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Palliative long-term abdominal drains vs large volume paracenteses for the management of refractory ascites in end-stage liver disease

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World Journal of Hepatology 2024年第3期16卷 428-438页

作者： Senamjit Kaur Rodrigo v Motta Bryony chapman victoria Wharton Jane D Collier Francesca Saffioti Oxford Liver Unit Department of Gastroenterology and HepatologyOxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom Oxford Liver Unit and Translational Gastroenterology Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom

BACKGROUND Long-term abdominal drains(LTAD)are a cost-effective palliative measure to manage malignant ascites in the community,but their use in patients with end-stage chronic liver disease and refractory ascites is not routine *** safety and cost-effectiveness of LTAD are currently being studied in this setting,with preliminary positive *** hypothesised that palliative LTAD are as effective and safe as repeat palliative large volume paracentesis(LvP)in patients with cirrhosis and refractory ascites and may offer advantages in patients’quality of *** To compare the effectiveness and safety of palliative LTAD and LvP in refractory ascites secondary to end-stage chronic liver *** A retrospective,observational cohort study comparing the effectiveness and safety outcomes of palliative LTAD and regular palliative LvP as a treatment for refractory ascites in consecutive patients with end-stage chronic liver disease followed-up at our United Kingdom tertiary centre between 2018 and 2022 was ***’s exact tests and the Mann-Whitney U test were used to compare qualitative and quantitative variables,***-Meier survival estimates were generated to stratify time-related outcomes according to the type of *** Thirty patients had a total of 35 indwelling abdominal drains and nineteen patients underwent regular *** baseline characteristics were similar between the *** antibiotics were more frequently prescribed in patients with LTAD(P=0.012),while the incidence of peritonitis did not differ between the two groups(P=0.46).The incidence of acute kidney injury(P=0.014)and ascites/drain-related hospital admissions(P=0.004)were significantly higher in the LvP *** overall survival was similar in the two groups(log-rank P=0.26),but the endpoint-free survival was significantly shorter in the LvP group(P=0.003,P<0.001,P=0.018 for first ascites/drain-related admission,acute kidney injury and drain

关键词： Decompensated liver cirrhosis Indwelling abdominal catheter Rocket drain Palliative care Safety Quality of life

流动家庭母亲的心声与社会工作的回应——基于T村母亲形象影像发声项目的分析

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中国青年政治学院学报 2013年第5期32卷 86-91页

作者：朱眉华吴世友 Mimi v.chapman 华东理工大学社会工作系上海200237 美国北卡罗来纳大学教堂山分校

运用影像发声法研究流动家庭母亲的生存状况与面临的挑战发现,子女教育、医疗健康、生活环境和闲暇时光是她们的主要关注点。这些主题既反映了她们在家庭教育、健康保护、生存环境和流动历程中的艰辛与困惑,同时也表达了她们对未来生活... 详细信息

运用影像发声法研究流动家庭母亲的生存状况与面临的挑战发现,子女教育、医疗健康、生活环境和闲暇时光是她们的主要关注点。这些主题既反映了她们在家庭教育、健康保护、生存环境和流动历程中的艰辛与困惑,同时也表达了她们对未来生活、社会保障及改善社会政策与社区环境等方面的强烈呼声。影像发声作为一种社区需求的评估方法,有利于社会工作有效地回应流动家庭的需求,并在此基础上提供更适切的专业服务。

关键词：流动家庭母亲社会工作需求评估社区服务影像发声

A tunable ferroelectric based unreleased RF resonator

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Microsystems & Nanoengineering 2020年第1期6卷 1334-1340页

作者： Yanbo He Bichoy Bahr Mengwei Si Peide Ye dana Weinstein Purdue University West LafayetteINUSA Kilby Labs Texas InstrumentsDallasTXUSA

