarily Existence galaxy

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Physical aspects of f(R,G_(μν)T^(μν))modified gravity theories

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Chinese Physics C 2023年第10期47卷 237-248页

作者： Mihai Marciu dana Maria Ioan Faculty of Physics University of Bucharest405 AtomistilorPOB MG-11RO-077125Bucharest-MagureleRomania

The paper extends basic Einstein–Hilbert action by incorporating an invariant derived from a specific contraction between the Einstein tensor and energy momentum *** represents a non–minimal coupling between the space–time geometry and matter *** fundamental Einstein–Hilbert action is extended by considering a generic function f(R,GμνTμν).This function is subsequently dissected into its primary components:a geometric part reliant on the scalar curvature,and another segment encapsulating the interaction between geometry and matter *** cosmological models are formulated at the backdrop of these dynamics,rooted in specific associations between the matter energy-momentum tensor and Einstein *** deriving the consequent field equations,the cosmological model's physical implications are explored through a dynamical system analysis applied to diverse coupling *** exploration reveals that the current model aligns with various phases in the Universe's evolution,potentially elucidating several late-time historical epochs.

关键词： dark energy cosmology modified gravity theories

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Foraminiferal biostratigraphy of the Miocene Qom Formation, northwest of the Qom, Central Iran

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Frontiers of Earth Science 2018年第1期12卷 237-251页

作者： Jahanbakhsh DANESHIAN Leila RAMEZANI dana Geology Department Kharazmi University Tehran 15719-14911 Iran

Near Dochah, in the type area of the Qom Formation, Central Iran, the Miocene is partly developed in pelagic facies. From the 894.1 meter thick, ＇a to e＇ members of this section, 152 samples were collected. Abundant planktonic foraminifera let us correlate the study section with the global planktonic foraminifera biozonations. High diversity of foraminifera in the study section allow us to adapt the study succession to global biozonations. Twenty-seven genera and thirty-four species are reported for the first time from the Dochah section. First reports of Praeorbulina sicana and Praeorbulina transitoria in the upper part of this section led to recognition of the Praeorbulina sicana lower occurrence subzone （M5a） biozone with a late Late Burdigalian age.

关键词： biostratigraphy foraminifera Miocene Central Iron

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Model Identification and Control of Electromagnetic Actuation in Continuous Casting Process With Improved Quality

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 203-215页

作者： Isabela Birs Cristina Muresan dana Copot Clara Ionescu Research Group of Dynamical Systems and Control Faculty of Engineering and ArchitectureGhent University and with EEDT Decision&ControlFlanders Make ConsortiumTech Lane Science Park 125 and 131B-9052 GhentBelgium.I.Birs the Automation Department Faculty of Automation and Applied InformaticsTechnical University of Cluj-NapocaRomania IEEE

This paper presents an original theoretical framework to model steel material properties in continuous casting line process. Specific properties arising from non-Newtonian dynamics are herein used to indicate the natural convergence of distributed parameter systems to fractional order transfer function models. Data driven identification from a real continuous casting line is used to identify model of the electromagnetic actuator device to control flow velocity of liquid steel. To ensure product specifications, a fractional order control is designed and validated on the system. A projection of the closed loop performance onto the quality assessment at end production line is also given in this paper.

关键词： Electromagnetic actuator fractional order control fractional order system model non-Newtonian material

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