This paper introduces the first tunable ferroelectric capacitor(FeCAP)-based unreleased RF MEMS resonator,integrated seamlessly in Texas Instruments’130 nm Ferroelectric RAM(FeRAM)*** designs presented here are monolithically integrated in solid-state CMOS technology,with no post-processing or release step typical of other MEMS *** array of FeCAPs in this complementary metal-oxide-semiconductor(CMOS)technology’s back-end-of-line(BEOL)process were used to define the acoustic resonance cavity as well as the electromechanical *** achieve high quality factor(Q)of the resonator,acoustic waveguiding for vertical confinement within the CMOS stack is studied and *** design considerations are discussed to obtain lateral confinement and suppression of spurious *** FeCAP resonator is demonstrated with fundamental resonance at 703 MHz and Q of *** gives a frequency-quality factor product f·Q=7:11×10^(11) which is 1.6×higher than the most state-of-the-art Pb(Zr,Ti)O_(3)(PZT)*** to the ferroelectric characteristics of the FeCAPs,transduction of the resonator can be switched on and off by adjusting the electric *** this case,the resonance can be turned off completely at±0.3 v corresponding to the coercive voltage of the constituent FeCAP *** novel switchable resonators may have promising applications in on-chip timing,ad-hoc radio front ends,and chip-scale sensors.

关键词： resonator tunable switched

深圳市2022—2023年输入性恶性疟原虫耐药基因突变情况

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中国热带医学 2024年第4期24卷 382-387页

作者：刘小莲高世同李媛唐屹君张倩彭博阳帆张仁利黄达娜深圳市疾病预防控制中心广东深圳518055

目的分析了解深圳市输入性恶性疟原虫耐药基因突变情况,帮助评估抗疟药的疗效和指导有效用药。方法收集2022—2023年从境外输入深圳市的恶性疟荧光定量聚合酶链反应(polymerase chain reaction,PCR)阳性的样本85例,提取基因组DNA,使用巢... 详细信息

目的分析了解深圳市输入性恶性疟原虫耐药基因突变情况,帮助评估抗疟药的疗效和指导有效用药。方法收集2022—2023年从境外输入深圳市的恶性疟荧光定量聚合酶链反应(polymerase chain reaction,PCR)阳性的样本85例,提取基因组DNA,使用巢式PCR扩增耐药基因:恶性疟原虫Kelch螺旋体蛋白基因(Plasmodium falciparum Kelch 13,PfK13)、多药耐药基因1(multidrug resistance 1,Pfmdr1)、氯喹抗性转运基因(chloroquine resistance transporter,Pfcrt)、二氢叶酸还原酶基因(dihydrofolate reductase,Pfdhfr)和二氢蝶酸合成酶基因(dihydropteroate synthase,Pfdhps),并进行双向测序,使用MEGA11.06软件分析这些耐药基因突变情况。结果研究发现PfK13错义突变(S549P)1例,同义突变4例。Pfmdr162.69%样本存在Y184F突变,未检测到N86Y突变体。Pfcrt基因中,未检测到72和73位点的突变,M74I、N75E和K76T突变分别占17.46%、15.87%和15.87%。Pfcrt基因野生型占主导(82.54%,52例),其次是I_(74)E_(75)T_(76)三重突变体(15.87%,10例)。Pfdhfr最常见的突变型为I_(51)R_(59)N_(108)(91.78%,67例),其次是野生型(2.74%,2例)。Pfdhps野生型占60.32%(38例),单突变K540E为最常见突变类型,检测到S436A、G437A、K540E、A581G、A613S、I431v、G556K、G579E位点突变。Pfdhfr-Pfdhps组合突变中,I_(51)R_(59)N_(108)-E540是频率最高的组合突变(11.48%),59.02%样本为Pfdhfr单独突变体。结论在本研究中,PfK13突变率低,且无报导的耐药突变,Y184F成为Pfmdr1突变主导,未发现有N86Y。Pfcrt野生型为主,其次为I_(74)E_(75)T_(76)三重突变体,Pfdhfr I_(51)R_(59)N_(108)三重突变非常普遍,本研究并未发现PfdhfrPfdhps完全抗性和超抗性突变体,但有其他的五重七重突变型。在未来的工作中,需要继续加强疟原虫耐药基因的监测,同时进一步结合体内疗效的监测来有效指导临床用药。

关键词：恶性疟原虫输入性耐药性基因突变

Role of phase separation in nanocomposite indium-tin-oxide films for transparent thermoelectric applications

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Journal of Materiomics 2021年第3期7卷 612-620页

作者： Peter P.Murmu Akhil Shettigar Shen v.Chong Zihang Liu dana Goodacre vedran Jovic Takao Mori Kevin E.Smith John Kennedy National Isotope Centre GNS SciencePO Box 30368Lower Hutt5010New Zealand The MacDiarmid Institute for Advanced Materials and Nanotechnology New Zealand Robinson Research Institute Victoria University of WellingtonPO Box 33436Lower Hutt5046New Zealand International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki305-0044Japan School of Chemical Sciences University of AucklandAuckland1142New Zealand Department of Physics Boston University BostonMA02215USA

We report that oxygen vacancies have a profound impact on phase separation and thermoelectric properties of ITO films grown at room *** vacancies in non-stoichiometric In1.8Sn0.2O2.5 films aided the formation of In-rich metallic *** yields a high electrical conductivity s=1540 Scm1 and Seebeck coefficient|a|=27.2 mvK1,which resulted in the highest power factor(a2 s=113.8 mW m1 K2)but low optical transmission(Top-25%).An increase in oxygen partial pressure resulted in stochiometric In1.8Sn0.2O3 films which improved the optical transparency by 300%(Top-75.4%),but power factor was reduced by-85%due to a decrease in a and s.A decrease in a was due to the lack of energy filtering of charge carriers in the stoichiometric ITO film which did not have In-rich metallic *** results showed that the valence band energy shifts with a change in oxygen partial pressure due to a decrease in carrier density,which implied a change in Fermi energy due to the reverse Moss-Burstein *** results showed that phase separation can be obtained in nanocomposite ITO films by tuning their stoichiometry simply by varying the oxygen partial pressure during deposition of thermoelectric materials at low temperatures.

关键词： Thermoelectric Indium-tin-oxide(ITO) Seebeck coefficient Power factor X-ray photoelectron spectroscopy(XPS)

First Principle Study on the Rectification of Molecular Junctions Based on the Thiol-ended Oligosilane

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Chinese Journal of Structural Chemistry 2015年第6期34卷 813-821页

作者： ZHANG Rong-Fang YANG E LI Yi LIN Li-Xiang LING Qi-dana College of Materials Science & Engineering Fujian Normal University College of Chemistry Fuzhou University

The electron transport properties of various molecular junctions based on the thiol-ended oligosilane are investigated through density functional theory combined with non-equilibrium Green＇s function formalism. Our calculations show that oligosilanes doped by the phenyl and -C10H6 groups demonstrate better rectifying effect and their rectification ratios are up to 15.41 and 65.13 for their molecular junctions. The current-voltage （I-v） curves of all the Au/ modified oligosilane/Au systems in this work are illustrated by frontier molecular orbitals, transmission spectra and density of states under zero bias. And their rectifying behaviors are analyzed through transmission spectra.

关键词： first principle thiol-ended oligosilane rectification

Physical aspects of f(R,GμvTμv) modified gravity theories

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Chinese Physics C 2023年第10期47卷 241-252页

作者： Mihai Marciu dana Maria Ioan Faculty of Physics University of Bucharest

The paper extends basic Einstein-Hilbert action by incorporating an invariant derived from a specific contraction between the Einstein tensor and energy momentum *** represents a non-minimal coupling between the space-time geometry and matter *** fundamental Einstein-Hilbert action is extended by considering a generic function f(R,GμvTμv).This function is subsequently dissected into its primary components:a geometric part reliant on the scalar curvature,and another segment encapsulating the interaction between geometry and matter *** cosmological models are formulated at the backdrop of these dynamics,rooted in specific associations between the matter energy-momentum tensor and Einstein *** deriving the consequent field equations,the cosmological model’s physical implications are explored through a dynamical system analysis applied to diverse coupling *** exploration reveals that the current model aligns with various phases in the Universe’s evolution,potentially elucidating several late-time historical epochs.

关键词： dark energy cosmology modified gravity theories

Global Wheat Head Detection Challenges:Winning Models and Application for Head Counting

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Plant Phenomics 2023年第3期5卷 460-473页

作者： Etienne David Franklin Ogidi Daniel Smith Scott chapman Benoit de Solan Wei Guo Frederic Baret Ian Stavness UMR 1114 EMMAH INRAEAvignonFrance Arvalis–Institut du végétal ParisFrance Department of Computer Science University of SaskatchewanSaskatoonCanada School of Food and Agricultural Sciences University of QueenslandBrisbaneAustralia Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan

Data competitions have become a popular approach to crowdsource new data analysis methods for general and specialized data science *** competitions have a rich history in plant phenotyping,and new outdoor field datasets have the potential to embrace solutions across research and commercial *** developed the Global Wheat Challenge as a generalization competition in 2020 and 2021 to find more robust solutions for wheat head detection using field images from different *** analyze the winning challenge solutions in terms of their robustness when applied to new *** found that the design of the competition had an influence on the selection of winning solutions and provide recommendations for future competitions to encourage the selection of more robust solutions.

关键词： Wheat specialized competition

Assessment of the exploitable biomass of thread herring(Opisthonema spp.)in northwestern Mexico

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Acta Oceanologica Sinica 2021年第9期40卷 53-65页

作者： Marcelino Ruiz-Dominguez Casimiro Quinonez-velazquez dana Isela Arizmendi-Rodriguez victor Manuel Gomez-Munoz Manuel Otilio Nevarez-Martinez Facultad de Ciencias del Mar Universidad Autonoma de SinaloaMazatlan 82000Mexico Instituto Politecnico Nacional Centro Interdisciplinario de Ciencias MarinasLa Paz 23000Mexico Instituto Nacional de Pesca y Acuacultura Centro Regional de Investigacion Pesquera Unidad GuaymasGuaymas 85400Mexico

In recent years,the small pelagic fishery on the Pacific northwest coast of Mexico has significantly increased fishing pressure on thread herring Opisthonema *** fishery is regulated using a precautionary approach(acceptable biological catch(ABC)and minimum catch size).However,due to fishing dynamics,fish aggregation habits and increased fishing mortality,periodic biomass assessments are necessary to estimate ABC and assess the resource *** Catch-MSY approach was used to analyze historical series of thread herring catches off the western Baja California Sur(BCS,1981–2018)and the Gulf of California(GC,1972–2018)to estimate exploitable biomass and target reference points in order to obtain catch *** to the results,in GC,the maximum biomass reached in 1972(at the beginning of fishery)and minimum biomass reached in 2015;the estimated exploitable biomass for 2019 was 42.2×10^(4) t;and the maximum sustainable yield(MSY)was 15.4×10^(4) *** the western BCS coast,the maximum biomass was reached in 1981(at the beginning of fishery)and minimum biomass was reached in 2017;the estimated exploitable biomass for 2019 was 3.2×10^(4) t;and the MSY was 1.2×10^(4) *** stocks showed a decrease in biomass over the past years and were currently near to point of full *** results suggest that the use of the Catch-MSY method is suitable to obtain annual biomass estimates,in order to establish an ABC,to know the current state of the resource,and to avoid overcoming the potential recovery of the stocks.

关键词： Catch-MSY thread herring exploitable biomass estimate